scholarly journals Evaluation of a First-Line Spectrophotometric Screening Test for Increased Faecal Porphyrin Concentration

1995 ◽  
Vol 33 (5) ◽  
Author(s):  
Floris M. J. Zuijderhoudt ◽  
Jenneke Dorresteijn-de Bok ◽  
Kornelis te Velde
Keyword(s):  
Screening Test ◽  
First Line

Evaluation of a First-Line Spectrophotometric Screening Test for Increased Urine Porphyrin Excretion

1995 ◽  
Vol 32 (2) ◽  
pp. 186-189 ◽  
Author(s):  
F M J Zuijderhoudt ◽  
J Dorresteijn-De Bok ◽  
K Te Velde
Keyword(s):  
High Performance Liquid Chromatography ◽  
Screening Test ◽  
High Performance ◽  
Operating Characteristic ◽  
Screening Method ◽  
Hplc Method ◽  
First Line ◽  
Receiver Operating Characteristic Plot ◽  
Plot Analysis ◽  
Total Urine

We compared a spectrophotometric screening test for urine porphyrin concentration with a high performance liquid chromatography (HPLC) method. The screening test gave lower values than those obtained by HPLC, but the overall correlation was good. Occasionally, spectrophotometry failed to detect porphyrins in the urine which were detected by HPLC. The type of porphyria had no influence on the efficacy of the screening method. Receiver operating characteristic plot analysis of the screening test led to a cut-off value of 110 nmol/24 h with a sensitivity of 96% and a specificity of 86%. We conclude that the spectrophotometric screening method is useful for detection of increased total urine porphyrin concentration.

scholarly journals Cell-free DNA analysis in maternal blood: comparing genome-wide versus targeted approach as a first-line screening test

2019 ◽  
pp. 1-10 ◽  
Author(s):  
Sidonie de Wergifosse ◽  
Elisa Bevilacqua ◽  
Iris Mezela ◽  
Sarah El Haddad ◽  
Caroline Gounongbe ◽  
...  
Keyword(s):  
Screening Test ◽  
Dna Analysis ◽  
Maternal Blood ◽  
First Line ◽  
Cell Free Dna ◽  
Free Dna ◽  
Genome Wide ◽  
Targeted Approach

Is it time to consider LC–MS/MS measurement of mucopolysaccharides as the first line screening test for Sanfilippo disease?

2014 ◽  
Vol 47 (15) ◽  
pp. 141-142
Author(s):  
Hilary Vallance ◽  
Graham Sinclair ◽  
Ramona Salvarinova ◽  
Michelle Demos ◽  
Tim Wood ◽  
...  
Keyword(s):  
Screening Test ◽  
First Line ◽  
Sanfilippo Disease

NGS-based, 107-gene resequencing panel as first-line screening test for lysosomal diseases

2019 ◽  
Vol 126 (2) ◽  
pp. S47-S48
Author(s):  
Francisco J. del Castillo ◽  
Gloria Muñoz ◽  
Crina Ciubotariu ◽  
Marta Gandía ◽  
Juan M. Rosa ◽  
...  
Keyword(s):  
Screening Test ◽  
First Line ◽  
Lysosomal Diseases

Serum CA 125 as a Marker of Hepatocellular Carcinoma

1996 ◽  
Vol 11 (3) ◽  
pp. 178-182 ◽  
Author(s):  
J.B. Lopez ◽  
M. Balasegaram ◽  
V. Thambyrajah
Keyword(s):  
Hepatocellular Carcinoma ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Screening Test ◽  
Liver Diseases ◽  
Ca 125 ◽  
First Line ◽  
Cutoff Value ◽  
Benign Liver ◽  
Rule Out

This study was undertaken to investigate whether serum CA 125 could complement alpha-fetoprotein (AFP) to improve the diagnosis of hepatocellular carcinoma (HCC). CA 125 showed a sensitivity of 92% for HCC against the 58.8% sensitivity of AFP at the cutoff value of 200 ng/ml. However, the former was less specific (48.5% versus 97.4%) in relation to benign liver diseases (BLD). CA 125 had a higher negative predictive value (NPV) of 84.6% compared to 69.2% for AFP; when both markers were combined, however, the NPV rose to 91.7%. Overall, AFP was more efficient than CA 125 for the diagnosis of HCC. While a positive AFP result was highly indicative of HCC, a negative result did not rule out the disease; however, negative AFP and CA 125 meant that the likelihood of the disease was low. In situations of low HCC prevalence, CA 125 could serve as a first-line screening test followed by confirmation of positives by AFP.

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