Umbilical cord blood concentrations of labetalol hydrochloride administered to patients with pregnancy induced hypertension, and subsequent neonatal findings

Background: Pregnancy induced hypertension (PIH) is a multisystem disease of unknown etiology which affects only human beings. It poses several problems to both mother and child. Complications in newborns like intrauterine death (IUD), intrauterine growth retardation (IUGR), perinatal asphyxia, neonatal sepsis and bleeding disorders are associated with toxaemia of pregnancy. To decrease the perinatal morbidity and mortality, babies of hypertensive mothers should be carefully monitored and managed. Aim of this study was to establish the changes in total platelet count, reticulocyte count and absolute neutrophil count of umbilical cord blood in pregnancy induced hypertension as compared to normotensive mothers.Methods: This case-control study was conducted among 60 subjects including 30 case (diagnosed cases of pregnancy induced hypertension) and 30 control (normotensive pregnant women). The case group was again categorized into three subgroups – gestational hypertension (06), pre-eclampsia (16) and eclampsia (08). In all the subjects, 2 ml of umbilical cord blood anticoagulated with EDTA was collected and haematological tests for reticulocyte count, total platelet count (TPC) and absolute neutrophil count was done.Results: There was significant decrease in TPC (p<0.01) and absolute neutrophil count (p<0.01), but significant rise in reticulocyte count (p<0.05) in umbilical cord blood of babies born to hypertensive mothers compared to normotensive mothersConclusions: From this study, it can be concluded that newborns of hypertensive mothers carry risks for infection and bleeding complications. So, these simple haematological tests can be done at early stage in neonates to reduce possible perinatal morbidities and mortality.

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Association between maternal or cord blood concentrations of 25-hydroxycholecalciferol or vitamin D supplementation during pregnancy and the cytokines profile in the umbilical cord blood: Systematic literature review

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2020.105739 ◽

2020 ◽

Vol 203 ◽

pp. 105739

Author(s):

Myrla C. de O. Farias ◽

Thayse de L.T. Cavalcante ◽

Monica L. Assunção ◽

Nassib B. Bueno

Keyword(s):

Vitamin D ◽

Literature Review ◽

Cord Blood ◽

Umbilical Cord ◽

Systematic Literature Review ◽

Umbilical Cord Blood ◽

Vitamin D Supplementation ◽

Blood Concentrations ◽

25 Hydroxycholecalciferol

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Maternal venous procalcitonin levels do not correlate with umbilical cord blood and venous blood concentrations in the neonate

Journal of Perinatal Medicine ◽

10.1515/jpm.2006.109 ◽

2006 ◽

Vol 34 (6) ◽

Cited By ~ 6

Author(s):

Agnieszka Kordek ◽

Andrzej Torbé ◽

Ryszard Czajka

Keyword(s):

Cord Blood ◽

Umbilical Cord ◽

Umbilical Cord Blood ◽

Venous Blood ◽

Blood Concentrations

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Estradiol and Progesterone Strongly Inhibit the Innate Immune Response of Mononuclear Cells in Newborns

Infection and Immunity ◽

10.1128/iai.00076-11 ◽

2011 ◽

Vol 79 (7) ◽

pp. 2690-2698 ◽

Cited By ~ 60

Author(s):

Eric Giannoni ◽

Laurence Guignard ◽

Marlies Knaup Reymond ◽

Matthieu Perreau ◽

Matthias Roth-Kleiner ◽

...

Keyword(s):

Cord Blood ◽

Umbilical Cord ◽

Umbilical Cord Blood ◽

Bacterial Infections ◽

Mononuclear Cells ◽

Innate Immune ◽

Mitogen Activated Protein Kinase ◽

Blood Concentrations ◽

Content Type ◽

Blood Mononuclear Cells

ABSTRACTNewborns are particularly susceptible to bacterial infections due to qualitative and quantitative deficiencies of the neonatal innate immune system. However, the mechanisms underlying these deficiencies are poorly understood. Given that fetuses are exposed to high concentrations of estradiol and progesterone during gestation and at time of delivery, we analyzed the effects of these hormones on the response of neonatal innate immune cells to endotoxin, bacterial lipopeptide, andEscherichia coliand group BStreptococcus, the two most common causes of early-onset neonatal sepsis. Here we show that at concentrations present in umbilical cord blood, estradiol and progesterone are as powerful as hydrocortisone for inhibition of cytokine production by cord blood mononuclear cells (CBMCs) and newborn monocytes. Interestingly, CBMCs and newborn monocytes are more sensitive to the effects of estradiol and progesterone than adult peripheral blood mononuclear cells and monocytes. This increased sensitivity is associated with higher expression levels of estrogen and membrane progesterone receptors but is independent of a downregulation of Toll-like receptor 2 (TLR2), TLR4, and myeloid differentiation primary response gene 88 in newborn cells. Estradiol and progesterone mediate their anti-inflammatory activity through inhibition of the NF-κB pathway but not the mitogen-activated protein kinase pathway in CBMCs. Altogether, these results suggest that elevated umbilical cord blood concentrations of estradiol and progesterone acting on mononuclear cells expressing high levels of steroid receptors contribute to impair innate immune responses in newborns. Therefore, intrauterine exposure to estradiol and progesterone may participate in increasing susceptibility to infection during the neonatal period.

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Effect of Maternal Retinol Status at Time of Term Delivery on Retinol Placental Concentration, Intrauterine Transfer Rate, and Newborn Retinol Status

Biomedicines ◽

10.3390/biomedicines8090321 ◽

2020 ◽

Vol 8 (9) ◽

pp. 321 ◽

Cited By ~ 1

Author(s):

Melissa Thoene ◽

Haley Haskett ◽

Jeremy Furtado ◽

Maranda Thompson ◽

Matthew Van Ormer ◽

...

Keyword(s):

Cord Blood ◽

Umbilical Cord ◽

Umbilical Cord Blood ◽

Transfer Rate ◽

Blood Concentrations ◽

United States Population ◽

Institutional Review ◽

Term Delivery ◽

Parametric Statistics ◽

Retinol Concentration

Retinol (vitamin A) is essential, so the objective of this Institutional Review Board approved study is to evaluate retinol placental concentration, intrauterine transfer, and neonatal status at time of term delivery between cases of maternal retinol adequacy, insufficiency, and deficiency in a United States population. Birth information and biological samples were collected for mother–infant dyads (n = 260). Maternal and umbilical cord blood retinol concentrations (n = 260) were analyzed by HPLC and categorized: deficient (≤0.7 umol/L), insufficient (>0.7–1.05 umol/L), adequate (>1.05 umol/L). Intrauterine transfer rate was calculated: (umbilical cord blood retinol concentration/maternal retinol concentration) × 100. Non-parametric statistics used include Spearman’s correlations, Mann–Whitney U, and Kruskal–Wallis tests. p-values <0.05 were statistically significant. Only 51.2% of mothers were retinol adequate, with 38.4% insufficient, 10.4% deficient. Only 1.5% of infants were retinol adequate. Placental concentrations (n = 73) differed between adequate vs. deficient mothers (median 0.13 vs. 0.10 μg/g; p = 0.003). Umbilical cord blood concentrations were similar between deficient, insufficient, and adequate mothers (0.61 vs. 0.55 vs. 0.57 μmol/L; p = 0.35). Intrauterine transfer increased with maternal deficiency (103.4%) and insufficiency (61.2%) compared to adequacy (43.1%), p < 0.0001. Results indicate that intrauterine transfer rate is augmented in cases of maternal retinol inadequacy, leading to similar concentrations in umbilical cord blood at term delivery.

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