A Wide-Ranging Analysis on Ethosomes

2015 ◽  
Vol 2 (2) ◽  
pp. 1-4
Author(s):  
Matilda K ◽  
Charlotte G
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Cationic Drugs ◽  
Delivery Service ◽  
Future Improvement ◽  
Challenges And Opportunities ◽  
And Training

Ethosomes are noninvasive release carriers that facilitate drugs to attain the deep skin layers and the universal movement. Though ethosomal systems are theoretically complicated, they are effortless in their training, safe for use an arrangement that can highly enlarge their relevance. Ethosomes are soft, compliant vesicles tailored for improved liberation of vigorous agents. Because of their exclusive organization, ethosomes are able to encapsulate and deliver during the skin highly lipophilic molecules such as cannabinoids, testosterone, and minoxidil, as well as cationic drugs such as propranolol, trihexaphenidyl, Cyclosporine, insulin, salbutamol etc. Improved release of bioactive molecules during the skin and cellular membranes by means of an ethosomal delivery service opens numerous challenges and opportunities for the research and future improvement of novel improved therapies. Ethosomes are gaining reputation in designing drug delivery systems for topical and transdermal use for their ability to reach deep skin layers and universal circulation. Although ethosomes are theoretically complicated, they are simple in training and safe for use. Although with their high efficiency, the ethosomes show possible for development of their applications. The aim of the review to make a inclusive description on properties and training of ethosomes followed by the classification and the list of drugs encapsulated in ethosomes.

Polymeric micelles as drug delivery systems in cancer: challenges and opportunities

Nanomedicine ◽  
2021 ◽  
Author(s):  
Swati Biswas
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Clinical Translation ◽  
Current Status ◽  
Chemotherapeutic Drugs ◽  
Challenges And Opportunities

Tweetable abstract Micelles are nanocarriers for hydrophobic chemotherapeutic drugs. This editorial discusses the current status of preclinical micellar research and sheds light on the possibility of their clinical translation.

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

2014 ◽  
Vol 50 (58) ◽  
pp. 7824-7827 ◽  
Author(s):  
Minghui Zan ◽  
Junjie Li ◽  
Shizhong Luo ◽  
Zhishen Ge
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Lysosomal Ph ◽  
Tumor Acidity

The multistage polymeric nanogel delivery systems were constructed via host–guest interactions, which showed tumor acidity-triggered disassembly into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

scholarly journals Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes

2018 ◽  
Vol 90 ◽  
pp. 356-364 ◽  
Author(s):  
Maira Gaspar Tosato ◽  
Julie V. Maya Girón ◽  
Airton A. Martin ◽  
Vamshi Krishna Tippavajhala ◽  
Mónica Fernández Lorenzo de Mele ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Comparative Study ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Transdermal Drug Delivery Systems

scholarly journals Food-Derived Nanoscopic Drug Delivery Systems for Treatment of Rheumatoid Arthritis

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3506
Author(s):  
Dong Han ◽  
Qilei Chen ◽  
Hubiao Chen
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Research Orientation ◽  
Therapeutic Outcomes ◽  
Systemic Inflammatory Disease ◽  
Recent Developments

Rheumatoid arthritis (RA) is a severe systemic inflammatory disease with no cure at present. Recent developments in the understanding of inflammation and nanomaterial science have led to increased applications of nanostructured drug delivery systems in the treatment of RA. The present review summarizes novel fabrications of nanoscale drug carriers using food components as either the delivered drugs or carrier structures, in order to achieve safe, effective and convenient drug administration. Polyphenols and flavonoids are among the most frequently carried anti-RA therapeutics in the nanosystems. Fatty substances, polysaccharides, and peptides/proteins can function as structuring agents of the nanocarriers. Frequently used nanostructures include nanoemulsions, nanocapsules, liposomes, and various nanoparticles. Using these nanostructures has improved drug solubility, absorption, biodistribution, stability, targeted accumulation, and release. Joint vectorization, i.e., using a combination of bioactive molecules, can bring elevated therapeutic outcomes. Utilization of anti-arthritic chemicals that can self-assemble into nanostructures is a promising research orientation in this field.

scholarly journals Interpenetrating Polymer Networks as Innovative Drug Delivery Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Alka Lohani ◽  
Garima Singh ◽  
Shiv Sankar Bhattacharya ◽  
Anurag Verma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymer Networks ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Interpenetrating Polymer Networks ◽  
Bioactive Molecules ◽  
Polymer Science ◽  
Natural Polymers ◽  
Innovative Drug

Polymers have always been valuable excipients in conventional dosage forms, also have shown excellent performance into the parenteral arena, and are now capable of offering advanced and sophisticated functions such as controlled drug release and drug targeting. Advances in polymer science have led to the development of several novel drug delivery systems. Interpenetrating polymer networks (IPNs) have shown superior performances over the conventional individual polymers and, consequently, the ranges of applications have grown rapidly for such class of materials. The advanced properties of IPNs like swelling capacity, stability, biocompatibility, nontoxicity and biodegradability have attracted considerable attention in pharmaceutical field especially in delivering bioactive molecules to the target site. In the past few years various research reports on the IPN based delivery systems showed that these carriers have emerged as a novel carrier in controlled drug delivery. The present review encompasses IPNs, their types, method of synthesis, factors which affects the morphology of IPNs, extensively studied IPN based drug delivery systems, and some natural polymers widely used for IPNs.

Therapeutic Efficacy of Herbal Formulations Through Novel Drug Delivery Systems

2021 ◽  
pp. 1-42
Author(s):  
Arvind Kumar Singh Chandel ◽  
Nutan Bhingradiya
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Herbal Medicines ◽  
Bioactive Compound ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Therapeutic Molecules ◽  
Dose Accuracy ◽  
The Many ◽  
Novel Drug

The herbal-based drugs have been getting wide attention over the last few decades. The herbal drugs have been used from the ancient times, but the dose accuracy, efficacy, and treatment was just based on symptomatic observatory. Modern research is focused on pure bioactive compound instead of crude. The researchers are trying to apply the current advanced nanotechnology-based knowledge on the herbal medicines to improve efficacy and reduces the unwanted pharmacological actions' adverse effects of the therapeutic molecules. The many novel drug delivery systems available used for the herbal bioactive molecules include polymeric micelle, injectable hydrogel, nano gel, nano emulsions, microsphere, polymeric nanoparticles, nano capsules, liposomes, phytosomes, transferosomes, dendrimer, and ethosomes. This chapter highlights the existing research and development of current standing of the of various novel formulations especially for the herbal bioactive molecules and summarizes their active ingredients, commercial formulations, route of drug administration, and pharmacological activity.

scholarly journals Lipid Nanoparticles as Carriers for Bioactive Delivery

2021 ◽  
Vol 9 ◽  
Author(s):  
Neerupma Dhiman ◽  
Rajendra Awasthi ◽  
Bhupesh Sharma ◽  
Harsha Kharkwal ◽  
Giriraj T. Kulkarni
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Nanodrug Delivery ◽  
Solid Lipid ◽  
Nanostructure Lipid Carriers ◽  
Approved Drugs

Nanotechnology has made a great impact on the pharmaceutical, biotechnology, food, and cosmetics industries. More than 40% of the approved drugs are lipophilic and have poor solubility. This is the major rate-limiting step that influences the release profile and bioavailability of drugs. Several approaches have been reported to administer lipophilic drugs with improved solubility and bioavailability. Nanotechnology plays a crucial role in the targeted delivery of poorly soluble drugs. Nanotechnology-based drug delivery systems can be classified as solid lipid nanoparticulate drug delivery systems, emulsion-based nanodrug delivery systems, vesicular drug delivery systems, etc. Nanotechnology presents a new frontier in research and development to conquer the limitations coupled with the conventional drug delivery systems through the formation of specific functionalized particles. This review presents a bird's eye view on various aspects of lipid nanoparticles as carriers of bioactive molecules that is, synthesis, characterization, advantage, disadvantage, toxicity, and application in the medical field. Update on recent development in terms of patents and clinical trials of solid lipid nanoparticles (SLNs) and nanostructure lipid carriers (NLCs) have also been discussed in this article.

scholarly journals Biodegradable Polycaprolactone Nanoparticles Based Drug Delivery Systems: A Short Review

2018 ◽  
Vol 15 (3) ◽  
pp. 679-685 ◽  
Author(s):  
Ranjith Ramanujam ◽  
Balraj Sundaram ◽  
Ganesh Janarthanan ◽  
Elamparithi Devendran ◽  
Moorthy Venkadasalam ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Drug Carrier ◽  
Short Review ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Simple Method ◽  
Nanoprecipitation Method

Nanoparticles based drug delivery systems showing greater potential in various biomedical applications to deliver the drugs/bioactive molecules in controlled manner to the targeted site. Polycaprolactone, biodegradable polyester, owing its tailorable properties, various forms of polycaprolactone are used as drug carrier for a range of biomedical applications. Nanoprecipitation is a simple method to prepare the polycaprolactone nanoparticles to improve the bioavailability and therapeutic potential of various drugs/bioactive molecules. This short review focused on the preparation of polycaprolactone nanoparticles using nanoprecipitation method, nanoparticles-drug formulations and its use in various drug delivery applications.

scholarly journals A pH-Responsive Supramolecular Drug Delivery System Constructed by Cationic Pillar[5]arene for Enhancing Antitumor Activity

2021 ◽  
Vol 9 ◽  
Author(s):  
Luzhi Liu ◽  
Qingqing Zhou ◽  
Qin He ◽  
Wengui Duan ◽  
Yan Huang
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Drug Loading ◽  
Sodium Dodecyl ◽  
Weak Acid ◽  
Delivery Systems ◽  
Acid Environment ◽  
Low Cytotoxicity

Drug delivery systems have good biocompatibiliy and low side effects for cancer treatment, but overcoming high efficiency of drug-loading and the drug-targeting controlled release still remains challenging. In this work, supramolecular vesicles, with pH-triggering effect, have been successfully constructed for drug delivery, which are fabricated by the complexation between a cationic pillar[5]arene (DAWP5) and a sodium dodecyl sulfonate (SDS) in aqueous solution. Drug-loading and releasing results demonstrated that anticancer drug doxorubicin (DOX) could be loaded efficiently by such cationic vesicles in neutral condition, and the drug release could be controlled in the simulated weak acid environment of tumor cells. Moreover, the vesicles had low cytotoxicity to normal human cell (L02), while the DOX-loaded vesicles could significantly enhance the cytotoxicity of free DOX for normal cell L02 and four tested tumor cells (Hela, HepG2, MGC-803 and T24). Especially for HepG2, after 24 h incubation time, IC50 of DOX-loaded vesicles was only 0.79 μM, about 23% of that of DOX (3.43 μM). These results suggested that such novel vesicles have promising potential to construct nano-drug delivery systems for various biomedical applications.

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