Effect of Maharishi Amrit Kalash on Age Dependent Variations in Mitochondrial Antioxidant Enzymes, Lipid Peroxidation and Mitochondrial Population in Different Regions of the Central Nervous System of Guinea-pigs

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

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A PARALYTIC DISEASE OF GUINEA PIGS DUE TO THE TUBERCLE BACILLUS

Journal of Experimental Medicine ◽

10.1084/jem.50.3.365 ◽

1929 ◽

Vol 50 (3) ◽

pp. 365-370 ◽

Cited By ~ 1

Author(s):

Richard E. Shope ◽

Paul A. Lewis

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Tuberculous Meningitis ◽

Guinea Pigs ◽

Tuberculous Infection ◽

Tubercle Bacillus ◽

Herpes Encephalitis ◽

Subsequent Publication ◽

The Central Nervous System ◽

Rule Out

The experimental data collected during this study of a transmissible type of paralysis developing in tuberculous guinea pigs indicate the condition to be a true tuberculous meningitis. We have been able to rule out the possibility that it is due to a non-tuberculous infection of the central nervous system caused by Roemer's virus, or by an atypical herpes virus, or by some bacterium other than the tubercle bacillus. Roemer's virus and herpes could be eliminated from consideration when Berkefeld N filtrates of infectious brain emulsions proved incapable of reproducing the disease. Furthermore, rabbits could be infected as they cannot with Roemer's virus, and the disease elicited in rabbits bears no semblance to herpes encephalitis. No organism other than the tubercle bacillus could be obtained on culturing brain or brain emulsions from experimental cases, and no others were seen in examining fresh smear preparations from the central nervous system. In a modified Noguchi medium a tubercle bacillus possessing atypical staining properties was obtained. This organism was capable of producing the typical paralytic disease when injected intracerebrally into guinea pigs, and also generalized tuberculosis in animals inoculated subcutaneously with it. Typical tuberde bacilli were readily demonstrable in sections of the meninges from animals with the disease, and culture of pieces of brain on Dorset's egg medium usually yielded a growth of tubercle bacilli. Only in the first of the experimental passages, on the other hand, was it possible to demonstrate acid-fast organisms in fresh smear preparations from the central nervous system. This fact and the attributes of the atypically staining organisms encountered in the cultures in Noguchi media will be considered more fully in a subsequent publication. In view of the much discussed question of the filtrability of the tubercle bacillus our observations concerning the failure of this organism to pass a Berkefeld N filter are of interest. No animal in our series inoculated intracerebrally with brain emulsion from either a "spontaneous" or experimental case of tuberculous meningitis failed to develop meningitis, and that rather acutely, while no animal in our series injected with a Berkefeld filtrate of brain emulsion has developed tuberculous meningitis or any other form of tuberculosis. In connection with this observation it must be recalled that the organism was atypical in respect to its staining qualities at least.

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Clinical and biochemical predictors of neurological disorders

Medical alphabet ◽

10.33667/2078-5631-2019-4-35(410)-34-39 ◽

2020 ◽

Vol 4 (35) ◽

pp. 34-39

Author(s):

I. Yu. Serikova ◽

G. I. Shumacher ◽

E. N. Vorobyova ◽

I. A. Batanina ◽

R. I. Vorobyov

Keyword(s):

Lipid Peroxidation ◽

Central Nervous System ◽

Nervous System ◽

Neurological Disorders ◽

Protein S ◽

Nerve Tissue ◽

S 100 ◽

The Central Nervous System ◽

Peroxidation Processes ◽

The City

The aim of this study is to identify clinical and biochemical predictors of neurological disorders in adolescents who have suffered mild perinatal damage of the central nervous system. We examined 120 adolescents (62 girls and 58 boys) aged 13–16 years, who were hospitalized in the city Children’s Neurological Department. It was found that adolescents with perinatal lesions of the central nervous system, activated lipid peroxidation processes and revealed an increase in the concentration of protein S 100, which in the future could lead to the development of neurodegeneration processes. In addition, a positive correlation between the lipid peroxidation processes nd the concentration of the nerve tissue damage marker was revealed. The results indicate that the level of neurospecific protein — protein S 100, parameters of the oxidant‑antioxidant system, perinatal factors can be used as predictors of chronic nervous tissue processes.

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Central nervous system control of airway tone in guinea pigs: the role of histamine

Journal of Applied Physiology ◽

10.1152/jappl.1988.65.5.2024 ◽

1988 ◽

Vol 65 (5) ◽

pp. 2024-2029 ◽

Cited By ~ 12

Author(s):

P. J. Mauser ◽

N. H. Edelman ◽

R. W. Chapman

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Guinea Pigs ◽

Lung Compliance ◽

System Control ◽

The Central Nervous System ◽

Dose Dependent Decrease ◽

Airway Tone ◽

Dynamic Lung Compliance ◽

H1 Antagonist

The central nervous system (CNS) plays an important role in the reflex control of bronchomotor tone, but the relevant neurotransmitters and neuromodulators have not been identified. In this study we have investigated the effect of histamine. Anesthetized male guinea pigs were prepared with a chronically implanted intracerebroventricular (icv) cannula and instrumented for the measurement of pulmonary resistance (RL), dynamic lung compliance (Cdyn), tidal volume (VT), respiratory rate (f), blood pressure (BP), and heart rate (HR). Administration of histamine (2-30 micrograms) icv caused a significant (P less than 0.05) reduction of Cdyn with no change in RL, VT, and f. At a dose of 100 micrograms icv, histamine caused an increase in RL (202 +/- 78%), a reduction of Cdyn (77 +/- 9%), an increase in f (181 +/- 64%), and a reduction of VT (53 +/- 18%). There were no changes in BP and HR after 100 micrograms of icv histamine. In contrast, intravenous administration of histamine (0.1-2 micrograms/kg) caused a dose-dependent decrease in Cdyn and increase in RL that was associated with tachypnea at each bronchoconstrictor dose. Intravenous histamine (2 micrograms/kg) produced a fall in BP and an increase in HR. The bronchoconstrictor responses to icv histamine were completely blocked by vagotomy and significantly reduced by atropine (0.1 mg/kg iv), whereas vagotomy and atropine did not block the bronchospasm due to intravenous histamine. Additional studies indicated that the pulmonary responses due to icv histamine (100 micrograms) were blocked by pretreatment with the H1-antagonist chlorpheniramine (1 and 10 micrograms, icv). These data indicate that histamine may serve a CNS neurotransmitter function in reflex bronchoconstriction in guinea pigs.

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Age-Related Elevation of Lipid Peroxidation Products: Diminution of Superoxide Dismutase Activity in the Central Nervous System of Rats

Gerontology ◽

10.1159/000213277 ◽

1991 ◽

Vol 37 (6) ◽

pp. 305-309 ◽

Cited By ~ 57

Author(s):

Achla Gupta ◽

Mahdi Hasan ◽

Ramesh Chander ◽

Narinder K. Kapoor

Keyword(s):

Lipid Peroxidation ◽

Central Nervous System ◽

Superoxide Dismutase ◽

Nervous System ◽

Superoxide Dismutase Activity ◽

Lipid Peroxidation Products ◽

Age Related ◽

The Central Nervous System

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Lipid Metabolism in Neurocognitive Disorders: Current Update

Journal of Regenerative Biology and Medicine ◽

10.37191/mapsci-2582-385x-3(4)-075 ◽

2021 ◽

Author(s):

Antonella Mandas

Keyword(s):

Lipid Peroxidation ◽

Central Nervous System ◽

Nervous System ◽

Lipid Metabolism ◽

Scientific Literature ◽

Scientific Research ◽

Neurocognitive Disorders ◽

Lipid Homeostasis ◽

The Central Nervous System ◽

E4 Allele

The physiology and the pathology of the Central Nervous System (CNS) is very complex, and only by understanding it the scientific research might develop effective treatments. Neurocognitive Disorders, extremely diffused diseases, have a multifactorial aetiology, in which lipid homeostasis plays an important role, as known. The aim of this mini-review is focus on interesting recently published researches on the topic, in order to put together some pieces of the puzzle of such an enormous physiopathology chapter. After a brief introduction, we will describe important aspects of CNS lipid metabolism, then we will examine the conclusions of recent articles relating to lipid role in neurodegeneration. The recent scientific literature has strengthened the position of some well-known “biological agents” – i.e. lipid peroxidation and apolipoprotein E4 allele –but also detailed the importance of new promising diagnostic and therapeutic targets.

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