scholarly journals Oral Symptoms and Mucosal Lesions in Patients with Diabetes Mellitus Type 2

2017 ◽  
Vol 21 (1) ◽  
pp. 50-54 ◽  
Author(s):  
Ana Cicmil ◽  
Olivera Govedarica ◽  
Jelena Lečić ◽  
Snežana Mališ ◽  
Smiljka Cicmil ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oral Cavity ◽  
Healthy Subjects ◽  
Control Level ◽  
Type 2 Diabetics ◽  
Significant Difference ◽  
Oral Mucosal Lesions ◽  
Patients With Diabetes ◽  
Mucosal Lesions

Summary Background: Good glycoregulation at patients with diabetes mellitus is essential for prevention of many complications, including those in oral cavity. Results of numerous studies indicate that xerostomia and neurosensory oral disorders are present in type 2 diabetics. A review of the literature shows contradictory results about prevalence of oral mucosal lesions in diabetics. The aim of this study was to evaluate the presence of xerostomia, neurosensory disorders and mucosal lesions in oral cavity of type 2 diabetics. Material and Methods: This study involved 90 adults, 60 with type 2 diabetes and 30 healthy subjects, aged 45-65 years. With regard to value of HbA1c level diabetics were divided into two groups: 30 subjects with satisfactory glycoregulation (HbA1c<9%) and 30 subjects with poor glycoregulation (HbA1c≥9%). All patients recruited into the study completed a questionnaire that included their demographic, medical and oral health data. Clinical examination of the oral mucosa was performed by a single examiner. Results: In relation to the presence of xerostomia and dysgeusia between satisfactory controlled diabetics and healthy subjects a significant difference was observed (p<0.05). Compared with healthy subjects, poor controlled diabetics had significantly higher presence of xerostomia (p<0.001) and neurosensory disoders (p<0.05). A higher prevalence of oral mucosal lesions was found in poor controlled diabetics, but significant difference between groups was not observed (p>0.05). A significant positive correlation was revealed between smoking and glossodynia as well as smoking and glossopyrosis (p>0.05). Conclusion: Glycemic control level seems to influence the susceptibility of type 2 diabetics to xerostomia and neurosensory disorders. Less clear is whether diabetes are corellated to oral mucosal lesions.

scholarly journals Thyroid hormones profile of patients with type 2 diabetes mellitus in Kano, Nigeria

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Mustapha Zainab Abubakar ◽  
Kabiru Abdulsalam ◽  
Isah A. Yahaya
Keyword(s):  
Diabetes Mellitus ◽  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
Endocrine Disorders ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
Type 2 Diabetics ◽  
Patients With Diabetes ◽  
Considerable Impact

Diabetes mellitus (DM) and thyroid disease are the two most common endocrine disorders in the general population. Several Studies have shown that thyroid dysfunction is common in patients with DM, and thyroid dysfunction have been found to have a considerable impact on the glycaemic control and often increases the risk of development of long-term complications in patients with diabetes mellitus. This study determined the prevalence of thyroid dysfunction in patients with type 2 DM in Kano, North-Western Nigeria. The study was a descriptive cross-sectional study conducted on 250 participants made up of 130 patients with type 2 DM and 120 apparently healthy non-diabetic controls. Questionnaires were used to collect information on bio data, medical history, duration of diagnosis of diabetes and type of treatment. Also, blood samples of the participants were collected and analyzed for fasting plasma glucose, fT3, fT4, and TSH. The results were interpreted using American Thyroid Associations’ criteria and the data was analyzed using the statistical software package, STATA version 20. Two hundred and thirty-four (93.6%) of the participants were euthyroid while sixteen (6.4%) were found to have various forms of thyroid dysfunction. The prevalence of thyroid dysfunction was 10% and 2.5% among type 2 diabetics and controls respectively. Among the type 2 DM patients with thyroid dysfunction, 38.5% had hypothyroidism. Thyroid dysfunction was found to be commoner among type 2 DM patients than non-diabetic individuals with hypothyroidism being the commonest disorder.

scholarly journals Prevalence of oral mucosal lesions among patients with diabetes mellitus types 1 and 2

2015 ◽  
Vol 90 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Miguel Franklin Alves Silva ◽  
Kevan Guilherme Nóbrega Barbosa ◽  
Jozinete Vieira Pereira ◽  
Patrícia Meira Bento ◽  
Gustavo Pina Godoy ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oral Mucosal Lesions ◽  
Patients With Diabetes ◽  
Mucosal Lesions

scholarly journals Evaluation of Oral Mucosal Lesions in 598 Referred Iranian Patients

2009 ◽  
Vol 3 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Jahanfar Jahanbani ◽  
Leiv Sandvik ◽  
Torstein Lyberg ◽  
Eva Ahlfors
Keyword(s):  
Diabetes Mellitus ◽  
Statistical Analysis ◽  
Oral Cavity ◽  
Oral Lesions ◽  
Disease Characteristics ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions ◽  
School Of Dentistry ◽  
Fissured Tongue ◽  
Iranian Patients

The mucosal membrane of the oral cavity displays at times classical developmental lesions considered to be variations of normal structures rather than having disease characteristics. Of these lesions leukoedema, Fordyce granules, geographic-, fissured- and hairy tongue, median rhomboid glossitis and lingual varices were studied in 598 patients referred to the School of Dentistry, Tehran, Iran. The prevalence was studied in relation to age, gender, occupation, education, smoking habits, general health, addictions and or drug therapies. Oral developmental lesions were seen in 295 patients (49.3%). Only Fordyce granules (27,9%), fissured tongue (12,9%), leukoedema (12,5%) and hairy tongue (8,9%) had enough cases for statistical analysis. Three of these lesions increased with age but not fissured tongue. All were more common in men. After adjusting for age, the parameters education, occupation and complaints upon referral had little influence on the prevalence of the lesions. Fewer Fordyce granules were seen in oral mucosa of smoking men. Leukoedema and hairy tongue were significantly associated with smoking, leukoedema with diabetes mellitus. We conclude that there was a highly significant association between these oral lesions and age, gender and smoking. Few significant associations were found between oral lesions and general diseases.

scholarly journals The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus

2011 ◽  
Vol 14 (3) ◽  
pp. 17-20
Author(s):  
Elina Alexandrovna Arakelova ◽  
Meri Robertovna Ovsepyan ◽  
Anna Surenovna Boyadzhyan ◽  
Arsen Artashesovich Arakelyan ◽  
Astkhik Artavazdovna Gevorkyan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Healthy Subjects ◽  
Membrane Attack Complex ◽  
Complement Components ◽  
Mean Values ◽  
Patients With Diabetes ◽  
History Of ◽  
The Complement System ◽  
Diabetes Mellitus 2

Aim. Comparative analysis of the levels of the membrane attack complex (MAC) - an end product of complement activation, and of hemolytic activitiesof C1 and C3 complement components in sera of patients with diabetes mellitus 2 (DM2) and healthy subjects. Materials and methods. 37 DM2 patients (7 men, 26 women, mean age 58?9 years (M?б) and 37 healthy subjects without a family history of hereditarydiabetes (17 men, 20 women, mean age 52?12 years). Serum MAC levels were measured by ELISA, C1 and C3 hemolytic activities by usingrabbit antibody-sensitized ram erythrocytes and C1, C3-deficient sera. Results. Mean values of all measured parameters in DM2 patients were significantly higher than in controls. Conclusion. Pathogenesis of DM2 is characterized by hyperactivation of the complement system including both the classical and terminal cascadesand by hyperproduction of its cytotoxic products.

scholarly journals The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Feryal Al-Saber ◽  
Waleed Aldosari ◽  
Mariam Alselaiti ◽  
Hesham Khalfan ◽  
Ahmed Kaladari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Aminolevulinic Acid ◽  
Antioxidant Properties ◽  
Ferrous Citrate ◽  
Gulf Countries ◽  
Significant Difference ◽  
Patients With Diabetes

Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients. A multifaceted treatment approach can include nutritional supplements with antioxidant properties such as 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC). This prospective, randomized, single-blind, placebo-controlled, dose escalating pilot clinical trial assessed the safety of 5-ALA with SFC at doses up to 200 mg 5-ALA/229.42 mg SFC per day in patients living in Bahrain with type 2 diabetes mellitus that was uncontrolled despite the use of one or more antidiabetic drugs. Fifty-three patients (n=53) from 3 sites at one center were enrolled by Dr. Feryal (Site #01), Dr. Hesham (Site #02), and Dr. Waleed (Site #03) (n=35, 5-ALA-SFC;n=18, placebo). There was no significant difference in incidence of adverse events reported, and the most frequent events reported were gastrointestinal in nature, consistent with the known safety profile of 5-ALA in patients with diabetes. No significant changes in laboratory values and no difference in hypoglycemia between patients receiving 5-ALA and placebo were noted. Overall, the current results support that use of 5-ALA-SFC up to 200 mg per day taken as 2 divided doses is safe in patients taking concomitant oral antidiabetic medications and may offer benefits in the diabetic population. This trial is registered with ClinicalTrials.govNCT02481141.

scholarly journals Noninvasive evaluation of density of coronary and carotid calcification in patients with type 2 diabetes mellitus

2019 ◽  
Vol 99 (6) ◽  
pp. 310-318 ◽  
Author(s):  
V. L. Masenko ◽  
A. N. Kokov ◽  
S. E. Semenov ◽  
O. L. Barbarash
Keyword(s):  
Diabetes Mellitus ◽  
Carotid Arteries ◽  
Noninvasive Evaluation ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Calcium Deposits ◽  
Group 2 ◽  
Dm Type 2 ◽  
Carotid Calcification

Objective. To estimate the density of calcium deposits of atherosclerotic plaques of coronary and carotid arteries in patients with diabetes mellitus (DM) type 2 using multislice computed tomography (MSCT).Material and methods. 251 patients with multifocal atherosclerosis (MA) were examined using MSCT. Determined equivalent density of calcium deposits (EDCD) atherosclerotic plaque of coronary and carotid arteries.Results. According to the data of MSCT in patients with MA irrespective of concomitant diabetes was a high incidence of calcification of the coronary and carotid arteries. In Group 1 EDCD coronary arteries was 0.235 (0.214; 0.254) mg/mm3, in the group 2 - 0,219 (0,192; 0,242) mg/mm3. EDCD of carotid arteries in patients with diabetes was 0.183 (0.171; 0.193) mg/mm3, in patients without diabetes - 0.226 (0.199; 0.247) mg/mm3. There was a significant difference in the groups EDCD values for coronary (p = 0.017), and the carotid (p = 0.000003) artery.Conclusion. Using index EDCD obtained on the basis of routine MSCT coronary and carotid arteries in patients with MA with DM compared with those without diabetes had significantly higher density calcifications in projection of coronary and low density of calcium deposits carotid arteries without regard to the degree of Agatston calcification scale.

Homocysteine induces caspase activation by endoplasmic reticulum stress in platelets from type 2 diabetics and healthy donors

2010 ◽  
Vol 103 (05) ◽  
pp. 1022-1032 ◽  
Author(s):  
Hanene Zbidi ◽  
Pedro Redondo ◽  
Jose López ◽  
Aghleb Bartegi ◽  
Gines Salido ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Healthy Subjects ◽  
Caspase 3 ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetics ◽  
Type 2 Diabetic

SummaryDiabetes mellitus is a disease characterised by hyperglycaemia and associated with several cardiovascular disorders, including angiopathy and platelet hyperactivity, which are major causes of morbidity and mortality in type 2 diabetes mellitus. In type 2 diabetic patients, homo-cysteine levels are significantly increased compared with healthy subjects. Hyperhomocysteinaemia is an independent risk factor for macro-and microangiopathy and mortality. The present study is aimed to investigate the effect of homocysteine on platelet apoptosis. Changes in cytosolic or intraluminal free Ca2+ concentration were determined by fluorimetry. Caspase activity and phosphorylation of the eukaryotic initiation factor 2α (eIF2α) were explored by Western blot. Our results indicate that homocysteine releases Ca2+ from agonist sensitive stores, enhances eIF2α phosphorylation at Ser51 and activates caspase-3 and -9 independently of extracellular Ca2+. Homocysteine induced activation of caspase-3 and -9 was abolished by salubrinal, an agent that prevents endoplasmic reticulum (ER) stress-induced apoptosis. Homo-cysteine-induced platelet effects were significantly greater in type 2 diabetics than in healthy subjects. These findings demonstrate that homocysteine induces ER stress-mediated apoptosis in human platelets, an event that is enhanced in type 2 diabetic patients, which might be involved in the pathogenesis of cardiovascular complications associated with type 2 diabetes mellitus.

scholarly journals Effect of Luseogliflozin on Heart Failure With Preserved Ejection Fraction in Patients With Diabetes Mellitus

2020 ◽  
Vol 9 (16) ◽  
Author(s):  
Kentaro Ejiri ◽  
Toru Miyoshi ◽  
Hajime Kihara ◽  
Yoshiki Hata ◽  
Toshihiko Nagano ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ejection Fraction ◽  
Sodium Glucose Cotransporter ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
To Receive

Background Effects of sodium‐glucose cotransporter 2 inhibitors on reducing hospitalization for heart failure have been reported in randomized controlled trials, but their effects on patients with heart failure with preserved ejection fraction ( HF p EF ) are unknown. This study aimed to evaluate the drug efficacy of luseogliflozin, a sodium‐glucose cotransporter 2 inhibitor, in patients with type 2 diabetes mellitus and HF p EF . Methods and Results We performed a multicenter, open‐label, randomized, controlled trial for comparing luseogliflozin 2.5 mg once daily with voglibose 0.2 mg 3 times daily in patients with type 2 diabetes mellitus suffering from HF p EF (left ventricular ejection fraction >45% and BNP [B‐type natriuretic peptide] concentrations ≥35 pg/mL) in a 1:1 randomization fashion. The primary outcome was the difference from baseline in BNP levels after 12 weeks of treatment between the 2 drugs. A total of 173 patients with diabetes mellitus and HF p EF were included. Of these, 83 patients were assigned to receive luseogliflozin and 82 to receive voglibose. There was no significant difference in the reduction in BNP concentrations after 12 weeks from baseline between the 2 groups. The ratio of the mean BNP value at week 12 to the baseline value was 0.79 in the luseogliflozin group and 0.87 in the voglibose group (percent change, −9.0% versus −1.9%; ratio of change with luseogliflozin versus voglibose, 0.93; 95% CI, 0.78–1.10; P =0.26). Conclusion In patients with type 2 diabetes mellitus and HF p EF , there is no significant difference in the degree of reduction in BNP concentrations after 12 weeks between luseogliflozin and voglibose. Registration URL : https://www.umin.ac.jp/ctr/index.htm ; Unique identifier: UMIN 000018395.

scholarly journals Salivary flow rate and oral health status in type 2 diabetics

2020 ◽  
Vol 67 (1) ◽  
pp. 7-14
Author(s):  
Ana Cicmil ◽  
Olivera Govedarica ◽  
Jelena Lecic ◽  
Dragana Puhalo-Sladoje ◽  
Ruzica Lukic ◽  
...  
Keyword(s):  
Health Status ◽  
Oral Health ◽  
Flow Rate ◽  
Healthy Subjects ◽  
Salivary Flow ◽  
Oral Health Status ◽  
Salivary Flow Rate ◽  
Type 2 Diabetics ◽  
Significant Difference

Introduction. Decreased salivary flow is frequently associated with numerous diseases such as diabetes mellitus and may lead to numerous oral diseases. The aim of this study was to compare salivary flow rate and oral health status in type 2 diabetics and healthy controls. Material and methods. The study involved 90 patients, divided into the three groups: 30 with well controlled (HbA1c<9%), 30 will poorly controlled (HbA1c?9%) diabetes and 30 healthy subjects. The following clinical parameters were determined: decayed, missing and filled teeth (DMFT); plaque index (PI), sulcus bleeding index (SBI), probing pocket depth (PPD) and clinical attachment level (CAL). Culture of Candida spp. specimens were obtained from tongue dorsum and inoculated into Sabouraud Dextrose Agar. Saliva was collected using ?a spit technique?. Results. Highest mean of unstimulated salivary flow was in healthy subjects; however significant difference between groups was not observed. Stimulated salivary flow results indicate significant reduction in diabetics as well as significant relation between metabolic control and salivary flow. Unstimulated and stimulated salivary flows were negatively and significantly correlated with periodontal parameters and DMFT. Conclusion. The present findings indicate that decreased salivary flow rate could have a significant impact on oral health status in type 2 diabetics.

scholarly journals TYPE 2 DIABETES MELLITUS;

2012 ◽  
Vol 19 (02) ◽  
pp. 259-263
Author(s):  
RAHEEL IFTIKHAR ◽  
MUHAMMAD ADNAN MANZAR ◽  
Fatima SAEED
Keyword(s):  
Diabetes Mellitus ◽  
Normal Population ◽  
Military Hospital ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Type 2 Diabetics ◽  
Increased Risk ◽  
Patients With Diabetes ◽  
Stage 1

Objectives: Determine frequency of hypertension in type 2 diabetics. Determine pattern of hypertension in type 2 diabetics.Study design: Cross sectional survey. Setting: The study was conducted in the out patient department of Combined Military Hospital, Lahore.Duration of study: Study was carried out over a period of 01 year from July 2010 to July 2011. Material and methods: Total 700 cases wererecruited in this study. Blood pressure of all the patients was recorded in a sitting position with a mercurial sphygmomanometer 4–6 hours apart.It was interpreted as prehypertension, stage 1 and stage 2 according to operational definitions. Results: Out of total 700 patients, 490 (70.0%)were hypertensive .Pattern of hypertension showed 100 (20.4%) pre-hypertension, 160 (32.6%) stage-I and 230 (47.0%) stage-II .Majority ofthe patients i.e. 245 (50.0%) were between 41-50 years and minimum 9 patients (1.8%) were 20-30 years old with mean age of 55.9±3.7 .Out of700 patients, 350 (50.0%) were male while remaining 350 (50.0%) were females. Married patients were 400 (57.1%) and unmarried 300(42.9%). Conclusions: Patients with diabetes mellitus have increased risk of developing hypertension than normal population.

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