Synthesis and encapsulation of iron oxide nanorods for application in magnetic hyperthermia and photothermal therapy

Abstract The synthesis, characterization, and applications of iron oxide nanorods have received attention in recent years. Even though there are several studies on the biological applications of iron oxide nanoparticles, recent studies have shown that rod-shaped iron oxides are effective in magnetic hyperthermia (MHT) as therapeutic technique to treat cancer. This review focused on the synthesis and encapsulation of magnetic iron oxide nanorods (MIONRs) and their use in (MHT) and photothermal therapy (PTT) for cancer cells. Among the synthetic methods that have been used to prepare MIONRs, some could be used to precisely control the particle size of the as-prepared magnetic iron oxide nanoparticles (MIONs), while others could be used to prepare monodisperse particles with uniform size distributions. Some of the results presented in this review showed that magnetic oxide nanorods are more potent in MHT than polyhedral-shaped MIONs. The review shows that mixtures of polyhedral- and rod-shaped MIONs resulted in 59 and 77% cell death, while monodisperse MIONRs resulted in 95% cell death. It could thus be concluded that, for magnetic iron oxide to be effective in MHT and PTT, it is important to prepare monodisperse magnetic oxide nanorods.

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pH and NIR-light-responsive magnetic iron oxide nanoparticles for mitochondria-mediated apoptotic cell death induced by chemo-photothermal therapy

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2017.07.014 ◽

2017 ◽

Vol 531 (1) ◽

pp. 1-13 ◽

Cited By ~ 22

Author(s):

Yunok Oh ◽

Jae-Young Je ◽

Madhappan Santha Moorthy ◽

Hansoo Seo ◽

Won Ho Cho

Keyword(s):

Cell Death ◽

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Photothermal Therapy ◽

Apoptotic Cell ◽

Apoptotic Cell Death ◽

Oxide Nanoparticles ◽

Magnetic Iron Oxide Nanoparticles ◽

Magnetic Iron Oxide ◽

Nir Light

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Monocore vs. multicore magnetic iron oxide nanoparticles: uptake by glioblastoma cells and efficiency for magnetic hyperthermia

Molecular Systems Design & Engineering ◽

10.1039/c7me00061h ◽

2017 ◽

Vol 2 (5) ◽

pp. 629-639 ◽

Cited By ~ 22

Author(s):

Gauvin Hemery ◽

Coralie Genevois ◽

Franck Couillaud ◽

Sabrina Lacomme ◽

Etienne Gontier ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Cancer Cell ◽

Magnetic Fluid ◽

Magnetic Hyperthermia ◽

Oxide Nanoparticles ◽

Proof Of Concept ◽

Magnetic Iron Oxide Nanoparticles ◽

Magnetic Fluid Hyperthermia ◽

Magnetic Iron Oxide

PEGylated magnetic iron oxide nanoparticles (IONPs) were synthesised with the aim to provide proof of concept results of remote cancer cell killing by magnetic fluid hyperthermia.

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Comparison of Iron Oxide Nanoparticles in Photothermia and Magnetic Hyperthermia: Effects of Clustering and Silica Encapsulation on Nanoparticles’ Heating Yield

Applied Sciences ◽

10.3390/app10207322 ◽

2020 ◽

Vol 10 (20) ◽

pp. 7322 ◽

Cited By ~ 3

Author(s):

Sebastjan Nemec ◽

Slavko Kralj ◽

Claire Wilhelm ◽

Ali Abou-Hassan ◽

Marie-Pierre Rols ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Heat Generation ◽

Photothermal Therapy ◽

Superparamagnetic Iron Oxide ◽

Magnetic Hyperthermia ◽

Silica Shell ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Silica Encapsulation

Photothermal therapy is gathering momentum. In order to assess the effects of the encapsulation of individual or clustered superparamagnetic iron oxide nanoparticles (SPIONs) on nanoparticle light-to-heat conversion, we designed and tested individual and clustered SPIONs encapsulated within a silica shell. Our study compared both photothermia and magnetic hyperthermia, and it involved individual SPIONs as well as silica-encapsulated individual and clustered SPIONs. While, as expected, SPION clustering reduced heat generation in magnetic hyperthermia, the silica shell improved SPION heating in photothermia.

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Multifunctional magnetic iron oxide nanoparticles: diverse synthetic approaches, surface modifications, cytotoxicity towards biomedical and industrial applications

BMC Materials ◽

10.1186/s42833-019-0002-6 ◽

2019 ◽

Vol 1 (1) ◽

Cited By ~ 13

Author(s):

Subramanian Natarajan ◽

Kannan Harini ◽

Gnana Prakash Gajula ◽

Bruno Sarmento ◽

Maria Teresa Neves-Petersen ◽

...

Keyword(s):

Surface Modification ◽

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Surface Modifications ◽

Synthetic Methods ◽

Biomedical Science ◽

Oxide Nanoparticles ◽

Magnetic Iron Oxide Nanoparticles ◽

Cytotoxic Effects ◽

Magnetic Iron Oxide

AbstractMagnetic iron oxide nanoparticles (MIONPs) play a major role in the emerging fields of nanotechnology to facilitate rapid advancements in biomedical and industrial platforms. The superparamagnetic properties of MIONPs and their environment friendly synthetic methods with well-defined particle size have become indispensable to obtain their full potential in a variety of applications ranging from cellular to diverse areas of biomedical science. Thus, the broadened scope and need for MIONPs in their demanding fields of applications required to be highlighted for a comprehensive understanding of their state-of-the-art. Many synthetic methods, however, do not entirely abolish their undesired cytotoxic effects caused by free radical production and high iron dosage. In addition, the agglomeration of MIONPs has also been a major problem. To alleviate these issues, suitable surface modification strategies adaptive to MIONPs has been suggested not only for the effective cytotoxicity control but also to minimize their agglomeration. The surface modification using inorganic and organic polymeric materials would represent an efficient strategy to utilize the diagnostic and therapeutic potentials of MIONPs in various human diseases including cancer. This review article elaborates the structural and magnetic properties of MIONPs, specifically magnetite, maghemite and hematite, followed by the important synthetic methods that can be exploited for biomedical approaches. The in vivo cytotoxic effects and the possible surface modifications employed to eliminate the cytotoxicity thereby enhancing the nanoparticle efficacy are also critically discussed. The roles and applications of surface modified MIONPs in medical and industrial platforms have been described for the benefits of global well-being.

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