scholarly journals Diagnostic criteria for diabetic polyneuropathy in a population study

2004 ◽  
Vol 50 (1) ◽  
pp. 9-13 ◽  
Author(s):  
T. R. Bursa ◽  
I. A. Strokov ◽  
M. V. Novosadova ◽  
O. I. Drepa ◽  
A. S. Ametov
Keyword(s):  
Children And Adolescents ◽  
Temperature Sensitivity ◽  
Neurological Examination ◽  
Age Groups ◽  
Diabetic Polyneuropathy ◽  
Diagnostic Value ◽  
Sensitivity Study ◽  
Diagnostic Methods ◽  
Type 1 Dm

Population surveys are of high informative value and reflect the actual prevalence of diabetic polyneuropathy (DPN) in society. The purpose of the present study was to examine the spread of DPN among patients with type 1 diabetes mellitus (DM) and to assess the diagnostic value of used diagnostic methods. Three hundred and forty-six patients (100 children and adolescents and 246 adults) with type 1 DM, living in Moscow and its region were examined. The criteria adopted at the Conference on Standardization of DPN Diagnosis in Saint Antonio in 1992 were used to diagnose DPN. The criteria proposed by P. Dyck et al. were applied to define DPN stages. The prevalence of DPN in the children and adolescents was 40%, the vast majority (75%) of the patients having subclinical (la and lb) stages of DPN. Autonomic deficit was revealed in 17% of the children and adolescents with type 1 DM. In the adults, the prevalence of DPN was 66.3% with a predominance (61%) of the clinical stages (2a and 2b) stages of DPN. Autonomic deficit was detected in 25.6% of the adults with type 1 DM. The most sensitive diagnostic tests in the examination of children and adolescents were found to be a neurological examination by using the NIS-LL scale (for neuropathic disorders), as well as temperature sensitivity study, and stimulation EMG. While examining the adults, an active detection of complaints showed a high sensitivity (79%) by applying the existing scales, which makes it possible to use this method at the first stage of a diagnostic search. The study of temperature sensitivity by employing the Thioterm tool increased the diagnostic value of a neurological examination by means of the NIS-LL in all age groups.

scholarly journals Diabetic polyneuropathy in children and adolescents: clinical picture and diagnosis

2003 ◽  
Vol 49 (6) ◽  
pp. 3-8
Author(s):  
G. I. Sivous ◽  
I. A. Strokov ◽  
I. V. Galeyev ◽  
E. P. Kasatkina
Keyword(s):  
Children And Adolescents ◽  
Neurological Examination ◽  
Age Groups ◽  
Diabetic Polyneuropathy ◽  
Childhood And Adolescence ◽  
Medical Academy ◽  
Impairment Score ◽  
Peripheral Polyneuropathy ◽  
History Of ◽  
Motor Nerves

The Department of Childhood and Adolescence Endocrinology, Russian Medical Academy of Postgraduate Training, Ministry of Health of the Russian Federation, examined 529 patients with type 1 diabetes mellitus (DM) whose age was 5 to 22 years. The study was undertaken to examine the prevalence and severity of diabetic peripheral polyneuropathy (DPN) in children, adolescents, and young individuals who fell ill with DM in childhood, to characterize the symptoms and neurological manifestations of this complication, and to choose adequate studies for their examination. DPN is most common in adolescents and young individuals having a longer history of the disease and worse values of compensation of carbohydrate metabolism. The specific feature of DPN in these age groups are the absence of severe forms of the disease and the presence of mainly the sensory pattern of disorders. The study defined the required scope of a neurological examination for early diagnosis of DPN in children and adolescents, which should include a thorough analysis of a patient’s complaints and a test by the Total Symptoms Score, a neurological examination by the modified Neuropathy Impairment Score for the Lower Extremities, stimulation electromyography of the sensory and motor nerves of the leg. By taking into account a poor DM compensation in the absolute majority of children and adolescents, the neurological examination should be regular at least once a year.

scholarly journals Assessment of type i diabetes mellitus compensation degree in children and adolescents of Perm Krai

2020 ◽  
Vol 36 (6) ◽  
pp. 57-63
Author(s):  
O. M. Khudorozhkova ◽  
E. N. Smirnova
Keyword(s):  
Children And Adolescents ◽  
Insulin Pump ◽  
Type I Diabetes ◽  
Insulin Pump Therapy ◽  
Type I ◽  
Chronic Complications ◽  
Pump Therapy ◽  
Perm Krai ◽  
Type 1 Dm

Aim. To assess the dependence of carbohydrate metabolism state in children and adolescents with type I diabetes mellitus (DM) in Perm Krai on patients age, disease duration, way of insulin administration (regimen of multiple insulin injections or insulin pump therapy), complications available. Materials and methods. The study enclosed 451 children and adolescents, living in Perm Krai, who were hospitalized for type 1 DM to Endocrine Unit of Regional Childrens Clinical Hospital during 2016-2017. Glycated hemoglobin level (HbA1c), daily insulin requirement, availability and character of complications were assessed in these patients. Conclusions. The state of decompensation more often is connected with the disease duration for more than 5 years and adolescent age. There was detected a feedback between the physical development level and the duration of disease and number of chronic complications. The period of development of type 1 DM chronic complications depends on patients age, sex and compensation of disease. The degree of compensation of the disease is higher when using insulin pump therapy or regimen of multiple injections of ultrashort analogs of insulin in combination with basal analogs.

Dentition and Oral Health Status in Children and Adolescents with Type 1 Diabetes Mellitus

2012 ◽  
Vol 9 (2) ◽  
pp. 19-21
Author(s):  
Farhana Nasrin ◽  
Mohammad Golam Iqbal ◽  
Md Shahed Shahed Rafi Pavel ◽  
Akashlynn Badruddoza ◽  
Riasat Hasan
Keyword(s):  
Health Status ◽  
Oral Health ◽  
Children And Adolescents ◽  
Oral Mucosa ◽  
Cross Sectional Study ◽  
Health Problems ◽  
Oral Health Status ◽  
Cross Sectional ◽  
Type 1 Dm

The descriptive type of cross-sectional study was conducted to find out the status of dentition and oral health in children and adolescents with type-1 DM in BIRDEM, Dhaka, from 1st January to 30th June 2010. Fifty two (52) samples of 5 to 19 years of age were studied to check their oral health problems. Results showed 35(67.3%) of respondents were suffering from gingivitis and dental caries, 13(25%) respondents had periodontitis and 4(7.7%) respondents had attrition and mobility. Overall prevalence of oral health problems were more in male (53.8%) than female respondents (46.2%). The Highest number (57.7%) of oral health problems occurred in 16~19 years age  group (mean age 15.29}3.35years). Majority (53.8%) of the respondents did not check their blood glucose level regularly and 76.9% respondents visit dental surgeon when needed. Three fourth (75%) of the respondents brush their teeth before breakfast and 92.3% respondents used to clean their teeth only once a day. With type 1 DM, maximum respondents have ulceration of oral mucosa (76.9%) and only 5.8% respondents have normal oral mucosa. Three fourth (73.1%) of the respondents had unhealthy tonsils and maximum (57.7%) respondents had ulceration of tongue. Near about half of the respondents (48.1%) had good oral health status among children and adolescents with type 1 DM. DOI: http://dx.doi.org/10.3329/cdcj.v9i2.12317 City Dental College J. Volume-9, Number-2, July-2012

Realtime Continuous Glucose Monitoring in Children and Adolescents— An Overview of the Current Technology and its Impact on Patient Outcomes

2012 ◽  
Vol 08 (01) ◽  
pp. 30
Author(s):  
Jeniece Trast ◽  
Neesha Ramchandani ◽  
◽  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Patient Outcomes ◽  
Continuous Glucose Monitoring ◽  
Diabetes Management ◽  
Age Groups ◽  
Glucose Monitoring ◽  
Parental Satisfaction ◽  
Patient Use

Continuous glucose monitoring (CGM) systems, available for patient use since 1999, and realtime continuous glucose monitoring (RT-CGM) systems, available since 2006, have helped optimize diabetes management. Previously, RT-CGM studies found benefits mainly in patients with type 1 diabetes over the age of 25. Children and adolescents often present a challenge when managing type 1 diabetes. However, it is now apparent that RT-CGM has clear benefits in these age groups as well as in adults. Not only have studies shown improvements in glycemic control in this population, they have also demonstrated parental satisfaction with the technology. Challenges with RT-CGM use still exist and must be addressed. Nevertheless, RT-CGM is a beneficial tool to assist in diabetes management, and its use should be encouraged in the majority of pediatric patients with type 1 diabetes.

Type 1 Diabetes in Children and Adolescents: What’s New?

2002 ◽  
Vol 18 (3) ◽  
pp. 144-149 ◽  
Author(s):  
Kathryn R. Kolar ◽  
Lisa Haynie ◽  
Robin Wilkerson ◽  
Wanda Fisher
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Glucose Monitoring ◽  
School Nurse ◽  
Legal Framework ◽  
Optimal Care ◽  
Recent Developments ◽  
Type 1 Dm ◽  
Major Consideration

As providers of care for children and adolescents with Type 1 diabetes mellitus (DM), it is imperative that the school nurse is familiar both with the legal framework guiding protection of these students’ rights in school and with ongoing developments regarding management of this disorder. Federal legislation, designed to prevent discrimination and to allow children and adolescents with certain disabilities and chronic disorders such as Type 1 DM to fully participate in activities within the academic setting, is a major consideration for those providing care in schools. Understanding of recent developments and future trends in the management of Type 1 DM is essential for the school nurse to facilitate optimal care for students with this disorder. These consist of new types and activity of insulin preparations, alternative devices for insulin delivery, improvements in glucose monitoring, and changes in nutritional management along with upcoming developments in Type 1 DM management.

scholarly journals Mathematical Models and Machine Learning Algorithms in the Diagnosis of Complications of Type 1 Diabetes Mellitus

2021 ◽  
pp. 97-101
Author(s):  
O.S. Krotova ◽  
L.A. Khvorova ◽  
A.I. Piyanzin
Keyword(s):  
Diabetes Mellitus ◽  
Machine Learning ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Diabetic Polyneuropathy ◽  
Medical Data ◽  
Classification Model ◽  
Complications Of Diabetes

The paper deals with the problem of diabetic polyneuropathy diagnosing. This is one of the earliest and most dangerous complications of diabetes among children and adolescents. The research aims to develop models for diagnosing diabetic polyneuropathy in children and adolescents based on various medical data. The developed models will make it possible to diagnose a complication without using neurophysiological research methods. Therefore, the proposed models can be used in small medical and obstetrical stations in rural areas as well as a support system for making medical decisions. In the course of the study, a review and analysis of scientific publications of domestic and foreign scientists on the topic of the research are carried out. A large set of textual medical data is processed, then a database is created, features are analyzed, and a model is developed to reveal the presence of diabetic polyneuropathy in children and adolescents with type 1 diabetes mellitus. The achieved quality of the classification model allows us to assert that machine learning methods can be used to find hidden dependencies in the development and course of complications of diabetes mellitus.

scholarly journals Diagnostic Value of Symptoms for Pediatric SARS-CoV-2 Infection in a Primary Care Setting

2021 ◽  
Author(s):  
Chien-Hsiang Weng ◽  
Wesley Wing Wah Butt ◽  
Meredith B Brooks ◽  
Claudia Clarke ◽  
Helen Jenkins ◽  
...  
Keyword(s):  
Primary Care ◽  
Children And Adolescents ◽  
Rhode Island ◽  
Age Groups ◽  
Diagnostic Value ◽  
Case Definition ◽  
Receiver Operating Curve ◽  
Older Children ◽  
Probable Case ◽  
Exposure History

Purpose To evaluate the diagnostic value of symptoms used in the screening approaches by daycares and schools for identifying children and adolescents with possible SARS-CoV-2 infection, we designed a large observational study utilizing the data from primary care settings. Methods This cohort study included children and adolescents evaluated in a network of clinics in Rhode Island. Participants were age-stratified: 0-4, 5-11, and 12-17 years. We estimated the sensitivity, specificity, and area under the receiver operating curve (AUC) of individual symptoms and three symptom combinations: a probable case definition published by the Rhode Island Department of Health (RIDOH), and two novel combinations generated by different statistical approaches to maximize sensitivity and AUC. We evaluated the test characteristics of symptom combinations both with and without consideration of COVID-19 exposure. Results Two-hundred seventeen (39.1%) of 555 participants were SARS-CoV-2-infected. Fever was more common among 0-4 years-olds (p=0.002); older children more frequently reported fatigue (p=0.02) and anosmia or ageusia (p=0.047). In children >5 years old, anosmia or ageusia had 94-98% specificity. In all age groups, exposure history most accurately predicted infection. In combination with COVID-19 exposure history, various symptom combinations had sensitivity >95% but specificity <30%. No individual symptom or symptom combination had AUC ≥0.70. Conclusions Anosmia or ageusia in children ≥5 years old and dyspnea in children 5-11 years old should raise providers' index of suspicion for COVID-19. However, our overall findings underscore the limited diagnostic value of symptoms and the critical need for widely available, efficient testing.

Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus

2013 ◽  
Vol 37 (4) ◽  
pp. 377-380 ◽  
Author(s):  
D Dakovic ◽  
M Colic ◽  
S Cakic ◽  
I Mileusnic ◽  
Z Hajdukovic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Statistical Significance ◽  
Control Group ◽  
Healthy Children ◽  
Study Results ◽  
Type 1 Dm

Objective: The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type 1 diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established. Methods: Twenty children and adolescents with Type 1 DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study. Results: The Salivary IL-8 level was statistically significantly (p&lt;0.005) elevated in subjects with Type 1 DM (474.47 ± 716.76) compared to non-diabetic control group (101.99 ± 68.32). There was no difference (p≯0.05) in the salivary IL-8 level when subjects with Type 1 DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type 1 DM was correlated with the clinical parameters, no statistical significance was found. Conclusion: An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.

scholarly journals Impaired awareness of hypoglycemia in children and adolescents with type 1 diabetes mellitus in north of Jordan

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Mohammad J. Alkhatatbeh ◽  
Nedaa A. Abdalqader ◽  
Mohammad A. Y. Alqudah
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Severe Hypoglycemia ◽  
Common Symptom ◽  
Insulin Regimen ◽  
Impaired Awareness ◽  
Type 1 Dm

Abstract Background Hypoglycemia is a common complication of insulin therapy in patients with Type 1 Diabetes Mellitus (DM). Awareness of hypoglycemic symptoms helps patients to recognize hypoglycemia and initiate self-treatment. Impaired Awareness of Hypoglycemia (IAH) exposes patients to severe hypoglycemia, which could be associated with seizures and unconsciousness. This study aimed to assess IAH, frequency of hypoglycemia, severe hypoglycemia and intensity of hypoglycemic symptoms among children and adolescents with Type 1 DM in North of Jordan. Methods Data were collected from 94 children and adolescents with Type 1 DM. Clarke’s and Edinburgh surveys were used to assess IAH and individual symptoms of hypoglycemia, respectively. Frequency of hypoglycemia and other related information were obtained by self-reporting or from medical records. Results 16.0% of participants were having IAH, 66.0% of participants reported recurrent hypoglycemia (>once/month) and 18.0% of participants developed ≥1 severe hypoglycemia during the previous year. IAH was not associated with age, gender, duration of DM, HbA1c, insulin regimen, adherence to insulin or development of severe hypoglycemia (p-values> 0.05). Instead, IAH was associated with frequency of hypoglycemia during the previous 6 months (p-value< 0.01). Hunger, tiredness, dizziness, drowsiness, inability to concentrate, trembling and weakness were the most common symptoms felt by participants when they develop hypoglycemia. Hunger was the only common symptom that was significantly higher in children compared to adolescent (p-value < 0.01). Conclusions This study has reported low prevalence of IAH in children and adolescents with Type 1 DM in North of Jordan. IAH was more common in subjects with more frequent hypoglycemia.

scholarly journals Impairment of carbohydrate metabolism in children and adolescents with obesity

2021 ◽  
pp. 174-182
Author(s):  
A. V. Vitebskaya ◽  
A. V. Popovich
Keyword(s):  
Children And Adolescents ◽  
Carbohydrate Metabolism ◽  
Insulin Pump ◽  
Pediatric Population ◽  
Insulin Pump Therapy ◽  
Type 2 Dm ◽  
Obesity Complications ◽  
Type 1 Dm

Obesity is one of the socially significant diseases of our time and is a generally recognized risk factor for the development of carbohydrate metabolism disorders, including type 2 diabetes mellitus (DM), the prevalence of which in the pediatric population is rapidly increasing.Aim of the study. To demonstrate the most frequent types of carbohydrate metabolism disorders in children and adolescents with obesity.Materials and methods. 123 obese patients under 18 years old were examined and the structure of obesity complications was analyzed.Results. Carbohydrate metabolism disorders were identified in 24 patients (19%): impaired fasting glycemia (IFG) (8 girls, 6 boys (11%)), type 2 DM (6 girls, 3 boys (7%)), and type 1 DM (1 boy (1%)). Descriptions of 4 clinical cases are given: 1) patient, 17 years old, with constitutional-exogenous obesity of 3rd degree, arterial hypertension (AH), dyslipidemia and nonalcoholic fatty liver disease (NAFLD) and a history of transient IFG; 2) patient, 16 years old, with morbid obesity, NAFLD, AH, polycystic ovarian syndrome (PCOS), type 2 DM, compensated on metformin therapy; 3) patient, 17 years old, with constitutional-exogenous obesity of the 3rd degree, AH, dyslipidemia, NAFLD, type 2 DM (on insulin pump therapy), complicated by diabetic nephropathy and diabetic polyneuropathy; 4) patient, 12 years old, with type 1 DM, manifested against the background of obesity.Conclusion. When screening for obesity complications in children and adolescents, carbohydrate metabolism disorders may be detected in one in five patients. Prediabetes in childhood can be transient. When a child with obesity is identified, differential diagnosis of type 1 and type 2 DM should be made. It is necessary to teach patients with type 2 DM the skills of self-monitoring on a par with patients with type 1 DM and motivate them to control glycemia regularly at home.

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