scholarly journals Cognitive impairments in type 2 diabetes, risk factors and preventive strategies

2020 ◽  
Vol 31 (2) ◽  
Author(s):  
Garima Sharma ◽  
Arti Parihar ◽  
Tanay Talaiya ◽  
Kirti Dubey ◽  
Bhagyesh Porwal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fruits And Vegetables ◽  
Early Stage ◽  
Cognitive Impairments ◽  
Diabetic Patients ◽  
Unhealthy Lifestyle

AbstractMild cognitive impairment (MCI) is a modifiable risk factor in progression of several diseases including dementia and type 2 diabetes. If cognitive impairments are not reversed at an early stage of appearance of symptoms, then the prolonged pathogenesis can lead to dementia and Alzheimer’s disease (AD). Therefore, it is necessary to detect the risk factors and mechanism of prevention of cognitive dysfunction at an early stage of disease. Poor lifestyle, age, hyperglycemia, hypercholesterolemia, and inflammation are some of the major risk factors that contribute to cognitive and memory impairments in diabetic patients. Mild cognitive impairment was seen in those individuals of type 2 diabetes, who are on an unhealthy diet. Physical inactivity, frequent alcohol consumptions, and use of packed food products that provides an excess of cheap calories are found associated with cognitive impairment and depression in diabetic patients. Omega fatty acids (FAs) and polyphenol-rich foods, especially flavonoids, can reduce the bad effects of an unhealthy lifestyle; therefore, the consumption of omega FAs and flavonoids may be beneficial in maintaining normal cognitive function. These functional foods may improve cognitive functions by targeting many enzymes and molecules in cells chiefly through their anti-inflammatory, antioxidant, or signaling actions. Here, we provide the current concepts on the risk factors of cognitive impairments in type 2 diabetes and the mechanism of prevention, using omega FAs and bioactive compounds obtained from fruits and vegetables. The knowledge derived from such studies may assist physicians in managing the health care of patients with cognitive difficulties.

scholarly journals Risk factors for developing dementia in type 2 diabetes mellitus patients with mild cognitive impairment

2019 ◽  
Vol Volume 15 ◽  
pp. 167-175 ◽  
Author(s):  
Oana Albai ◽  
Mirela Frandes ◽  
Romulus Timar ◽  
Deiana Roman ◽  
Bogdan Timar
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment

scholarly journals Mild cognitive impairment among type 2 diabetic patients attending Zagazig University outpatient clinics

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
N H Elshamy ◽  
I I Salama ◽  
M S Gabal ◽  
A M Hassan ◽  
G A Abdellatif
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Disorders ◽  
Outpatient Clinics ◽  
Control Group ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Abstract Objective The incidence of mild cognitive impairment increases with age, so this study is conducted to assess the relation between mild cognitive impairment and type 2 diabetes. Methods 100 type 2 diabetic patients attending Zagazig University outpatient clinics with age range from 40-60 years old was included in the study. These patients were matched with 100 non-diabetic controls regarding age, sex and educational class. Patients with important risk factors for cognitive disorders (cerebro-vascular stroke, organ failure, mental disorders, etc.) were not included in the study. Montreal cognitive assessment (MoCA) was done for all participants by an expert examiner using MoCA tool. Results Mild cognitive impairment was confirmed in 22% of diabetic patients and in 9% of control group (p < 0.05) with total MoCA score lower in diabetic group than control one (p < 0.01). Conclusion Type 2 diabetes may be associated with lower levels of cognitive function.

scholarly journals Mild Cognitive Impairment Subtypes and Type 2 Diabetes in Elderly Subjects

2020 ◽  
Vol 9 (7) ◽  
pp. 2055
Author(s):  
Silvia Valenza ◽  
Lucia Paciaroni ◽  
Susy Paolini ◽  
Anna Rita Bonfigli ◽  
Mirko Di Rosa ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Insulin Treatment ◽  
Amnestic Mild Cognitive Impairment ◽  
Elderly Subjects ◽  
Diabetic Patients ◽  
Immediate Recall

Background: Type 2 diabetes (T2D) is correlated to amnestic mild cognitive impairment (aMCI) and to non-amnestic mild cognitive impairment (naMCI). This study evaluated whether the T2D variable characterizes a peculiar cognitive profile in elderly patients. Moreover, it explores the association between glycated hemoglobin levels (HbA1c), T2D duration, insulin and oral hypoglycemic agent treatment, and cognition in elderly diabetic patients. Methods: Detailed neuropsychological battery was used to diagnose MCI subtypes. A total of 39 MCI subjects with T2D (T2D-MCI) and 37 MCI subjects without T2D (ND-MCI), matched for age, educational level, and Mini-Mental State Examination score, were included. Results: ND-MCI performed worse in memory and language domains than T2D-MCI. The amnestic subtype is more frequent among ND-MCI and non-amnestic subtype in T2D-MCI. In T2D-MCI, high HbA1c levels correlate with episodic memory (immediate recall) and T2D duration. Some indexes of episodic memory (immediate recall), attention, and visual-spatial ability correlate with insulin treatment. Conclusions: An association between T2D and non-amnestic MCI is suggested. In the T2D-MCI group, significant associations between insulin treatment and memory (immediate recall), complex figure copy, and attention were found.

Mild cognitive impairment in type 2 diabetes mellitus and related risk factors: a review

2017 ◽  
Vol 28 (7) ◽  
pp. 715-723 ◽  
Author(s):  
Xiao-Ying Yuan ◽  
Xu-Gang Wang
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Psychological Status ◽  
Epidemic Disease ◽  
Related Risk

AbstractType 2 diabetes mellitus (T2DM) is a global epidemic disease and has become a significant health problem. Many studies have raised concern about the mild cognitive impairment (MCI) with T2DM and even the Alzheimer’s disease patients with T2DM. The incidence of MCI is higher in individuals with T2DM than those without diabetes. Cognitive changes might affect everyday activities depending on the work and situation. Although the exact pathophysiology of MCI in T2DM is unclear, many studies suggest that the alterations in pathoglycemia, diabetic complications, related end products, and physical/psychological status are significant risk factors. In this article, we systematically overview the studies to illustrate the related risk factors of cognitive impairment in patients with T2DM. Further high quality studies and treatment need to be initiated and it will become incumbent on clinicians to identify and cure the earliest signs of clinical impairment.

Risk factors of mild cognitive impairment in middle aged patients with type 2 diabetes: A cross–section study

2012 ◽  
Vol 73 (3) ◽  
pp. 208-212 ◽  
Author(s):  
Rui-Hua Chen ◽  
Xiao-Zhen Jiang ◽  
Xiao-Hui Zhao ◽  
Yu-Lan Qin ◽  
Zhe Gu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cross Section ◽  
Middle Aged ◽  
Aged Patients ◽  
Section Study

Screening for Cognitive Disorders in Elderly Diabetics

2017 ◽  
Vol 41 (S1) ◽  
pp. S673-S673
Author(s):  
I. Baat ◽  
I. Abida ◽  
S. Omri ◽  
S. Ellouze ◽  
F. Hadj Kacem ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Cognitive Disorders ◽  
University Hospital ◽  
High Rate ◽  
Diabetic Patients ◽  
Cross Sectional

IntroductionOld people with diabetes are more likely to develop cognitive impairment, Alzheimer's disease and vascular dementia. However, the determinants of the association between diabetes and cognitive impairments are only partially known.ObjectivesTo evaluate cognitive disorders in elderly diabetic patients and to identify risk factors of cognitive impairment in this population.MethodsIt was a cross-sectional study. It involved outpatients aged 65 and older, who were followed for diabetes in the endocrinology department at the Hedi Chaker University Hospital in Sfax (Tunisia), from October 1 to December 31, 2015. For each patient, we collected sociodemographic, clinical and therapeutic data. We used the Montreal Cognitive Assessment (MoCA) to identify mild cognitive decline (score < 26/30).ResultsWe identified 70 patients, all with type 2 diabetes. The average age was 66.8 years. The sex ratio (M: F) was 0.7. The mean duration of diabetes was 14.76 years. The average MoCA score was 20.68 ± 6. Forty patients (57%) had cognitive decline. The cognitive impairment was statistically correlated with female sex (P = 0.02), low level of education (P = 0.00), high levels of glycated hemoglobin (Hb A1c ≥ 7%) (P = 0.00), presence of hypoglycemic episodes (P = 0.05) and presence of dyslipidemia (P = 0.00).ConclusionOur study confirmed the high rate of cognitive decline in older type 2 diabetes patients. The profile of subjects at risk was consistent with the literature: poorly controlled diabetes, severe recurrent hypoglycaemia and associated dyslipidemia. Acting on these risk factors would prevent cognitive decline and therefore progression to dementia.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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