scholarly journals Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling

2014 ◽  
Vol 37 (5) ◽  
pp. 383-388 ◽  
Author(s):  
Weidong Li ◽  
Qian Wang ◽  
Qiaozhen Su ◽  
Dandan Ma ◽  
Chang An ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition

scholarly journals The natural adaptive evolution of cancer: The metastatic ability of cancer cells

2020 ◽  
Author(s):  
Gheorghe-Emilian Olteanu ◽  
Ioana-Maria Mihai ◽  
Florina Bojin ◽  
Oana Gavriliuc ◽  
Virgil Paunescu
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
The Body ◽  
Mesenchymal Transition ◽  
Metastatic Pathway ◽  
New Treatment ◽  
New Hypothesis ◽  
Mesenchymal Epithelial Transition

The ability of cancer to adapt renders it one of the most challenging pathologies of all time. It is the most dreaded pathological entity because of its capacity to metastasize to distant sites in the body, and 90% of all cancer-related deaths recorded to date are attributed to metastasis. Currently, three main theories have been proposed to explain the metastatic pathway of cancer: the epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) hypothesis (1), the cancer stem cell hypothesis (2), and the macrophage–cancer cell fusion hybrid hypothesis (3). We propose a new hypothesis, i.e., under the effect of particular biochemical and/or physical stressors, cancer cells can undergo nuclear expulsion with subsequent macrophage engulfment and fusion, with the formation of cancer fusion cells (CFCs). The existence of CFCs, if confirmed, would represent a novel metastatic pathway and a shift in the extant dogma of cancer; consequently, new treatment targets would be available for this adaptive pathology.

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