scholarly journals DERMATITIS ULCERATIVA EN RATONES BALB/c Cmedc: REPORTE DE 3 CASOS

2021 ◽  
Vol 19 (suplemento) ◽  
Author(s):  
S C Sacco
Keyword(s):  
Disease Development ◽  
Laboratory Mice ◽  
Laboratory Studies ◽  
Clinical Issue ◽  
Dietary Variation ◽  
Initial Lesions ◽  
Premature Removal ◽  
Pruritic Skin ◽  
Important Clinical Issue ◽  
Comparative Medicine

Ulcerative dermatitis (UD) is a common and spontaneous condition in mice. The disease is characterized by a pruritic skin lesion, pain and a progressive evolution that often results in ulcerations. Sex, environmental conditions, dietary variation, chronic inflammation, barbering and follicular dystrophy are some predisposing factors for the clinical disease development. The aim of this study was report 3 cases of UD in BALBc/Cmedc mice from Center for Comparative Medicine, gross and histopathological lesions were described, and a review about relevance of UD in laboratory mice was made. These cases were characterized by dermatitis, ulcerative and proliferative, chronic, moderate, with neutrophils, hemorrhage and a serocellular crust. Although initial lesions may be mild, lesions in UD typically are unresponsive to treatment and euthanasia is often warranted in severe cases. This is the reason why UD is an important clinical issue that often affects biomedical research by causing problems in mice health and premature removal of animal from laboratory studies.

Dialysis Access: An Increasingly Important Clinical Issue

2009 ◽  
Vol 32 (12) ◽  
pp. 851-856 ◽  
Author(s):  
Maurizio Gallieni ◽  
Alma Martini ◽  
Nicoletta Mezzina
Keyword(s):  
Dialysis Access ◽  
Clinical Issue ◽  
Important Clinical Issue

scholarly journals Brugada-fenokópia

2016 ◽  
Vol 157 (13) ◽  
pp. 495-499
Author(s):  
János Tomcsányi
Keyword(s):  
Myocardial Infarction ◽  
Pulmonary Embolism ◽  
Brugada Syndrome ◽  
Cardiac Death ◽  
Specific Treatment ◽  
Metabolic Abnormalities ◽  
Mechanical Compression ◽  
Clinical Issue ◽  
Cardioverter Defibrillator ◽  
Important Clinical Issue

Brugada phenocopies are clinical entities that are different from the true Brugada syndrome which is a channelopathy. Brugada phenocopy has reversible underlying conditions and, if underlying conditions resolve, the ECG pattern disappears. In this paper the author reviews and illustrates the known Brugada phenocopies. The most important etiologic categories of Brugada phenocopy include metabolic abnormalities (most commonly hyperkalemia), myocardial infarction, pulmonary embolism (massive), right ventricular mechanical compression, and others. The most important clinical issue is the different treatment of the Brugada syndrome and phenocopies in order to prevent cardiac death. In Brugada syndrome the implantable cardioverter defibrillator is the only effective treatment, while in Brugada phenocopies early, etiology-specific treatment can prevent cardiac death. Orv. Hetil., 2016, 157(13), 495–499.

scholarly journals Design and enhance the vein recognition using near infrared light and projector

2017 ◽  
Vol 20 (K2) ◽  
pp. 91-95
Author(s):  
Tien Van Tran ◽  
Hieu Sy Dau ◽  
Dan Tri Nguyen ◽  
Sang Quoc Huynh ◽  
Linh Quang Huynh
Keyword(s):  
Near Infrared ◽  
New Technologies ◽  
Infrared Imaging ◽  
Infrared Light ◽  
Imaging Method ◽  
Clinical Issue ◽  
Intravenous Access ◽  
Nir Imaging ◽  
Vein Recognition ◽  
Important Clinical Issue

The difficulty of intravenous access in patients is an important clinical issue. Recently, many studies and several devices have been developed to assist physicians, nurses and surgeons in finding veins. Amongst them, near infrared imaging technology is one of the new technologies being widely used in the biomedical. NIR imaging allows visualizing veins underneath the skin of those having non-visibility of veins problem, mapping the normal and abnormal veins in treating disorders, or diagnosing related diseases. In this paper, we will introduce a portable device which can help doctors and nurses visualize blood vessel maps of their patients. On basic of combining a vein infrared imaging method and a projector system, this vein instrument can be optimally designed for viewing veins in the monitor or displaying vessel maps of patients directly on their skin.

scholarly journals The Dissolution of Language in Alzheimer's Disease

1986 ◽  
Vol 13 (S4) ◽  
pp. 415-418 ◽  
Author(s):  
Andrew Kertesz ◽  
Julian Appell ◽  
Michael Fisman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Language Impairment ◽  
Word Fluency ◽  
Clinical Issue ◽  
Word Finding ◽  
Semantic Access ◽  
Relationship Of ◽  
Number Of Individuals ◽  
Important Clinical Issue

Abstract:Language impairment in Alzheimer's disease has become an important clinical issue. It has been recognized for some time that the disease may begin with aphasia and even before frank aphasia develops, some of the earliest changes in a large number of individuals consist of impairment of word fluency and semantic access manifesting itself in word finding difficulty. The second major issue concerning language in Alzheimer's disease is that the cases which have early severe language impairment may represent a more progressive familial variety of disease as it has been suggested in the literature. This is still subject to controversy. Finally, it will be documented that the later stage of the disease shows language invariably impaired and goes through stages of dissolution that resemble anomic, transcortical sensory, Wernicke's and global aphasias. Accurate assessment of language may turn out to be one of the most reliable predictors of the stages of Alzheimer's disease and provides important insights into the cerebral organization of language, semantic access, relationship of semantic and episodic memory and the pathophysiology of the disease.

Personalised Antiplatelet Therapy – Whether to Choose Genotype or Phenotype

2010 ◽  
Vol 6 (4) ◽  
pp. 45 ◽  
Author(s):  
Laurent Bonello ◽  
Keyword(s):  
Interindividual Variability ◽  
Current Knowledge ◽  
Platelet Reactivity ◽  
Significant Proportion ◽  
Coronary Intervention ◽  
Clinical Issue ◽  
Percutaneous Coronary ◽  
Adp Receptor ◽  
Adp Receptor Antagonists ◽  
Important Clinical Issue

A significant proportion of patients do not achieve optimal platelet reactivity inhibition after a loading dose of clopidogrel. The large interindividual variability in clopidogrel responsiveness is related to several factors, including the genetic polymorphism of hepatic cytochromes 2C19 2*, which has recently been highlighted by a US Food and Drug Administration (FDA) warning. In fact, patients exhibiting reduced clopidogrel metabolism and/or low clopidogrel responsiveness (i.e. high on-treatment platelet reactivity) have an increased rate of thrombotic events following percutaneous coronary intervention. In this article, current knowledge on this important clinical issue is summarised. While the future of genetic testing remains undetermined, several trials are under way to demonstrate the potential utility of platelet reactivity testing with P2Y12-ADP receptor antagonists.

scholarly journals Bone health in cancer patients - An important clinical issue

2017 ◽  
Vol 26 (6) ◽  
pp. e12791
Author(s):  
David Weller ◽  
Aristotelis Bamias
Keyword(s):  
Cancer Patients ◽  
Bone Health ◽  
Clinical Issue ◽  
Important Clinical Issue

Hydrogen Cyanide Polymers from the Impact of Comet P/Shoemaker-Levy 9 on Jupiter

1997 ◽  
Vol 161 ◽  
pp. 179-187
Author(s):  
Clifford N. Matthews ◽  
Rose A. Pesce-Rodriguez ◽  
Shirley A. Liebman
Keyword(s):  
Amino Acids ◽  
Solar System ◽  
Hydrogen Cyanide ◽  
Nitrogen Heterocycles ◽  
Laboratory Studies ◽  
Heterogeneous Solids ◽  
The Many ◽  
Comet Halley ◽  
The Impact ◽  
By Products

AbstractHydrogen cyanide polymers – heterogeneous solids ranging in color from yellow to orange to brown to black – may be among the organic macromolecules most readily formed within the Solar System. The non-volatile black crust of comet Halley, for example, as well as the extensive orangebrown streaks in the atmosphere of Jupiter, might consist largely of such polymers synthesized from HCN formed by photolysis of methane and ammonia, the color observed depending on the concentration of HCN involved. Laboratory studies of these ubiquitous compounds point to the presence of polyamidine structures synthesized directly from hydrogen cyanide. These would be converted by water to polypeptides which can be further hydrolyzed to α-amino acids. Black polymers and multimers with conjugated ladder structures derived from HCN could also be formed and might well be the source of the many nitrogen heterocycles, adenine included, observed after pyrolysis. The dark brown color arising from the impacts of comet P/Shoemaker-Levy 9 on Jupiter might therefore be mainly caused by the presence of HCN polymers, whether originally present, deposited by the impactor or synthesized directly from HCN. Spectroscopic detection of these predicted macromolecules and their hydrolytic and pyrolytic by-products would strengthen significantly the hypothesis that cyanide polymerization is a preferred pathway for prebiotic and extraterrestrial chemistry.

Cognitive Aging in a Precision Sport Context

1996 ◽  
Vol 1 (3) ◽  
pp. 166-179 ◽  
Author(s):  
Bo Molander ◽  
Lars Bäckman
Keyword(s):  
Older Adult ◽  
Cognitive Abilities ◽  
Cognitive Aging ◽  
Motor Performance ◽  
Intervention Programs ◽  
Laboratory Studies ◽  
High Arousal ◽  
Memory And Attention ◽  
Age Related ◽  
Principal Finding

Highly skilled miniature golf players were examined in a series of field and laboratory studies. The principal finding from these studies is that young and young adult players (range = 15-38 years) score equally well or better in competition than in training whereas older adult players (range = 46-73 years) perform worse in competitive events than under training conditions. It was also found that the impairment in motor performance on the part of the older players is associated with age-related deficits in basic cognitive abilities, such as memory and attention. These results support the hypothesis that older players may be able to compensate for age-related deficits under relaxed conditions, but not under conditions of high arousal. The possibility of improving the performance of the older players in stressful situations by means of various intervention programs is discussed.

Automation Surprise

2017 ◽  
Vol 7 (1) ◽  
pp. 28-41 ◽  
Author(s):  
Robert J. de Boer ◽  
Karel Hurts
Keyword(s):  
Flight Control ◽  
Representative Sample ◽  
Aviation Safety ◽  
Control Mode ◽  
Cognitive Errors ◽  
Laboratory Studies ◽  
Airline Pilots ◽  
Flight Operations ◽  
Widespread Phenomenon ◽  
Few Data

Abstract. Automation surprise (AS) has often been associated with aviation safety incidents. Although numerous laboratory studies have been conducted, few data are available from routine flight operations. A survey among a representative sample of 200 Dutch airline pilots was used to determine the prevalence of AS and the severity of its consequences, and to test some of the factors leading to AS. Results show that AS is a relatively widespread phenomenon that occurs three times per year per pilot on average but rarely has serious consequences. In less than 10% of the AS cases that were reviewed, an undesired aircraft state was induced. Reportable occurrences are estimated to occur only once every 1–3 years per pilot. Factors leading to a higher prevalence of AS include less flying experience, increasing complexity of the flight control mode, and flight duty periods of over 8 hr. It is concluded that AS is a manifestation of system and interface complexity rather than cognitive errors.

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