The Ability of 1a, 25-Dihydroxycholecalciferol to Alter the Fatty Acid Composition of Phosphoglycerides in Rat Intestinal Mucosa and Smooth Muscle

1979 ◽  
pp. 1031-1034
Keyword(s):  
Smooth Muscle ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Intestinal Mucosa

scholarly journals Effect of temperature acclimatization on the fatty acid composition of goldfish intestinal lipids

1970 ◽  
Vol 117 (1) ◽  
pp. 9-15 ◽  
Author(s):  
P. Kemp ◽  
M. W. Smith
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Intestinal Mucosa ◽  
Neutral Lipids ◽  
Effect Of Temperature ◽  
Membrane Phospholipids ◽  
Ethanolamine Phosphoglycerides ◽  
Different Temperatures

1. The fatty acid composition of whole goldfish, whole-intestinal mucosa, intestinal mucosal membranes and individual phospholipids extracted from mucosal membranes were measured, fish adapted to different temperatures being used. 2. Alterations of the adaptation temperature did not noticeably affect the fatty acid composition of the whole-fish lipids, but there were marked changes in the fatty acids of lipids extracted from homogenates of goldfish intestinal mucosa. These changes were more pronounced in a membrane fraction prepared from these homogenates. Raising the adaptation temperature by 20°C halved the percentage of C20:1, C20:4 and C22:6 fatty acids and nearly doubled the percentage of C18:0 and C20:3 fatty acids recovered. 3. Choline phosphoglycerides constituted about one-half and ethanolamine phosphoglycerides about one-quarter of the total membrane phospholipids. 4. The fatty acids of choline and ethanolamine phosphoglycerides were more susceptible to temperature-dependent changes than were the phosphoglycerides of inositol or serine. 5. The increase in C18:0 fatty acid that occurred in membranes of warm-adapted fish was greatest for ethanolamine phosphoglycerides, but increases also occurred in other phospholipid fractions and in membrane neutral lipids.

Lipid and fatty acid composition of intestinal mucosa of two Antarctic teleosts

1996 ◽  
Vol 115 (4) ◽  
pp. 303-307 ◽  
Author(s):  
R. Acierno ◽  
M. Maffia ◽  
P. Sicuro ◽  
L. Fiammata ◽  
M. Rollo ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Intestinal Mucosa ◽  
Antarctic Teleosts

Influence of dietary fatty acids on the fatty acid composition of intestinal mucosa in the milk fed pre-ruminant calf

2001 ◽  
Vol 2001 ◽  
pp. 121-121
Author(s):  
R. O’Brian ◽  
N. Muturi ◽  
M. Birnie ◽  
M. Wallace ◽  
J. Struthers ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Intestinal Mucosa ◽  
Dietary Fatty Acids ◽  
The Body ◽  
Antigenic Exposure ◽  
Turn Over ◽  
Dietary Fatty Acid Intake

Dietary fatty acids have been shown to affect the activity of the immune system in a variety of species (Calder, 1998) although the exact mechanism by which they influence the nature of the immune response is unclear. The effect of dietary fatty acids on the fatty acid composition of intestinal mucosa is important since this tissue has a rapid turn over and is a major site of antigenic exposure and immune defence. The speed with which changes in dietary fatty acid intake are reflected in the fatty acid composition of cells and tissue of the body varies. In ruminants the development of a functional rumen greatly influences the nature of the fatty acids available for absorption from the small intestine, however, in pre-ruminant animals, milk may be used as a medium to supplement the diet with specific dietary fatty acids. This work was carried out to establish the extent to which different oil supplements could change the fatty acid composition of intestinal mucosa in milk fed pre-ruminant calves.

scholarly journals 297 Effect of feeding DHA on the fatty acid composition of intestinal mucosa in adults with CF

2006 ◽  
Vol 5 ◽  
pp. S69
Author(s):  
M.T. Clandinin ◽  
N.E. Brown ◽  
A.B.R. Thomson ◽  
S.E.P. Man ◽  
Y.K. Goh ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Intestinal Mucosa ◽  
Effect Of Feeding

scholarly journals Analysis of the physical state of cholesteryl esters in arterial-smooth-muscle-derived foam cells by differential scanning calorimetry

1990 ◽  
Vol 268 (3) ◽  
pp. 693-697 ◽  
Author(s):  
D P Hajjar ◽  
K B Pomerantz ◽  
J W Snow
Keyword(s):  
Differential Scanning Calorimetry ◽  
Smooth Muscle ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Physical State ◽  
Foam Cells ◽  
Cholesteryl Esters ◽  
Scanning Calorimetry ◽  
Treatment Groups

The physical state of cholesteryl esters (CE) in the arterial-smooth-muscle-derived foam cells may contribute to the documented reduction in CE hydrolysis. The physical state of CE may also provide a potential enhancing mechanism for increased CE accumulation. To explore these concepts, we therefore examined the influence of alterations in CE and triacylglycerol (TG) content and their fatty acid composition on the thermotropic behaviour of these lipids by differential scanning calorimetry (d.s.c.). After exposure to cationized LDL (cLDL) or after infection with herpes simplex virus type I (HSV), smooth-muscle cells accumulated significant amounts of CE. The CE/TG ratio was significantly higher in cells treated with cLDL compared with HSV infection. TG content was unaffected by either treatment. However, the fatty acid profile of both CE and TG was significantly different between treatment groups, with the polyunsaturated fatty acid/saturated fatty acid (PUFA/SFA) ratio being significantly higher in cLDL-treated cells than in HSV-infected cells. The d.s.c.-generated thermograms of intact cells revealed that neutral lipids of both treatment groups were in the isotropic-liquid state, similar to the state of lipids derived from ‘fatty streak’ types of atherosclerotic lesions. Differences in the thermograms between HSV-infected and cLDL-treated cells can be ascribed to differences in the CE content and the fatty acid composition of CE and TG (PUFA/SFA ratio). Polarizing optical microscopy revealed the presence of isotropic lipids in both groups. Biochemical and physicochemical data confirm the lysosomal localization of engorged CE, and indicate that the cellular isotropic CE in these foam cells are in a physical state which favours enzymic hydrolysis.

Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue

1985 ◽  
Vol 54 (03) ◽  
pp. 563-569 ◽  
Author(s):  
M K Salo ◽  
E Vartiainen ◽  
P Puska ◽  
T Nikkari
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Platelet Aggregation ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Free Living ◽  
Ω3 Fatty Acids ◽  
Induced Aggregation

SummaryPlatelet aggregation and its relation to fatty acid composition of platelets, plasma and adipose tissue was determined in 196 randomly selected, free-living, 40-49-year-old men in two regions of Finland (east and southwest) with a nearly twofold difference in the IHD rate.There were no significant east-southwest differences in platelet aggregation induced with ADP, thrombin or epinephrine. ADP-induced platelet secondary aggregation showed significant negative associations with all C20-C22 ω3-fatty acids in platelets (r = -0.26 - -0.40) and with the platelet 20: 5ω3/20: 4ω 6 and ω3/ ω6 ratios, but significant positive correlations with the contents of 18:2 in adipose tissue (r = 0.20) and plasma triglycerides (TG) (r = 0.29). Epinephrine-induced aggregation correlated negatively with 20: 5ω 3 in plasma cholesteryl esters (CE) (r = -0.23) and TG (r = -0.29), and positively with the total percentage of saturated fatty acids in platelets (r = 0.33), but had no significant correlations with any of the ω6-fatty acids. Thrombin-induced aggregation correlated negatively with the ω3/6ω ratio in adipose tissue (r = -0.25) and the 20: 3ω6/20: 4ω 6 ratio in plasma CE (r = -0.27) and free fatty acids (FFA) (r = -0.23), and positively with adipose tissue 18:2 (r = 0.23) and 20:4ω6 (r = 0.22) in plasma phospholipids (PL).The percentages of prostanoid precursors in platelet lipids, i. e. 20: 3ω 6, 20: 4ω 6 and 20 :5ω 3, correlated best with the same fatty acids in plasma CE (r = 0.32 - 0.77) and PL (r = 0.28 - 0.74). Platelet 20: 5ω 3 had highly significant negative correlations with the percentage of 18:2 in adipose tissue and all plasma lipid fractions (r = -0.35 - -0.44).These results suggest that, among a free-living population, relatively small changes in the fatty acid composition of plasma and platelets may be reflected in significant differences in platelet aggregation, and that an increase in linoleate-rich vegetable fat in the diet may not affect platelet function favourably unless it is accompanied by an adequate supply of ω3 fatty acids.

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