scholarly journals Differential diagnosis of hyperthyroidism with highly sensitive assay of blood TTH: clinical review and practical recommendations for use in Russia and USA

1994 ◽  
Vol 40 (5) ◽  
pp. 36-39
Author(s):  
J. Figge ◽  
G. A. Gerasimov

Highly sensitive methods for determining the level of TSH, carried out using test kits of the second and third generation, make it possible to differentiate with high accuracy the normal and subnormal levels of TSH in the blood and are currently widely used to examine patients with thyroid pathology. These methods have been used for a long time in clinical practice in the United States of America, and recently they are also increasingly used in Russia. The level of TSH below normal values ​​is determined in almost all cases of hyperthyroidism (with the exception of cases of TSH-secreting pituitary adenoma or resistance of the pituitary to thyroid hormones), which makes it possible to do without additional testing with tyroliberin (TRH). Methods for determining second generation TSH usually have a lower sensitivity limit of about 0.1 mU/L. When using the third generation methods, it is possible to accurately determine the level of TSH up to 0.01 mU/L. The fourth generation methods, which are still under development, will have a lower limit of determination of 0.001 mU/L, but they are unlikely to be used for routine clinical studies in the near future. At the Endocrinology Research Center of the Russian Academy of Medical Sciences in Moscow, third-generation methods are currently being used for routine clinical research (the Amerlight system, produced in Russia by the Amerkard joint venture). In addition to this system, other test systems of both domestic and foreign production are also available in Russia. In the USA, methods for determining TTG of the second and third generation are used. Third-generation systems are noticeably more expensive than second-generation systems. Given that in most patients with hyperthyroidism, the TSH level is in the range of less than 0.1 mU/L, methods for determining the third generation are more preferable. In general, the normal level of TSH in the blood of individuals in a state of euthyroidism is from 0.5 to 5.0 mU/L, although there are some interlaboratory differences in the standards for the level of TSH.

Author(s):  
В.И. Щуров ◽  
А.С. Замотайлов

Развитие первой генерации Corythucha arcuata в предгорьях и низкогорьях Северо-Западного Кавказа начинается в первых числах мая. При нижнем пороге пост-диапаузного развития имаго +11°С и при естественной длине дня ей требуется не менее 43 суток (аккумуляция 333-404 гр.-дн.). Гибель перезимовавших самок в этой зоне наблюдается к концу июня, совпадая с сокращением общей доли самок до 2-7%. В высокогорьях перезимовавшие имаго расселяются и в июне, доживая до июля на ивах и березах. Пик выхода имаго первого поколения приходится на конец июня. Массовая яйцекладка самками первого поколения (начало второго поколения) предваряется миграцией оплодотворенных самок на новые кормовые растения. Развитие преимагиальных стадий второго поколения (без смены кормовых растений) протекает с середины июня. Метаморфоз длится не менее 16-23 суток (361-430 гр.-дн.). Пик выхода имаго второго поколения в конце июля совпадает с массовым расселением, в котором всегда преобладают самки. Третье поколение развивается в августе. Метаморфоз занимает 19-28 суток (329-350 гр.-дн.). Пик выхода имаго третьего поколения приходится на первую декаду сентября. Его предваряет более ранний выход самцов, определяемый по их локальным и региональным миграциями с конца августа. Четвертое поколение является факультативным и развивается (без смены кормовых растений) с конца августа до третьей декады сентября. Развитие преимагиальных стадий этого поколения занимает не менее 26 суток (378 гр.-дн.). Последняя миграция клопов наблюдается в начале-середине октября. Самки третьего поколения первыми уходят в места зимовки в предгорьях и низкогорьях уже в середине сентября. Здесь, в дубовых лесах, зимуют имаго третьего и четвертого поколений обычно с преобладанием самок. В среднегорьях с ними могут зимовать особи-иммигранты второго поколения, но с преобладанием самцов, сохраняющимся с сентября. Development of the first generation of Corythucha arcuata in the climate of the foothills and lowlands of the Northwest Caucasus starts in the early May. With a natural day length and the threshold for post-diapause imago development of 11 °C, it requires 333-404 degree-days and at least 43 days. The death of the overwintered females in this zone is observed by the end of June, coinciding with the reduction of the total portion of females to 2-7%. In the highlands imagoes are dispersing in June as well, surviving until July on willows and birch trees. Peak of the first-generation imago outcome occurs at the end of June. Migration of fertilized females of the first generation to new forage plants is followed by mass egg laying (i.e. beginning of the second generation). During the formation of large nests in the foothills, the flight of bugs is observed even in treeless highlands. Development of the preadult stages of the second generation (without changing feed plants) takes place starting at mid-June. Metamorphosis requires 361-430 degree-days and takes at least 16-23 days. The peak of the emergence of the second generation imagoes at the end of July coincides with their dispersal, which is also dominated by females. The third generation develops in August. It requires 329-350 degree-days and takes 19-28 days. The peak of the emergence of the G3 imagoes falls on the first third of September. It is preceded by anearlier emergence of males, determined by their mass local and regional migrations since the end of August. The fourth generation is obligated and develops (without changing feed plants) from the end of August to the end of September. It requires at least 378 degree-days and takes at least 26 days. Late nymphs resulting from female immigrant of the third generation (on new trees) give imagoes only by mid-October. The last migration of bugs is observed in early to mid-October. Imagoes of the third and fourth generations with the predominance of females hibernate in the oak forests of the foothills and low-mountain. In the midlands they may be accompanied by the overwintering immigrants of the second generation, with the predominance of males, formed in September.


ATAVISME ◽  
2017 ◽  
Vol 20 (2) ◽  
pp. 168-180
Author(s):  
Muhri Muhri

This research aims to classify the Bangkalan poets into generations and trends on the themes of each generation. The underlying theories are those that affect the subdiscipline of literary history, especially the theories within the deconstructive paradigm. Data were obtained through interviews and study of literary work, namely the works of Bangkalan poets. From the analysis, generation of poets of Bangkalan can be divided into four generations based on tradition and common interests as manifested in the organization or forum where those poets gather. The first generation was in the Arts Council of Bangkalan (Dewan Kesenian Bangkalan or DKB), the second generation was raised in the Tera' Bulan Community, the third generation came from the campus theater communities around Bangkalan, and the fourth generation was in Masyarakat Lumpur Community and Bawah Arus Community. Metaphysical and social were dominant themes in the early generation, libidinal love theme was a theme that tended to appear in the second generation, local and lyrical themes tended to emerge in the third and fourth generation.


TO review the course of nuclear physics over many decades of time in the space of an hour’s talk and yet leave time for predicting its future requires a rather impressionistic technique in the presentation. I have chosen as my time markers the human generations which, as I hope you will see, also mark distinct phases in the development of the subject. Conventionally, a generation spans twenty-five years; hence a hundred years covers four generations. The first generation was that of Rutherford and Bohr, followed in the second generation by Heisenberg, Pauli, Blackett, Fermi and their contemporaries, many of whom are here today. The third generation is represented by the nuclear physicists of my own age and finally the fourth generation are those young physicists, now about 25 years old, on whom the development of this subject will depend in the next twenty-five years. I will try to trace through these generations four main themes each of which, in different ways, affects the future of nuclear physics. Firstly, and most importantly, the progress of the research itself; secondly, the development of the research apparatus; thirdly, the evolution of the organization of the research and lastly, the relationships between nuclear physics and the industrial societies which support it.


2007 ◽  
Vol 60 ◽  
pp. 21-25 ◽  
Author(s):  
X.Z. He ◽  
Q. Wang

This study reports an investigation on the aestivation and overwintering strategies of Platygaster demades an egg parasitoid of apple leafcurling midge (ALCM) Dasineura mali under natural conditions during 2005 2006 The first three generations of ALCM developed into adults during the springautumn of 2005/2006 and the fourth generation overwintered as larvae All first generation P demades emerged in the spring of 2005 About 64 of live individuals of P demades in the second generation and 38 in the third generation entered aestivation as eggs which hatched in mid March and early May 2006 respectively Parasitoid eggs of the fourth generation started to hatch four weeks after the parasitised ALCM larvae entered the soil The aestivated and fourth generation parasitoids overwintered as immature stages and started emerging in late September 2006 The emergence patterns of overwintered parasitoids and ALCM were highly synchronized in the following season


2015 ◽  
Vol 5 (5) ◽  
pp. 1-11
Author(s):  
Sonia Mehrotra ◽  
Anil Rao Paila

Subject area Entrepreneurship, family business. Study level/applicability MBA, executive MBA Case overview PN Rao Fine Suits, famously known as the “best tailors” for men's suits and groom wear, started with their first shop in 1923 as a small business of a tailoring shop catering to the needs of the British ladies in Bangalore, India, and by 2013, had four showrooms spread across Bangalore and Chennai, with an annual turnover of INR360 million. Over the years, the patrons of PN Rao have grown not only in Bangalore but across the globe, from countries such as the USA, the UK, Germany, Japan, Denmark, Sweden and The Netherlands. The PN group had three business arms: the PN Rao showrooms, Rupasi and PN Rao Creations. This family business has survived nine decades in business, with the third generation of family now actively involved in the operations and expansion of the business. Chandramohan Pishe and Machender Pishe, the second-generation brothers in the business, believe in a conservative growth path for their brand, compared to the third-generation cousins, Naveen Pishe and Ketan Pishe. Naveen and Ketan are aware of the market opportunities and the competition and often look for the differentiator that their brand can offer. They are very enthusiastic about their future expansion plans and would like to open 100 showrooms by 2023, their centennial year. The market indicators are favourable and, if leveraged strategically, do offer opportunities to fulfil their expansion plans. Naveen and Ketan firmly believe in the need of instituting a family constitution as they move forward with their expansion plans. The second generation is not very confident of this idea, however, as they believe the family values to be strong enough to continue in the same fashion. Expected learning outcomes Understand the challenges of a small business and the importance of re-inventing by leveraging a mix of market opportunities to grow and sustain; to evaluate the need and importance of family constitution at the PN Rao Group to sustain, scale and govern in a manner so as to avoid any kind of future family business conflicts. supplementary materials teaching notes are available for educators only. please contact your library to gain login details or email [email protected] to request teaching notes.


1965 ◽  
Vol 97 (12) ◽  
pp. 1303-1318 ◽  
Author(s):  
H. J. Herbert

AbstractIn Nova Scotia one leaf cluster with an adjoining 1 inch of twig taken from the inside of each of 10 apple trees replicated four times is an adequate sample unit to measure the density of the brown mite.The brown mite has one generation with a partial second in some orchards and one with a partial second and partial third in others. The first generation adults in the bivoltine and trivoltine populations lay summer eggs on the leaves and twigs, and diapause eggs on tin twigs. The second generation adults in the bivoltine populations lay only diapause eggs; in the trivoltine populations they lay both summer and diapause eggs. The adults of the third generation lay only diapause eggs.The brown mite is found on both the leaves and woody parts of the tree. In orchards with bivoltine populations the proportion of mites on leaves reached a peak of 80% by mid-July, but thereafter gradually decreased to 10% by the end of August. However, in orchards with trivoltine populations the proportion of mites on leaves reached a peak of 80 to 90% by mid-July, remained constant until mid-August, and thereafter decreased to approximately 40% by the end of August.The number of diapause eggs laid by adults of each generation in both the bivoltine and trivoltine populations varies widely. The eggs are deposited on the trunk as well as on the branches, with the heaviest deposition in the central area of the tree. The diapause eggs laid by adults of the first generation are the last to hatch and those laid by the third generation are the first to hatch the following spring.The factors responsible for the differences in the number of generations and in the number of diapause eggs laid are unknown.


2020 ◽  
Vol 26 ◽  
pp. 11-41
Author(s):  
Maciej Ziemierski

17th century testaments of the Królik family from Krakow The article is dedicated to the Królik family from Krakow, who lived in the town from the late 16th century until the first years of the 18th century. The family members initially worked as tailors, later reinforcing the group of Krakow merchants in the third generation (Maciej Królik). Wojciech Królik – from the fourth generation – was a miner in Olkusz. The text omits the most distinguished member of the family, Wojciech’s oldest brother, the Krakow councillor Mikołaj Królik, whose figure has been covered in a separate work. The work shows the complicated religious relations in the family of non-Catholics, initially highly engaged in the life of the Krakow Congregation, but whose members gradually converted from Evangelism to Catholicism. As a result, Wojciech Królik and his siblings became Catholics. This work is complemented by four testaments of family members, with the first, Jakub Królik’s, being written in 1626 and the last one, Wojciech Królik’s, written in 1691.


2010 ◽  
Vol 2 (2) ◽  
pp. 46-62 ◽  
Author(s):  
Elie Podeh

Previous research on the way in which the Arab-Israeli conflict and the image of the Arab have been presented in Jewish history and civics textbooks established that there have been three phases, each typified by its own distinctive textbooks. The shift from the first to the third generation of textbooks saw a gradual improvement in the way the Other has been described, with the elimination of many biases, distortions and omissions. This article explores whether new history textbooks, published from 2000 to 2010, have entrenched or reversed this trend. With the escalation of the Israeli-Palestinian conflict since the early 2000s, one might have expected that the past linear process of improvement would be reversed. However, textbooks written over the last decade do not substantially differ from those written in the 1990s, during the heyday of the peace process. The overall picture is, therefore, that the current textbooks do not constitute a fourth generation.


2002 ◽  
Vol 36 (4) ◽  
pp. 1037-1060 ◽  
Author(s):  
Monica Boyd

In this article, I study the educational attainments of the adult offspring of immigrants, analyzing data from the 1996 panel of the Survey of Labour and Income Dynamics (SLID). Fielded annually since 1993 by Statistics Canada, respondents are asked for the first time in 1996 to report the birthplaces of their parents, making it possible to define and study not only the foreign-born population (the first generation), but also the second generation (Canadian born to foreign-born parents) and the third-plus generation (Canadian born to Canadian-born parents). The survey also asked respondents to indicate if they are members of a visible minority group, thus permitting a limited assessment of whether or not color conditions educational achievements of immigrant offspring. I find that “1.5” and second generation adults, age 20–64 have more years of schooling and higher percentages completing high school compared with the third-plus generation. Contrary to the segmented “underclass” assimilation model found in the United States, adult visible minority immigrant offspring in Canada exceed the educational attainments of other not-visible-minority groups. Although the analysis is hampered by small sample numbers, the results point to country differences in historical and contemporary race relations, and call for additional national and cross-national research.


1975 ◽  
Vol 74 ◽  
pp. 8-21

The economy appears to be reaching the bottom of the cycle. Industrial production after a precipitous drop in the second quarter has levelled off since May. Retail prices have decelerated to show month on month rises at annual rates near to 10 per cent since July. The current account deficit, after falling sharply from 1974 levels in the first half of the year, increased again in the third quarter to an annual rate of £2½ billion. The growth of M3 has recently started to exceed the inflation rate, which it has not done since 1973 IV. These indicators suggest that the UK is at this point lagging only a few months behind Japan and the USA and barely if at all behind the other major European economies (see Chapter 2). Unemployment, a lagging indicator, continues to rise in this country, but has started to turn down in the United States and appears to be levelling off in Japan, Germany and France.


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