A new procedure for the synthesis of 2-[(4-dodecyloxyphenyl)sulfonyl]butanoic acid

2015 ◽  
Vol 69 (9) ◽  
Author(s):  
Yun-Long Shi ◽  
Ling Wang ◽  
Chao Qian ◽  
Ming Tao ◽  
Zu-Tai Liao ◽  
...  
Keyword(s):  
High Purity ◽  
Cost Effective ◽  
Target Product ◽  
Synthetic Route ◽  
Butanoic Acid ◽  
Nucleophilic Reaction ◽  
Synthetic Strategy ◽  
Scalable Synthesis ◽  
Optimized Conditions ◽  
Important Objective

AbstractA new, practical and cost-effective route for scalable synthesis of 2-[(4-dodecyloxyphenyl)sulfonyl] butanoic acid, a key intermediate of a new cyan dye-forming coupler containing a sulfone group, was developed by adopting phenol as the starting material. The synthesis was accomplished in five steps with etherification, chlorosulfonation, reduction, nucleophilic reaction by C-S coupling and hydrolyzation. An important objective of the new synthetic route was the synthesis of 2-[4- (dodecyloxyphenyl)sulfonyl]butanoate. Overall yield obtained at optimized conditions increased to 66 %. The synthetic strategy was proven to be a process enabling rapid delivery of the target product with high purity.

scholarly journals A simple and cost-effective paper-based and colorimetric dual-mode detection of arsenic(iii) and lead(ii) based on glucose-functionalized gold nanoparticles

RSC Advances ◽  
2021 ◽  
Vol 11 (34) ◽  
pp. 20769-20780
Author(s):  
Bhuneshwari Sahu ◽  
Ramsingh Kurrey ◽  
Manas Kanti Deb ◽  
Kamlesh Shrivas ◽  
Indrapal Karbhal ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cost Effective ◽  
Dual Mode ◽  
Functionalized Gold Nanoparticles ◽  
Mode Detection ◽  
Optimized Conditions

We report a simple and cost-effective paper-based and colorimetric dual-mode detection of As(iii) and Pb(ii) based on glucose-functionalized gold nanoparticles under optimized conditions.

Cost-effective synthesis and solution processing of porous polymer networks through methanesulfonic acid-mediated aldol triple condensation

2018 ◽  
Vol 2 (2) ◽  
pp. 396-401 ◽  
Author(s):  
Zi-Hao Guo ◽  
Chenxu Wang ◽  
Qiang Zhang ◽  
Sai Che ◽  
Hong-Cai Zhou ◽  
...  
Keyword(s):  
Polymer Networks ◽  
Methanesulfonic Acid ◽  
Cost Effective ◽  
Porous Polymer ◽  
Solution Processing ◽  
Condensation Method ◽  
Highly Efficient ◽  
Effective Synthesis ◽  
Scalable Synthesis

A highly efficient aldol triple condensation method was developed for scalable synthesis and solution processing of conjugated porous polymer networks.

A simple synthetic route to polyoxovanadate-based organic–inorganic hybrids using EEDQ as an ester coupling agent

2017 ◽  
Vol 46 (14) ◽  
pp. 4602-4608 ◽  
Author(s):  
Aruuhan Bayaguud ◽  
JianDa Li ◽  
Shan She ◽  
Yongge Wei
Keyword(s):  
Coupling Agent ◽  
Synthetic Route ◽  
Synthetic Strategy ◽  
Post Functionalization

A simple synthetic strategy for the post-functionalization of organically derivatized hexavanadates is presented.

Zinc carbonate recovery from brass melting slag

2021 ◽  
Vol 98 ◽  
pp. 14-18
Author(s):  
Thao Nguyen Thi ◽  
◽  
Nam Pham Ky ◽  
Ngoc Tran Vu Diem
Keyword(s):  
Sulfuric Acid ◽  
High Purity ◽  
Room Temperature ◽  
Ph Value ◽  
Zinc Carbonate ◽  
Leaching Solution ◽  
Optimized Conditions ◽  
Melting Slag

Brass melting slag (20.38 wt.% Zn) was leached in sulfuric acid with concentration of (50 + 80) g/l H2SO4, leaching temperature of (30 + 60) °C for (30 + 120) min. The optimized conditions for 94.16% Zn extraction from brass melting slag were found as 70 g/l H2SO4, room temperature and 90 min. The leaching solution was purified by removal of Fe through Fe(OH)3 precipitation when adding ZnO to adjust pH value of 5. The solution was continuously cemented by Zn metal at 60 °C for 60 min to obtain Cu metal with high purity of 99 wt.% Cu. The purified solution with 37.64 g/l Zn was modified by Na2C03 to have pH value of about 6 and precipitation of ZnC03 (94.14 %).

Size-tunable and scalable synthesis of uniform copper nanocrystals

RSC Advances ◽  
2015 ◽  
Vol 5 (4) ◽  
pp. 2756-2761 ◽  
Author(s):  
Hwansu Sim ◽  
Jihwan Lee ◽  
Taekyung Yu ◽  
Kyungpil Kim ◽  
Seong Jun Lee ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Synthetic Method ◽  
Synthetic Route ◽  
Scalable Synthesis

A facile and scalable synthetic route to uniform Cu nanocrystals with tunable sizes in the range of 20–100 nm based on an ethylene glycol-assisted synthetic method was developed.

scholarly journals Scalable Synthesis of High-Purity (R, R)-Dexmethylphenidate Free Base

2016 ◽  
Vol 8 (4) ◽  
pp. 28 ◽  
Author(s):  
Guan Wang ◽  
Dongsheng Chen ◽  
Yuanyuan Sun ◽  
Qing Cao ◽  
Bonan Li ◽  
...  
Keyword(s):  
Amino Acid ◽  
High Purity ◽  
Industrial Production ◽  
Acid Ester ◽  
Substitution Reaction ◽  
Practical Method ◽  
Amino Acid Ester ◽  
Free Base ◽  
Hydrochloride Salt ◽  
Scalable Synthesis

<p>A practical method for the preparation of high-purity (<em>R, R</em>)-dexmethylphenidate free base was developed. The method involves a substitution reaction of 2-chloropyridine and phenylacetonitrile via hydrolysis followed by hydrogenation, configuration inversion, chiral resolution, methyl esterification, and salification to give high-purity dexmethylphenidate hydrochloride. The hydrochloride salt was then neutralized by powder sodium hydroxide overnight to give dexmethylphenidate free base with over 99% purity. This method can be used for the industrial production of the dexmethylphenidate patch API, which could also be further applied for the preparation of other types of amino acid ester free bases.</p>

scholarly journals Production of Gamma Alumina Using Plasma-Treated Aluminum and Water Reaction Byproducts

Materials ◽  
2020 ◽  
Vol 13 (6) ◽  
pp. 1300 ◽  
Author(s):  
Marius Urbonavicius ◽  
Sarunas Varnagiris ◽  
Liudas Pranevicius ◽  
Darius Milcius
Keyword(s):  
High Purity ◽  
High Efficiency ◽  
Morphological Changes ◽  
Cost Effective ◽  
Electrical Energy ◽  
High Specific Surface Area ◽  
Direct Reaction ◽  
Gamma Alumina ◽  
Novel Method ◽  
High Purity Hydrogen

High purity hydrogen and solid-state byproducts are produced using a proposed plasma-activated aluminum and water reactions approach. These byproducts could be transformed into pure gamma Al2O3 powder material, while hydrogen can be used for electricity generation. Various chemical methods can be used for the synthesis of gamma alumina, but most could result in high levels of remaining impurities. Boehmite is a cost-effective starting material for the production of high-purity Al2O3. Herein, we present a novel method for the synthesis of boehmite and its transformation into high-specific-surface-area γ-alumina. Specifically, this method implicates the direct reaction between distilled water and plasma-treated aluminum powder. The results show the structural and morphological changes of the byproduct of the aluminum/water reaction to boehmite and γ-Al2O3 after a simple heating procedure (at 280 and 500 °C respectively). The high-purity hydrogen produced during the aluminum/water reaction can be used for the high-efficiency and environmentally friendly production of electrical energy.

A Scalable Synthesis of Biaryl Unit of the HIV Protease Inhibitor Atazanavir

2019 ◽  
Vol 17 (1) ◽  
pp. 68-72
Author(s):  
Chapala Vijayalakshmi ◽  
Malavattu G. Prasad ◽  
Naresh K. Katari ◽  
Pedavenkatagari N. Reddy
Keyword(s):  
Protease Inhibitor ◽  
Large Scale ◽  
Cyano Group ◽  
Cost Effective ◽  
Pharmacokinetic Profile ◽  
Hiv Protease ◽  
Tert Butyl ◽  
Palladium Catalyzed ◽  
Scalable Synthesis

Atazanavir is one of the most prescribed HIV-1 protease inhibitors approved by the FDA. It was the first protease inhibitor approved for once-a-day dosing to treat AIDS due to good oral bioavailability and favorable pharmacokinetic profile. This research aims to develop a new synthetic cost effective process for biaryl-hydrazine unit {tert-butyl 2-[4-(2-pyridinyl)benzyl]hydrazinecarboxylate} of atazanavir on a large scale. The synthesis involved palladium catalyzed Suzuki-Miyaura coupling of 2-chloropyridine and (4-cyanophenyl)boronic acid followed by DIBAL-H reduction of cyano group to aldehyde which is then treated with tert-butyl carbazate to furnish hydrazone subsequently in situ reduction with NaBH4. A large scale synthesis of biaryl-hydrazine unit of atazanavir was accomplished in three steps with 71% overall yield. We have developed a short and efficient synthesis of atazanavir key intermediate biaryl-hydrazine unit. The process does not require the usage of Grignard reagent, expensive catalyst, protection/deprotection of aldehyde moiety and catalytic hydrogenation.

scholarly journals Scalable synthesis of high-purity TiO2 whiskers via ion exchange method enables versatile applications

RSC Advances ◽  
2019 ◽  
Vol 9 (41) ◽  
pp. 23735-23743 ◽  
Author(s):  
Mingxu Wang ◽  
Qiang Gao ◽  
Hao Duan ◽  
Mingqiao Ge
Keyword(s):  
Titanium Dioxide ◽  
Ion Exchange ◽  
High Purity ◽  
Exchange Method ◽  
Crystal Forms ◽  
Ion Exchange Method ◽  
Scalable Synthesis ◽  
Purity Titanium

In this work, high-purity titanium dioxide (TiO2) whiskers with different crystal forms were synthesized via ion exchange and controlled calcination methods.

scholarly journals An Automated and High-Throughput Immunoaffinity Magnetic Bead-Based Sample Clean-Up Platform for the Determination of Aflatoxins in Grains and Oils Using UPLC-FLD

Toxins ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 583 ◽  
Author(s):  
Zhihong Xuan ◽  
Jin Ye ◽  
Bing Zhang ◽  
Li Li ◽  
Yu Wu ◽  
...  
Keyword(s):  
High Throughput ◽  
High Performance ◽  
Cost Effective ◽  
Magnetic Bead ◽  
The Novel ◽  
Analysis Method ◽  
Automated Method ◽  
Accuracy And Precision ◽  
Optimized Conditions

Sample clean-up remains the most time-consuming and error-prone step in the whole analytical procedure for aflatoxins (AFTs) analysis. Herein, an automated and high-throughput sample clean-up platform was developed with a disposable, cost-effective immunoaffinity magnetic bead-based kit. Under optimized conditions, the automated method takes less than 30 min to simultaneously purify 20 samples without requiring any centrifugation or filtering steps. When coupled to ultra-high performance liquid chromatography with fluorescence detection, this new analysis method displays excellent accuracy and precision as well as outstanding efficiency. Furthermore, an interlaboratory study was performed in six laboratories to validate the novel protocol. Mean recovery, repeatability, reproducibility, and Horwitz ratio values were within 91.9%–107.4%, 2.5%–7.4%, 2.7%–10.6%, and 0.26%–0.90, respectively. Results demonstrate that the developed sample clean-up platform is a reliable alternative to most widely adopted clean-up procedures for AFTs in cereals and oils.

Sign in / Sign up

Export Citation Format

Share Document