Effect of HOTAIR rs12826786 and rs1899663 polymorphisms on lung cancer susceptibility and clinicopathological characteristics in a turkish population: a hospital-based case-control study

The purpose of the current study is to explore the contribution of single-nucleotide polymorphisms (SNPs) of REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 to the risk of lung cancer. A questionnaire survey was used to obtain basic information of the included subjects. A case control study was performed in 1121 patients and 1121 controls. All subjects were subjected to blood sampling for genomic DNA extraction and genotyping of the cancer stem cell-associated gene SNPs, including REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 by real-time PCR. The association with the risk of primary lung cancer and interaction with environmental factors were assessed using unconditional logistic regression for the odds ratios and corresponding 95% confidence intervals. The genotype frequency distribution of OCT4 rs13409 loci was statistically significant, but there was no significant difference in the rest of the loci between lung cancer patients and healthy controls. The OCT4 gene was also related with lung cancer susceptibility in the genetic model after adjusting for lung cancer-related factors. Despite the presence of the dominant or recessive model, the four loci polymorphisms were associated with pollution near the place of residence, house type, worse ventilation situation, smoking, passive smoking, cooking oil fumes (COF), and family history of cancer, which increased the risk of lung cancer. Nonmarried status, 18.5≤BMI, COF, smoking, passive smoking, family history of cancer, and history of lung disease were independent risk factors of lung cancer susceptibility. Additionally, college degree or above, no pollution near the place of residence, protective genotype 1 or 2, and well ventilation can reduce the occurrence of lung cancer. There is an interaction between the four loci and environmental factors, and OCT4 rs13409 is a risk factor of primary lung cancer.

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A functional HOTAIR rs12826786 C>T polymorphism is associated with breast cancer susceptibility and poor clinicopathological characteristics in a Turkish population: a hospital-based case–control study

Tumor Biology ◽

10.1007/s13277-015-4430-y ◽

2015 ◽

Vol 37 (4) ◽

pp. 5577-5584 ◽

Cited By ~ 32

Author(s):

Süleyman Bayram ◽

Ahmet Taner Sümbül ◽

Erdoğan Dadaş

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Cancer Susceptibility ◽

Turkish Population ◽

Breast Cancer Susceptibility ◽

Clinicopathological Characteristics ◽

Case Control ◽

Control Study

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A Case-Control Study of the Relationship between LINC01495, TRAPPC9 Polymorphisms and Lung Cancer Susceptibility in Northeast Chinese Population

International Journal of Research in Environmental Science ◽

10.20431/2454-9444.0401001 ◽

2018 ◽

Vol 4 (1) ◽

Keyword(s):

Lung Cancer ◽

Chinese Population ◽

Case Control Study ◽

Cancer Susceptibility ◽

Case Control ◽

The Relationship ◽

Control Study ◽

Lung Cancer Susceptibility

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The Association of OGG1 Ser326Cys Polymorphism and Urinary 8-OHdG Levels With Lung Cancer Susceptibility: A Hospital-Based Case-Control Study in Turkey

Archives of Industrial Hygiene and Toxicology ◽

10.2478/10004-1254-59-2008-1924 ◽

2008 ◽

Vol 59 (4) ◽

pp. 241-250 ◽

Cited By ~ 25

Author(s):

Bensu Karahalil ◽

Esra Emerce ◽

Bülent Koçer ◽

Serdar Han ◽

Necati Alkiş ◽

...

Keyword(s):

Lung Cancer ◽

Molecular Mechanisms ◽

Case Control Study ◽

Cancer Susceptibility ◽

Association Studies ◽

Case Control ◽

Major Health Problem ◽

Ser326cys Polymorphism ◽

Control Study ◽

Lung Cancer Susceptibility

The Association of OGG1 Ser326Cys Polymorphism and Urinary 8-OHdG Levels With Lung Cancer Susceptibility: A Hospital-Based Case-Control Study in TurkeyHigh incidence and poor prognosis of lung cancer make it a major health problem worldwide. Although smoking is a major cause of lung cancer, only some smokers develop lung cancer, which suggests that there is a genetic predisposition in some individuals. 8-OHG is an important oxidative base lesion and may elevate due to cancer and smoking. It is repaired by 8-hydroxyguanine DNA glycosylase 1 (OGG1), which has several polymorphisms. Although the Ser326Cys polymorphism is consistently associated with a range of cancers, findings about this polymorphism and lung cancer risk are contradictory. To date, no study has examined this association in the Turkish population. We conducted a case-control study to investigate the association between OGG1 Ser326Cys polymorphism and the risk of lung cancer using PCR-RFLP. We also evaluated gene-smoking interaction and excretion of urinary 8-OHdG. Our results suggest that the OGG1 Ser326Cys polymorphism is not a genetic risk factor for lung cancer, and that the heterozygous genotype is associated with a significantly reduced risk for lung cancer. The levels of 8-OHdG did not correlate with the polymorphism and smoking. Larger association studies are needed to validate our findings, and mechanistic studies are needed to elucidate the underlying molecular mechanisms of this association.

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Clinicopathological characteristics of solitary cavitary lung cancer: a case-control study

Journal of Thoracic Disease ◽

10.21037/jtd-20-426 ◽

2020 ◽

Vol 12 (6) ◽

pp. 3148-3156

Author(s):

Zhan Liu ◽

Hongxiang Feng ◽

Zhenrong Zhang ◽

Hongliang Sun ◽

Deruo Liu

Keyword(s):

Lung Cancer ◽

Case Control Study ◽

Clinicopathological Characteristics ◽

Case Control ◽

Control Study

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Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population

Human Genomics ◽

10.1186/s40246-019-0240-4 ◽

2019 ◽

Vol 13 (1) ◽

Cited By ~ 2

Author(s):

Xiaoting Lv ◽

Zhigang Cui ◽

Hang Li ◽

Juan Li ◽

Zitai Yang ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Case Control Study ◽

Lung Cancer Risk ◽

Cancer Susceptibility ◽

Lung Squamous Cell Carcinoma ◽

Case Control ◽

Recessive Model ◽

Lung Cancer Patients ◽

Control Study

Abstract Background Long non-coding RNAs became the hot spots in the carcinogenesis of various tumors. This case-control study evaluated the association between the rs2151280 in lncRNA CDKN2B-AS1 and lung cancer risk. Methods This study included 507 lung cancer patients and 542 healthy individuals. Odds ratios and their 95% confidence intervals were calculated by unconditional logistic regression analysis to evaluate the association between the rs2151280 and lung cancer risk. Results Compared with individuals carrying TT genotype, individuals carrying CC genotype of rs2151280 had a decreased risk of lung cancer (OR = 0.640, 95%CI = 0.421–0.972, P = 0.036). In the recessive model, rs2151280 CC genotype was observed to reduce the risk of lung cancer (OR = 0.684). C allele was associated with non-small cell lung cancer risk (OR = 0.674). The rs2151280 was significantly associated with lung adenocarcinoma risk (CCvsTT: OR = 0.567, 95%CI = 0.333–0.965, P = 0.037; CCvsTC+TT: OR = 0.543, 95%CI 0.330–0.893, P = 0.016, respectively). However, there was no significant association between rs2151280 and lung squamous cell carcinoma risk in five models. The quantitative analysis suggested that there were no significant interactions of rs2151280 with smoking exposure to lung cancer susceptibility. Conclusions This hospital-based case-control study suggested that CDKN2B-AS1 rs2151280 T>C was associated with the risk of lung cancer.

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