scholarly journals Sevoflurane-medicated the pathway of chemokine receptors bind chemokines in patients undergoing CABG

2017 ◽  
Vol 12 (1) ◽  
pp. 443-451
Author(s):  
Bing Kong ◽  
Yu-Wu Ma ◽  
De-Xue Li ◽  
Xi-Jiang Liu ◽  
Yong-Guang Xu
Keyword(s):  
Chemokine Receptors ◽  
Molecular Mechanisms ◽  
Permutation Test ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Random Permutation ◽  
Snowball Sampling ◽  
Differential Modules ◽  
Pathway Analyses ◽  
Selection Of

AbstractBackgroundWe aim to identify sevoflurane-induced modules and pathways in patients following coronary artery bypass graft (CABG) surgery, and to further elucidate the molecular mechanisms of the cardioprotective effects of sevoflurane.MethodsDifferential co-expression network (DCN) was constructed. Candidate modules were identified via three steps: selection of seed genes, search of modules using snowball sampling, and refinement of modules. Afterwards, the significance of the candidate modules was assessed. Ultimately, pathway analyses for genes in differential modules were implemented to illuminate the biological processes.ResultsOverall, 122 genes were identified to serve as seed genes. From every seed gene, we extracted 122 modules and the mean node size in a module was 3. By setting the classification accuracy cutoff at 0.9 and the number of nodes in a module at 5, 7 candidate modules were identified, including module 80, 82, 82, 84, 85, 86 and 89. Based on the random permutation test, we found that these 7 candidate modules were all differential ones. Moreover, pathway analysis showed that genes in the differential modules 80, 82, and 85 were all enriched in the pathway of chemokine receptors bind chemokines.ConclusionSevoflurane might exert cardioprotective functions in patients following CABG, partially through regulating the pathway of chemokine receptors bind chemokines.

1306 Recommendations for the Use of Simulators in Cardiothoracic Surgical Training

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
G Whittaker ◽  
Y Salmasi ◽  
G Asimakopoulos ◽  
T Athanasiou
Keyword(s):  
Literature Search ◽  
Basic Skills ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Cardiothoracic Surgery ◽  
Circulatory Support ◽  
Mesh Terms ◽  
Analysis Of Results ◽  
Early Training ◽  
Selection Of

Abstract Aim To systematically review the simulators that are currently available for cardiothoracic surgical procedures and the validation evidence supporting them. Additionally, to recommend several simulators for training based on analysis of results. Method A systematic literature search of the MEDLINE® (1946 to December 2019) and EMBASE® (1947 to December 2019) databases was performed to identify simulators for basic skills and procedures in cardiothoracic surgery. A selection of keywords and MeSH terms were used to execute the literature search. After identification of relevant articles, data were extracted and analysed. Results Ninety simulators were found in eighty-one articles. Simulators for basic skills (n=24) and coronary artery bypass graft (n=22) were the most commonly described, followed by miscellaneous (n=14), valve surgery (n=13), thoracic lobectomy (n=10), and mechanical circulatory support (n=7). The majority of models were either benchtop (n=42) or hybrid (n=33) modalities. Evidence of validity was demonstrated in 38 (42.2%) simulators. Five (5.6%) simulators had three or more elements of validity established and only one (1.1%) accomplished full validation. Conclusions Five simulators were recommended for supplemental training in cardiothoracic surgery. Low-fidelity models can provide a broad foundation for surgical skills development and high-fidelity simulators can be used for immersive training scenarios and appraisals. These should be utilised in early training, at which point the learning curve of trainees is steepest.

scholarly journals Subclavian-coronary bypass graft re-operation according to the MICS technique in a patient with angina relapse

2019 ◽  
pp. 94-96
Author(s):  
I. Yu. Sigaev ◽  
M. A. Keren ◽  
A. V. Kazaryan ◽  
I. V. Pilipenko ◽  
G. G. Getsadze
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Median Sternotomy ◽  
Coronary Bypass ◽  
Patient Comfort ◽  
Successful Implementation ◽  
Coronary Bypass Graft ◽  
Selection Of

Coronary artery bypass graft (CABG) using short-scar incision (without median sternotomy) allows minimizing the invasiveness of the intervention, reducing the risks of postoperative complications, and also ensuring patient comfort and quick social and physical rehabilitation. The successful implementation of such operations is due not only to surgical skills and the integration of technological achievements into practice, but also to the appropriate selection of patients. The article presents a clinical case of successful re-operation of the subclavian-coronary artery bypass grafting on a beating heart using antero-lateral thoracotomy approach in a patient with angina relapse after CABG.

scholarly journals Radial artery in myocardial revascularization

2009 ◽  
Vol 62 (5-6) ◽  
pp. 241-247 ◽  
Author(s):  
Aleksandar Redzek ◽  
Zivojin Jonjev
Keyword(s):  
Radial Artery ◽  
Personal Experience ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Myocardial Revascularization ◽  
Coronary Bypass ◽  
Current Status ◽  
Vessel Stenosis ◽  
Harvest Techniques ◽  
Selection Of

In the past decade, the use of the radial artery as a coronary artery bypass graft has been revitalized. However, there has been controversy regarding harvest techniques, antispasm protocols, and selection of target vessels. It is widely accepted that the patency of radial-artery grafts depends on the severity of native-vessel stenosis. Thus, radial artery grafts should be preferentially used for target vessels with high-grade (>75% stenosis) lesions. In this review article, we analyzed the current status of radial artery grafts as a coronary bypass conduit based on our personal experience and recently published literature data.

Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man

1987 ◽  
Vol 57 (01) ◽  
pp. 55-58 ◽  
Author(s):  
J F Martin ◽  
T D Daniel ◽  
E A Trowbridge
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Control Group ◽  
Artery Bypass Graft ◽  
Platelet Volume ◽  
Young Males ◽  
The Mean

SummaryPatients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 ± 0.11 × 1011/1 (n = 26) fell significantly to 1.35 ± 0.09 × 1011/1 immediately post-operatively (p <0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 ± 0.66 × 1011/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 ± 0.14 and 7.20 ± 0.14 fl respectively to a minimum of 6.16 ± 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 ± 0.33 × 1011/1, significantly higher than the pre-operative value (p <0.05), while their average mean platelet volume was 6.63 ± 0.21 fl, significantly lower than before surgery (p <0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.

Noninvasive Follow-Up of Coronary Artery Bypass Graft Patency Using Multi-Slice Computed Tomography

2006 ◽  
Vol 55 (5) ◽  
pp. 451
Author(s):  
Seung Ho Joo ◽  
Byoung Wook Choi ◽  
Jae Seung Seo ◽  
Young Jin Kim ◽  
Tae Hoon Kim ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Graft Patency ◽  
Artery Bypass Graft

Quantification of Coronary Artery Stenosis with 16-Slice MSCT in Patients before CABG Surgery: Comparison to Standard Invasive Coronary Angiography

2005 ◽  
Vol 8 (1) ◽  
pp. 42 ◽  
Author(s):  
C. Probst ◽  
A. Kovacs ◽  
C. Schmitz ◽  
W. Schiller ◽  
H. Schild ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Angiography ◽  
Coronary Arteries ◽  
Artery Bypass ◽  
Invasive Coronary Angiography ◽  
Bypass Graft ◽  
Heart Association ◽  
Artery Stenosis ◽  
Vessel Disease ◽  
Selective Coronary Angiography

Objective: Invasive, selective coronary angiography is the gold standard for evaluation of coronary artery disease (CAD) and degree of stenosis. The purpose of this study was to compare 3-dimensional (3D) reconstructed 16-slice multislice computed tomographic (MSCT) angiography and selective coronary angiography in patients before elective coronary artery bypass graft (CABG) procedure. Methods: Sixteen-slice MSCT scans (Philips Mx8000 IDT) were performed in 50 patients (42 male/8 female; mean age, 64.44 8.66 years) scheduled for elective CABG procedure. Scans were retrospectively electrocardiogram-gated 3D reconstructed. The images of the coronary arteries were evaluated for stenosis by 2 independent radiologists. The results were compared with the coronary angiography findings using the American Heart Association segmental classification for coronary arteries. Results: Four patients (8%) were excluded for technical reasons. Thirty-eight patients (82.6%) had 3-vessel disease, 4 (8.7 %) had 2-vessel disease, and 4 (8.7%) had an isolated left anterior descending artery stenosis. In the proximal segments all stenoses >50% (56/56) were detected by MSCT; medial segment sensitivity was 97% (73/75), specificity 90.3%; distal segment sensitivity was 90.7% (59/65), specificity 77%. Conclusion: Accurate quantification of coronary stenosis greater than 50% in the proximal and medial segments is possible with high sensitivity and specificity using the new generation of 16-slice MSCTs. There is still a tendency to overestimate stenosis in the distal segments. MSCT seems to be an excellent diagnostic tool for screening patients with possible CAD.

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