scholarly journals Neurological impairment of children with history of prematurity and neonatal hyperbilirubinemia

2016 ◽  
Vol 43 (2) ◽  
pp. 59
Author(s):  
Ida Bagus Subanada ◽  
I Komang Kari ◽  
Abdul Hamid
Keyword(s):  
Multivariate Analysis ◽  
Serum Albumin ◽  
Univariate Analysis ◽  
Neurological Impairment ◽  
Unconjugated Bilirubin ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Bilirubin Concentration ◽  
History Of ◽  
High Bilirubin

Background In premature infants, the incidence of hyperbiliru-binemia is still high. Bilirubin encephalopathy can develop withoutmarked hyperbilirubinemia.Objective To know the incidence of neurological impairment inpremature with hyperbilirubinemia and the association betweenneurological impairment and serum unconjugated billirubin con-centration.Methods A retrospective study was conducted on 54 prematureswith history of hyperbilirubinemia and 54 without history of hyper-bilirubinemia born between 1997 and 1998 and discharged fromSanglah Hospital. Consecutive sampling was done. After univariateanalysis, multivariate analysis was used to identify the associationbetween serum unconjugated bilirubin concentration and neuro-logical impairment at the adjusted age of 318 months.Results There were statistically significant differences in mean ofage and neurological impairment between subjects with and with-out hyperbilirubinemia (p<0.0001 and 0.026). In subjects with hy-perbilirubinemia, univariate analysis showed significant differencesin means of serum unconjugated bilirubin concentration, gesta-tional age, birth weight, and serum albumin concentration betweensubject who had neurological impairment and who had no neuro-logical impairment with p = 0.005; 0.001; 0.002; <0.0001, respec-tively. Multivariate analysis found there were association betweenneurological impairment and serum unconjugated bilirubin concen-tration, gestational age, and serum albumin concentration withp<0.0001; 0.004; and <0.0001, respectively.Conclusion Neurological impairment in subject with hyperbiliru-binemia was greater than subject without hyperbilirubinemia. Se-rum unconjugated bilirubin concentration is one of three factorsthat associated with neurological impairment

scholarly journals Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0259064
Author(s):  
Yuichiro Ueda ◽  
Susumu Ookawara ◽  
Kiyonori Ito ◽  
Yusuke Sasabuchi ◽  
Hideyuki Hayasaka ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Regression Analysis ◽  
Serum Albumin ◽  
Oxygen Saturation ◽  
Linear Regression Analysis ◽  
Splanchnic Circulation ◽  
Control Group ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
History Of

The hepato-splanchnic circulation directly influences oxygenation of the abdominal organs and plays an important role in compensating for the blood volume reduction that occurs in the central circulation during hemodialysis (HD) with ultrafiltration. However, the hepato-splanchnic circulation and oxygenation cannot be easily evaluated in the clinical setting of HD therapy. We included 185 HD patients and 15 healthy volunteers as the control group in this study. Before HD, hepatic regional oxygen saturation (rSO2), a marker of hepatic oxygenation reflecting the hepato-splanchnic circulation and oxygenation, was monitored using an INVOS 5100c oxygen saturation monitor. Hepatic rSO2 was significantly lower in patients undergoing HD than in healthy controls (56.4 ± 14.9% vs. 76.2 ± 9.6%, p < 0.001). Multivariable regression analysis showed that hepatic rSO2 was independently associated with body mass index (BMI; standardized coefficient: 0.294), hemoglobin (Hb) level (standardized coefficient: 0.294), a history of cardiovascular disease (standardized coefficient: -0.157), mean blood pressure (BP; standardized coefficient: 0.154), and serum albumin concentration (standardized coefficient: 0.150) in Model 1 via a simple linear regression analysis. In Model 2 using the colloid osmotic pressure (COP) in place of serum albumin concentration, the COP (standardized coefficient: 0.134) was also identified as affecting hepatic rSO2. Basal hepatic oxygenation before HD might be affected by BMI, Hb levels, a history of cardiovascular disease, mean BP, serum albumin concentration, and the COP. Further prospective studies are needed to clarify whether changes in these parameters, including during HD, affect the hepato-splanchnic circulation and oxygenation in HD patients.

scholarly journals Serum Albumin and Future Risk of Hip, Humeral, and Wrist Fractures in Caucasian Men: New Findings from a Prospective Cohort Study

2019 ◽  
Vol 28 (5) ◽  
pp. 401-409 ◽  
Author(s):  
Setor K. Kunutsor ◽  
Ari Voutilainen ◽  
Michael R. Whitehouse ◽  
Samuel Seidu ◽  
Jussi Kauhanen ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Area Under The Curve ◽  
Fracture Prevention ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Baseline Serum ◽  
Increased Risk ◽  
New Findings ◽  
Caucasian Men ◽  
Low Serum

Objective: Low serum albumin concentration is associated with poor health outcomes, but its relationship with the risk of fractures has not been reliably quantified. We aimed to assess the prospective association of serum albumin with the risk of fractures in a general population. Subjects and Methods: Baseline serum albumin concentrations were measured in 2,245 men aged 42–61 years in the Kuopio Is­chemic Heart Disease study. Hazard ratios (HRs) (95% confidence intervals) were calculated for incident fractures. Results: A total of 121 fractures (hip, humeral, or wrist) were recorded during a median follow-up of 25.6 years. The risk of fractures increased linearly below a serum albumin concentration of ∼48 g/L. The age-adjusted HR (95% CI) for fractures per 1 standard deviation lower serum albumin was 1.24 (1.05–1.48). On further adjustment for several conventional and emerging risk factors, the HR was attenuated to 1.21 (1.01–1.45). Comparing the bottom versus top quartile of serum albumin levels, the corresponding adjusted HRs were 2.48 (1.37–4.48) and 2.26 (1.23–4.14). The association of serum albumin with fracture risk did not differ substantially according to age, body mass index, blood pressure, physical activity, alcohol consumption, socioeconomic status, inflammation, prevalent diseases, and smoking. Serum albumin at a threshold of 41.5 g/L demonstrated an area under the curve of 0.5850. Conclusion: In middle-aged Caucasian men, low serum albumin is associated with an increased risk of future fractures. The potential relevance of serum albumin concentrations in fracture prevention and prediction deserves further evaluation.

scholarly journals Trends and Outcomes Associated With Serum Albumin Concentration Among Incident Dialysis Patients in the United States

2008 ◽  
Vol 18 (4) ◽  
pp. 323-331 ◽  
Author(s):  
George A. Kaysen ◽  
Kirsten L. Johansen ◽  
Su-Chun Cheng ◽  
Chengshi Jin ◽  
Glenn M. Chertow
Keyword(s):  
United States ◽  
Serum Albumin ◽  
The United States ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Dialysis Patients

scholarly journals Serum albumin concentration of donor cows as an indicator of developmental competence of oocytes

2019 ◽  
Vol 125 ◽  
pp. 184-192 ◽  
Author(s):  
Mario P. Smuts ◽  
Sonya de Bruyn ◽  
Peter N. Thompson ◽  
Dietmar E. Holm
Keyword(s):  
Serum Albumin ◽  
Developmental Competence ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Donor Cows

Low serum albumin concentration predicts the need for surgical intervention in neonates with necrotizing enterocolitis

2020 ◽  
Vol 55 (12) ◽  
pp. 2625-2629
Author(s):  
Shazia P. Sharif ◽  
Florian Friedmacher ◽  
Amir Amin ◽  
Rafdzah A. Zaki ◽  
Michael F. Hird ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Necrotizing Enterocolitis ◽  
Surgical Intervention ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Low Serum
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