Relationship between polymorphisms in the CRP, LEP and LEPR genes and high sensitivity C-reactive protein levels in Spanish children

2017 ◽  
Vol 55 (11) ◽  
Author(s):  
Pilar Navarro ◽  
Olaya de Dios ◽  
Teresa Gavela-Pérez ◽  
Leandro Soriano-Guillen ◽  
Carmen Garcés
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
High Sensitivity ◽  
Nucleotide Polymorphisms ◽  
C Reactive Protein ◽  
Single Nucleotide ◽  
Elisa Kit ◽  
Protein Levels ◽  
Reactive Protein ◽  
Hs Crp

AbstractBackground:We investigated the association of single nucleotide polymorphisms (SNPs) in the C-reactive protein (Methods:We measured hs-CRP levels in 646 6–8-year-old and 707 12–16-year-old children using a high-sensitivity C-Reactive Protein ELISA kit. Four SNPs in theResults:The four CRP SNPs studied were significantly (p<0.05) associated with hs-CRP levels in both cohorts. Furthermore, two common CRP haplotypes (constructed using the SNPs in order: rs1205, rs1130864, rs1800947, rs2794521) ACGA and GCGG were associated with significantly lower CRP levels (p<0.05) at both ages. The LEPR SNPs rs1137100 (K109R) and rs1137101 (Q223R), and LEP SNP rs7799039 (G2548A) were also associated to hs-CRP levels (p<0.05) in both cohorts.Conclusions:hs-CRP levels in healthy Spanish children, besides being associated to common polymorphisms in the

scholarly journals Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults

2011 ◽  
Vol 56 (12) ◽  
pp. 823-827 ◽  
Author(s):  
Ghenadie Curocichin ◽  
Ying Wu ◽  
Thomas W McDade ◽  
Christopher W Kuzawa ◽  
Judith B Borja ◽  
...  
Keyword(s):  
Young Adults ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
C Reactive Protein ◽  
Single Nucleotide ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Reduction in High-Sensitivity C-Reactive Protein Levels in Patients with Ischemic Stroke by Statin Treatment: Hs-CRP Sub-Study in J-STARS

2017 ◽  
Vol 24 (10) ◽  
pp. 1039-1047 ◽  
Author(s):  
Kazuo Kitagawa ◽  
Naohisa Hosomi ◽  
Yoji Nagai ◽  
Tatsuo Kagimura ◽  
Toshiho Ohtsuki ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
High Sensitivity ◽  
Statin Treatment ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Hs Crp

Combined Effects of Single Nucleotide Polymorphisms (SNPs) within C-reactive Protein (CRP) and Environmental Parameters on Risk and Prognosis for Diabetic Foot Osteomyelitis Patients

2020 ◽  
Vol 128 (08) ◽  
pp. 528-539
Author(s):  
Shanjin Wang ◽  
Haowei Xu ◽  
Ningfeng Zhou ◽  
Weidong Zhao ◽  
Desheng Wu ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Single Nucleotide Polymorphisms ◽  
Diabetic Foot ◽  
Environmental Parameters ◽  
Combined Effects ◽  
Nucleotide Polymorphisms ◽  
C Reactive Protein ◽  
Single Nucleotide ◽  
Reactive Protein ◽  
Diabetic Foot Osteomyelitis

Abstract Purpose This study was aimed to discover the combined effects of single nucleotide polymorphisms (SNPs) within the C-reactive protein (CRP) gene and potential environmental factors on the risk and prognosis for diabetic foot osteomyelitis (DFO). Methods A total of 1734 diabetes mellitus patients, 681 with DFO and 1053 without DFO, were successfully recruited, as well as 1261 healthy control individuals. Participants data were recorded regarding age, gender, smoking and drinking history, body mass index (BMI), hypertension, cacosmia, and ulceration. A total of 11 SNPs within the CRP gene were designated for exploration, by logistic regression analyses, of how they might interact with environmental factors to affect susceptibility to DFO. Results Frequencies of smoking and drinking, and incidence of hypertension, cacosmia, or ulceration displayed marked differences (all P<0.05) between DFO and non-DFO patients. Furthermore, allele G of rs11265260 (A>G), allele G of rs1800947 (C>G), and allele T of rs3093059 (T>C) and rs1130864 (C>T) exhibited a trend to increase risk of DFO (all P<0.05). Allele G of rs11265260 (A>G), allele G of rs1800947 (C>G) and rs3093068 (G>C), and allele T of rs1130864 (C>T) were significant predictors of poor prognosis among DFO patients (P<0.05). In addition, genotypes of rs11265260 (i.e., GG and AG), rs1800947 (i.e., CG and GG), rs3093059 (i.e., TT) and rs113084 (i.e., CT and TT) amplified the influence of smoking, alcohol consumption, cacosmia, and ulceration on progression from non-DFO to DFO (all γ>1). Conclusion Genetic mutations within CRP functioned interactively with external factors to affect DFO risk.

Relationship between airway obstruction and C-reactive protein levels in a community-based population of Korea

2019 ◽  
Vol 23 (11) ◽  
pp. 1228-1234
Author(s):  
B. Yoo ◽  
S. H. Lee ◽  
S. Y. Kim ◽  
A. Y. Leem ◽  
K. S. Chung ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Airway Obstruction ◽  
High Sensitivity ◽  
Healthy Person ◽  
Forced Expiratory Volume ◽  
C Reactive Protein ◽  
Community Based ◽  
Protein Levels ◽  
Reactive Protein ◽  
Hs Crp

OBJECTIVE: To examine the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and lung function in a community-based cohort of South Korea.DESIGN: The Ansung-Ansan cohort database (an ongoing prospective study of a community-based population) was used in the analysis. We defined airway obstruction as the ratio between forced expiratory volume in 1 sec:forced vital capacity ratio (FEV1:FVC) of <95% of the predicted value for a healthy person. We also used the serum level of hs-CRP as a marker of inflammation. Multivariate analysis was performed with adjustment for the clinical characteristics of the participants.RESULTS: A total of 5528 individuals were eligible for the study. The average age was 55.1 years, and 47.8% were males. The prevalence of airway obstruction was 9.0%, and the mean hs-CRP level was 1.51 mg/dl. Serum hs-CRP levels increased with the severity of airway obstruction, and the latter worsened with an increase in the hs-CRP level. In multivariate analysis, as the hs-CRP level increased, FEV1 and FVC decreased. A higher FEV1:FVC ratio was associated with lower hs-CRP levels in males.CONCLUSION: Higher hs-CRP levels were associated with decreased FEV1 and FVC in a general population of Korea. The FEV1:FVC ratio decreased with an increase in the hs-CRP level in males.

The Influence of COX-2 Single Nucleotide Polymorphisms on Abdominal Aortic Aneurysm Development and the Associated Inflammation

Angiology ◽  
2009 ◽  
Vol 60 (5) ◽  
pp. 576-581 ◽  
Author(s):  
Stephen A. Badger ◽  
Chee V. Soong ◽  
Ian S. Young ◽  
Ann McGinty ◽  
Caroline Mercer ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Serum Concentration ◽  
High Sensitivity ◽  
Nucleotide Polymorphisms ◽  
C Reactive Protein ◽  
Single Nucleotide ◽  
Reactive Protein ◽  
Abdominal Aortic ◽  
Cox 2

Introduction Cyclooxygenase (COX)-2 influences cardiovascular disease and serum concentration of high-sensitivity C-reactive protein (hsCRP). The study purpose was to determine the influence of single nucleotide polymorphisms (SNPs) of the COX-2 gene on abdominal aortic aneurysm (AAA) development and serum hsCRP concentrations. Patients and Methods Patients with AAA and disease-free controls were recruited. High-sensitivity C-reactive protein was measured by an enzyme-linked immunosorbent assay (ELISA) test. The distributions of COX-2 SNPs were investigated (rs20417 and rs4648307). The influence of the COX-2 SNPs on the hsCRP serum concentration was assessed. Results A total of 230 patients with AAA and 279 controls were included. No difference was found in the genotype distribution of the COX-2 SNPs rs20417 ( P = .26) and rs4648307 ( P = .90). They did not influence the hsCRP concentration ( P = .24 and P = .61, respectively). Haplotype analysis of COX-2 SNPs revealed no difference. Conclusion These COX-2 SNPs do not play any role in AAA development and do not influence serum hsCRP. These results differentiate AAA development from atherosclerotic diseases.

scholarly journals Identifying single nucleotide polymorphisms (SNPs) and detecting c-reactive protein (CRP) levels associated with posterior circulation ischemia and cerebral infarction

2021 ◽  
Author(s):  
Wanhua Chen ◽  
Teng Lin ◽  
Lei Xiao ◽  
Wenjie Cai ◽  
Zhiwei Zeng ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Cerebral Infarction ◽  
Cerebrovascular Diseases ◽  
Posterior Circulation ◽  
Diagnostic Methods ◽  
Healthy Controls ◽  
Nucleotide Polymorphisms ◽  
C Reactive Protein ◽  
Single Nucleotide ◽  
Reactive Protein

Abstract Background: Posterior circulation ischemia (PCI) and cerebral infarction (CI) are major cerebrovascular diseases. Screening potential genetic variations such as single nucleotide polymorphisms (SNPs) in genes involved in the immune system pathway is a reliable assessment of potential risk factors for PCI and CI. Moreover, C-reactive protein (CRP) is recognized as a sensitive biomarker for systemic inflammation and secondary lesions related to cerebrovascular diseases, which has a significant clinical significance.Methods: We collected whole blood and plasma samples from 39 healthy controls, 23 PCI and 18 CI subjects. Allele-specific polymerase chain reaction (AS-PCR) was used to detect mutations in SNPs. The plasma CRP levels were measured using the newly developed single molecule array (Simoa) method. Results: We detected mutations in three SNPs such as rs3093077, rs3917368 and rs4129267, which are associated with an increased risk of PCI and CI. We also captured a significant increase in Simoa-measured CRP levels in plasma of patients with PCI and CI, compared to healthy controls.Conclusions: These three identified SNPs can be used as a prediction and evaluation of risk for PCI and CI. Our results demonstrate the high sensitivity of Simoa in detecting plasma CRP levels. Our study highlights that AS-PCR and Simoa technology can be used as sensitive clinical diagnostic methods for PCI and CI.

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