Younger Age at Diagnosis Predicts Disease Severity in Ulcerative Colitis

Objectives The lesion distribution of juvenile-onset recurrent respiratory papillomatosis (JORRP) during first-time surgery has been rarely reported. The purpose of this study was to describe the anatomical distribution of papilloma across 25 Derkay sites during initial surgery and to assess the impact of the lesion distribution on disease severity. Methods Surgical videos and medical records of 106 patients with JORRP (27 aggressive and 79 nonaggressive cases) were retrospectively reviewed. Lesion locations were recorded using Derkay anatomical sites. Logistic regression was used to analyze the effect of the lesion distribution on disease severity. Results Among the 106 patients, the true vocal cords (90.6% left, 84.0% right) were the most frequently involved site, followed by the false vocal cords (39.6% left, 35.8% right) and the anterior commissure (26.4%). Two patients (1.9%) had tracheal involvement. Patients with false vocal cord involvement (odds ratio [OR] = 3.425, 95% confidence interval [CI] [1.285, 9.132], P = .014) and a younger age at diagnosis (OR = .698, 95% CI [.539, .905], P = .007) were more likely to require more than 4 procedures in the year following first-time surgery. Conclusions Lesions were most common on the true vocal cords. False vocal cord involvement and a younger age at diagnosis were risk factors for disease severity.

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Association between the interleukin-1 receptor antagonist polymorphism and ulcerative colitis with younger age at diagnosis

Immunology Letters ◽

10.1016/s0165-2478(03)00175-5 ◽

2003 ◽

Vol 90 (1) ◽

pp. 53-57 ◽

Cited By ~ 8

Author(s):

Hiroaki Nohara ◽

Nagamu Inoue ◽

Toshifumi Hibi ◽

Kiwamu Okita ◽

Yuji Hinoda

Keyword(s):

Ulcerative Colitis ◽

Receptor Antagonist ◽

Interleukin 1 ◽

Age At Diagnosis ◽

Interleukin 1 Receptor Antagonist ◽

Younger Age

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Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Nature Communications ◽

10.1038/s41467-018-07841-3 ◽

2019 ◽

Vol 10 (1) ◽

Cited By ~ 43

Author(s):

Yael Haberman ◽

Rebekah Karns ◽

Phillip J. Dexheimer ◽

Melanie Schirmer ◽

Judith Somekh ◽

...

Keyword(s):

Ulcerative Colitis ◽

Treatment Response ◽

Disease Severity ◽

Underlying Disease

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POR polymorphisms are associated with 21 hydroxylase deficiency

Journal of Endocrinological Investigation ◽

10.1007/s40618-021-01527-2 ◽

2021 ◽

Author(s):

F. Pecori Giraldi ◽

S. Einaudi ◽

A. Sesta ◽

F. Verna ◽

M. Messina ◽

...

Keyword(s):

Clinical Features ◽

Modifier Genes ◽

Age At Diagnosis ◽

Adrenal Hyperplasia ◽

Phenotype Correlation ◽

Hydroxylase Deficiency ◽

Salt Wasting ◽

Control Subjects ◽

Younger Age ◽

21 Hydroxylase Deficiency

Abstract Purpose Genotype–phenotype correlation in congenital 21 hydroxylase deficiency is strong but by no means absolute. Indeed, clinical and hormonal features may vary among patients carrying similar CYP21A2 mutations, suggesting that modifier genes may contribute to the phenotype. Aim of the present study was to evaluate whether polymorphisms in the p450 oxidoreductase (POR) gene may affect clinical features in patients with 21 hydroxylase deficiency Methods Sequencing of the POR gene was performed in 96 patients with 21 hydroxylase deficiency (49 classic, 47 non-classic) and 43 control subjects. Results Prevalence of POR polymorphisms in patients with 21 hydroxylase was comparable to controls and known databases. The rs2228104 polymorphism was more frequently associated with non-classic vs classic 21 hydroxylase deficiency (allelic risk 7.09; 95% C.I. 1.4–29.5, p < 0.05). Classic 21 hydroxylase-deficient carriers of the minor allele in the rs2286822/rs2286823 haplotype presented more frequently the salt-wasting form (allelic risk 1.375; 95% C.I. 1.138–1.137), more severe Prader stage at birth (allelic risk 3.85; 95% C.I. 3.78–3.92), higher ACTH levels, and younger age at diagnosis. Conclusions Polymorphisms in the POR gene are associated with clinical features of 21 hydroxylase deficiency both as regards predisposition to classic vs non-classic forms and severity of classic adrenal hyperplasia.

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Increased circulating PD-1hiCXCR5- peripheral helper T cells are associated with disease severity of active ulcerative colitis patients

Immunology Letters ◽

10.1016/j.imlet.2021.03.001 ◽

2021 ◽

Vol 233 ◽

pp. 2-10

Author(s):

Yan Long ◽

Changsheng Xia ◽

Yuanyuan Sun ◽

Yinting Ma ◽

Lijuan Xu ◽

...

Keyword(s):

Ulcerative Colitis ◽

T Cells ◽

Disease Severity ◽

Helper T Cells ◽

Active Ulcerative Colitis

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Vitamin D deficiency in adult patients with ulcerative colitis: Prevalence and relationship with disease severity, extent, and duration

Indian Journal of Gastroenterology ◽

10.1007/s12664-019-00932-z ◽

2019 ◽

Vol 38 (1) ◽

pp. 6-14 ◽

Cited By ~ 3

Author(s):

Arjun Datt Law ◽

Usha Dutta ◽

Rakesh Kochhar ◽

Chetana Vaishnavi ◽

Shiva Kumar ◽

...

Keyword(s):

Ulcerative Colitis ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Disease Severity ◽

Adult Patients

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Predicting therapeutic outcome in severe ulcerative colitis by measuring in vitro steroid sensitivity of proliferating peripheral blood lymphocytes

Gut ◽

10.1136/gut.45.3.382 ◽

1999 ◽

Vol 45 (3) ◽

pp. 382-388 ◽

Cited By ~ 84

Author(s):

S D Hearing ◽

M Norman ◽

C S J Probert ◽

N Haslam ◽

C M Dayan

Keyword(s):

Ulcerative Colitis ◽

T Lymphocytes ◽

Disease Severity ◽

T Lymphocyte ◽

Peripheral Blood ◽

Steroid Treatment ◽

Steroid Resistance ◽

Severe Ulcerative Colitis ◽

Steroid Sensitivity

BACKGROUNDUp to 29% of patients with severe ulcerative colitis (UC) fail to respond to steroid treatment and require surgery. Previous studies have failed to show a clear correlation between failure of steroid treatment in severe UC and measures of disease severity. The reasons for treatment failure therefore remain unknown.AIMTo investigate the hypothesis that patients with severe UC who fail to respond to steroid treatment have steroid resistant T lymphocytes.METHODSEighteen patients with severe UC were studied. After seven days’ treatment with high dose intravenous steroids they were classified as complete responders (CR), incomplete responders (IR), or treatment failures (TF). Within 48 hours of admission blood was taken and the antiproliferative effect of dexamethasone on phytohaemagglutinin stimulated peripheral blood T lymphocytes was measured. Maximum dexamethasone induced inhibition of proliferation (Imax) was measured.RESULTSIn vitro T lymphocyte steroid sensitivity of TF and IR patients was significantly less than that of CR patients. Both TF and 3/5 IR patients had an Imax of less than 60%; all CR patients had an Imax of greater than 60%. No significant correlation was seen between response to treatment and disease severity on admission. When in vitro T lymphocyte steroid sensitivity was remeasured three months later, there was no difference between the groups.CONCLUSIONSResults suggest that T lymphocyte steroid resistance is an important factor in determining response to steroid treatment in patients with severe UC and may be more predictive of outcome than disease severity.

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Tu1927 Matrix Metalloproteinase 9 (MMP9) Expression in Ulcerative Colitis Is Associated With Histologic Score of Disease Severity

Gastroenterology ◽

10.1016/s0016-5085(16)33320-0 ◽

2016 ◽

Vol 150 (4) ◽

pp. S979-S980

Author(s):

William Sandborn ◽

Scott Lee ◽

Erik G. Huntzicker ◽

Guang Chen ◽

Victoria Smith ◽

...

Keyword(s):

Ulcerative Colitis ◽

Matrix Metalloproteinase ◽

Disease Severity ◽

Matrix Metalloproteinase 9 ◽

Mmp9 Expression ◽

Metalloproteinase 9

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ΔF508 Genotype Does Not Predict Disease Severity in an Ethnically Diverse Cystic Fibrosis Population

PEDIATRICS ◽

10.1542/peds.93.1.114 ◽

1994 ◽

Vol 93 (1) ◽

pp. 114-118

Author(s):

Lucille A. Lester ◽

Jerome Kraut ◽

John Lloyd-Still ◽

Theodore Karrison ◽

Carol Mott ◽

...

Keyword(s):

Cystic Fibrosis ◽

Disease Severity ◽

Ethnically Diverse ◽

Clinical Parameter ◽

Population Based ◽

Age At Diagnosis ◽

Chest Roentgenogram ◽

Sweat Chloride ◽

Cystic Fibrosis Population ◽

Cftr Mutations

Objective. As part of a study to determine population-based frequencies of CFTR mutations in an ethnically diverse, midwestern cystic fibrosis (CF) population, clinical histories were studied in 119 CF patients. Methodology. We sought to examine the association between genotype as characterized by the ΔF508 and 11 other commonly occurring mutations and clinical parameters including age at diagnosis, clinical presentation, sweat chloride level, chest roentgenogram score, clinical scores, pulmonary function test results, percent weight for height, and presence of associated CF complications. Results. Age at diagnosis of CF was significantly associated with homozygosity for ΔF508 (mean age at diagnosis ± SE: 1.7 ± 0.3 years for ΔF508/ΔF508 vs 3.9 ± 0.9 years for ΔF508/other and other/other; P = .03). No other age-adjusted clinical parameter was significantly associated with ΔF508 or any other genotype. Conclusion. These data suggest that in this sample of CF patients, ΔF508 genotype is not predictive of disease severity. The lack of association between disease severity and genotype in this ethnically diverse sample may reflect the presence of more severe undetected mutations in our sample, or the effects of modifying genes at other, non-CF loci.

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