Hyperhomocysteinemia and high-density lipoprotein metabolism in cardiovascular disease

2007 ◽  
Vol 45 (12) ◽  
Author(s):  
Dan Liao ◽  
Xiaofeng Yang ◽  
Hong Wang
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
High Density Lipoprotein ◽  
Independent Risk Factor ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Underlying Mechanism ◽  
High Density ◽  
Apolipoprotein Ai ◽  
Plasma High Density

AbstractHyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular disease (CVD) and the underlying mechanism is unclear. We and others have reported that homocysteine (Hcy) is inversely correlated with plasma high-density lipoprotein cholesterol (HDL-C) and apolipoprotein AI (apoA-I) in patients with coronary heart disease (CHD). We confirmed this negative correlation in mice with targeted deletions of the genes for apolipoprotein E (apoE) and cystathionine β-synthase (CBS). Severe HHcy (plasma Hcy 210 μmol/L) accelerates spontaneous arthrosclerosis in the CBSClin Chem Lab Med 2007;45:1652–9.

scholarly journals High-Density Lipoproteins and Cardiovascular Disease: The Good, the Bad and the Future

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 857
Author(s):  
Josep Julve ◽  
Joan Carles Escolà-Gil
Keyword(s):  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Epidemiological Studies ◽  
High Density ◽  
High Density Lipoproteins ◽  
Atherosclerotic Cardiovascular Disease ◽  
Plasma High Density ◽  
Low Levels

Epidemiological studies have shown that low levels of plasma high-density lipoprotein cholesterol (HDL-C) are associated with increased atherosclerotic cardiovascular disease (CVD) [...]

Plasma High-Density Lipoprotein Metabolism in Subjects with Primary Hypertriglyceridaemia: Altered Metabolism of Apoproteins AI and AII

1980 ◽  
Vol 59 (5) ◽  
pp. 359-367 ◽  
Author(s):  
S. N. Rao ◽  
P. J. Magill ◽  
N. E. Miller ◽  
B. Lewis
Keyword(s):  
High Density Lipoprotein ◽  
Kinetic Analysis ◽  
Specific Radioactivity ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
High Density ◽  
Fractional Catabolic Rate ◽  
Plasma High Density Lipoprotein ◽  
Catabolic Rate ◽  
Plasma High Density

1. The metabolism of the major proteins of plasma high-density lipoprotein (HDL), apoproteins AI and AII, have been studied in 10 normotriglyceridaemic subjects and in 11 hypertriglyceridaemic subjects (plasma triglyceride 4.5–25 mmol/l) by kinetic analysis of the plasma specific radioactivity versus time curves of the apoproteins after intravenous injection of autologous 125I-labelled high-density lipoprotein. 2. The specific radioactivity versus time curves of both apoproteins (followed for 14 days) were bi-exponential in all subjects. 3. The plasma apoprotein AI and AII concentrations were significantly lower in the hypertriglyceridaemic subjects than in the normotriglyceridaemic subjects. Kinetic analysis showed that this was associated with a lower rate of synthesis of apoprotein AI (P < 0.01) and a higher fractional catabolic rate of apoprotein AII (P < 0.01) in the hypertriglyceridaemic group. 4. There were no significant differences between the two groups in the synthetic rate of apoprotein AII, the fractional catabolic rate of apoprotein AI or the intravascular/extravascular distributions of the apoproteins. 5. Thus hypertriglyceridaemia appears to be frequently associated with divergent abnormalities of the metabolism of the major high-density lipoprotein apoproteins.

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