scholarly journals Efficacy of program for treatment and training of patients with type 1 diabetes

1994 ◽  
Vol 40 (3) ◽  
pp. 15-19
Author(s):  
Ye. G. Starostina ◽  
M. B. Antsiferov ◽  
G. R. Galstyan ◽  
I. I. Dedov
Keyword(s):  
Diabetes Mellitus ◽  
Age Groups ◽  
Basic Principles ◽  
Results Of Treatment ◽  
Glycemia Level ◽  
New Strategy ◽  
Traditional Approaches ◽  
And Training ◽  
Insulindependent Diabetes

The authors analyze the results of comprehensive, prospective, controlled investigation of the program for intensive care and training of 121 patients with insulindependent diabetes mellitus (IDDM). The basic principles of the program are training on a teams basis, intensive insulin therapy, automonitoring of metabolism, and liberal diet. The results demonstrate that glycemia level approaching the normal may be attained and maintained in the majority of patients without increasing the risk of grave hypoglycemia, cases with severe diabetic ketoacidosis may be eliminated, and periods of temporary invalidity of patients reduced by 7-10 times. The selected training program was equally effective for patients of various age groups and levels of education, as well as for patients with labile diabetes. Results of treatment did not depend on the type of insulin preparations used. The authors conclude on a higher efficacy of new strategy of IDDM treatment in comparison with the traditional approaches.

scholarly journals Decrease in Mandibular Cortical in Patients With Type 1 Diabetes Mellitus Combined with Poor Glycemic Control

2017 ◽  
Vol 28 (5) ◽  
pp. 552-558 ◽  
Author(s):  
Francisco Ivison Rodrigues Limeira ◽  
Patrícia Ravena Meneses Rebouças ◽  
Denise Nóbrega Diniz ◽  
Daniela Pita de Melo ◽  
Patrícia Meira Bento
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Cortical Bone ◽  
Age Groups ◽  
Exact Test ◽  
Chi Squared ◽  
Panoramic Images ◽  
And Gender

Abstract In this study we analyzed the mandibular cortical bone of patients with type 1 diabetes mellitus (T1DM) and non-diabetic. Fifty patients with T1DM and 100 non-diabetic ones paired by age and gender were analyzed. Two double-blinded observers evaluated 150 digital panoramic images of both groups. The mandibular cortical bone was analyzed using the Mandibular Cortical Index (MCI), Mental Index (MI), Gonial Index (GI), Antegonial Index (AI) and Upper and Lower Panoramic Mandibular Indexes (UPMI and LPMI), with the aid of RADIOIMP® software. Influence of T1DM in the morphology of the mandibular cortical bone was studied based on obtaining data related to T1DM diagnosis time, blood glucose level, T1DM control and the presence of chronic complications. Collected data were submitted to descriptive (mean and standard deviation) and inferential analyzes (Pearson’s chi-squared test and Fisher’s exact test) (p≤0.05). According to the MCI, individuals with T1DM had higher frequencies of mandibular cortical alterations, in both sexes and all age groups (p<0.01). For quantitative indexes, MI, GI, AI, UPMI and LPMI, female patients showed statistically significant differences for GI and AI, while male patients had statistically significant differences for all indexes (p<0.05), presenting the individuals with TDM1 inferior measures. Individuals with poor T1DM control showed significantly higher frequency of mandibular cortical alteration (92.3%), with lower means for MI, GI, AI and LPMI (p≤0.05). In conclusion, patients with T1DM showed decrease in the mandibular cortical bone when compared to non-diabetic ones, indicating that poor disease control is associated with these alterations.

scholarly journals Prevalence, morbidity and mortality of hypertriglyceridemic acute pancreatitis in the General Hospital of Playa del Carmen, México. Analysis of five years

2019 ◽  
pp. 01-06
Author(s):  
Argel de Jesús Concha May ◽  
Guillermo Padrón Arredondo
Keyword(s):  
Diabetes Mellitus ◽  
Acute Pancreatitis ◽  
Age Groups ◽  
Morbidity And Mortality ◽  
Cross Sectional ◽  
History Of ◽  
Hospital Stays ◽  
Clinical Conditions

Introduction: Hypertriglyceridemia (HTG) is the underlying cause of pancreatitis in 7% of the general population and is the third cause after gallstones and alcohol. HTG may be associated with acute pancreatitis as an epiphenomenon or as a precipitant thereof. Generally, more than 75% of pancreatitis induced by hypertriglyceridemia is due to secondary causes and although these are not sufficient to elevate triglycerides to cause pancreatitis, a preexisting defect is required to obtain a TG>1000 mg/dL to induce acute pancreatitis. Material and Method: To identify the prevalence morbidity and mortality of acute pancreatitis due to hypertriglyceridemia, a retrospective and cross-sectional observational clinical study was performed for a period of five years. Results: During the study period, 100 cases of acute pancreatitis of various etiologies were collected, 29 (29%) of which corresponded to acute pancreatitis of hypertriglyceridemic origin; history of risk: type 1 Diabetes mellitus one case (3.4%); Type 2 Diabetes mellitus 27 cases (24%); history of alcoholism nine cases (31%); positive smoking 4 cases (13.8%); hypertriglyceridemia 27 cases (94%); obesity 17 cases (59%); lipemic serum 19 cases (65.5%), and In-hospital stays average six days. Mortality in one case. Discussion: In the Mexican national survey of ENASUT 2012, it was found by age group that hypercholesterolemia is highest in the age groups of 50-69 years of age. (Table 1) The frequency of hyperlipidemia in patients with pancreatitis ranges from 12 to 38%, and of hypertriglyceridemia, between 4 and 53%; what is important is to define whether its presence is primary or causal, or secondary or consequence of other clinical conditions such as Diabetes mellitus, alcohol abuse, pregnancy or use of medications. The triglycerides were obtained on routine laboratory tests in our hospital and their values were steadily elevated and the hipertrigliceridemic acute pancreatitis is the principal cause instead the alcoholic acute pancreatitis. Keywords: Pancreatitis acute;Hypertriglyceridemic; Prevalence; Morbidity; Mortality

scholarly journals The prevalence of type 1 diabetes mellitus among adolescents and adults in Lithuania during 1991–2004

Medicina ◽  
2007 ◽  
Vol 43 (3) ◽  
pp. 242 ◽  
Author(s):  
Rytas Ostrauskas
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Age Groups ◽  
Diabetic Patients ◽  
Female Age ◽  
Adolescents And Adults ◽  
The Mean ◽  
Type 1 Diabetic Patients

Objective. The goal of this study was to summarize the data on the prevalence of type 1 diabetes mellitus among Lithuanian population aged more than 15 years. Material and methods. The data on patients aged more than 16 years were collected with the help of general practitioners, endocrinologists, and physicians-internists working in the diabetes care in all towns and regions of Lithuania. The data on patients aged 14 to 16 years were obtained from the National Register of Diabetes Mellitus in Childhood in Lithuania. Results. In Lithuania, on December 31, 1991, there were 2179 adolescent and adult patients with type 1 diabetes mellitus or 75.21 per 100 000 inhabitants of the same age group (95% Poisson CI 72.12–78.43), and at the end of 2004 – 3996 or 140.69 (95% Poisson CI 136.40– 145.12), respectively. During a 14-year period, the mean increase in the number of type 1 diabetic patients was 144.85±23.32 persons per year or 4.66±1.17% or 4.04±1.19 cases per 100 000 population (for males 85.54±10.82 or 5.06±1.02% or 6.81±1.57/100 000 and for females 54.23±9.05 or 3.93±0.86% or 3.56±1.05/100 000). Regression-based linear trends showed that the prevalence of type 1 diabetes mellitus among population aged more than 15 years had a tendency to increase. The prevalence rates of type 1 diabetes mellitus among adolescent and adult subjects, adjusted for Lithuanian male and female age groups, were 80.64/100 000 and 70.23/100 000 in 1991 (P<0.05) and 166.52 and 117.63 in 2004 (P<0.05), respectively. Conclusions. The prevalence of type 1 diabetes mellitus among Lithuanian females aged more than 15 years was lower than among males. The register provides the possibility of highly precise collection of the data on patients from various medical care units in Lithuania.

scholarly journals A new strategy for vascular complications in young people with type 1 diabetes mellitus

2019 ◽  
Vol 15 (7) ◽  
pp. 429-435 ◽  
Author(s):  
M. Loredana Marcovecchio ◽  
◽  
R. Neil Dalton ◽  
Denis Daneman ◽  
John Deanfield ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Young People ◽  
Type 1 Diabetes Mellitus ◽  
Vascular Complications ◽  
New Strategy

P1358 New insights into cardiac dysfunction assessed by left atrial function in patients with type 1 diabetes mellitus

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Ifuku ◽  
K Takahashi ◽  
T Iso ◽  
S Akimoto ◽  
Y Hosono ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Cardiac Dysfunction ◽  
Left Atrial ◽  
Age Groups ◽  
Left Ventricular ◽  
Stiffness Index ◽  
Lv Function

Abstract BACKGROUND There have been many reports of heart failure due to diabetic cardiomyopathy and decreased left ventricular (LV) function with increasing age in patients with type 1 diabetes mellitus (T1DM). Recently, although left atrial (LA) function has been occasionally reported to be a more useful prognostic indicator than LV function in acquired heart diseases, LA function in patients with T1DM has not yet been studied. PURPOSE To investigate LA dysfunction in patients with T1DM. METHODS Fifty patients with T1DM were recruited (age, 5–41 years). We excluded patients who had a history of heart disease, hypertension, and those taking cardioprotective agents. The patients and 50 age-matched controls were classified into 3 age groups (D1, C1, 5–14 years; D2, C2, 15–29 years; D3, C3, 30–41 years). The LA phasic function serving as the reservoir, conduit, and pump strains; the LA strain rate (SR) in the systole, early diastole, and late diastole; and the LV global longitudinal strain (LV-LS) as determined via 2-dimensional speckle tracking imaging were measured from the apical four- and two-chamber views. We also calculated the LA stiffness index as the ratio of E/e’ to the LA reservoir strain. RESULTS There was no significant difference in left ventricular ejection fraction in each age group. The LA reservoir strains in D2 and D3 were significantly lower than those in C2 (40.8 ± 5.7% vs. 47.2 ± 5.5%, p = 0.005) and C3 (39.2 ± 5.5% vs. 47.3 ± 5.7%, p = 0.004), respectively. The LA conduit strain in D2 was significantly lower than that in C2 (28.9 ± 5.8% vs. 35.0 ± 5.0%, p = 0.006). The LA pump strain and the three phases of LA SR were not significantly different among the age groups. The LA stiffness index in D3 increased significantly compared to that in N3 (0.18 ± 0.05 vs. 0.13 ± 0.01, p &lt;0.001). The LV-LS in D2 and D3 was significantly lower than that in C2 (-15.7 ± 1.7% vs. -18.7 ± 2.1%, p &lt;0.001) and C3 (-15.3 ± 1.8% vs. -19.3 ± 2.0%, p &lt;0.001), respectively. The LA reservoir strain significantly correlated with LV-LS (r = -0.468, p &lt; 0.001). Both the LA reservoir strain and LV-LS in patients with T1DM decreased significantly (p = 0.028, p &lt; 0.042, respectively) and correlated with increasing age (r = -0.323, r = 0.286, respectively). The LV stiffness index did not correlate with age or LV-LS. CONCLUSIONS The LA reservoir strain might be as useful as LV-LS as an early marker of cardiac dysfunction in patients with T1DM. The correlation coefficient between the LA reservoir strain and LV-LS was not strong. Therefore, although LV-LS might affect the LA reservoir strain, it might represent other aspects of cardiac dysfunction. The increase of LA stiffness might represent the changes in LA wall properties and could be another useful indicator of cardiac dysfunction during long-term follow-ups, which is independent of LV-LS. Overall, these findings provide new insights into cardiac dysfunction in patients with T1DM.

An increasing incidence of type 1 diabetes mellitus in Romanian children aged 0 to 17 years

2015 ◽  
Vol 0 (0) ◽  
Author(s):  
Viorel Serban ◽  
Stuart Brink ◽  
Bogdan Timar ◽  
Alexandra Sima ◽  
Mihaela Vlad ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Medical Center ◽  
Demographic Data ◽  
Age Groups ◽  
Diabetes Registry ◽  
And Gender ◽  
Adjusted Incidence

AbstractThe epidemiology of type 1 diabetes mellitus may provide insights into the pathogenesis of the disease.The aim of this work was to characterize the trend of the incidence of type 1 diabetes mellitus in Romanian children aged from 0 to 17 years over a 10-year interval.Data regarding new cases were obtained from two sources: (1) The Romanian Childhood Diabetes Registry and (2) Records of the Medical Center “Cristian Serban”, Buzias. The demographic data were retrieved from the National Institute for Statistics. The incidence was calculated for the age groups 0–4, 5–9, 10–14, and 15–17 years.A total of 3196 new cases, aged below 18 years, were found by both the sources. There were significant differences between the groups (p=0.012), the mean incidence being highest in the age group 10–14 years (9.6/100,000/year, 95% CI 9–10.1) and lowest in children aged from 0 to 4 years (4.8/100,000/year, 95% CI 4.4–5.3). Boys were slightly more frequently affected than girls (p=0.038). The age and gender adjusted incidence of type 1 diabetes mellitus increased significantly (p<0.001) from 6.2/100,000/year (95% CI 5.5–6.9) in 2002 to 9.3/100,000/year (95% CI 8.4–10.3) in 2011. The raise in incidence was noticed in all age groups except for 15–17 years.Romania is a country with an intermediate incidence of type 1 diabetes mellitus in children, which is slightly higher in boys than in girls. The incidence of type 1 diabetes mellitus increased continuously during the 10-year survey, with the exception of the oldest teens.

scholarly journals The analysis of a diabetes mellitus of type 1 desease and prevalence among children and teenagers of Tomsk Region

2010 ◽  
Vol 9 (6) ◽  
pp. 148-154
Author(s):  
Yu. G. Samoilova ◽  
A. V. Enert
Keyword(s):  
Diabetes Mellitus ◽  
Age Groups ◽  
Developed Countries ◽  
Federal Register ◽  
Younger Age ◽  
The World ◽  
Tomsk Region ◽  
The Developed Countries ◽  
The Given

The diabetes mellitus of 1 type (DM1) represents a huge problem all over the world. In spite of the fact that there is a plenty of the saved up knowledge on эпидемиологии and management of the given disease in the developed countries, there is a number of mistakes and the discrepancies supposed at creation of the Federal register of a diabetes that is connected with absence of completeness of scope of all regions. With the purpose of reception of the full information on prevalence and desease DM1 among children and teenagers, for duly maintenance sick DM1 necessary quantity of insulin and means of self-checking and as with the purpose of updating of data of the Federal register there was a necessity to estimate an epidemiological situation on DM1 among children and teenagers of Tomsk Region. The lead analysis has shown, that growth DM1 in all age groups and especially among children of younger age is marked.

scholarly journals Immunohystochemical study of the largest islets of human pancreas in aging and diabetes mellitus: perspectives for the transplantation

2013 ◽  
Vol 16 (4) ◽  
pp. 38-43
Author(s):  
Alexandra Evgen'evna Proshchina ◽  
Yulia Sergeevna Krivova ◽  
Valeriy Mikhaylovich Barabanov ◽  
Sergey Vyacheslavovich Savelyev
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Islets ◽  
Age Groups ◽  
Diabetes Mellitus Type 1 ◽  
Pancreatic Tissue ◽  
Control Group ◽  
Human Pancreas ◽  
Patients With Diabetes ◽  
The Rich

Aim.  To study the distribution and cellular architecture of the largest human pancreatic islets (with a diameter of more than 200 micron) in aging and diabetes mellitus types 1 and 2. Materials and methods.  Antibodies to insulin, glucagon, somastatin and nturon-specific enolase were applied. The autopsy samples of the pancreatic tissue of patients with diabetes mellitus type 1 (DMT1) and type 2 (DMT2) and 2 age groups (up to 50 years old (control) and after 50 (aging control)), not suffering from diseases of the pancreas and carbohydrate metabolism malfunction were investigated. Results.  The number of islets with diameter more than 200 mkm compared to control group increased both in aging and diabetes groups. Their number reaches in some cases 15% (and higher in DM) of the total number of islets. These islets compared to the other are rich-vascularized. It was shown that glucagon and somatostatin-containing cells are found both on the periphery of the large islets, and inside them only in the immediate proximity of the capillaries. Insulin-containing cells form clusters, surrounded by the capillaries and the ?- and ?-cells, while the inner part of such clusters has no direct contact with the capillaries. In the large islets the number of glucagon-containing cells is often increased, and insulin-containing cells show signs of degradation. Conclusion.  The largest of the pancreatic islets may be useless for the transplantation, because of the high content of glucagon-containing cells, the rich vascularization and, in some cases, the limited functionality of ?-cells.

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