scholarly journals Potentially predictive factors for hearing function improvement in pediatric cytomegalovirus infection therapy

2021 ◽  
Vol 61 (5) ◽  
pp. 235-9
Author(s):  
Agung Triono ◽  
Elisabeth Siti Herini ◽  
Braghmandita Widya ◽  
Dian Kesumapramudya Nurputra

Background Symptomatic congenital cytomegalovirus (CMV) infection has an impact mainly on neurological sequelae, including sensorineural deafness. Because of the long-term impact, early treatment of CMV infection is mandatory. However, predictive factors for hearing function improvement in CMV infection therapy remain unexamined. Objective To evaluate potential predictive factors for hearing improvement in pediatric CMV infection therapy. Methods All medical record data of patients aged 0-6 years with CMV infection who completed a 6-week course of ganciclovir therapy or a combination of a 4-week course of ganciclovir and a 2-week course valganciclovir from January 2013 to December 2017 were collected. Age at onset of therapy, gender, gestational age, nutritional status, multi-organ involvement, and neurological symptoms were studied as potential predictive factors of hearing improvement in CMV therapy. The effectiveness of CMV infection therapy on improving hearing function was measured with the brainstem evoked response audiometry (BERA) test. Results BERA tests proportion in the right, left, and best ear showed significant improvement after therapy. All variables analyzed were not statistically significant as predictive factors for hearing improvement in CMV infection therapy. Conclusion Ganciclovir/valganciclovir therapy in CMV infection patients accounted for the improvement of hearing impairment. However, none of the assessed factors were considered predictive for improving hearing function in CMV infection therapy.

2020 ◽  
Vol 102 (2) ◽  
pp. 84-93
Author(s):  
R Haihua ◽  
W Xiaobing ◽  
P Jie ◽  
H Xinxin

Objective Elastofibroma is a rare soft-tissue tumour. This study retrospectively analysed and summarised the clinical, imaging and typical pathological features, together with the short- and long-term surgical outcomes of patients with pathologically confirmed soft-tissue elastofibroma to improve their management. Materials and methods We enrolled 73 patients with pathologically confirmed soft-tissue elastofibroma from January 2010 to December 2018. The general, clinical, diagnostic and treatment-related data, operation notes, pathological examination results and follow-up status were obtained by reviewing inpatient medical records. Disease onset age, sex, tumour location and size were statistically analysed using the chi square and rank sum tests. Results A total of 90 lesions from 73 patients were examined. Among these, 56 patients had single lesions: 27 were under the right scapula, 26 were under the left scapula, 1 at the umbilicus, 1 on the aortic valve, 1 on the right hip and 17 at the bilateral inferior angles of the scapula. The average age at onset was 56.4 years (range: 6–82 years). The male-to-female incidence ratio was about one to three. Tumour diameter and follow-up duration ranged from 2cm to 12cm and from one month to nine years, respectively; recurrence was not observed. The main postoperative complication was wound effusion, occurring in 24 sites among the 90 lesions, corresponding to an incidence rate of 26.7%. Conclusions A correct diagnosis of elastofibroma can be made prior to surgical resection by examining typical clinical features and characteristic imaging findings. Short- and long-term outcomes of local excision are good, with no further recurrence.


2016 ◽  
pp. 873-886
Author(s):  
Jonathan Bishop

A disability is a physical or mental impairment that has an adverse long-term impact on someone's ability to carry out normal day-to-day activities. This is often thought of in terms of medical conditions with clearly defined symptoms. This chapter, however, argues that it is these symptoms that can be considered to be the impairments and that in the right environment can in fact be advantageous. Someone may be have a medical diagnosis but not be symptomatic due to medication, for instance. In this chapter, a set of symptoms is made up from a number of different scales, called Social-Behavioural Traits (SBTs), which are affected by a person's Serotonergic-Dopamagenic Asynchronicity (SDA). This chapter discusses the role of affective computing in achieving harmony between people with various personality differences, including a model for explaining how technology can influence SDA and SBTs for the better.


2019 ◽  
Vol 11 (1) ◽  
pp. 243-272 ◽  
Author(s):  
Xavier Vives

This review surveys technological disruption in banking, examining its impact on competition and its potential to increase efficiency and customer welfare. It analyzes the possible strategies of the players involved—incumbents and FinTech and BigTech firms—and the role of regulation. The industry is facing radical transformation and restructuring, as well as a move toward a customer-centric platform-based model. Competition will increase as new players enter the industry, but the long-term impact is more open. Regulation will decisively influence to what extent BigTech will enter the industry and who the dominant players will be. The challenge for regulators will be to keep a level playing field that strikes the right balance between fostering innovation and preserving financial stability. Consumer protection concerns rise to the forefront.


2021 ◽  
Vol 20 (2) ◽  
pp. 234-251
Author(s):  
Laurence M. Hauptman

AbstractIn November 1876, two Oneida Indians, Abram Elm and Lewis Doxtator, were arrested for voting illegally in the twenty-third congressional district election in New York. Their trial was held the next year in a federal court in the Northern District of New York, the same venue where Susan B. Anthony had been tried and convicted on a similar charge four years earlier. This essay focuses on the significance of the historically neglected United States v. Elm case, its origins, why the decision was rendered, and its short-term and long-term impact. Importantly, United States v. Elm has cast a long shadow over Supreme Court decisions—from the time of Elk v. Wilkins in 1884 right up to City of Sherrill v. Oneida Indian Nation in New York in 2005. In going to the polls, the two Native Americans were not trying to deny their Oneida identity; they saw themselves as dual citizens advocating a different course of resistance.


2015 ◽  
Vol 7 (3) ◽  
Author(s):  
Esther Boas

Abstract: Regardless of age, malignant diseases and deaths can occur even in children. About 100 of one million children suffering from cancer every year. Indonesian laws do not allow the children to give any decision or refusal about the medical treatment directed to them. Moreover, there are posibilities that they do not get any information from the medical staff. The children know that something wrong is going to happen to them although their parents and doctors tell them nothing. Lack of information make them frightened and anxious. These feelings can give a long term impact if they finally being cured from their diseases. Medical staffs and family members have very important roles in giving the right information to the children concerning the current problem and the worst possibility, and also in giving physicological support.Keywords: dying child, cancer, communicationAbstrak: Kematian tidak memilih usia; anak-anak pun tidak luput dari kanker dan kematian. Sekitar 100 dari 1 juta anak terkena kanker setiap tahunya. Menurut undang-undang yang berlaku di Indonesia, anak-anak tidak diperbolehkan memberikan persetujuan atau penolakan atas tindakan kedokteran yang akan dilakukan padanya. Bahkan, informasi dari petugas kesehatan bisa saja tidak pernah mereka dengar. Anak-anak dapat mengetahui singkatnya harapan hidup mereka meskipun orangtua dan dokter tidak menceritakannya. Kurangnya informasi yang mereka dapatkan bisa menimbulkan rasa takut dan cemas, bahkan bisa berdampak panjang jika ternyata mereka dapat sembuh dari sakitnya. Tenaga medis dan keluarga berperan penting untuk memberikan informasi tentang masalah yang dihadapi, kemungkinan terburuk yang akan mereka hadapi, serta memberikan dukungan secara psikologis.Kata kunci: anak masa kritis, kanker, komunikasi


2019 ◽  
Vol 19 (2) ◽  
pp. 225-241 ◽  
Author(s):  
Vikki McCall ◽  
Madhu Satsangi ◽  
Corinne Greasley-Adams

This article explores older owner occupiers in lower value properties who, having acquired their home through the Right to Buy (RTB) in the 1980s, are now experiencing housing-related challenges in older age. This article outlines the views and perceptions of older owner occupiers, social landlords, voluntary groups and housing organisations to explore the legacy of the RTB. Current and future policy challenges in the area include the differentiation of home owners, difficulties of selling property with low equity in older age and the relationship between health and housing. This article calls to widen the analysis of the long-term impact of the RTB to owner occupiers in lower value properties and notes that ‘ageing in place’ goes beyond looking at people’s current house to the linked housing choices available to them. We recommend that policy support be extended to older home owners to increase housing choice in older age.


Author(s):  
Jonathan Bishop

A disability is a physical or mental impairment that has an adverse long-term impact on someone's ability to carry out normal day-to-day activities. This is often thought of in terms of medical conditions with clearly defined symptoms. This chapter, however, argues that it is these symptoms that can be considered to be the impairments and that in the right environment can in fact be advantageous. Someone may be have a medical diagnosis but not be symptomatic due to medication, for instance. In this chapter, a set of symptoms is made up from a number of different scales, called Social-Behavioural Traits (SBTs), which are affected by a person's Serotonergic-Dopamagenic Asynchronicity (SDA). This chapter discusses the role of affective computing in achieving harmony between people with various personality differences, including a model for explaining how technology can influence SDA and SBTs for the better.


Author(s):  
Terry Buss

Governments around the world recently launched policies to make public data more accessible and transparent. Policies are intended to encourage more interaction between government and citizens, foster accountability, and improve efficiency, effectiveness, economy, and perhaps equity. Open data initiatives depend almost entirely on information technology, applications, data and security. Policies while laudable have produced mixed results as governments implement them. Governments have been more or less successful depending on how much support they have among policy makers and the civil service, the extent to which whistle blowers and hackers have exploited the systems, met demands of citizens and stakeholders, made available funding in the right amounts over the long-term, and held people accountable. In spite of advances in open data, its long term impact on government performance and indeed democracy has yet to be determined.


Author(s):  
J. L. Gattis

Signs warning motorists that traffic on the cross street does not stop can be found at some intersections that are not all-way stop controlled. These “cross traffic” signs have been installed to furnish a special warning where some motorists on the minor approaches may incorrectly assume that the major crossing street also has stop signs. The variety of cross traffic signs in use lack uniformity of message, color, shape, and placement location. A literature review and two surveys were conducted to examine (a) present usage of cross traffic signs, (b) circumstances under which these signs have been installed, (c) studies of the effectiveness of the signs, and (d) future actions. The accident data reviewed offered mixed results about the signs’ effectiveness: at some locations the signs appeared to reduce accident frequencies; at others, accidents continued despite their presence. If the intersections at which these signs have been installed are experiencing right-angle accidents due to a number of different factors, then countermeasures aimed at the right-of-way misperception problem may affect only some of the accidents. Expanded use of the signs could cause drivers to expect them at all two-way stop-controlled situations. More information on the long-term impact of the signs and a study of alternative approaches would help traffic engineers evaluate the desirability of these signs.


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