The effects of oral monosodium glutamate consumption on lipid profile of experimental rats

2015 ◽  
pp. 6-12
Author(s):  
MM Sani ◽  
AB Bello ◽  
AA Adam ◽  
H Abubakar ◽  
S Ahmad ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Monosodium Glutamate

scholarly journals Effect oftrans-fat, fructose and monosodium glutamate feeding on feline weight gain, adiposity, insulin sensitivity, adipokine and lipid profile

2011 ◽  
Vol 106 (2) ◽  
pp. 218-226 ◽  
Author(s):  
Kate S. Collison ◽  
Marya Z. Zaidi ◽  
Soad M. Saleh ◽  
Angela Inglis ◽  
Rhea Mondreal ◽  
...  
Keyword(s):  
Weight Gain ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Lipid Profile ◽  
Clinical Chemistry ◽  
Monosodium Glutamate ◽  
Dietary Factors ◽  
High Fat ◽  
High Fructose ◽  
Feline Model

The incidence of obesity and type 2 diabetes mellitus (T2DM) is increasing, and new experimental models are required to investigate the diverse aspects of these polygenic diseases, which are intimately linked in terms of aetiology. Feline T2DM has been shown to closely resemble human T2DM in terms of its clinical, pathological and physiological features. Our aim was to develop a feline model of diet-induced weight gain, adiposity and metabolic deregulation, and to examine correlates of weight and body fat change, insulin homeostasis, lipid profile, adipokines and clinical chemistry, in order to study associations which may shed light on the mechanism of diet-induced metabolic dysregulation. We used a combination of partially hydrogenated vegetable shortening and high-fructose corn syrup to generate a high-fat–high-fructose diet. The effects of this diet were compared with an isoenergetic standard chow, either in the presence or absence of 1·125 % dietary monosodium glutamate (MSG). Dual-energy X-ray absorptiometry body imaging and a glucose tolerance test were performed. The present results indicate that dietary MSG increased weight gain and adiposity, and reduced insulin sensitivity (P < 0·05), whereas high-fat–high-fructose feeding resulted in elevated cortisol and markers of liver dysfunction (P < 0·01). The combination of all three dietary constituents resulted in lower insulin levels and elevated serum β-hydroxybutyrate and cortisol (P < 0·05). This combination also resulted in a lower first-phase insulin release during glucose tolerance testing (P < 0·001). In conclusion, markers of insulin deregulation and metabolic dysfunction associated with adiposity and T2DM can be induced by dietary factors in a feline model.

scholarly journals Pulverized Mangifera indica (Mango) Seed-kernel Modulated Serum Lipid Profile in Monosodium Glutamate-challenged Rats

2017 ◽  
Vol 5 (2) ◽  
pp. 72 ◽  
Author(s):  
Anthony Cemaluk C. Egbuonu ◽  
Gladys A. Ekwuribe
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Mangifera Indica ◽  
Monosodium Glutamate ◽  
Density Lipoprotein ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Oral Exposure ◽  
Seed Kernel ◽  
Sample Extract

Mangifera indica seed kernel was assessed for antinutirent content and effects on serum lipid profile of monosodium glutamate-challenged rats. Group A rats received 8000 mg/kg body weight, b.w of monosodium glutamate (MSG). Group B rats received the sample extract (300 mg/kg b.w). Group C rats were sham-administered distilled water. Groups D and E rats received 8000 mg/kg b.w of MSG in addition to 200 and 400 mg/kg b.w, respectively of sample extract. Tannin (29.21±5.39 mg/100 g) was highest (p<0.05) while phytate (0.38±0.02 mg/100g) was least. After fourteen days daily oral exposure, MSG-exposed rats had higher (p<0.05) total cholesterol (CHOL), triacylglycerol (TAG) and low density lipoprotein (LDL) but lower (p<0.05) high density lipoprotein (HDL) concentration compared to rats in the other groups. MSG-intoxicated rats co-treated respectively with 200 and 400 mg/kg b.w of the extract had dose dependent reduction (p<0.05) compared to the corresponding effects in non-extract-co-treated MSG-intoxicated rats. Compared to others, rats in the Extract group had higher (p<0.05) CHOL: TAG but lower (p<0.05) TAG:CHOL ratios while rats in the MSG-group had higher (p<0.05) HDL:LDL but lower (p<0.05) LDL:HDL ratios. Results demonstrated the preponderance of tannin in, and significant serum lipid lowering potential in normal and MSG-challenged rats of, the sample. Studies using antinutrient-process-reduced sample in hyperlipidemia-related health-challenged models and collaborating the suggested implication of lipid-profile-component-ratios are warranted and recommended.

scholarly journals Alterations in the lipid profile and liver enzymes of rats treated with monosodium glutamate

2015 ◽  
Vol 12 (3) ◽  
pp. 42 ◽  
Author(s):  
BS Okediran ◽  
AE Olurotimi ◽  
SA Rahman ◽  
OG Michael ◽  
JO Olukunle
Keyword(s):  
Lipid Profile ◽  
Liver Enzymes ◽  
Monosodium Glutamate

Taurine prevents fat deposition and ameliorates plasma lipid profile in monosodium glutamate-obese rats

Amino Acids ◽  
2010 ◽  
Vol 41 (4) ◽  
pp. 901-908 ◽  
Author(s):  
Tarlliza Romanna Nardelli ◽  
Rosane Aparecida Ribeiro ◽  
Sandra Lucinei Balbo ◽  
Emerielle Cristine Vanzela ◽  
Everardo Magalhães Carneiro ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Monosodium Glutamate ◽  
Plasma Lipid ◽  
Fat Deposition ◽  
Plasma Lipid Profile ◽  
Obese Rats

Effect of billary sphincterotomy on serum lipid profile: A pilot study

2001 ◽  
Vol 120 (5) ◽  
pp. A576-A576
Author(s):  
E FOGEL ◽  
T IMPERIALE ◽  
B DEVERAUX ◽  
S SHERMAN ◽  
J WATKINS ◽  
...  
Keyword(s):  
Pilot Study ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile
Sign in / Sign up

Export Citation Format

Share Document