scholarly journals The ability of platelet-rich plasma to regenerate a non-vital immature permanent teeth

2021 ◽  
Vol 24 (3) ◽  
Author(s):  
Salma Abdo ◽  
Amera Alkaisi
Keyword(s):  
Platelet Rich Plasma ◽  
Cold Test ◽  
Apical Periodontitis ◽  
Permanent Teeth ◽  
Pulp Chamber ◽  
Pulp Regeneration ◽  
Immature Teeth ◽  
Therapeutic Protocol ◽  
Regenerative Endodontic Treatment

Objectives: To test the ability of platelet-rich plasma clinically and radiologically for pulp regeneration of immature teeth with apical periodontitis. Material and Methods: An experimental study was conducted From (March/2018-July/2020)   12 upper central immature incisors with acute apical periodontitis and necrotic pulp from six patients receiving regenerative endodontic treatment using concentrated platelets rich plasma were performed by the same endodontist at Mediclinic Middle East Hospitals. Informed consent, including explanation of risks and alternative treatments or no treatment were prepared and filled by the patient parents. The therapeutic protocol was involved accessing the pulp chamber; irrigation copiously with sodium hypochlorite; applying calcium hydroxide as intracanal medicament and a provisionally sealing it after 4 weeks. The canal was cleaned, dried and injected with concentrated platelets rich plasma which serve as a scaffold for pulp regeneration. MTA was used to seal the chamber before final filling with composite.  Evaluations: All teeth were monitored clinically (mobility, palpation, percussion, and sensitivity cold test) and radiographically. Results: Twenty months follow-up all teeth showed resolution of periapical radiolucencies, continued root development with positive response to sensitivity cold test and no discoloration. Conclusion:  The results of this study confirmed the previous finding that pulp regeneration can be gained by using cPRP successfully   Keywords Immature teeth; Necrosis; cPRP; Regeneration.

scholarly journals Revascularization in Immature Permanent Teeth with Necrotic Pulp and Apical Pathology: Case Series

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
López Carmen ◽  
Mendoza Asunción ◽  
Solano Beatriz ◽  
Yáñez-Vico Rosa
Keyword(s):  
Case Series ◽  
Permanent Teeth ◽  
Pulp Chamber ◽  
Immature Teeth ◽  
Therapeutic Protocol ◽  
Triple Antibiotic Paste ◽  
Restorative Materials ◽  
Pulp Revascularization ◽  
Clinical Cases

Introduction. To present and discuss the results of five clinical cases treated using the revascularization protocol, showing clinical and radiographic monitoring. Necrotic immature teeth with periapical pathology present a challenge to dentists because the techniques used in apexification leave the tooth susceptible to fracture, since the root does not continue to grow in length and the canal walls are thin. Revascularization has emerged as an alternative to resolve these deficiencies, enabling apical closure, continued development of the roots, and thickening of the dentinal walls. Case Series. Five clinically and radiographically diagnosed necrotic immature permanent teeth were treated using revascularization treatment. The therapeutic protocol involved accessing the pulp chamber; irrigating copiously with NaOCl; applying a triple antibiotic paste as intracanal dressing; then provisionally sealing it. After 3 weeks, the canal was cleaned and the apex irritated with a size 15 K-file to induce blood that would serve as a scaffold for pulp revascularization. MTA was used to seal the chamber before final obturation (composite or metallic crown). Conclusion. The discussion of the results leads to debate about different restorative materials and other published protocols.

scholarly journals Clinical and Radiographic Outcomes of Vital Inflamed Pulp Therapy in Immature Permanent Teeth with Irreversible Pulpitis: A Retrospective Case Series

2020 ◽  
Author(s):  
Wen Xiao ◽  
Wentao Shi ◽  
Jun Wang
Keyword(s):  
Root Length ◽  
Case Series ◽  
Pediatric Dentistry ◽  
Apical Periodontitis ◽  
Permanent Teeth ◽  
Pulp Therapy ◽  
Immature Teeth ◽  
Irreversible Pulpitis ◽  
Radiographic Changes

Abstract Background To assess the resolution of clinical symptoms and radiographic changes in root length and apical diameter in immature permanent teeth with irreversible pulpitis or apical periodontitis with vital inflamed pulp therapy (VIPT).Methods The faculty members at the Ninth People’s Hospital pediatric dentistry department were invited to submit consecutive VIPT cases treated by them, irrespective of outcome, between 2014 and 2016. Clinical success rate, radiographic changes in periapical radiolucency, and apical closure were analyzed, and radiographic changes in the apical diameter and root length were quantified.Results Thirteen of 14 submitted cases of irreversible pulpitis in immature teeth met the inclusion criteria. The follow-up period ranged from 17 to 37 (average, 26.5 ± 7) months. All 13 treated teeth (100%) survived and 12 (92.3%) met the clinical criteria for success throughout the follow-up period, with 92.3% of cases (12 of 13) showing a significant periapical radiolucency decrease and 84.6% (11 of 13) showing complete apical closure at the last visit. The change in apical diameter and root length were obvious. Conclusions Vital inflamed pulp therapy approaches might be of particular value in restoring root development and apical closure and can be an option in treating immature teeth with irreversible pulpitis, even apical periodontitis.

Regeneration of dental pulp tissue in immature teeth with apical periodontitis using platelet-rich plasma and dental pulp cells

2013 ◽  
Vol 46 (10) ◽  
pp. 962-970 ◽  
Author(s):  
W. Zhu ◽  
X. Zhu ◽  
G. T.-J. Huang ◽  
G. S. P. Cheung ◽  
W. L. Dissanayaka ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Platelet Rich Plasma ◽  
Apical Periodontitis ◽  
Dental Pulp Cells ◽  
Pulp Tissue ◽  
Immature Teeth ◽  
Dental Pulp Tissue ◽  
Pulp Cells

scholarly journals 12-Year Follow-Up of Regenerative Endodontic Treatment of Immature Permanent Upper Incisors with Acute Abscess

2020 ◽  
Vol 31 (6) ◽  
pp. 680-684
Author(s):  
Claudio Maniglia-Ferreira ◽  
Eduardo Diogo Gurgel Filho ◽  
Fabio de Almeida Gomes ◽  
Sthefanny Amaral Reis ◽  
Fernanda Geraldo Pappen
Keyword(s):  
Clinical Success ◽  
Glass Ionomer Cement ◽  
Mineral Trioxide Aggregate ◽  
Endodontic Treatment ◽  
Treatment Access ◽  
Root Canals ◽  
Immature Teeth ◽  
The Right ◽  
Regenerative Endodontic Treatment

Abstract This case report discusses the endodontic treatment of a 7-year-old girl who suffered trauma (intrusion) to the immature upper central incisors secondary to a fall from a bicycle. Thirty days after the accident the patient was brought by her mother for clinical and radiographic assessment with a chief complaint of swelling and tenderness to percussion and palpation. Acute apical abscess associated with immature teeth were diagnosed. A decision was made to perform regenerative endodontic treatment. Access cavities were made and the root canals were disinfected by irrigation with 2.5% sodium hypochlorite. Final irrigation was performed with 17% EDTA. Due to pain and presence of secretions, 2% chlorhexidine gel was applied as an intracanal medicament. Seven days later, at the second visit, the root canals were once again disinfected and the canals of the right and left permanent upper central incisors were filled with double antibiotic paste (metronidazole/ciprofloxacin) and calcium hydroxide paste, respectively. Zinc oxide was mixed in both pastes. At the third visit, after 21 more days, the pastes were removed and the periapical areas were stimulated with a #80 K-file to encourage clot formation within the pulp cavities. A mineral trioxide aggregate (MTA) paste cervical plug was placed and the teeth were restored with glass ionomer cement. Radiographs and CBCT scans demonstrated complete root formations. The patient has been followed for 12 years, with evidence of clinical success throughout.

scholarly journals Management of Invasive Cervical Resorption Involving the Pulp by Surgical and Restorative Therapy

2015 ◽  
Vol 4 (2) ◽  
pp. 130-133
Author(s):  
Vinisha Ranna ◽  
Abrar Sayed
Keyword(s):  
Cone Beam ◽  
Permanent Teeth ◽  
Central Incisor ◽  
Pulp Chamber ◽  
Tooth Structure ◽  
Root Region ◽  
Treatment Equipment ◽  
Restorative Therapy ◽  
Cervical Area

ABSTRACT Invasive cervical resorption (ICR) is a form of external resorption which affects the cervical area of permanent teeth and may progress to involve the pulp. It can cause insidious loss of tooth structure, which often is undetected until late in the process. Two cases, both involving the maxillary left central incisor where cone-beam computed tomography (CBCT) revealed an invasive cervical resorptive lesion, extending from the cervical to mid root region and perforating the pulp chamber. The cases were managed surgically with the help of a dental operating microscope (DOM). Nine months follow-up revealed resolution of the lesion and restoration of the affected teeth to functional occlusion. This report emphasizes the restorability of advanced lesions of ICR, if adequate diagnostic and treatment equipment is used. How to cite this article Ranna V, Sayed A. Management of Invasive Cervical Resorption Involving the Pulp by Surgical and Restorative Therapy. Int J Experiment Dent Sci 2015;4(2): 130-133.

scholarly journals Histological Evaluation of the Effect of Platelet-rich Plasma on Pulp Regeneration in Nonvital Open Apex Teeth: An Animal Study

2017 ◽  
Vol 18 (11) ◽  
pp. 1045-1050 ◽  
Author(s):  
Maryam Forghani ◽  
Hamid Jafarzadeh ◽  
Jamileh Ghoddusi ◽  
Amir Maghsudlu ◽  
Amirhossein Jafarian
Keyword(s):  
Animal Study ◽  
Platelet Rich Plasma ◽  
Mineral Trioxide Aggregate ◽  
Nerve Tissue ◽  
Permanent Teeth ◽  
Histological Evaluation ◽  
Chi Square ◽  
Pulp Regeneration ◽  
Suitable Material ◽  
Significant Difference

ABSTRACT Aim Platelet-rich plasma (PRP), which is a concentration of growth factors found in platelets, may be a suitable material for pulp regeneration. The aim of this animal study was a histological evaluation of PRP on pulp regeneration in nonvital teeth with immature apices. Materials and methods A total of 40 premolar dogs’ teeth were chosen for this study. After general anesthesia, the teeth were exposed, and subsequently, pulps were removed and the cavities were opened to the oral cavity. After 2 weeks, root canals were irrigated and disinfected with sodium hypochlorite with noninstrumentation technique, and triple antibiotic paste was placed inside the canals. Cavities were sealed with a temporary restoration. About 4 weeks later, canals were irrigated again and the teeth were randomly divided into three groups. Bleeding was evoked with overinstrumentation, then experimental materials for each group [PRP, mineral trioxide aggregate (MTA), and parafilm respectively] were placed over the bleeding, and orifices were sealed with MTA and glass ionomer. After 3 months, dogs were sacrificed and the teeth were separated from the jaws and sections prepared for histological evaluation. Results Regeneration was shown in 44.7% of the samples. About 47.3% of the samples in the MTA group and 42.1% of the samples in the PRP group showed regeneration; however, no regeneration was observed in the parafilm group. Chi-square test showed no significant difference between groups I and II. The soft regenerative tissue included pulp-like tissue and vessels. Mineralized regenerative tissue included cementumlike, periodontal ligament-like, and bone-like tissues. No normal pulp and nerve tissue were observed. Conclusion Both PRP and MTA may be ideal scaffolds to accelerate the regeneration process. Clinical significance Pulp repair in immature permanent teeth with weak roots has a better outcome than replacement of the pulp with gutta-percha or biomaterials. How to cite this article Ghoddusi J, Maghsudlu A, Jafarzadeh H, Jafarian A, Forghani M. Histological Evaluation of the Effect of Platelet-rich Plasma on Pulp Regeneration in Nonvital Open Apex Teeth: An Animal Study. J Contemp Dent Pract 2017;18(11):1045-1050.

scholarly journals Regenerative endodontic treatment performed with platelet-rich plasma presents better periapical healing than only induced blot clot: a systematic review

2021 ◽  
Vol 10 (13) ◽  
pp. e147101321219
Author(s):  
Christine Men Martins ◽  
Milena Filippini Knecht ◽  
Larissa dos Santos de Moraes ◽  
Victor Eduardo de Souza Batista
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Primary Outcome ◽  
Randomized Clinical Trials ◽  
Platelet Rich Plasma ◽  
Permanent Teeth ◽  
Cochrane Library ◽  
Eligibility Criteria ◽  
Periapical Healing ◽  
Regenerative Endodontic Treatment

This study comprehensively reviewed two different treatments for regenerative endodontic: platelet-rich plasma and induced blot clot, in regarding to periapical healing.  Two investigators performed a systematic review. MEDLINE/PubMed, Cochrane Library and Scopus supplied relevant data from studies published until December 2020 to answer the PICO question. Primary outcome was periapical healing. Eight randomized clinical trials fulfilled eligibility criteria. Primary outcome indicated that platelet-rich plasma results in similar or better periapical healing compared to blot clot group. The reported failures were related to blot clot group due to incomplete radiographic parameters, pain and reinfection; however, few cases of unsuccess were reported to platelet-rich plasma group. Only two studies observed better results to blot clot group in relation to increase of radiographic area and partial pulp canal obliteration. This review showed that procedures using platelet-rich plasma were successful in treating permanent teeth with root development.

scholarly journals Single Sitting Revitalization of Nonvital Young Permanent Teeth

2020 ◽  
Vol 8 (03) ◽  
pp. 127-130
Author(s):  
Avninder Kaur ◽  
Anchal Soni ◽  
Harees Shabir
Keyword(s):  
Glass Ionomer Cement ◽  
Thick Layer ◽  
Permanent Teeth ◽  
Radiographic Examination ◽  
Radiographic Evaluation ◽  
Periapical Lesion ◽  
Immature Teeth ◽  
Pulp Revascularization ◽  
Ionomer Cement

AbstractA 9-year-old child reported with chief complaint of broken teeth (11 and 21) and discolored tooth (21). Diagnosis of pulp necrosis with apical periodontitis with regard to 11 and 21 was made based on clinical and radiographic examination. The canals were irrigated with sodium hypochlorite and then dried with paper points. Disinfection of canals was done using photoactivated disinfection (PAD). Platelet-rich fibrin (PRF) was placed as scaffold in canals till the cementoenamel junction (CEJ). A 2-mm thick layer of white MTA was placed, followed by dual seal using glass–ionomer cement (GIC) and composite resin. Follow-up examination was done for 1 year. Clinical examination showed no pain, tenderness on percussion, and no mobility and improvement in color of teeth. Radiographic evaluation revealed continued thickening of the dentinal walls, root lengthening, regression of the periapical lesion, and partial apical closure. This report of pulp revascularization shows that disinfection with photodynamic therapy combined with PRF resulted in satisfactory root development in necrotic immature teeth.

Regenerative Endodontic Therapy with Platelet Rich Fibrin: Case Series

2020 ◽  
Vol 44 (1) ◽  
pp. 15-19 ◽  
Author(s):  
G Kandemir Demirci ◽  
P Güneri ◽  
MK Çalışkan
Keyword(s):  
Case Series ◽  
Cone Beam ◽  
Permanent Teeth ◽  
Platelet Rich Fibrin ◽  
Periapical Lesions ◽  
Root Canals ◽  
Immature Teeth ◽  
Triple Antibiotic Paste ◽  
Cone Beam Computerized Tomography

Regenerative endodontic therapy (RET) provides a novel treatment modality for the immature teeth with pulp necrosis. The aim of this case series was to evaluate RET of immature permanent teeth using platelet rich fibrin (PRF) at 36-month follow-up periods. In the present case series, three immature maxillary incisors diagnosed with pulp necrosis and apical periodontitis were treated with RET. The root canals were irrigated with 1.5% sodium hypochlorite (NaOCl) and medicated with triple antibiotic paste(TAP). At the second visit, TAP was removed and root canals were conditioned with 17% EDTA. PRF was used as a scaffold. MTA was placed over PRF and the teeth were restored with composite resin. Periapical radiographs and cone beam computerized tomography(CBCT) were used to evaluate the healing. At the end of the 36-month follow-up periods, there was no response to pulp sensibility tests with cold and electric pulp tester, but all teeth showed decreased periapical lesions or evidence of healing.

scholarly journals What is the best long-term treatment modality for immature permanent teeth with pulp necrosis and apical periodontitis?

2021 ◽  
Author(s):  
A. Wikström ◽  
M. Brundin ◽  
M. F. Lopes ◽  
M. El Sayed ◽  
G. Tsilingaridis
Keyword(s):  
Systematic Review ◽  
Treatment Modality ◽  
Current Knowledge ◽  
Case Series ◽  
Apical Periodontitis ◽  
Permanent Teeth ◽  
Cochrane Library ◽  
Wall Thickening ◽  
Immature Teeth ◽  
Long Term Treatment

Abstract Purpose To evaluate and assess the current knowledge about apexification and regenerative techniques as a meaningful treatment modality and to map the scientific evidence for the efficacy of both methods for the management of traumatised immature teeth with pulp necrosis and apical periodontitis. Methods This systematic review searched five databases: PubMed, Web of Science, Cochrane Library, Ovid (Medline), and Embase. Published articles written in English were considered for inclusion. The following keywords were used: Regenerative endodontic treatment OR regenerat* OR revital* OR endodontic regeneration OR regenerative endodontics OR pulp revascularization OR revasculari* OR ‘traumatized immature teeth’. Only peer-reviewed studies with a study size of at least 20 cases followed up for 24 months were included. Eligibility assessment was performed independently in a blinded manner by three reviewers and disagreements were resolved by consensus. Subgroup analyses were performed on three clinical outcomes: survival, success, and continued root development. Results Seven full texts out of 1359 citations were included and conventional content analysis was performed. Most of the identified citations were case reports and case series. Conclusions In the present systematic review, the qualitative analysis revealed that both regenerative and apexification techniques had equal rates of success and survival and proved to be effective in the treatment of immature necrotic permanent teeth. Endodontic regenerative techniques appear to be superior to apexification techniques in terms of stimulation of root maturation, i.e. root wall thickening and root lengthening. Knowledge gaps were identified regarding the treatment and follow-up protocols for both techniques.

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