Fractionation of Horse Spleen Ferritin. Relationship of Fe/N-Ratio to some Physico-Chemical Properties

1969 ◽  
Vol 350 (2) ◽  
pp. 1331-1339 ◽  
Author(s):  
HELMUT HAUSER
Keyword(s):  
Chemical Properties ◽  
Physico Chemical ◽  
Relationship Of ◽  
Horse Spleen Ferritin

scholarly journals Relationship of soil physico chemical properties with elevation and geographical directions

2021 ◽  
Vol 788 (1) ◽  
pp. 012172
Author(s):  
Imran ◽  
Amanullah ◽  
S Naveed ◽  
I Khan ◽  
M Sajid ◽  
...  
Keyword(s):  
Chemical Properties ◽  
Physico Chemical ◽  
Relationship Of

Structure-function relationship of the human antimicrobial peptide LL-37 and LL-37 fragments in the modulation of TLR responses

2009 ◽  
Vol 390 (4) ◽  
Author(s):  
E. Margo Molhoek ◽  
Alice L. den Hertog ◽  
Anne-Marij B.C. de Vries ◽  
Kamran Nazmi ◽  
Enno C.I. Veerman ◽  
...  
Keyword(s):  
Mononuclear Cells ◽  
Inflammatory Responses ◽  
Human Peripheral Blood ◽  
Chemical Properties ◽  
Peripheral Blood Mononuclear ◽  
Physico Chemical ◽  
Saccharide Binding ◽  
Host Defense System ◽  
Function Relationship ◽  
Relationship Of

AbstractCathelicidins are effector molecules of the innate host defense system that establish an antimicrobial barrier at epithelial interfaces. The human cathelicidin LL-37, in addition to its antimicrobial activity, also exhibits immunomodulatory effects, such as inhibition of pro-inflammatory responses to bacterial LPS in human monocytic cells. In this report, we demonstrate that LL-37 almost completely prevents the pro-inflammatory cytokine release by human peripheral blood mononuclear cells (PBMCs) following stimulation with Toll-like receptor (TLR)4 and TLR2/1 agonists while leaving TLR2/6, TLR5, TLR7 and TLR8 responses unchanged. Modulation of the TLR response by LL-37 occurred at least partly through the MAP kinase pathway via inhibition of p38 phosphorylation. By using an LL-37 library with overlapping sequences, we identified the mid-region of LL-37, comprising amino acids 13–31, as the active domain for the modulation of TLR responses. The mechanism of immunomodulation of LL-37 and LL-37 fragments is lipopoly-saccharide binding. Correlations between the capacity of LL-37 fragments to modulate TLR responses and their physico-chemical properties revealed that cationicity and hydrophobicity are essential for the modulation of LL-37-mediated TLR responses.

scholarly journals Agroecological evaluation of interrelationships of soil properties in time and space

2021 ◽  
pp. 163-175
Author(s):  
V. I. Savich ◽  
V. V. Gukalov ◽  
A. E. Sorokin ◽  
M. D. Konakh
Keyword(s):  
Soil Properties ◽  
Mutual Influence ◽  
Chemical Properties ◽  
Farming Systems ◽  
Water Soluble ◽  
Soil Fertilization ◽  
Podzolic Soils ◽  
Physico Chemical ◽  
Relationship Of ◽  
The Relationship

This paper assesses the relationship between the physico-chemical and agro-chemical properties of sod-podzolic soils in the Moscow region and ordinary heavy-loamy chernozems in the Krasnodar region within the catenas and down the soil profile. Soil properties changed significantly through seasonal dynamics. From the end of April to the middle of June in the soil solution of sod-podzolic soils, the value of Eh varied from 534 to 759 mv, the ratio of NO3/NH4 – from 0.2 to 15.4; the content of water-soluble manganese – from 4.0 to 10.1. At the same time, there was a delay in change of soil properties, as humidity and temperature varied. It is shown that in different intervals of soil properties between individual indicators of fertility, the effects of synergism and antagonism are manifested. The degree of mutual influence of soil properties depended on both the degree of soil fertilization and the degree of their cultivation. Information relationships were manifested not only between the soil properties, but also between the processes. Temporary excessive moistening of the soil led to acidification of the soil in the washing type of water mode, and to alkalinization in the non-washing type. It is proposed to account for the relationship of soil properties with humidity, temperature, pH, and Eh to adjust the components of farming systems.

Decoration of specific sites on freeze-fractured membranes

1978 ◽  
Vol 36 (2) ◽  
pp. 140-141
Author(s):  
H. Gross ◽  
H. Moor
Keyword(s):  
Pure Water ◽  
Freeze Fracture ◽  
Chemical Properties ◽  
Surface Forces ◽  
Sulfate Pentahydrate ◽  
Copper Sulfate Pentahydrate ◽  
Physico Chemical ◽  
Water Of Hydration ◽  
Small Container ◽  
Binding Forces

Fracturing under ultrahigh vacuum (UHV, p ≤ 10-9 Torr) produces membrane fracture faces devoid of contamination. Such clean surfaces are a prerequisite foe studies of interactions between condensing molecules is possible and surface forces are unequally distributed, the condensate will accumulate at places with high binding forces; crystallites will arise which may be useful a probes for surface sites with specific physico-chemical properties. Specific “decoration” with crystallites can be achieved nby exposing membrane fracture faces to water vopour. A device was developed which enables the production of pure water vapour and the controlled variation of its partial pressure in an UHV freeze-fracture apparatus (Fig.1a). Under vaccum (≤ 10-3 Torr), small container filled with copper-sulfate-pentahydrate is heated with a heating coil, with the temperature controlled by means of a thermocouple. The water of hydration thereby released enters a storage vessel.

Physico-Chemical Properties of Recombinant Desulphatohirudin

1990 ◽  
Vol 63 (03) ◽  
pp. 499-504 ◽  
Author(s):  
A Electricwala ◽  
L Irons ◽  
R Wait ◽  
R J G Carr ◽  
R J Ling ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gel Filtration ◽  
Chemical Properties ◽  
Alpha Helix ◽  
Apparent Molecular Weight ◽  
Correlation Spectroscopy ◽  
Nmr Studies ◽  
Recombinant Hirudin ◽  
Physico Chemical ◽  
Recombinant Molecule

SummaryPhysico-chemical properties of recombinant desulphatohirudin expressed in yeast (CIBA GEIGY code No. CGP 39393) were reinvestigated. As previously reported for natural hirudin, the recombinant molecule exhibited abnormal behaviour by gel filtration with an apparent molecular weight greater than that based on the primary structure. However, molecular weight estimation by SDS gel electrophoresis, FAB-mass spectrometry and Photon Correlation Spectroscopy were in agreement with the theoretical molecular weight, with little suggestion of dimer or aggregate formation. Circular dichroism studies of the recombinant molecule show similar spectra at different pH values but are markedly different from that reported by Konno et al. (13) for a natural hirudin-variant. Our CD studies indicate the presence of about 60% beta sheet and the absence of alpha helix in the secondary structure of recombinant hirudin, in agreement with the conformation determined by NMR studies (17)

Physico-chemical properties of the rare-earth metals, scandium, and yttrium

1963 ◽  
Vol 79 (2) ◽  
pp. 263-293 ◽  
Author(s):  
E.M. Savitskii ◽  
V.F. Terekhova ◽  
O.P. Naumkin
Keyword(s):  
Rare Earth ◽  
Rare Earth Metals ◽  
Chemical Properties ◽  
Physico Chemical ◽  
The Rare Earth
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