scholarly journals Dose‐effect relation between regular consumption of 100% cocoa powder and blood pressure in young, healthy black Africans

2021 ◽  
Vol 9 (20) ◽  
Author(s):  
Edwige Balayssac‐Siransy ◽  
Soualiho Ouattara ◽  
Kotchi Joël Michée Boka ◽  
Hugues Ahiboh ◽  
Téniloh Augustin Yéo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Dose Effect ◽  
Black Africans ◽  
Cocoa Powder ◽  
Regular Consumption ◽  
Effect Relation

scholarly journals Weekly Physiological Changes in Blood Pressure During Three Weeks Daily Consumption of 10 Grams of Cocoa Powder Among Young Black Africans in Côte d’Ivoire

2021 ◽  
Vol 12 ◽  
Author(s):  
Edwige Siransy-Balayssac ◽  
Soualiho Ouattara ◽  
Hugues Ahiboh ◽  
Toh Bi Youzan ◽  
Fagnan Levy Gouh ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Cote D'ivoire ◽  
Control Group ◽  
Consumer Group ◽  
Black Africans ◽  
Cocoa Powder ◽  
Black African ◽  
Arterial Blood ◽  
Regular Consumption

BackgroundIn Caucasians, regular consumption of cocoa induces a drop in arterial blood pressure via an increase in nitric oxide (NO) production. However, black individuals have a different NO biodisponibility compared to Caucasians. The aim of this study was to determine, in black Africans, the physiological variations in arterial blood pressure among cocoa consumers.MethodIn total, 49 male black African volunteers, aged between 18 and 30 years old, were randomized into two groups; those consuming 10 g of cocoa powder per day (1,680 mg of flavonoids per day) for 3 weeks (consumer group), and those not consuming cocoa (control group). Systolic (SBP) and diastolic blood pressures (DBP), and heart rate (HR) were measured in the morning on an empty stomach (fasting), on day (D) 1 (without cocoa), D8, D15, and D22. Data were collected by groups and by subgroups established according to the level of SBP, DBP, or HR on D1. The means and variations of the means (between D1 and the subsequent days) of the recorded parameters were calculated and compared between groups and between subgroups.ResultsOn D8, the variations in SBP in the consumer group were significantly different from the control group (−3.72 ± 6.01 versus 0.57 ± 6.66 mmHg; p = 0.02). Between the control and consumer subgroups according to SBP, no statistical difference in the means or variations in SBP was noted. On D8 and D22, the variations in the SBP of consumers with SBP ≥ 110 mmHg on D1 were significantly different from those of other consumers (D8: −6.55 ± 5.96 versus −1.1 ± 4.93 mmHg; p = 0.01; D22: −6.63 ± 7.77 versus 0.35 ± 5.58 mmHg; p = 0.01). In the subgroups with a DBP < 75 mmHg on D1, the mean DBP of the consumers was significantly lower than that of the controls on D8 (65 ± 5 versus 69 ± 6 mmHg; p = 0.03).ConclusionIn young black African men living in Côte d’Ivoire, regular consumption of cocoa resulted in a decrease in SBP and DBP. The decrease in SBP appeared to be greater the higher the baseline SBP was.

scholarly journals High prevalence of non-dipping patterns among Black Africans with uncontrolled hypertension: a secondary analysis of the CREOLE trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Prossie Merab Ingabire ◽  
◽  
Dike B. Ojji ◽  
Brian Rayner ◽  
Elijah Ogola ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Secondary Analysis ◽  
Uncontrolled Hypertension ◽  
African Countries ◽  
Night Time ◽  
Black Africans ◽  
Long Term Outcome ◽  
Black African ◽  
High Prevalence

Abstract Background Dipping of blood pressure (BP) at night is a normal physiological phenomenon. However, a non-dipping pattern is associated with hypertension mediated organ damage, secondary forms of hypertension and poorer long-term outcome. Identifying a non-dipping pattern may be useful in assessing risk, aiding the decision to investigate for secondary causes, initiating treatment, assisting decisions on choice and timing of antihypertensive therapy, and intensifying salt restriction. Objectives To estimate the prevalence and factors associated with non-dipping pattern and determine the effect of 6 months of three antihypertensive regimens on the dipping pattern among Black African hypertensive patients. Methods This was a secondary analysis of the CREOLE Study which was a randomized, single blind, three-group trial conducted in 10 sites in 6 Sub-Saharan African countries. The participants were 721 Black African patients, aged between 30 and 79 years, with uncontrolled hypertension and a baseline 24-h ambulatory blood pressure monitoring (ABPM). Dipping was calculated from the average day and average night systolic blood pressure measures. Results The prevalence of non-dipping pattern was 78% (564 of 721). Factors that were independently associated with non-dipping were: serum sodium > 140 mmol/l (OR = 1.72, 95% CI 1.17–2.51, p-value 0.005), a higher office systolic BP (OR = 1.03, 95% CI 1.01–1.05, p-value 0.003) and a lower office diastolic BP (OR = 0.97, 95% CI 0.95–0.99, p-value 0.03). Treatment allocation did not change dipping status at 6 months (McNemar’s Chi2 0.71, p-value 0.40). Conclusion There was a high prevalence of non-dipping among Black Africans with uncontrolled hypertension. ABPM should be considered more routinely in Black Africans with uncontrolled hypertension, if resources permit, to help personalise therapy. Further research is needed to understand the mechanisms and causes of non-dipping pattern and if targeting night-time BP improves clinical outcomes. Trial registration ClinicalTrials.gov (NCT02742467).

scholarly journals Synthesis, Characterization of Liposomes Modified with Biosurfactant MEL-A Loading Betulinic Acid and Its Anticancer Effect in HepG2 Cell

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3939 ◽  
Author(s):  
Qin Shu ◽  
Jianan Wu ◽  
Qihe Chen
Keyword(s):  
Betulinic Acid ◽  
Hepg2 Cells ◽  
Lipid A ◽  
Clinical Applications ◽  
Dose Effect ◽  
Anticancer Effect ◽  
Mannosylerythritol Lipid ◽  
Anti Cancer ◽  
Effect Relation

As a novel natural compound delivery system, liposomes are capable of incorporating lipophilic bioactive compounds with enhanced compound solubility, stability and bioavailability, and have been successfully translated into real-time clinical applications. To construct the soy phosphatidylcholine (SPC)–cholesterol (Chol) liposome system, the optimal formulation was investigated as 3:1 of SPC to Chol, 10% mannosylerythritol lipid-A (MEL-A) and 1% betulinic acid. Results show that liposomes with or without betulinic acid or MEL-A are able to inhibit the proliferation of HepG2 cells with a dose-effect relation remarkably. In addition, the modification of MEL-A in liposomes can significantly promote cell apoptosis and strengthen the destruction of mitochondrial membrane potential in HepG2 cells. Liposomes containing MEL-A and betulinic acid have exhibited excellent anticancer activity, which provide factual basis for the development of MEL-A in the anti-cancer applications. These results provide a design thought to develop delivery liposome systems carrying betulinic acid with enhanced functional and pharmaceutical attributes.

DOSE–EFFECT RELATION BETWEEN DAILY ETHANOL INTAKE IN THE RANGE 0–70 GRAMS AND %CDT VALUE: VALIDATION OF A CUT-OFF VALUE

2005 ◽  
Vol 40 (6) ◽  
pp. 531-534 ◽  
Author(s):  
FRANÇOIS SCHELLENBERG ◽  
RAYMUND SCHWAN ◽  
LOUISE MENNETREY ◽  
MARIE-NADIA LOISEAUX ◽  
JEAN CHRISTOPHE PAGÈS ◽  
...  
Keyword(s):  
Ethanol Intake ◽  
Dose Effect ◽  
Effect Relation

Error bands for the linear-quadratic dose-effect relation

2003 ◽  
Vol 42 (2) ◽  
pp. 77-85 ◽  
Author(s):  
A. M. Kellerer
Keyword(s):  
Dose Effect ◽  
Linear Quadratic ◽  
Effect Relation

Effects of brisk walking on blood pressure in the Chinese Han occupational population with a sedentary lifestyle: A baseline control trial

2020 ◽  
Author(s):  
Yingxiang Yu ◽  
Cuiqing Chang ◽  
Yifan Wu ◽  
Lan Xie ◽  
Chengcheng Guo
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Exercise Intervention ◽  
Sedentary Lifestyle ◽  
Dose Effect ◽  
Brisk Walking ◽  
Chinese Han ◽  
Effect Relationship ◽  
Level 1 ◽  
Level 2

Abstract Background: Physical activity has proven to be effective in improving blood pressure (BP), but research on the beneficial exercise volume for BP control is limited. We assessed the intervention effects of walking on BP in the Chinese Han occupational population with a sedentary lifestyle to explore the appropriate exercise volume needed for BP control.Methods: A total of 802 subjects were recruited from enterprises and institutions for our study. This study was designed as an intervention study for a baseline control trial. All participants received a 3-month open and prescription pedometer-assisted self-monitoring walking intervention. Multiple linear regression models were used to assess the association between physical activity and changes in systolic (SBP) and diastolic (DBP) BP. We divided the effective step counts into five levels: 4000-<6000 (level 1), 6000-<8000 (level 2), 8000-<10000 (level 3), 10000-12000 (level 4), and >12000 (level 5) steps/day for statistical analysis to evaluate the exercise intervention efficiency.Results: Data of 688 participants who completed the study were analyzed. After 3 months, SBP and DBP decreased by 1.9 and 2.0 mmHg, respectively (P < 0.05). Taking level 5 (>12000 steps/day) as reference, SBP can be better controlled at levels 1-4: level 1 had the best effect (-6.05 mmHg, P=0.007), followed by level 2 (-3.54 mmHg, P=0.006), showing a significant dose-effect relationship between exercise and SBP. Furthermore, the effective step count of 6000-<8000 steps/day was better in controlling SBP in males (-4.26 mmHg, P = 0.014), while 4000-<6000 steps/day had a better effect on females (-6.86 mmHg, P = 0.037). The significant dose-effect relationship was only observed in the 36-50 age group. However, no significant dose-effect relationship between exercise and DBP.Conclusions: Brisk walking can effectively control BP in the Chinese Han occupational population with a sedentary lifestyle. There was a significant dose-effect relationship between exercise and SBP with differences in sex and age. Trial registration: ChiCTR-OOh-16010229. Registered 5 January 2017 - Retrospectively registered, http://www.chictr.org.cn/showprojen.aspx?proj=17362.

scholarly journals Physiological variations of blood pressure according to gender and age among healthy young black Africans aged between 18 and 30 years in Côte d’Ivoire, West Africa

2020 ◽  
Vol 8 (18) ◽  
Author(s):  
Edwige Siransy‐Balayssac ◽  
Soualiho Ouattara ◽  
Téniloh Augustin Yéo ◽  
Aya Liliane Kondo ◽  
Massiré Touré ◽  
...  
Keyword(s):  
Blood Pressure ◽  
West Africa ◽  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Black Africans ◽  
Cote D’Ivoire ◽  
Côte D'ivoire ◽  
Gender And Age ◽  
Physiological Variations
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