scholarly journals Assembly: Performing the materiality of Muslim prayer spaces

Scene ◽  
2018 ◽  
Vol 6 (2) ◽  
pp. 133-151 ◽  
Author(s):  
Julie Marsh
Keyword(s):  
Social Boundaries ◽  
Research Project ◽  
Site Specific ◽  
Specific Research ◽  
A Site ◽  
The Impact

This article reflects on the significance and impact of Assembly, a site-specific research project made and exhibited in Birmingham Central Mosque, Brick Lane Mosque and Old Kent Road Mosque from 2016 to 2020. Assembly provided an opportunity for Muslims and non-Muslims to experience Jumu’ah prayer first-hand via the site performances, which temporarily dissolved the religious/social boundaries of each mosque. Each performance highlighted the differences and relations between each site, furthering ideas of performativity in Muslim prayer spaces. This article summarizes the impact reported by each mosque community as well as reflecting upon the relationships built within the wider community.

scholarly journals Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Vera M. Todd ◽  
Lawrence A. Vecchi ◽  
Miranda E. Clements ◽  
Katherine P. Snow ◽  
Cayla D. Ontko ◽  
...  
Keyword(s):  
Primary Tumor ◽  
Hypoxia Inducible Factor ◽  
Metastatic Tumor ◽  
Breast Tumors ◽  
Tumor Burden ◽  
Site Specific ◽  
Tumor Dissemination ◽  
Specific Manner ◽  
A Site ◽  
The Impact

AbstractHypoxia is a common feature in tumors and induces signaling that promotes tumor cell survival, invasion, and metastasis, but the impact of hypoxia inducible factor (HIF) signaling in the primary tumor on dissemination to bone in particular remains unclear. To better understand the contributions of hypoxia inducible factor 1 alpha (HIF1α), HIF2α, and general HIF pathway activation in metastasis, we employ a PyMT-driven spontaneous murine mammary carcinoma model with mammary specific deletion of Hif1α, Hif2α, or von Hippel-Lindau factor (Vhl) using the Cre-lox system. Here we show that Hif1α or Hif2α deletion in the primary tumor decreases metastatic tumor burden in the bone marrow, while Vhl deletion increases bone tumor burden, as hypothesized. Unexpectedly, Hif1α deletion increases metastatic tumor burden in the lung, while deletion of Hif2α or Vhl does not affect pulmonary metastasis. Mice with Hif1α deleted tumors also exhibit reduced bone volume as measured by micro computed tomography, suggesting that disruption of the osteogenic niche may be involved in the preference for lung dissemination observed in this group. Thus, we reveal that HIF signaling in breast tumors controls tumor dissemination in a site-specific manner.

scholarly journals Sensitivity of Potential Groundwater Recharge to Projected Climate Change Scenarios: A Site-Specific Study in the Nebraska Sand Hills, USA

Water ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 950 ◽  
Author(s):  
Zablon Adane ◽  
Vitaly A. Zlotnik ◽  
Nathan R. Rossman ◽  
Tiejun Wang ◽  
Paolo Nasta
Keyword(s):  
Climate Change ◽  
Climate Projections ◽  
Emission Scenarios ◽  
Worst Case ◽  
Site Specific ◽  
Nebraska Sand Hills ◽  
Sand Hills ◽  
A Site ◽  
The Impact ◽  
The Relationship

Assessing the relationship between climate forcings and groundwater recharge (GR) rates in semi-arid regions is critical for water resources management. This study presents the impact of climate forecasts on GR within a probabilistic framework in a site-specific study in the Nebraska Sand Hills (NSH), the largest stabilized sand dune region in the USA containing the greatest recharge rates within the High Plains Aquifer. A total of 19 downscaled climate projections were used to evaluate the impact of precipitation and reference evapotranspiration on GR rates simulated by using HYDRUS 1-D. The analysis of the decadal aridity index (AI) indicates that climate class will likely remain similar to the historic average in the RCP2.6, 4.5, and 6.0 emission scenarios but AI will likely decrease significantly under the worst-case emission scenario (RCP8.5). However, GR rates will likely decrease in all of the four emission scenarios. The results show that GR generally decreases by ~25% under the business-as-usual scenario and by nearly 50% in the worst-case scenario. Moreover, the most likely GR values are presented with respect to probabilities in AI and the relationship between annual-average precipitation and GR rate were developed in both historic and projected scenarios. Finally, to present results at sub-annual time resolution, three representative climate projections (dry, mean and wet scenarios) were selected from the statistical distribution of cumulative GR. In the dry scenario, the excessive evapotranspiration demand in the spring and precipitation deficit in the summer can cause the occurrence of wilting points and plant withering due to excessive root-water-stress. This may pose significant threats to the survival of the native grassland ecology in the NSH and potentially lead to desertification processes if climate change is not properly addressed.

scholarly journals Identifying New Approaches for U.S. Drug Policy using Ownership, Location, and Internalization Factors

2020 ◽  
Vol 12 (3) ◽  
pp. 271-319
Author(s):  
Mariana Saenz ◽  
Antony G. Barilla
Keyword(s):  
Latin American ◽  
Economic Freedom ◽  
Political Stability ◽  
Site Specific ◽  
Eclectic Paradigm ◽  
A Site ◽  
The Impact ◽  
Drug Prohibition ◽  
Control Of Corruption ◽  
Latin American Countries

Abstract Dunning’s Eclectic Paradigm is used to assess the effectiveness and impact of U.S. drug prohibition policy on economic growth and political stability in Latin American countries as well as the decision making of Latin American Transnational Criminal Enterprises (TCE) in the cocaine-coca market. Results showed U.S. drug prohibition policy reduces the on-site supply but does not significantly reduce the transportation of cocaine and coca. U.S. drug prohibition policy also generated political instability for the region, and revealed policy externalities that facilitated TCE expansion. Tougher U.S. drug prohibition policy advances TCE by amplifying the impact that unemployment and local wages have on increases in cocaine-coca production, and by limiting the impact of control of corruption and economic freedom on coca eradication. Our results signal that a site-specific approach accompanied with policies that improve the farmers’ economic freedom, such as land formalization rights, and policies that lower unemployment rate facilitate effective U.S. drug prohibition policy.

Topographies of the Obsolete

2018 ◽  
Author(s):  
◽  
Neil Brownsword ◽  
◽  
Anne Helen Mydland
Keyword(s):  
Research Project ◽  
Site Specific ◽  
Art And Design ◽  
The Uk ◽  
A Site ◽  
Artistic Research

Topographies of the Obsolete is an artistic research project initiated by Professors Neil Brownsword and Anne Helen Mydland at Bergen Academy of Art and Design (KHiB) in collaboration with partner universities/institutions in Denmark, Germany, Switzerland, France and the UK. In 2012 the British Ceramics Biennial invited Bergen Academy of Art and Design (KHiB) to develop a site-specific artistic response to the former Spode Factory in Stoke-on-Trent as a key element of their 2013 exhibition programme. The project explores the landscape and associated histories of post-industry, with an initial emphasis on Stoke-on-Trent, a world-renowned ceramics capital that bears evidence of fluctuations in global fortunes.

Fictive Fathers in the Field

2020 ◽  
Vol 1 (3) ◽  
pp. 265-273
Author(s):  
Katrina Daly Thompson
Keyword(s):  
Cultural Studies ◽  
Ethnographic Research ◽  
A Site ◽  
The Impact

Through my own narrative about my relationship with my fictive father in Zanzibar and the impact of this relationship on my research, in this autoethnographic essay I explore three themes: fictiveness, fatherhood, and the field. These themes tie together different aspects of the term “patriography,” linking them to ethnography and its subgenre autoethnography. Drawing on the term “patriography” as the science or study of fathers, I use the concept of “the field” to examine the impact of narratives about fathers on not only the field as a site of ethnographic research but also on the field of African cultural studies.

The Impact of Bioconjugation on the Interfacial Activity of a Protein Biosurfactant

2018 ◽  
Author(s):  
Hossam H Tayeb ◽  
Marina Stienecker ◽  
Anton Middelberg ◽  
Frank Sainsbury
Keyword(s):  
Polyethylene Glycol ◽  
Colloidal Stability ◽  
Point Mutations ◽  
Pharmaceutical Formulations ◽  
Industrial Processes ◽  
Parent Molecule ◽  
Site Specific ◽  
Interfacial Activity ◽  
Surface Active ◽  
The Impact

Biosurfactants, are surface active molecules that can be produced by renewable, industrially scalable biologic processes. DAMP4, a designer biosurfactant, enables the modification of interfaces via genetic or chemical fusion to functional moieties. However, bioconjugation of addressable amines introduces heterogeneity that limits the precision of functionalization as well as the resolution of interfacial characterization. Here we designed DAMP4 variants with cysteine point mutations to allow for site-specific bioconjugation. The DAMP4 variants were shown to retain the structural stability and interfacial activity characteristic of the parent molecule, while permitting efficient and specific conjugation of polyethylene glycol (PEG). PEGylation results in a considerable reduction on the interfacial activity of both single and double mutants. Comparison of conjugates with one or two conjugation sites shows that both the number of conjugates as well as the mass of conjugated material impacts the interfacial activity of DAMP4. As a result, the ability of DAMP4 variants with multiple PEG conjugates to impart colloidal stability on peptide-stabilized emulsions is reduced. We suggest that this is due to constraints on the structure of amphiphilic helices at the interface. Specific and efficient bioconjugation permits the exploration and investigation of the interfacial properties of designer protein biosurfactants with molecular precision. Our findings should therefore inform the design and modification of biosurfactants for their increasing use in industrial processes, and nutritional and pharmaceutical formulations.

scholarly journals Functional expression of a yeast mitochondrial intron-encoded protein requires RNA processing at a conserved dodecamer sequence at the 3' end of the gene.

1989 ◽  
Vol 9 (4) ◽  
pp. 1507-1512 ◽  
Author(s):  
H Zhu ◽  
H Conrad-Webb ◽  
X S Liao ◽  
P S Perlman ◽  
R A Butow
Keyword(s):  
Genetic Analysis ◽  
Rna Processing ◽  
Fold Increase ◽  
Functional Expression ◽  
Rrna Gene ◽  
Yeast Mitochondria ◽  
Wild Type ◽  
Site Specific ◽  
Var1 Gene ◽  
A Site

All mRNAs of yeast mitochondria are processed at their 3' ends within a conserved dodecamer sequence, 5'-AAUAAUAUUCUU-3'. A dominant nuclear suppressor, SUV3-I, was previously isolated because it suppresses a dodecamer deletion at the 3' end of the var1 gene. We have tested the effects of SUV3-1 on a mutant containing two adjacent transversions within a dodecamer at the 3' end of fit1, a gene located within the 1,143-base-pair intron of the 21S rRNA gene, whose product is a site-specific endonuclease required in crosses for the quantitative transmission of that intron to 21S alleles that lack it. The fit1 dodecamer mutations blocked both intron transmission and dodecamer cleavage, neither of which was suppressed by SUV3-1 when present in heterozygous or homozygous configurations. Unexpectedly, we found that SUV3-1 completely blocked cleavage of the wild-type fit1 dodecamer and, in SUV3-1 homozygous crosses, intron conversion. In addition, SUV3-1 resulted in at least a 40-fold increase in the amount of excised intron accumulated. Genetic analysis showed that these phenotypes resulted from the same mutation. We conclude that cleavage of a wild-type dodecamer sequence at the 3' end of the fit1 gene is essential for fit1 expression.

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