scholarly journals Oral Submucous Fibrosis - A Review

2021 ◽  
Vol 10 (32) ◽  
pp. 2665-2671
Author(s):  
Falguni Patel ◽  
Shreyas N. Shah ◽  
Christina James
Keyword(s):  
Oral Cavity ◽  
Precancerous Lesions ◽  
Oral Submucous Fibrosis ◽  
Classification Systems ◽  
Oral Disease ◽  
Areca Nut ◽  
Functional Aspects ◽  
Premalignant Condition ◽  
Submucous Fibrosis ◽  
Upper Third

A common oral disease named as oral submucous fibrosis (OSMF) has the tendency to usually affect many areas of the oral cavity as well as involving the area of pharynx. The characteristic feature of oral submucous fibrosis is the fibrosis in submucosal area which involves maximum part of oral cavity leading to advanced lock jaw as a result of rigidity in cheeks, pharynx, lips and upper third part of the oesophageal canal progressing to dysphagia. It has been reported that OSMF occurs mainly in persons who are habituated to chew areca nut or products containing areca nut along with other ingredients. In recent years with the introduction of commercially available Gutka and other areca nut products, the incidence of OSMF is increasing especially in the younger generations. OSMF is irreversible and persists even after cessation of chewing habit and the severity increases along with the duration of habit. In 2007, the categorization of oral submucous fibrosis was done as a premalignant condition by WHO and it has higher chances of malignant transformation. Early diagnosis and application of proper treatment modality is mandatory to reduce morbidity and mortality rate. There are many classification systems that have been proposed in literature for oral submucous fibrosis, among which many are based on clinical features, some of them on functional aspects and others are based on histopathological aspects. Here is an attempt to enlighten the facts and recent updates of clinical, functional, histopathological features as well as pathogenesis and management of oral submucous fibrosis. The complete knowledge of oral submucous fibrosis is a useful to the clinicians as well as academicians and researchers for timely detection and proper management of the disease. KEY WORDS Oral Submucous Fibrosis, Precancerous Lesions, Precancerous Conditions, Sclerosing Stomatitis

scholarly journals Hypoxia Inducible Factor-1α (HIF-1α): A Biomarker for Detection of Malignant Transformation in Oral Submucous Fibrosis

2021 ◽  
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Hypoxia Inducible Factor ◽  
Asian Population ◽  
Hypoxia Inducible Factor 1Α ◽  
Cell Stability ◽  
Premalignant Condition ◽  
Submucous Fibrosis ◽  
And Function ◽  
Upper Third

Oral submucous fibrosis (OSMF) is a premalignant condition, which involves the oral cavity as well as pharynx and upper third of the esophagus. It is a predominant disease of South and South-East Asian population. OSMF has the highest rate of malignant transformation among the other oral premalignant disorders (OPMD) that is 7-30% with a prevalence of about 0.03% to 6.42%. OSMF is described by extensive fibrosis of submucosa and reduced vascularity, which results in compromised blood supply guiding to hypoxia of tissue. This tissue hypoxia brings about the transcription of a set of genes associated with angiogenesis, breakdown of iron/glucose, cell division and cell stability. Hypoxia Inducible Factor-1α (HIF-1α) is the main biomarker intervening in this reaction. The alteration of cells to hypoxia emerges to be mediated through hypoxia inducible factor, which is said to be linked with malignant transformation of epithelium. Research-based studies covered on the probable mechanism of HIF-1α were explored using PubMed and Google Scholar. In this review, we analyzed over 40 articles from the years 2004-2021, which were published regarding the structure and function of HIF-1α, and its association with OSMF. Research articles in which HIF-1α is used separately or in combination with other biomarkers in oral submucous fibrosis have been selected. Keywords: Biomarker; Oral Submucous Fibrosis; Esophagus; Hypoxia.

scholarly journals A clinical study on precancerous lesions of oral cavity in patients attending dental hospital, Telangana

2019 ◽  
Vol 6 (11) ◽  
pp. 4739
Author(s):  
Soundarya Hanumakonda ◽  
Marri Swetha ◽  
Mallela Bhashitha ◽  
Harsha Mudigonda
Keyword(s):  
Oral Cavity ◽  
Oral Lichen Planus ◽  
Precancerous Lesions ◽  
Oral Submucous Fibrosis ◽  
Age Distribution ◽  
Precancerous Lesion ◽  
Number Of Patients ◽  
Dental Hospital ◽  
Submucous Fibrosis ◽  
Oral Lichen

Background: Aim of the retrospective study is to determine the type and frequency of the precancerous lesions of the oral cavity and to assess their sex, age distribution among the patients.Methods: Study was conducted based on year-wise data collected during 2015 to 2018 of all the patients with precancerous lesions of oral cavity.Results: The total number of patients was 1247, out of which 803 (64.39%) were males and 444 (35.60%) were females. Most common precancerous lesion is oral submucous fibrosis (70.24%) followed by oral lichen planus (19.08%), leukoplakia (8.98%), erythroplakia (1.68%).Conclusions: We observed marked geographical variation in the incidences of various precancerous lesions. Mostly males are affected by precancerous lesions than females.

scholarly journals Oral Submucous Fibrosis: An Overview

2017 ◽  
Vol 1 (1) ◽  
pp. 22-26
Author(s):  
Ramandeep S Narang
Keyword(s):  
Oral Cavity ◽  
Severe Disease ◽  
Oral Submucous Fibrosis ◽  
Combination Drug ◽  
Slaked Lime ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Upper Third ◽  
Malignant Condition ◽  
Combination Drug Treatment

ABSTRACT Oral submucous fibrosis (OSMF) is a chronic and potentially malignant condition of the oral cavity. It occurs predominantly in India and Southeast Asia. The pathogenesis of OSMF is not well established, but it is believed to be multifactorial. Chewing of betel quid (containing areca nut, tobacco, and slaked lime) has been recognized as one of the most important risk factors. It is characterized by a juxtaepithelial inflammatory reaction followed by fibroelastic changes in the lamina propria and associated epithelial atrophy. The disease affects most parts of the oral cavity as well as the upper third of the esophagus. The abnormal fibrosis causes blanching and stiffness of the mouth, with eventual immobility of the lips, cheeks, tongue, soft palate, and uvula. Treatment of OSMF is difficult; a combination drug treatment is administered. In patients with severe disease, physical therapy and/or surgery is added to drug therapy. How to cite this article Narang RS, Arora A. Oral Submucous Fibrosis: An Overview. Curr Trends Diagn Treat 2017;1(1):22-26.

scholarly journals KNOWLEDGE, ATTITUDE AND PRACTICE TOWARDS ORAL SUBMUCOUS FIBROSIS AND ITS ADJUVANT THERAPY

2020 ◽  
pp. 1-3
Author(s):  
Manju J ◽  
Mutum Sangeeta Devi ◽  
Rahul B ◽  
Vasant M Bhanushali
Keyword(s):  
High Risk ◽  
Adjuvant Therapy ◽  
Oral Cavity ◽  
Oral Submucous Fibrosis ◽  
Areca Nut ◽  
Oral Diseases ◽  
Traditional Medicines ◽  
Attitude And Practice ◽  
Submucous Fibrosis ◽  
Knowledge Attitude And Practice

Introduction: Oral Submucous Fibrosis (OSMF) is a chronic progressive debilitating disease of oral cavity resulting from the habits like chewing areca nut and its products. It has a high risk of morbidity. The aim of the present study is to evaluate the awareness of osmf and its adjuvant therapy for treatment of osmf. Material and methods: It include 100 dentists from various parts of India and a questionnaire of 10 questions were preformed and distributed to them. Response were collected and assessment has been done accordingly. Results: Most of the dentist are aware of osmf and the adjuvant therapy of treating osmf. Conclusion: OSMF is mostly a disease of the Indian sub-continent, where chewing arecanut is widespread. Traditional medicine helps also often cure symptoms, but also eliminates root causes of illness. However, more research is still needed on alternative and traditional medicines and their efficacy and effectiveness in the treatment of oral diseases.

scholarly journals A prospective study of evaluation of methods to decrease the morbidity in oral submucous fibrosis

2015 ◽  
Vol 1 (1) ◽  
pp. 28 ◽  
Author(s):  
Dr. Kamal Devgan ◽  
Dr. Priyank Mistry ◽  
Dr. Tapan Nagpal
Keyword(s):  
Oral Cavity ◽  
Prospective Study ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Burning Pain ◽  
Chronic Disorder ◽  
Submucous Fibrosis ◽  
A Prospective Study ◽  
Upper Third ◽  
Tongue Mobility

Aim: To evaluate the effect of antioxidants, intralesional steroids and laser in decreasing morbidity in patients of oral submucous fibrosisIntroduction: Oral submucous fibrosis (OSMF) is a chronic disorder characterized by progressive fibrosis of the lining mucosa of the upper digestive tract involving the oral cavity, oropharynx, and rarely the upper third of the esophagus, resulting in intolerance to spicy foods, burning sensation in the mouth, limitation of mouth opening and tongue mobility, xerostomia, dysphagia and hoarseness. OSMF has been reported to occur commonly in conjunction with premalignant diseases such as leukoplakia and lichen planus and therefore aprecursor to oral cavity cancer in many cases.Materials and Methods: This prospective study included 60 patients with OSMF attending the Ear Nose & Throat Clinic of Dhiraj Hospital, Piparia. Patients of OSMF were evaluated as per Performa and for proper treatment planning were broadly classified into 4 groups based on classification suggested by Sinha et al.Conclusion: Lycopene, an antioxidant has significant response in early cases of OSMF in decreasing the burning pain in oral cavity in OSMF. Inj. triamcinolone and Inj. hyaluronidase, given submucosally havesignificant response in early cases of OSMF to improve cheek flexibility.CO2 laser have significant results in achieving satisfactory mouth opening in OSMF but notcheek flexibility.

scholarly journals Immunohistochemical Analysis of Myofibroblasts Using α- SMA in Oral Submucous Fibrosis Turning into Malignancy- A Case Report and Review

2021 ◽  
pp. 192-198
Author(s):  
Swapan Kumar Purkait ◽  
. Abhinandan ◽  
Nimisha Priya ◽  
Sriyanshi Singh ◽  
Sneha Singh
Keyword(s):  
Case Report ◽  
Immunohistochemical Study ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Immunohistochemical Analysis ◽  
Invasive Front ◽  
Premalignant Condition ◽  
Submucous Fibrosis ◽  
Very High ◽  
Premalignant Conditions

Oral submucous fibrosis is a premalignant condition, characterized by fibrosis in oral mucosa causing stiffness of mucosa and leading to reduced mouth opening. The malignant transformation of oral submucous fibrosis is very high among the rest of the premalignant conditions. Chronic chewing of arecanut causes production of myofibroblasts. These myofibroblasts plays an important role in neoangiogenesis as well as disintegration of the basement membrane at the tumor invasive front leading to carcinoma.  Here, we are doing an Immunohistochemical study using alpha SMA for proper microscopic visulizations of myofibroblastic activity in an OSF patient, encompassing the pathogenesis and malignant potentiality of the disease.

scholarly journals Nasolabial Flap in the Management of Oral Submucous Fibrosis

2016 ◽  
Vol 1 (1) ◽  
pp. 27-29
Author(s):  
Vaishali Jamdade ◽  
Amit LNU
Keyword(s):  
Surgical Treatment ◽  
Physical Therapy ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Oral Carcinoma ◽  
Treatment Modalities ◽  
Nasolabial Flap ◽  
Mahatma Gandhi ◽  
Premalignant Condition ◽  
Submucous Fibrosis

ABSTRACT Oral submucous fibrosis (OSMF) is a premalignant condition associated with restricted mouth opening. Oral submucous fibrosis is poorly understood and unsatisfactorily treated disease. Serious complication is the risk of development of oral carcinoma. Different treatment modalities like medical, surgical, physical therapy or combination are used to improve the condition of the patient. Surgical treatment is usually indicated in late and irreversible stage of the disease. Successful use of nasolabial flap in the management of OSMF is presented. How to cite this article Jamdade V, Sharma S, Chitlangia P, Amit. Nasolabial Flap in the Management of Oral Submucous Fibrosis. J Mahatma Gandhi Univ Med Sci Tech 2016;1(1):27-29.

scholarly journals Oral submucous fibrosis: a premalignant condition in a 14-year-old Indian girl

2013 ◽  
Vol 2013 (dec12 1) ◽  
pp. bcr2013200786-bcr2013200786 ◽  
Author(s):  
A. Deshpande ◽  
S. Kiran ◽  
S. Dhillon ◽  
R. Mallikarjuna
Keyword(s):  
Oral Submucous Fibrosis ◽  
Indian Girl ◽  
Premalignant Condition ◽  
Submucous Fibrosis

Reasons for Initiation of Areca Nut and Related Products in Patients with Oral Submucous Fibrosis within an Endemic Area in Gujarat, India

2020 ◽  
Vol 55 (9) ◽  
pp. 1413-1421 ◽  
Author(s):  
Chandramani B. More ◽  
Naman Rajeshkumar Rao ◽  
Sucheta More ◽  
Newell W. Johnson
Keyword(s):  
Endemic Area ◽  
Oral Submucous Fibrosis ◽  
Areca Nut ◽  
Submucous Fibrosis
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