Biomineralized organic–inorganic hybrids aiming for smart drug delivery

2014 ◽  
Vol 86 (5) ◽  
pp. 671-683
Author(s):  
Jun Shi ◽  
Li Zhang ◽  
Yingliang Liu ◽  
Shengang Xu ◽  
Shaokui Cao
Keyword(s):  
Drug Delivery ◽  
Hybrid Materials ◽  
Drug Carriers ◽  
Successful Development ◽  
Inorganic Hybrid ◽  
Polymer Templates ◽  
Diffusion Controlled ◽  
Controlled Deposition ◽  
Smart Drug ◽  
Smart Drug Delivery

AbstractOrganic–inorganic hybrid materials have received great interest in the last 10 years in the controlled drug delivery area because of their excellent biocompatible, biomimetic, and pH-sensitive properties. Biomineralization is a biomineral-inspired route to prepare novel organic–inorganic hybrids, which involves a diffusion-controlled deposition of inorganic minerals within porous polymeric matrices. Proper combination of controlled biomineralization technique with the rational choice of polymer templates would lead to the successful development of smart self-assembled drug carriers. The present work mainly summarizes our recent work about the biomineralized organic–inorganic hybrid materials aiming for smart drug delivery including hybrid beads, membranes, and micro/nano gels. Furthermore, prospect for future development of the smart organic–inorganic hybrids is also discussed.

Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Medical Science ◽  
Drug Carriers ◽  
Anticancer Drug Delivery ◽  
Ph Values ◽  
Delivery Vector ◽  
Future Challenges ◽  
Smart Drug ◽  
Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

Recent Insights into Effective Nanomaterials and Biomacromolecules Conjugation in Advanced Drug Targeting

2019 ◽  
Vol 20 (7) ◽  
pp. 526-541 ◽  
Author(s):  
Abbas H. Azandaryani ◽  
Soheila Kashanian ◽  
Tahereh Jamshidnejad-Tosaramandani
Keyword(s):  
Drug Delivery ◽  
Monoclonal Antibodies ◽  
Targeted Drug Delivery ◽  
Drug Targeting ◽  
Active Drug ◽  
Drug Carriers ◽  
Targeted Drug ◽  
Pharmaceutical Agents ◽  
Smart Drug ◽  
Smart Drug Delivery

Targeted drug delivery, also known as smart drug delivery or active drug delivery, is a subcategory of nanomedicine. Using this strategy, the medication is delivered into the infected organs in the patient’s body or to the targeted sites inside the cells. In order to improve therapeutic efficiency and pharmacokinetic characteristics of the active pharmaceutical agents, conjugation of biomacromolecules such as proteins, nucleic acids, monoclonal antibodies, aptamers, and nanoparticulate drug carriers, has been mostly recommended by scientists in the last decades. Several covalent conjugation pathways are used for biomacromolecules coupling with nanomaterials in nanomedicine including carbodiimides and “click” mediated reactions, thiol-mediated conjugation, and biotin-avidin interactions. However, choosing one or a combination of these methods with suitable coupling for application to advanced drug delivery is essential. This review focuses on new and high impacted published articles in the field of nanoparticles and biomacromolecules coupling studies, as well as their advantages and applications.

Adult Stem Cells and Biocompatible Scaffolds as Smart Drug Delivery Tools for Cardiac Tissue Repair

2013 ◽  
Vol 20 (28) ◽  
pp. 3429-3447 ◽  
Author(s):  
Stefania Pagliari ◽  
Sara Romanazzo ◽  
Diogo Mosqueira ◽  
Perpetua Pinto-do-O ◽  
Takao Aoyagi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Tissue Repair ◽  
Adult Stem Cells ◽  
Cardiac Tissue ◽  
Smart Drug ◽  
Smart Drug Delivery

Multi-responsive core-crosslinked poly (thiolether ester) micelles for smart drug delivery

Polymer ◽  
2017 ◽  
Vol 110 ◽  
pp. 235-241 ◽  
Author(s):  
Yanfang Hu ◽  
Ming Deng ◽  
Huailin Yang ◽  
Li Chen ◽  
Chunsheng Xiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Smart Drug ◽  
Smart Drug Delivery

Diatom mediated smart drug delivery system

2021 ◽  
Vol 63 ◽  
pp. 102433
Author(s):  
Sakshi Phogat ◽  
Abhishek Saxena ◽  
Neha Kapoor ◽  
Charu Aggarwal ◽  
Archana Tiwari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Erratum: Corrigendum: Doxorubicin-loaded platelets as a smart drug delivery system: An improved therapy for lymphoma

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Peipei Xu ◽  
Huaqin Zuo ◽  
Bing Chen ◽  
Ruju Wang ◽  
Arsalan Ahmed ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Smart Drug ◽  
Smart Drug Delivery

Bicontinuous, Thermoresponsive, L3-Phase Silica Nanocomposites and Their Smart Drug-Delivery Applications

2005 ◽  
Vol 17 (5) ◽  
pp. 634-637 ◽  
Author(s):  
J. H. Chang ◽  
C. H. Shim ◽  
B. J. Kim ◽  
Y. Shin ◽  
G. J. Exarhos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silica Nanocomposites ◽  
Drug Delivery Applications ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

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