Dopamine concentration in blood platelets is elevated in patients with head and neck paragangliomas

2016 ◽  
Vol 54 (8) ◽  
Author(s):  
Thamara E. Osinga ◽  
Anouk N.A. van der Horst-Schrivers ◽  
Martijn van Faassen ◽  
Michiel N. Kerstens ◽  
Robin P.F. Dullaart ◽  
...  
Keyword(s):  
Cohort Study ◽  
Head And Neck ◽  
Healthy Subjects ◽  
Blood Platelets ◽  
Healthy Controls ◽  
Single Center ◽  
Dopamine Concentration ◽  
Head And Neck Paragangliomas

AbstractPlasma 3-methoxytyramine (3-MT), a metabolite of dopamine, is elevated in up to 28% of patients with head and neck paragangliomas (HNPGLs). As free dopamine is incorporated in circulating platelets, we determined dopamine concentration in platelets in patients with a HNPGL.A single center cohort study was performed between 2012 and 2014. Thirty-six patients with a HNPGL were compared to healthy controls (68 for dopamine in platelets and 120 for plasma 3-MT).Dopamine concentration in platelets was elevated in HNPGL patients compared to healthy controls (median [interquartile ranges] 0.48 [0.32–0.82] pmol/10Dopamine concentration in platelets is elevated in patients with a HNPGL compared to healthy subjects, and may be a novel biomarker for dopamine producing paraganglioma.

scholarly journals Head and neck paragangliomas: Ten years of experience in a third health center. A cohort study

2021 ◽  
pp. 102412
Author(s):  
Merzouqi Boutaina ◽  
El Bouhmadi Khadija ◽  
Oukessou Youssef ◽  
Rouadi Sami ◽  
Abada Redallah Larbi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Head And Neck ◽  
Health Center ◽  
Years Of Experience ◽  
Head And Neck Paragangliomas

Patterns of Care in Elderly Head-and-Neck Cancer Radiation Oncology Patients: A Single-Center Cohort Study

2011 ◽  
Vol 79 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Shao Hui Huang ◽  
Brian O'Sullivan ◽  
John Waldron ◽  
Gina Lockwood ◽  
Andrew Bayley ◽  
...  
Keyword(s):  
Cohort Study ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Radiation Oncology ◽  
Patterns Of Care ◽  
Single Center ◽  
Oncology Patients

scholarly journals Serum CA72-4 is specifically elevated in gout patients and predicts flares

Rheumatology ◽  
2020 ◽  
Vol 59 (10) ◽  
pp. 2872-2880
Author(s):  
Xueshan Bai ◽  
Mingshu Sun ◽  
Yuwei He ◽  
Ruhua Liu ◽  
Lingling Cui ◽  
...  
Keyword(s):  
Cohort Study ◽  
Septic Arthritis ◽  
Healthy Subjects ◽  
Gouty Arthritis ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Sectional Study ◽  
Cross Sectional ◽  
Gout Flares

Abstract Objectives Serum CA72-4 levels are elevated in some gout patients but this has not been comprehensively described. The present study profiled serum CA72-4 expression in gout patients and verified the hypothesis that CA72-4 is a predictor of future flares in a prospective gout cohort. Methods To profile CA72-4 expression, a cross-sectional study was conducted in subjects with gouty arthritis, asymptomatic hyperuricaemia, four major arthritis types (OA, RA, SpA, septic arthritis) and healthy controls. A prospective gout cohort study was initiated to test the value of CA72-4 for predicting gout flares. During a 6-month follow-up, gout flares, CA72-4 levels and other gout-related clinical variables were observed at 1, 3 and 6 months. Results CA72-4 was highly expressed in patients with gouty arthritis [median (interquartile range) 4.55 (1.56, 32.64) U/ml] compared with hyperuricaemia patients [1.47 (0.87, 3.29) U/ml], healthy subjects [1.59 (0.99, 3.39) U/ml] and other arthritis patients [septic arthritis, 1.38 (0.99, 2.66) U/ml; RA, 1.58 (0.95, 3.37) U/ml; SpA, 1.56 (0.98, 2.85) U/ml; OA, 1.54 (0.94, 3.34) U/ml; P < 0.001, respectively]. Gout patients with frequent flares (twice or more in the last year) had higher CA72-4 levels than patients with fewer flares (fewer than twice in the last year). High CA72-4 level (>6.9 U/ml) was the strongest predictor of gout flares (hazard ratio = 3.889). Prophylactic colchicine was effective, especially for patients with high CA72-4 levels (P = 0.014). Conclusion CA72-4 levels were upregulated in gout patients who experienced frequent flares and CA72-4 was a useful biomarker to predict future flares.

Head and Neck Paragangliomas Radiosurgery: Long-Term, Single-Institution Experience

2016 ◽  
Vol 77 (S 02) ◽  
Author(s):  
Marcello Marchetti ◽  
Valentina Pinzi ◽  
Francesco Prada ◽  
Elena De Martin ◽  
Valeria Cuccarini ◽  
...  
Keyword(s):  
Head And Neck ◽  
Single Institution ◽  
Head And Neck Paragangliomas
Sign in / Sign up

Export Citation Format

Share Document