scholarly journals The Association of OGG1 Ser326Cys Polymorphism and Urinary 8-OHdG Levels With Lung Cancer Susceptibility: A Hospital-Based Case-Control Study in Turkey

2008 ◽  
Vol 59 (4) ◽  
pp. 241-250 ◽  
Author(s):  
Bensu Karahalil ◽  
Esra Emerce ◽  
Bülent Koçer ◽  
Serdar Han ◽  
Necati Alkiş ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Molecular Mechanisms ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Association Studies ◽  
Case Control ◽  
Major Health Problem ◽  
Ser326cys Polymorphism ◽  
Control Study ◽  
Lung Cancer Susceptibility

The Association of OGG1 Ser326Cys Polymorphism and Urinary 8-OHdG Levels With Lung Cancer Susceptibility: A Hospital-Based Case-Control Study in TurkeyHigh incidence and poor prognosis of lung cancer make it a major health problem worldwide. Although smoking is a major cause of lung cancer, only some smokers develop lung cancer, which suggests that there is a genetic predisposition in some individuals. 8-OHG is an important oxidative base lesion and may elevate due to cancer and smoking. It is repaired by 8-hydroxyguanine DNA glycosylase 1 (OGG1), which has several polymorphisms. Although the Ser326Cys polymorphism is consistently associated with a range of cancers, findings about this polymorphism and lung cancer risk are contradictory. To date, no study has examined this association in the Turkish population. We conducted a case-control study to investigate the association between OGG1 Ser326Cys polymorphism and the risk of lung cancer using PCR-RFLP. We also evaluated gene-smoking interaction and excretion of urinary 8-OHdG. Our results suggest that the OGG1 Ser326Cys polymorphism is not a genetic risk factor for lung cancer, and that the heterozygous genotype is associated with a significantly reduced risk for lung cancer. The levels of 8-OHdG did not correlate with the polymorphism and smoking. Larger association studies are needed to validate our findings, and mechanistic studies are needed to elucidate the underlying molecular mechanisms of this association.

scholarly journals Association of Single-Nucleotide Polymorphism REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 with Primary Lung Cancer Susceptibility: A Case-Control Study in a Chinese Population

2019 ◽  
Vol 2019 ◽  
pp. 1-23
Author(s):  
Qi Shen ◽  
Wen-xiang Wang ◽  
Qiu-ping Xu ◽  
Wen-min Xiong ◽  
Zhi-qiang Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Primary Lung Cancer ◽  
Case Control ◽  
Single Nucleotide ◽  
History Of ◽  
Control Study ◽  
History Of Cancer ◽  
Lung Cancer Susceptibility

The purpose of the current study is to explore the contribution of single-nucleotide polymorphisms (SNPs) of REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 to the risk of lung cancer. A questionnaire survey was used to obtain basic information of the included subjects. A case control study was performed in 1121 patients and 1121 controls. All subjects were subjected to blood sampling for genomic DNA extraction and genotyping of the cancer stem cell-associated gene SNPs, including REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 by real-time PCR. The association with the risk of primary lung cancer and interaction with environmental factors were assessed using unconditional logistic regression for the odds ratios and corresponding 95% confidence intervals. The genotype frequency distribution of OCT4 rs13409 loci was statistically significant, but there was no significant difference in the rest of the loci between lung cancer patients and healthy controls. The OCT4 gene was also related with lung cancer susceptibility in the genetic model after adjusting for lung cancer-related factors. Despite the presence of the dominant or recessive model, the four loci polymorphisms were associated with pollution near the place of residence, house type, worse ventilation situation, smoking, passive smoking, cooking oil fumes (COF), and family history of cancer, which increased the risk of lung cancer. Nonmarried status, 18.5≤BMI, COF, smoking, passive smoking, family history of cancer, and history of lung disease were independent risk factors of lung cancer susceptibility. Additionally, college degree or above, no pollution near the place of residence, protective genotype 1 or 2, and well ventilation can reduce the occurrence of lung cancer. There is an interaction between the four loci and environmental factors, and OCT4 rs13409 is a risk factor of primary lung cancer.

scholarly journals Genetic Variants Modifying the Risk of Lung Cancer and Its Subtypes: A Comprehensive Meta-analysis and a Case-control Study

2020 ◽  
Author(s):  
Debmalya Sengupta ◽  
Souradeep Banerjee ◽  
Ritabrata Mitra ◽  
Tamohan Chaudhuri ◽  
Abhijit Sarkar ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Random Effects ◽  
Case Control Study ◽  
Association Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Effect Modification ◽  
Fixed Effect ◽  
Significant Heterogeneity ◽  
Control Study

Abstract Association studies on lung cancer have often yielded conflicting and inconclusive results. We performed a comprehensive meta-analysis to dissect the precise effects of the candidate variants. We searched for association studies on lung cancer from the Indian subcontinent. Cochran’s Q-test assessed heterogeneity. Both overall and histotype-stratified meta-analysis was done using fixed-effect and random-effects models. Smoking status stratified subgroup analysis and effect modification tests were done. An associated variant with significant heterogeneity was genotyped in an eastern Indian population to investigate the contribution of potential confounders followed by a comprehensive meta-analysis across world populations. Significant heterogeneity was observed for the 8 variants. Both fixed-effect and random-effects meta-analysis of 24 variants showed FDR-corrected associations of rs3547/XRCC1 and rs1048943/CYP1A1 with lung cancer along with 5 nominal associations. del1/GSTT1, rs4646903/CYP1A1, and rs10488943/CYP1A1 were associated with adenocarcinoma, squamous cell carcinoma, and both, respectively. rs4646903/CYP1A1 was associated with lung cancer among smokers with significant effect modification by smoking. rs10488943/CYP1A1 was associated with lung adenocarcinoma in the East Indian case-control study. rs1048943/CYP1A1 was associated with lung cancer across world populations. Our work confirms the risk loci for lung cancer and its subtypes in the context of smoking and other aetiological factors, which could aid in personalised treatment.

scholarly journals Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Xiaoting Lv ◽  
Zhigang Cui ◽  
Hang Li ◽  
Juan Li ◽  
Zitai Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Cancer Susceptibility ◽  
Lung Squamous Cell Carcinoma ◽  
Case Control ◽  
Recessive Model ◽  
Lung Cancer Patients ◽  
Control Study

Abstract Background Long non-coding RNAs became the hot spots in the carcinogenesis of various tumors. This case-control study evaluated the association between the rs2151280 in lncRNA CDKN2B-AS1 and lung cancer risk. Methods This study included 507 lung cancer patients and 542 healthy individuals. Odds ratios and their 95% confidence intervals were calculated by unconditional logistic regression analysis to evaluate the association between the rs2151280 and lung cancer risk. Results Compared with individuals carrying TT genotype, individuals carrying CC genotype of rs2151280 had a decreased risk of lung cancer (OR = 0.640, 95%CI = 0.421–0.972, P = 0.036). In the recessive model, rs2151280 CC genotype was observed to reduce the risk of lung cancer (OR = 0.684). C allele was associated with non-small cell lung cancer risk (OR = 0.674). The rs2151280 was significantly associated with lung adenocarcinoma risk (CCvsTT: OR = 0.567, 95%CI = 0.333–0.965, P = 0.037; CCvsTC+TT: OR = 0.543, 95%CI 0.330–0.893, P = 0.016, respectively). However, there was no significant association between rs2151280 and lung squamous cell carcinoma risk in five models. The quantitative analysis suggested that there were no significant interactions of rs2151280 with smoking exposure to lung cancer susceptibility. Conclusions This hospital-based case-control study suggested that CDKN2B-AS1 rs2151280 T>C was associated with the risk of lung cancer.

Smoking of hand-rolled cigarettes as a risk factor for small cell lung cancer in men: a case-control study from Uruguay

Lung Cancer ◽  
1994 ◽  
Vol 11 (3-4) ◽  
pp. 191-199 ◽  
Author(s):  
Eduardo De Stéfani ◽  
Luis Fierro ◽  
María T. Larrinaga ◽  
Julio C. Balbi ◽  
Alvaro Ronco ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Risk Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Small Cell ◽  
Small Cell Lung ◽  
Control Study
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