scholarly journals Profil Kadar Kolagen Kulit dan Tulang Tikus Wistar pada Berbagai Umur yang Mendapat Perlakuan Stres Oksidatif Hiperkolesterolemia dan Oleoresin Kulit Batang Kayu Manis (Cinnamomum sp)

2012 ◽  
Vol 12 (2) ◽  
pp. 56
Author(s):  
Sunarno Sunarno ◽  
Sri Isdadiyanto
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Age Groups ◽  
Aging Effect ◽  
Cholesterol Content ◽  
Collagen Content ◽  
Bone Collagen ◽  
Treatment Groups ◽  
Skin Collagen ◽  
Male Wistar Rats

Oleoresin cinnamon bark belonging to the phenolic compounds that are known to have potential as antioxidants. On the basis of the potential of these compounds may be used to prevent or repair tissue damage, whether caused by the factors of age and condition of oxidative stress hypercholesterolemia. This study aimed to obtain skin and bone collagen profile of Wistar rats at various ages after oxidative stress treated hypercholesterolemia and oleoresin from the bark of cinnamon (Cinnamomum sp). This study used 54 male Wistar rats with body weight (200 ± 5 g), which are grouped into six treatment groups combined with the three age groups of mice that is three, six or nine months with three replications. Each group received treatment oleoresin and hypercholesterolemia. Giving oral oleoresin conducted on rats given oral way during the 7 days with a dose of 12 rats mg/200-gr bw / day. Hypercholesterolemic rats was conducted by feeding cholesterol content within 1% during the two months. The results showed that the profile of skin and bone collagen content of the highest found on threemonth old rats treated with oleoresin, oleoresin hypercholesterolemia and given again (P6, 2), namely 57.44 tg / mg and 33.47 tg / mg, while the profile of skin and bone collagen content of the lowest found in rats aged 9 months to get treatment without treatment of hypercholesterolemia oleoresin (P2, 9), namely 28.26 tg / mg and 10.65 tg / mg. From this research can be concluded that the condition of hypercholesterolemia and duration of the aging effect on skin collagen levels decrease and bone, and vice versa oleoresin at the age of young rats that received the treatment of oxidative stress could repair or prevent hypercholesterolemia decreased content of skin collagen and bone. In general, the rats are treated oleoresin and young age profile of the collagen content of skin and bones better compared with rats that do not get treatment in conditions of oxidative stress oleoresin hypercholesterolemia.

scholarly journals The Relation between Malondialdehyde (MDA) and Histopatological Appearance in male Wistar Rats Model

1970 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Febrina Sylva Fridayanti ◽  
Erma Sulistyaningsih ◽  
Elly Nurus Sakinah
Keyword(s):  
Oxidative Stress ◽  
Fracture Healing ◽  
Wistar Rats ◽  
Healing Process ◽  
Ethanolic Extract ◽  
Negative Control ◽  
Control Group ◽  
Oxidation Stress ◽  
Treatment Groups ◽  
Male Wistar Rats

Fractures are a serious health problem in Indonesia due to increasing prevalence. The healing process of fracture is disturbed by the oxidative stress that caused by imbalance quantity of free radical and antioxidant. An antioxidant such as polyphenol, which can be found in cocoa, is needed to suppress oxidative stress. The study aimed to investigate the effect of the ethanolic extract of cacao on fracture healing process in a rat model through MDA concentration and histopatological appearance. This study is in vivo experimental study with post-test only controlled group design. 30 male Wistar rats were randomized and divided into 5 groups. 1 group was rats without fractured. The negative control and three treatment groups were rats with fractured manually on left tibia under anesthesia and immobilized by bandage. The treatment groups treated with cocoa ethanolic extract in a dose of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW orally for 21 days. The result showed that there was a significant different between the treatment groups and the negative control group on MDA concentration and histopatological appearance (p>0,05). The corelation between them were strong and had negative direction (R=-0,771). The study concluded that cocoa ethanolic extract had a positive effect to supress oxidation stress and increases the number of osteoblast on fracture healing process. Key words: cocoa ethanolic extract, polyphenol, fracture healing process, oxidative stress

Mechanism Involved in Fortification by Berberine in CDDP-Induced Nephrotoxicity

2020 ◽  
Vol 13 (4) ◽  
pp. 342-352 ◽  
Author(s):  
Vipin K. Verma ◽  
Salma Malik ◽  
Ekta Mutneja ◽  
Anil K. Sahu ◽  
Kumari Rupashi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Tissue ◽  
Isoquinoline Alkaloid ◽  
Experimental Models ◽  
Beclin 1 ◽  
Control Treatment ◽  
Control Group ◽  
Treatment Groups ◽  
Single Intraperitoneal Injection ◽  
Male Wistar Rats

Background: The activation of Nrf2/HO-1 pathway has been shown to protect against cisplatin- induced nephrotoxicity by reducing oxidative stress. Berberine (Ber), an isoquinoline alkaloid, has demonstrated antioxidant, anti-inflammatory and anti-apoptotic activities in various experimental models. Aim: To check the effect of Ber on cisplatin-induced nephrotoxicity and to explore the involved mechanism. Methods: Adult male Wistar rats were divided into 6 groups: Normal, cisplatin-control, treatment groups and per se group. Normal saline and Ber (20, 40 and 80 mg/kg; p.o.) was administered to rats for 10 days. A single intraperitoneal injection of cisplatin (8 mg/kg) was injected on 7th day to induced nephrotoxicity. On 10th day, rats were sacrificed, the kidney was removed and stored for the estimation of various parameters. Results: As compared to cisplatin-control group, Ber pretreatment improved renal function system and preserved renal architecture. It also diminished oxidative stress by upregulating the expression of Nrf2/HO-1 proteins. In addition, Ber attenuated the cisplatin mediated inflammation and apoptosis. Furthermore, it also reduced the phosphorylation of p38/JNK and PARP/Beclin-1 expression in the kidney. Conclusion: Ber attenuated renal injury by activating Nrf2/HO-1 and inhibiting JNK/p38MAPKs/ PARP/Beclin-1 expression which prevented oxidative stress, inflammation, apoptosis and autophagy in renal tissue.

Aortic-banding induces myocardial oxidative stress and changes in concentration and activity of antioxidants in male Wistar rats

Life Sciences ◽  
2006 ◽  
Vol 79 (23) ◽  
pp. 2187-2193 ◽  
Author(s):  
Maria H.V.M. Jacob ◽  
Mauro R.N. Pontes ◽  
Alex S.R. Araújo ◽  
Jaqueline Barp ◽  
Maria C. Irigoyen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Aortic Banding ◽  
Myocardial Oxidative Stress ◽  
Male Wistar Rats

scholarly journals The subchronic effects of 3,4-methylendioxymethamphetamine on oxidative stress in rat brain

2014 ◽  
Vol 66 (3) ◽  
pp. 1075-1081
Author(s):  
Ivan Simic ◽  
Violeta Iric-Cupic ◽  
Rada Vucic ◽  
Marina Petrovic ◽  
Violeta Mladenovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Rat Brain ◽  
Wistar Rats ◽  
Superoxide Radical ◽  
Reduced Glutathione ◽  
Oxidative Stress Markers ◽  
Sod Activity ◽  
Stress Markers ◽  
Male Wistar Rats

The aim of the present study was to evaluate the subchronic effects of 3,4-methylenedioxymethamphetamine on several oxidative stress markers: index of lipid peroxidation (ILP), superoxide dismutase (SOD) activity, superoxide radical (O2.-) levels, and reduced glutathione (GSH) levels in the frontal cortex, striatum and hippocampus of the rat. The study included 64 male Wistar rats (200-250g). The animals were treated per os with of 5, 10, or 20 mg/kg of 3,4-methylenedioxymethamphetamine (MDMA) every day for 15 days. The subchronic administration of MDMA resulted in an increase in ILP, SOD and O2.-, and a decrease in GSH, from which we conclude that oxidative stress was induced in rat brain.

Chronic consumption of Hypericum humifusum leaf extracts impairs epididymis spermatozoa characters in association with oxidative stress in adult male Wistar rats

2017 ◽  
Vol 93 ◽  
pp. 616-625 ◽  
Author(s):  
Imen Hammami ◽  
Ridha Ben Ali ◽  
Afef Nahdi ◽  
Olfa Kallech-Ziri ◽  
Marwa Boussada ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adult Male ◽  
Wistar Rats ◽  
Leaf Extracts ◽  
Male Wistar Rats
Sign in / Sign up

Export Citation Format

Share Document