The Analysis of the Relationship Between Subjective Tinnitus and Vascular Loop, and Age and Gender Distribution: An MRI Study

Background:The prevalence of osteoporosis in inflammatory rheumatic diseases such as psoriatic arthritis (PsA) has not been sufficiently clarified yet, and the data in the literature are heterogeneous. In addition, it is still unclear to what extent patients with PsA differ in terms of bone density from patients with other forms of spondyloarthritis such as ankylosing spondylitis (AS).Objectives:In an interim analysis of the Rh-GIOP Study (ClinicalTrials.gov IdentifierNCT02719314), we observed that PsA patients demonstrated more frequently normal bone density than any other patient group analyzed (suffering from e.g. rheumatoid arthritis or systemic sclerosis). The main objective of this investigation was to compare bone density data from patients with PsA and AS, as both diseases belong to the spondyloarthritis group. 1100 patients with inflammatory rheumatic diseases provided the basis of Rh-GIOP, a prospective study monitoring glucocorticoid (GC)-induced osteoporosis in patients with rheumatic diseases. Rh-GIOP was established in 2015 at the Charité University Hospital. Bone mineral density data were measured by dual x-ray absorptiometry (DXA).Methods:92 patients with PsA (65% female) were compared with 51 patients suffering from AS (35% female). Potential risk and protective factors (e.g. data on GC treatment, anti-rheumatic therapy), laboratory parameters (e.g. Vitamin D, alkaline phosphatase, calcium and inflammatory markers) and functional status (e.g. Health Assessment Questionnaire, sporting activities, back pain) were compared between these groups. Statistical analysis was performed descriptively using mean and standard deviation, t-tests for metric variables, and chi-square tests for nominal variables. Due to the heterogeneous gender distribution, an additional statistical matching was performed to compare patients matched by age and gender.Results:Patients with PsA displayed significantly higher minimal T-scores than patients with AS (p=0.003) even though patients with AS were younger and more often male (p<0.001). AS patients showed a higher frequency of osteopenic bone densities (p<0.05), however, no differences in the frequency of osteoporotic bone densities were found. Body-mass-index (BMI) was significantly higher (p<0.001) in PsA patients. PsA patients demonstrated a higher frequency of csDMARD use (p<0.001). Additional analyses among PsA patients with and without csDMARDs revealed also significantly higher minimal T-scores in PsA patients taking csDMARDs (90% Methotrexate), and both groups showed the same average of age and gender distribution. Furthermore, AS patients complained significantly more often of back pain (96 % vs. 74%, p=0.001) than PsA patients. No differences in GC use or cumulative GC dose were found. All results could be confirmed when groups were matched by age and gender.Conclusion:Our results demonstrate that patients with PsA display higher bone density compared to age and gender matched patients with ankylosing spondylitis. Possible influencing factors could be the higher frequency of csDMARD use, higher BMI or the lower frequency of back pain in PsA patients. Multivariate tests and additional biomarker investigations in larger cohorts are necessary to corroborate these findings and to identify underlying pathogenic differences which could serve for an explanation.Disclosure of Interests:Desiree Freier: None declared, Edgar Wiebe: None declared, Robert Biesen: None declared, Thomas Buttgereit: None declared, Sandra Hermann: None declared, Timo Gaber: None declared, Frank Buttgereit Grant/research support from: Amgen, BMS, Celgene, Generic Assays, GSK, Hexal, Horizon, Lilly, medac, Mundipharma, Novartis, Pfizer, Roche, and Sanofi.

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No Self Without Salience: Affective and Self-relevance Ratings of 552 Emotionally Valenced and Neutral Dutch Words

Journal of Psycholinguistic Research ◽

10.1007/s10936-021-09784-1 ◽

2021 ◽

Author(s):

Lora I. Dimitrova ◽

Eline M. Vissia ◽

Hanneke Geugies ◽

Hedwig Hofstetter ◽

Sima Chalavi ◽

...

Keyword(s):

Repeated Measures ◽

Emotional Valence ◽

Age And Gender ◽

Gender And Age ◽

Main Effect ◽

Emotional Salience ◽

And Gender ◽

The Relationship

AbstractIt is unknown how self-relevance is dependent on emotional salience. Emotional salience encompasses an individual's degree of attraction or aversion to emotionally-valenced information. The current study investigated the interconnection between self and salience through the evaluation of emotional valence and self-relevance. 56 native Dutch participants completed a questionnaire assessing valence, intensity, and self-relevance of 552 Dutch nouns and verbs. One-way repeated-measures ANCOVA investigated the relationship between valence and self, age and gender. Repeated-measures ANCOVA also tested the relationship between valence and self with intensity ratings and effects of gender and age. Results showed a significant main effect of valence for self-relevant words. Intensity analyses showed a main effect of valence but not of self-relevance. There were no significant effects of gender and age. The most important finding presents that self-relevance is dependent on valence. These findings concerning the relationship between self and salience opens avenues to study an individual's self-definition.

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Age and gender distribution among the patients with Gilbert’s syndrome

Fundamental and Clinical Medicine ◽

10.23946/2500-0764-2021-6-1-75-81 ◽

2021 ◽

Vol 6 (2) ◽

pp. 75-81

Author(s):

A. N. Volkov ◽

E. V. Tsurkan

Keyword(s):

Age Distribution ◽

Significant Proportion ◽

Age And Gender ◽

Gender Distribution ◽

Gilbert’S Syndrome ◽

Ugt1a1 Gene ◽

Screening Programs ◽

Gilbert's Syndrome ◽

Syndrome Diagnosis ◽

And Gender

Aim. To analyze age and gender distribution in patients with Gilbert's syndrome.Materials and Methods. We consecutively recruited 115 patients with Gilbert's syndrome. All patients underwent genotyping of the rs8175347 polymorphism within the UGT1A1 gene using allele-specific polymerase chain reaction to confirm the diagnosis.Results. The age of initial diagnosis ranged from 3 years to 71 years, with the majority (44.3%) of cases detected ≤ 20 years of age. Mean ± standard error and median age of the diagnosis were 30.03 ± 1.72 years and 23 years. Despite the proportion of females and males among patients was similar, age distribution at primary diagnosis was significantly different across the genders. In women, Gilbert's syndrome was most frequently detected between 11 and 20 years (23.1%) and between 51 and 60 years (19.2%). In contrast, male adolescents were more prone to the development of Gilbert's syndrome, as 47.6% of male patients belonged to this age category.Conclusions. Variable age of Gilbert's syndrome diagnosis is probably determined by an individual combination of genetic causes (e.g., mutation of the UGT1A1 gene) and additional risk factors. Adolescents compose a significant proportion of patients. Because of relatively mild disease in many patients and unpredictability of the provoking factors, primary detection of Gilbert's syndrome can be delayed. Differences in age of Gilbert's syndrome diagnosis across the genders can be partially explained by organizational reasons associated with the current screening programs.

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Assessment of Age and Gender Distribution of Patients Having Cervical Abrasion and the Treatment of Choice for Abraded Teeth

Bioscience Biotechnology Research Communications ◽

10.21786/bbrc/13.8/149 ◽

2020 ◽

Vol 13 (8) ◽

pp. 266-271

Author(s):

Manthra Prathoshni. S

Keyword(s):

Age And Gender ◽

Gender Distribution ◽

And Gender

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Focus on Text Messages: A Review of Studies in French

Encyclopedia of Mobile Phone Behavior ◽

10.4018/978-1-4666-8239-9.ch085 ◽

2015 ◽

pp. 1037-1050

Author(s):

Olga Volckaert-Legrier ◽

Antonine Goumi ◽

Alain Bert-Erboul ◽

Josie Bernicot

Keyword(s):

Text Message ◽

Text Messages ◽

French Language ◽

Age And Gender ◽

Future Studies ◽

Linguistic Markers ◽

Production Processes ◽

Language Research ◽

And Gender ◽

The Relationship

The study of text messages has given rise to a number of French language research topics. First, databases of natural text messages have been created in multiple Francophone countries in an effort to link the texters' characteristics with the linguistic markers of the text messages. Many studies have focused on textisms (changes in spelling as compared to the traditional written code), creating repertoires of spelling processes and classifying them into typologies. With regard to linguistic aspects, a few studies have analyzed vocabulary and syntax. Sociolinguistic aspects have also been studied, taking into account the relationship among textisms, age, and gender. To address the question of whether text message writing is a threat to spelling, several studies have analyzed the link between text message writing and traditional writing. Finally, a number of studies have focused on the production processes of text message writing. Future studies will need to take into account the dialogical and conversational aspects of text messages.

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Medial injuries of the clavicle: more prevalent than expected? A big data analysis of incidence, age, and gender distribution based on nationwide routine data

European Journal of Trauma and Emergency Surgery ◽

10.1007/s00068-019-01293-0 ◽

2020 ◽

Cited By ~ 1

Author(s):

Mustafa Sinan Bakir ◽

Jan Unterkofler ◽

Lyubomir Haralambiev ◽

Simon Kim ◽

Roman Carbon ◽

...

Keyword(s):

Big Data ◽

Data Analysis ◽

Routine Data ◽

Big Data Analysis ◽

Age And Gender ◽

Gender Distribution ◽

And Gender

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Effects of Feature Variations on Attributions for Schematic Faces

Psychological Reports ◽

10.2466/pr0.1993.73.1.275 ◽

1993 ◽

Vol 73 (1) ◽

pp. 275-288 ◽

Cited By ~ 12

Author(s):

Stuart J. McKelvie

Keyword(s):

Age And Gender ◽

Short Nose ◽

Folk Wisdom ◽

Perceived Age ◽

Six Dimensions ◽

Individual Features ◽

And Gender ◽

The Relationship

31 subjects classified 16 schematic faces on six dimensions. Attractiveness was generally associated with widely separated eyes, a short nose, and high feature placement. When features were considered in combination, faces with low placement were judged attractive, although the effect was mitigated by a narrow mouth. Previous findings concerning perceived age and gender were partially replicated, but folk wisdom linking intelligence to low placement (high forehead) was refuted. It is suggested that the relationship between individual features and attributions is nonlinear and interactive, and that researchers should investigate these hypotheses by exercising finer control over feature variations.

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