scholarly journals Phytotherapy for Peptic-ulcer: An overview on important Indian herbal plants having flavonoid as antiulcer activity.

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Avijit Mazumder ◽  
Bharti Yadav ◽  
Harender Sharma
Keyword(s):  
Peptic Ulcer ◽  
Gastric Acid ◽  
Antioxidant Properties ◽  
Experimental Models ◽  
High Recurrence Rate ◽  
Antiulcer Activity ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
Limited Effectiveness ◽  
Herbal Plants

Peptic ulcers are described by erosions of the gastrointestinal mucosa that can reach the muscular layer. Peptic ulcers are a widespread health condition that affects millions of individuals and has a high recurrence rate. “No gastric acid, no peptic ulcer” is a flawed assumption. Excessive gastric acid secretion is only one factor in the pathogenesis of peptic ulcer disease. Their etiology is multifactorial and develops when the balance of offensive and protective components is disrupted. Its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. Natural products such as herbal plants and their isolated compounds have been widely used in experimental models of peptic ulcers. Flavonoids strengthened defensive factors had cytoprotective and rehabilitative actions. Flavonoids are among the molecules of greatest interest in biological assays due to their anti-inflammatory, antioxidant properties. The present study is a literature review of herbal plants having flavonoid that have been reported to show peptic ulcer activity in experimental models using the divergent mechanism of action.

scholarly journals A Review of the Role of Flavonoids in Peptic Ulcer (2010–2020)

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5431
Author(s):  
Catarina Serafim ◽  
Maria Elaine Araruna ◽  
Edvaldo Alves Júnior ◽  
Margareth Diniz ◽  
Clélia Hiruma-Lima ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Antioxidant Properties ◽  
Muscle Layer ◽  
In Vitro Models ◽  
Experimental Models ◽  
Antiulcer Activity ◽  
Peptic Ulcers ◽  
Anti Inflammatory

Peptic ulcers are characterized by erosions on the mucosa of the gastrointestinal tract that may reach the muscle layer. Their etiology is multifactorial and occurs when the balance between offensive and protective factors of the mucosa is disturbed. Peptic ulcers represent a global health problem, affecting millions of people worldwide and showing high rates of recurrence. Helicobacter pylori infection and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most important predisposing factors for the development of peptic ulcers. Therefore, new approaches to complementary treatments are needed to prevent the development of ulcers and their recurrence. Natural products such as medicinal plants and their isolated compounds have been widely used in experimental models of peptic ulcers. Flavonoids are among the molecules of greatest interest in biological assays due to their anti-inflammatory and antioxidant properties. The present study is a literature review of flavonoids that have been reported to show peptic ulcer activity in experimental models. Studies published from January 2010 to January 2020 were selected from reference databases. This review refers to a collection of flavonoids with antiulcer activity in vivo and in vitro models.

The Role of Gastric Acid in Preventing Foodborne Disease and How Bacteria Overcome Acid Conditions†

2003 ◽  
Vol 66 (7) ◽  
pp. 1292-1303 ◽  
Author(s):  
JAMES L. SMITH
Keyword(s):  
Peptic Ulcer ◽  
Acid Secretion ◽  
Peptic Ulcer Disease ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Gastric Fluid ◽  
The Body ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
H Pylori

The secretion of hydrochloric acid by the stomach plays an important role in protecting the body against pathogens ingested with food or water. A gastric fluid pH of 1 to 2 is deleterious to many microbial pathogens; however, the neutralization of gastric acid by antacids or the inhibition of acid secretion by various drugs may increase the risk of food- or waterborne illnesses. Peptic ulcer disease is often treated by decreasing or eliminating gastric acid secretion, and such treatment blocks the protective antibacterial action of gastric fluid. The majority of peptic ulcer disease cases originate from Helicobacter pylori infections. Treatment of H. pylori–induced peptic ulcers with antibiotics reduces the need for drugs that inhibit gastric acid secretion and thereby diminishes the risk of food- and waterborne illness for peptic ulcer disease patients. Many bacterial pathogens, such as Escherichia coli, Salmonella Typhimurium, and H. pylori, can circumvent the acid conditions of the stomach by developing adaptive mechanisms that allow these bacteria to survive in acid environments. As a consequence, these bacteria can survive acidic stomach conditions and pass into the intestinal tract, where they can induce gastroenteritis.

scholarly journals EVALUATION OF GASTROPROTECTIVE EFFECT OF COENZYME Q 10 AND L - GLUTAMINE IN STRESS AND ETHANOL-INDUCED PEPTIC ULCER IN WISTAR RATS: A NOVEL PRECLINICAL STUDY

2018 ◽  
Vol 11 (9) ◽  
pp. 365
Author(s):  
Balaji Ommurugan ◽  
Shalini Adiga ◽  
Vijetha Shenoy Belle
Keyword(s):  
Peptic Ulcer ◽  
Coenzyme Q ◽  
Antioxidant Property ◽  
Preclinical Study ◽  
Experimental Models ◽  
Ulcer Formation ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
Ulcer Model ◽  
Post Hoc

Objective: Coenzyme Q 10 (CoQ10) and L-glutamine have antioxidant property their role in peptic ulcer diseases is not well known. Hence, the aim of present study is to evaluate the gastroprotective role of CoQ10 and L-glutamine in stress and ethanol-induced peptic ulcers in Wistar albino rats.Methods: A total of 90 rats were used for the conduct of study in two experimental models, the stress- and the ethanol-induced ulcer model. Each model consists of eight groups with six rats in each group. Sucralfate and pantoprazole were used as standard drugs along with CoQ10 and L- glutamine as test drugs. Drugs were administered for 10 days in stress model and 7 days in case of ethanol model. Statistically analyzed using analysis of variance and post-hoc test with significance as p>0.05Results: CoQ10 and L- glutamine when used alone as well in combination with pantoprazole and sucralfate showed no ulcer formation. Test drugs showed decrease in gastric acid secretion, decreased total and free acidity levels, higher gastric pH, increased mucous secreting ability, higher levels of reduced glutathione levels in both tissue as well as blood and lower malondialdehyde levels when compared with pantoprazole and sucralfate suggestive of their antioxidative benefit, in both the models.Conclusion: Well-designed clinical trials can be done to evaluate the use of CoQ10 and L- glutamine in the treatment of peptic ulcer disease due to various etiology.

scholarly journals A Review on Antiulcer Activity of Few Indian Medicinal Plants

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
G. Vimala ◽  
F. Gricilda Shoba
Keyword(s):  
Peptic Ulcer ◽  
Medicinal Plants ◽  
Herbal Medicines ◽  
Modern Science ◽  
Gastrointestinal Disorder ◽  
Ulcer Recurrence ◽  
Antiulcer Activity ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
Synthetic Drugs

Ulcer is a common gastrointestinal disorder which is seen among many people. It is basically an inflamed break in the skin or the mucus membrane lining the alimentary tract. Ulceration occurs when there is a disturbance of the normal equilibrium caused by either enhanced aggression or diminished mucosal resistance. It may be due to the regular usage of drugs, irregular food habits, stress, and so forth. Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. The formation of peptic ulcers depends on the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defenses. A number of synthetic drugs are available to treat ulcers. But these drugs are expensive and are likely to produce more side effects when compared to herbal medicines. The literature revealed that many medicinal plants and polyherbal formulations are used for the treatment of ulcer by various ayurvedic doctors and traditional medicinal practitioners. The ideal aims of treatment of peptic ulcer disease are to relieve pain, heal the ulcer, and delay ulcer recurrence. In this review attempts have been made to know about some medicinal plants which may be used in ayurvedic as well as modern science for the treatment or prevention of peptic ulcer.

scholarly journals Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4626
Author(s):  
Wenji Zhang ◽  
Yingyi Lian ◽  
Qiuhua Li ◽  
Lingli Sun ◽  
Ruohong Chen ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Gastrointestinal Tract ◽  
Therapeutic Potential ◽  
Antibacterial Activities ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
Limited Effectiveness ◽  
Tract Disorder

Peptic ulcer disease is a common gastrointestinal tract disorder that affects up to 20% of the population of the world. Treatment of peptic ulcer remains challenging due to the limited effectiveness and severe side effects of the currently available drugs. Hence, natural compounds, owing to their medicinal, ecological, and other safe properties, are becoming popular potential candidates in preventing and treating peptic ulcers. Flavonoids, the most abundant polyphenols in plants, exhibit gastroprotective effects against peptic ulcer both in vivo and in vitro. In this review, we summarized the anti-ulcer functions and mechanisms, and also the bioavailability, efficacy, and safety, of flavonoid monomers in the gastrointestinal tract. Flavonoids exerted cytoprotective and rehabilitative effects by not only strengthening defense factors, such as mucus and prostaglandins, but also protecting against potentially harmful factors via their antioxidative, anti-inflammatory, and antibacterial activities. Although controlled clinical studies are limited at present, flavonoids have shown a promising preventable and therapeutic potential in peptic ulcers.

scholarly journals Causes and Management of Gastric and Duodenal Ulcer in Adolescents

2021 ◽  
pp. 289-297
Author(s):  
Bader Maiedh Mohsen Aladainan ◽  
Mahdi Turki Bin Ali Alfataih ◽  
Alhassan Ahmed Mohammed Aldundur ◽  
Rashed Saleh Mohammed Balhareth ◽  
Eisa Yazeed Ghazwani
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Review Literature ◽  
Peptic Ulcers ◽  
Significant Progress ◽  
Duodenal Ulcers ◽  
Ulcer Disease ◽  
Last 300 Years ◽  
Made In

Many etiological hypotheses have been suggested to explain the development of peptic ulcers during the last 300 years (including gastric ulcer and duodenal ulcer). In the last two decades, significant progress has been made in understanding the pathophysiology of peptic ulcer disease, particularly with regard to the involvement of Helicobacter pylori and nonsteroidal anti-inflammatory medications (NSAIDs). This study will attempt to review literature on etiology and management of gastric and duodenal ulcers among adolescents.

scholarly journals RECURRENCE RATE OF HELICOBACTER PYLORI IN PATIENTS WITH PEPTIC ULCER FIVE YEARS OR MORE AFTER SUCCESSFUL ERADICATION

2016 ◽  
Vol 53 (3) ◽  
pp. 152-155 ◽  
Author(s):  
Yuri Costa Farago FERNANDES ◽  
Gabriel da Rocha BONATTO ◽  
Mauro Willeman BONATTO
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Recurrence Rate ◽  
Early Recurrence ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
Gastroduodenal Mucosa ◽  
H Pylori

ABSTRACT Background Infection with Helicobacter pylori is highly prevalent worldwide, especially in developing countries. Its presence in the gastroduodenal mucosa is related with development of peptic ulcer and other illnesses. The eradication of H. pylori improves mucosal histology in patients with peptic ulcers. Objective This study was aimed to verify if H. pylori recurrence occurs five years or more after confirmed eradication in patients with peptic ulcer. Moreover, we sought to determine the recurrence rate. Methods Retrospective and longitudinal, this study was based on a sample of 201 patients from western Paraná, Brazil. The patients were diagnosed with peptic ulcer disease, in the period of 1990-2000, and followed for five years or more after successful H. pylori eradication. Patients with early recurrence - prior to five years after eradication - were excluded from the sample. Results During an average follow-up of 8 years, 180 patients (89.55%) remained negative, and 21 (10.45%) became positive for H. pylori infection. New ulcers appeared in two-thirds of the patients with H. pylori recurrence. Conclusion The recurrence of H. pylori in patients with peptic ulcer can occur in the long-term - even if the infection had been successfully eradicated and the patients had remained free of recurrence in the first years of follow-up.

scholarly journals P-BN10 Seasonal Variation of Presentation of Perforated Peptic Ulcer Disease: An Overview of Patient Demographics, Management and Outcomes in Northern Ireland

2021 ◽  
Vol 108 (Supplement_9) ◽  
Author(s):  
Bakhat Yawar ◽  
Ahmed Marzouk ◽  
Heba Ali ◽  
Alsarah Diab ◽  
Hassan Abdulrahman ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Seasonal Variation ◽  
Peptic Ulcer Disease ◽  
Perforated Peptic Ulcer ◽  
Peptic Ulcers ◽  
Northern Irish ◽  
Mortality And Morbidity ◽  
Ulcer Disease ◽  
Patient Demographics ◽  
Acute Peritonitis

Abstract Background Perforated peptic ulcer disease is one of the most common causes of acute peritonitis. It carries significant mortality and morbidity. Several previous studies have reported a seasonal variation in presentation of patients with perforated ulcers. Here we present this study from a Northern Irish perspective on perforated peptic ulcers. Methods A retrospective cohort study was conducted on perforated peptic ulcer patients who presented to Altnagelvin Area Hospital emergency department between 2015 to 2020. Data on patient demographics, clinical presentation, investigations, management and outcomes were collected. Primary outcome was to investigate if seasonality was associated with incidence of perforated peptic ulcers. Follow-up data was also collected. Seasons were defined as per UK Met Office. Results Results:  A total of 50 patients presented with perforated PUD. Male:female ratio was approximately 3:2. Peaks were noted in spring and winter. April was the most common month for presentation followed by December. Smoking was the most common risk factor followed by alcohol abuse. 14 patients (28%) were either very frail or had contained perforations and were conservatively managed. 3 deaths were noted (6%). 13 patients (26%) required ICU admission at some stage in their management. Conclusions Slight seasonal variation was noted in presentation of perforated peptic ulcers in our study with more common incidence in winter and spring months. The month of April was noted to have the peak incidence of the disease in our study.

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