A theoretical study of digital silicon photomultiplier utilization in diffuse optical imaging systems

2019 ◽  
Vol 64 (3) ◽  
pp. 357-363 ◽  
Author(s):  
Taha Haddadifam ◽  
Mohammad Azim Karami
Keyword(s):  
Optical Imaging ◽  
Continuous Wave ◽  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Diffuse Optical Imaging ◽  
Silicon Photomultiplier ◽  
Thoracic Imaging ◽  
Low Level

Abstract Digital silicon photomultiplier (dSiPM) is introduced for diffuse optical imaging (DOI) applications instead of conventional photomultiplier tubes and avalanche photodiodes (APDs) as a state-of-the-art detector. According to the low-level light regime in DOI applications, high sensitivity and high dynamic range (DR) image sensors are needed for DOI systems. dSiPM is proposed as a developing detector which can detect low-level lights. Also, an accurate equation is obtained for calculating the DR of dSiPMs. Different dSiPMs and the corresponding benefits are studied for DOI applications. Furthermore, a 120 dB DR dSiPM is chosen for use in DOI systems. It is shown that dSiPMs can be utilized in DOI configurations such as time domain (TD), frequency domain (FD) and continuous wave (CW) systems. Ultimately, by utilizing dSiPM in DOI systems, the DOI method can be used for thoracic imaging due to the high DR and signal-to-noise ratio (SNR) of the detector.

scholarly journals Methods for Voltage-Sensitive Dye Imaging of Rat Cortical Activity With High Signal-to-Noise Ratio

2007 ◽  
Vol 98 (1) ◽  
pp. 502-512 ◽  
Author(s):  
Michael T. Lippert ◽  
Kentaroh Takagaki ◽  
Weifeng Xu ◽  
Xiaoying Huang ◽  
Jian-Young Wu
Keyword(s):  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
Field Potential ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
High Signal ◽  
Blue Dye ◽  
Voltage Sensitive Dye ◽  
Imaging Device

We describe methods to achieve high sensitivity in voltage-sensitive dye (VSD) imaging from rat barrel and visual cortices in vivo with the use of a blue dye RH1691 and a high dynamic range imaging device (photodiode array). With an improved staining protocol and an off-line procedure to remove pulsation artifact, the sensitivity of VSD recording is comparable with that of local field potential recording from the same location. With this sensitivity, one can record from ∼500 individual detectors, each covering an area of cortical tissue 160 μm in diameter (total imaging field ∼4 mm in diameter) and a temporal resolution of 1,600 frames/s, without multiple-trial averaging. We can record 80–100 trials of intermittent 10-s trials from each imaging field before the VSD signal reduces to one half of its initial amplitude because of bleaching and wash-out. Taken together, the methods described in this report provide a useful tool for visualizing evoked and spontaneous waves from rodent cortex.

scholarly journals Ultrahigh-speed point scanning two-photon microscopy using high dynamic range silicon photomultipliers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vincent D. Ching-Roa ◽  
Eben M. Olson ◽  
Sherrif F. Ibrahim ◽  
Richard Torres ◽  
Michael G. Giacomelli
Keyword(s):  
High Speed ◽  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Photomultiplier Tubes ◽  
Silicon Photomultipliers ◽  
Two Photon Microscopy ◽  
Two Photon ◽  
Detection Technology

AbstractConventional two-photon microscopes use photomultiplier tubes, which enable high sensitivity but can detect relatively few photons per second, forcing longer pixel integration times and limiting maximum imaging rates. We introduce novel detection electronics using silicon photomultipliers that greatly extend dynamic range, enabling more than an order of magnitude increased photon detection rate as compared to state-of-the-art photomultiplier tubes. We demonstrate that this capability can dramatically improve both imaging rates and signal-to-noise ratio (SNR) in two-photon microscopy using human surgical specimens. Finally, to enable wider use of more advanced detection technology, we have formed the OpenSiPM project, which aims to provide open source detector designs for high-speed two-photon and confocal microscopy.

scholarly journals High-frequency rectifiers based on type-II Dirac fermions

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Libo Zhang ◽  
Zhiqingzi Chen ◽  
Kaixuan Zhang ◽  
Lin Wang ◽  
Huang Xu ◽  
...  
Keyword(s):  
High Frequency ◽  
Dynamic Range ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Anisotropy Ratio ◽  
Dirac Fermions ◽  
Topological States ◽  
Topological Semimetals ◽  
Polarized Surface ◽  
Symmetry Protected

AbstractThe advent of topological semimetals enables the exploitation of symmetry-protected topological phenomena and quantized transport. Here, we present homogeneous rectifiers, converting high-frequency electromagnetic energy into direct current, based on low-energy Dirac fermions of topological semimetal-NiTe2, with state-of-the-art efficiency already in the first implementation. Explicitly, these devices display room-temperature photosensitivity as high as 251 mA W−1 at 0.3 THz in an unbiased mode, with a photocurrent anisotropy ratio of 22, originating from the interplay between the spin-polarized surface and bulk states. Device performances in terms of broadband operation, high dynamic range, as well as their high sensitivity, validate the immense potential and unique advantages associated to the control of nonequilibrium gapless topological states via built-in electric field, electromagnetic polarization and symmetry breaking in topological semimetals. These findings pave the way for the exploitation of topological phase of matter for high-frequency operations in polarization-sensitive sensing, communications and imaging.

scholarly journals Ab initiostructure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector

2016 ◽  
Vol 72 (2) ◽  
pp. 236-242 ◽  
Author(s):  
E. van Genderen ◽  
M. T. B. Clabbers ◽  
P. P. Das ◽  
A. Stewart ◽  
I. Nederlof ◽  
...  
Keyword(s):  
Electron Diffraction ◽  
Room Temperature ◽  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
Three Dimensional ◽  
Direct Methods ◽  
Liquid Nitrogen Temperature ◽  
High Dynamic Range ◽  
Electron Diffraction Data ◽  
High Signal

Until recently, structure determination by transmission electron microscopy of beam-sensitive three-dimensional nanocrystals required electron diffraction tomography data collection at liquid-nitrogen temperature, in order to reduce radiation damage. Here it is shown that the novel Timepix detector combines a high dynamic range with a very high signal-to-noise ratio and single-electron sensitivity, enablingab initiophasing of beam-sensitive organic compounds. Low-dose electron diffraction data (∼0.013 e− Å−2 s−1) were collected at room temperature with the rotation method. It was ascertained that the data were of sufficient quality for structure solution using direct methods using software developed for X-ray crystallography (XDS,SHELX) and for electron crystallography (ADT3D/PETS,SIR2014).

scholarly journals 2D Legendre Moments-Based Visual Control

2012 ◽  
Vol 162 ◽  
pp. 487-496 ◽  
Author(s):  
Aurelien Yeremou Tamtsia ◽  
Youcef Mezouar ◽  
Philippe Martinet ◽  
Haman Djalo ◽  
Emmanuel Tonye
Keyword(s):  
Visual Servoing ◽  
Dynamic Range ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Interaction Matrix ◽  
Geometric Moments ◽  
Control Scheme ◽  
Control Schemes ◽  
Legendre Moments ◽  
Set Of Points

Among region-based descriptors, geometric moments have been widely exploited to design visual servoing schemes. However, they present several disadvantages such as high sensitivity to noise measurement, high dynamic range and information redundancy (since they are not computed onto orthogonal basis). In this paper, we propose to use a class of orthogonal moments (namely Legendre moments) instead of geometric moments to improve the behavior of moment-based control schemes. The descriptive form of the interaction matrix related to the Legendre moments computed from a set of points is rst derived. Six visual features are then selected to design a partially-decoupled control scheme. Finally simulated and experimental results are presented to illustrate the validity of our proposal.

scholarly journals Electronic Optical Sky Surveys

1998 ◽  
Vol 179 ◽  
pp. 49-55
Author(s):  
T.A. McKay
Keyword(s):  
Dynamic Range ◽  
Large Fraction ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Low Noise ◽  
Computer Hardware ◽  
Optical Detectors ◽  
Small Fields ◽  
Technical Advances ◽  
High Dynamic

The introduction of of Charge Coupled Devices (CCDs) in the middle 1970s provided astronomy with nearly perfect (linear, high-sensitivity, low-noise, high dynamic-range, digital) optical detectors. Unfortunately, restrictions imposed by CCD production and cost has typically limited their use to observations of relatively small fields. Recently a combination of technical advances have made practical the application of CCDs to survey science. CCD mosaic cameras, which help overcome the size restrictions imposed by CCD manufacture, allow electronic access to a larger fraction of the available focal plane. Multi-fiber spectrographs, which couple the low-noise, high QE performance of CCDs with the ability to observe spectra for many objects at once, have improved the spectroscopic efficiency of telescopes by factors approaching half a million. An improved understanding of image distortion gives us telescopes on which we expect sub-arcsecond images a large fraction of the time. Finally, and perhaps most important, the performance of computer hardware continues to advance, to the point where analysis of multi-terabyte datasets, while still daunting, is at least conceivable.

scholarly journals Probing the cold magnetised Universe with SPICA-POL (B-BOP)

2019 ◽  
Vol 36 ◽  
Author(s):  
Ph. André ◽  
A. Hughes ◽  
V. Guillet ◽  
F. Boulanger ◽  
A. Bracco ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
European Space Agency ◽  
Dust Emission ◽  
Far Infrared ◽  
High Dynamic Range ◽  
Wide Field ◽  
Infrared Telescope ◽  
Nearby Galaxies

Abstract Space Infrared Telescope for Cosmology and Astrophysics (SPICA), the cryogenic infrared space telescope recently pre-selected for a ‘Phase A’ concept study as one of the three remaining candidates for European Space Agency (ESA's) fifth medium class (M5) mission, is foreseen to include a far-infrared polarimetric imager [SPICA-POL, now called B-fields with BOlometers and Polarizers (B-BOP)], which would offer a unique opportunity to resolve major issues in our understanding of the nearby, cold magnetised Universe. This paper presents an overview of the main science drivers for B-BOP, including high dynamic range polarimetric imaging of the cold interstellar medium (ISM) in both our Milky Way and nearby galaxies. Thanks to a cooled telescope, B-BOP will deliver wide-field 100–350 $\mu$ m images of linearly polarised dust emission in Stokes Q and U with a resolution, signal-to-noise ratio, and both intensity and spatial dynamic ranges comparable to those achieved by Herschel images of the cold ISM in total intensity (Stokes I). The B-BOP 200 $\mu$ m images will also have a factor $\sim $ 30 higher resolution than Planck polarisation data. This will make B-BOP a unique tool for characterising the statistical properties of the magnetised ISM and probing the role of magnetic fields in the formation and evolution of the interstellar web of dusty molecular filaments giving birth to most stars in our Galaxy. B-BOP will also be a powerful instrument for studying the magnetism of nearby galaxies and testing Galactic dynamo models, constraining the physics of dust grain alignment, informing the problem of the interaction of cosmic rays with molecular clouds, tracing magnetic fields in the inner layers of protoplanetary disks, and monitoring accretion bursts in embedded protostars.

scholarly journals Performance assessment of imaging plates for the JHR transfer Neutron Imaging System

2018 ◽  
Vol 170 ◽  
pp. 04021
Author(s):  
E. Simon ◽  
P. Guimbal
Keyword(s):  
Performance Assessment ◽  
Dynamic Range ◽  
Imaging System ◽  
Computed Radiography ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Neutron Imaging ◽  
Imaging Plate ◽  
Intimate Contact ◽  
Imaging Plates

The underwater Neutron Imaging System to be installed in the Jules Horowitz Reactor (JHR-NIS) is based on a transfer method using a neutron activated beta-emitter like Dysprosium. The information stored in the converter is to be offline transferred on a specific imaging system, still to be defined. Solutions are currently under investigation for the JHR-NIS in order to anticipate the disappearance of radiographic films commonly used in these applications. We report here the performance assessment of Computed Radiography imagers (Imaging Plates) performed at LLB/Orphée (CEA Saclay). Several imaging plate types are studied, in one hand in the configuration involving an intimate contact with an activated dysprosium foil converter: Fuji BAS-TR, Fuji UR-1 and Carestream Flex XL Blue imaging plates, and in the other hand by using a prototypal imaging plate doped with dysprosium and thus not needing any contact with a separate converter foil. The results for these imaging plates are compared with those obtained with gadolinium doped imaging plate used in direct neutron imaging (Fuji BAS-ND). The detection performances of the different imagers are compared regarding resolution and noise. The many advantages of using imaging plates over radiographic films (high sensitivity, linear response, high dynamic range) could palliate its lower intrinsic resolution.

scholarly journals Configuration and Registration of Multi-Camera Spectral Image Database of Icon Paintings

Computation ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 47
Author(s):  
Arash Mirhashemi
Keyword(s):  
Dynamic Range ◽  
Specular Reflection ◽  
Signal To Noise Ratio ◽  
Simulated Data ◽  
Image Database ◽  
High Dynamic Range ◽  
Registration Method ◽  
Spatial Registration ◽  
Feature Based ◽  
The Cost

At the cost of added complexity and time, hyperspectral imaging provides a more accurate measure of the scene’s irradiance compared to an RGB camera. Several camera designs with more than three channels have been proposed to improve the accuracy. The accuracy is often evaluated based on the estimation quality of the spectral data. Currently, such evaluations are carried out with either simulated data or color charts to relax the spatial registration requirement between the images. To overcome this limitation, this article presents an accurately registered image database of six icon paintings captured with five cameras with different number of channels, ranging from three (RGB) to more than a hundred (hyperspectral camera). Icons are challenging topics because they have complex surfaces that reflect light specularly with a high dynamic range. Two contributions are proposed to tackle this challenge. First, an imaging configuration is carefully arranged to control the specular reflection, confine the dynamic range, and provide a consistent signal-to-noise ratio for all the camera channels. Second, a multi-camera, feature-based registration method is proposed with an iterative outlier removal phase that improves the convergence and the accuracy of the process. The method was tested against three other approaches with different features or registration models.

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