scholarly journals Diabetes mellitus, chronic pancreatitis and primary hyperparathyroidism: is there a connection?

2019 ◽  
Vol 22 (4) ◽  
pp. 392-398
Author(s):  
Anna M. Gorbacheva ◽  
Nataliya V. Zaytseva
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Pancreatitis ◽  
Glycaemic Control ◽  
Primary Hyperparathyroidism ◽  
Clinical Case ◽  
Duodenal Ulcers ◽  
Severe Hypertriglyceridemia ◽  
Frequent Relapses ◽  
Previously Treated ◽  
The Impact

Hyperparathyroidism is a relatively frequent condition characterized by hypersecretion of parathyroid hormone. There are several forms of primary hyperparathyroidism. Each form affects its target region. In the visceral form, nephrocalcinosis, nephrolithiasis and peptic and duodenal ulcers are common. The pancreas is also a target organ. This article describes a clinical case of a patient with diabetes mellitus and previously treated primary hyperparathyroidism. The patient was admitted to the hospital due to poor glycaemic control. During the hospitalization, diabetes mellitus developed as a consequence of frequent relapses of chronic pancreatitis (outcome of the visceral form of primary hyperparathyroidism and severe hypertriglyceridemia). Glycaemic control was achieved after treatment of acute pancreatitis and insulin administration. This clinical case is an example of the impact of previous primary hyperparathyroidism (even after radical treatment and remission) on the development of a multi-faceted comorbidity.

scholarly journals Narushenie purinovogo obmena u patsienta s pervichnym giperparatireozom i sakharnym diabetom 2 tipa

2010 ◽  
Vol 7 (3) ◽  
pp. 43-48
Author(s):  
N G Mokrysheva ◽  
A Yu Tokmakova ◽  
I A Voronkova ◽  
L Ya Rozhinskaya ◽  
A I Bukhman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Primary Hyperparathyroidism ◽  
Diabetes Mellitus Type 2 ◽  
Clinical Case ◽  
Diabetes Mellitus Type ◽  
The Relationship

In this article we describe a clinical case of primary hyperparathyroidism, gout tophus and diabetes mellitus type 2. The relationship between hyperuricemia and hypercalcemia linked to primary hyperparathyroidism is discussed.

EVALUATION OF PARAMETERS OF ACTUAL TYPICAL PATHOGENETIC SYNDROMES IN COMORBIDITY OF TYPE 2 DIABETES MELLITUS AND CHRONIC PANCREATITIS

2021 ◽  
Vol 74 (10) ◽  
pp. 2557-2559
Author(s):  
Olena V. Redkva ◽  
Liliya S. Babinets ◽  
Iryna M. Halabitska
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Pancreatitis ◽  
Antioxidant Protection ◽  
Enzymatic Antioxidant ◽  
Evaluation Of Parameters ◽  
Remission Phase ◽  
The Impact

The aim: To assess the state of typical pathogenetic syndromes (inflammation, endotoxicosis, liperoxidation, enzymatic and non-enzymatic antioxidant deficiency) in the comorbidity of type 2 diabetes mellitus (DM2) and chronic pancreatitis (CP). Materials and methods: We examined 137 patients (112 patients with comorbidity of CP and DM2 and 25 patients with isolated CP. Typical pathogenetic syndromes (inflammation, endotoxicosis, liperoxidation, enzymatic and non-enzymatic antioxidant deficiency) were determined. Results: It was proved that patients with CP even in the remission phase of the active course of EI and LPO, which was significantly more significant in comorbidity with DM2. Statistically significant more significant changes in the parameters of antioxidant protection in the comorbidity of CP and DM2 in relation to those in isolated CP. Conclusions: Treatment of CP and DM2 is a difficult task and should take into account the impact on the studied common typical pathogenetic syndromes – inflammation, endotoxicosis, lipid peroxidation, and enzyme and non-enzymatic antioxidant protection – to address short-term and prevent long-term complications.

scholarly journals A Systematic Review to Assess the Impact of Hyperbaric Oxygen Therapy on Glycaemia in People with Diabetes Mellitus

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1134
Author(s):  
Sudhanshu Baitule ◽  
Aaran Patel ◽  
Narasimha Murthy ◽  
Sailesh Sankar ◽  
Ioannis Kyrou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Glycaemic Control ◽  
Hyperbaric Oxygen ◽  
Oxygen Therapy ◽  
Hyperbaric Oxygen Treatment ◽  
Oxygen Treatment ◽  
Diabetic Foot Disease ◽  
Foot Disease ◽  
The Impact

Background and Objectives: Hyperbaric oxygen is a recognised treatment for a range of medical conditions, including treatment of diabetic foot disease. A number of studies have reported an impact of hyperbaric oxygen treatment on glycaemic control in patients undergoing treatment for diabetic foot disease. There has been no systematic review considering the impact of hyperbaric oxygen on glycaemia in people with diabetes. Materials and Methods: A prospectively PROSPERO-registered (PROSPERO registration: CRD42021255528) systematic review of eligible studies published in English in the PUBMED, MEDLINE, and EMBASE databases, based on the following search terms: hyperbaric oxygen therapy, HBO2, hyperbaric oxygenation, glycaemic control, diabetes, diabetes Mellitus, diabetic, HbA1c. Data extraction to pre-determined piloted data collection form, with individual assessment of bias. Results: In total, 10 eligible publications were identified after screening. Of these, six articles reported a statistically significant reduction in blood glucose from hyperbaric oxygen treatment, while two articles reported a statistically significant increase in peripheral insulin sensitivity. Two articles also identified a statistically significant reduction in HbA1c following hyperbaric oxygen treatment. Conclusions: There is emerging evidence suggesting a reduction in glycaemia following hyperbaric oxygen treatment in patients with diabetes mellitus, but the existing studies are in relatively small cohorts and potentially underpowered. Additional large prospective clinical trials are required to understand the precise impact of hyperbaric oxygen treatment on glycaemia for people with diabetes mellitus.

scholarly journals Elective hip arthroplasty rates and related complications in people with diabetes mellitus

2020 ◽  
pp. 112070002098157
Author(s):  
Lindsey C McVey ◽  
Nicholas Kane ◽  
Helen Murray ◽  
RM Dominic Meek ◽  
S Faisal Ahmed
Keyword(s):  
Diabetes Mellitus ◽  
Postoperative Complications ◽  
Glycaemic Control ◽  
Hip Arthroplasty ◽  
Surgical Complications ◽  
Complication Rates ◽  
Obese Patients ◽  
Poor Glycaemic Control ◽  
Increased Risk ◽  
The Impact

Background and Aims: Diabetes mellitus (DM), poor glycaemic control and raised body mass index (BMI) have been associated with postoperative complications in arthroplasty, although the relative importance of these factors is unclear. We describe the prevalence of DM in elective hip arthroplasty in a UK centre, and evaluate the impact of these factors. Methods: We analysed retrospective data for DM patients undergoing arthroplasty over a 6-year period and compared with non-diabetic matched controls (1 DM patient: 5 controls). DM was present in 5.7% of hip arthroplasty patients (82/1443). Results: Postoperative complications occurred in 12.2% of DM patients versus 12.9% of controls ( p = 1.000); surgical complications were present in 6.1% of those with DM and 2.4% of controls ( p = 0.087), while medical complications occurred in 8.5% of DM patients versus 10.7% of controls ( p = 0.692). Complications developed in 23.1% of DM patients with poor glycaemic control (HbA1c > 53 mmol/mol) versus 9.8% with good control ( p = 0.169). In DM patients and controls combined, complications occurred in 16.3% of obese patients versus 10.0% of non-obese patients ( p = 0.043). In the DM cohort, 13.7% of overweight patients had complications versus 0% with a normal or low BMI ( p = 0.587). Conclusions: DM rates were lower than expected, and glycaemic control was good. Overall complication rates were unrelated to the presence of DM or to glycaemic control, although surgical complications were observed more frequently in those with DM and poor glycaemic control was uncommon within our cohort. Complications were more frequent in those with a higher BMI. Whether some patients with DM but without an increased risk of complications are currently being excluded from surgery requires exploration.

scholarly journals Impact of COVID-19 Lockdown on Glycaemic Control and Lifestyle Changes in Children and Adolescents with Type 1 And Type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Hooi Peng Cheng ◽  
Jeanne Sze Lyn Wong ◽  
Nalini M Selveindran ◽  
Janet Yeow Hua Hong
Keyword(s):  
Diabetes Mellitus ◽  
Glycaemic Control ◽  
Children And Adolescents ◽  
Glycated Haemoglobin ◽  
Lifestyle Changes ◽  
Activity Level ◽  
Significant Deterioration ◽  
Cross Sectional ◽  
The Impact

Abstract Aims: Malaysia implemented nation-wide lockdown from 18th March till 5th May 2020 to mitigate the spread of coronavirus disease (COVID-19). This study aimed to examine the impact of the lockdown on glycaemic control and lifestyle changes in children and adolescents with type 1 (T1DM) and 2 diabetes mellitus (T2DM) aged less than 18 years old.Methods: In this cross-sectional study, interviews and a standardised questionnaire comparing lifestyle changes before and during the lockdown were performed in follow-up clinic visits after the lockdown. Anthropometry measurements and glycated haemoglobin (HbA1c) values were compared three months prior and after the lockdown.Results: Participants were 93 patients with T1DM (4.64 ± 3.10 years) and 30 patients with T2DM (11.08 ± 3.47 years). Male gender, T2DM and pubertal adolescents were found to have a significant deterioration in glycaemic control. A significant increment of HbA1c was observed in patients with T2DM (8.5 ± 0.40% vs 9.9 ± 0.46%), but not in patients with T1DM (8.6 ± 0.28% vs 8.7 ± 0.33%). Contrarily, there was an improved glycaemic control in pre-pubertal T1DM children likely due to parental supervision during home confinement. Weight and BMI SDS increased in T1DM patients but surprisingly reduced in T2DM patients possibly due to worsening diabetes control. Reduced meal frequency mainly due to skipping breakfast, reduced physical activity level scores, increased screen time and sleep duration were observed in both groups. Conclusions: Adverse impact on glycaemic control and lifestyle were seen mostly in patients with T2DM and pubertal adolescent boys.

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