scholarly journals Use of propolis in difficult to heal diabetic wounds. Short review

2017 ◽  
Vol 127 (4) ◽  
pp. 173-175
Author(s):  
Patrycja Chylińska-Wrzos ◽  
Marta Lis-Sochocka ◽  
Barbara Jodłowska-Jędrych
Keyword(s):  
Diabetic Foot ◽  
Morphological Changes ◽  
Heart Diseases ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Short Review ◽  
Laboratory Animals ◽  
Diabetic Patients ◽  
Anti Inflammatory ◽  
Diabetic Wounds

Abstract According to WHO, about 347 million of people worldwide suffer from diabetes. Diabetes has complex etiology, and the consequences of this illness are seen in the morphological changes of many tissues and organs i.e. neuropathy leading to the risk of diabetic foot. Due to the diabetic condition, injuries to blood vessels in diabetic foot can be classified as chronic. This is because such wounds remain unresponsive to treatment for months or even years. There are many therapeutic methods employed in treating such injuries. These involve the use of silver, iodine or multi-antibiotic preparations, but treatment is expensive and cumbersome for patients. In the natural environment, however, there are many anti-inflammatory preparations, among them propolis which was the subject of our focus. Due to its anti-inflammatory, antimicrobial, and antioxidant properties, propolis is widely used in the treatment of colds, caries, rheumatic diseases, heart diseases and treatment of burns, wounds and frostbites. Numerous studies also indicate the beneficial effects of propolis on the difficult to heal diabetic wounds in which the use of propolis can significantly accelerate the healing process. The treatment utilizing propolis is easy, inexpensive and does not seem to cause any side effects, therefore costs can be reduced to minimum. The few studies conducted in diabetic patients confirm the results obtained in laboratory animals.

Pro- and Anti-Angiogenic Factors: Their Relevance in Diabetic Foot Syndrome—A Review

Angiology ◽  
2021 ◽  
pp. 000331972110426
Author(s):  
Martyna Schönborn ◽  
Patrycja Łączak ◽  
Paweł Pasieka ◽  
Sebastian Borys ◽  
Anna Płotek ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Healing Process ◽  
Arterial Disease ◽  
Angiogenic Factors ◽  
Diabetic Foot Syndrome ◽  
Tissue Loss ◽  
Comprehensive Treatment ◽  
Diabetic Patients ◽  
Impaired Wound Healing ◽  
Peripheral Arterial

Peripheral arterial disease can involve tissue loss in up to 50% of patients with diabetic foot syndrome (DFS). Consequently, revascularization of narrowed or occluded arteries is one of the most common forms of comprehensive treatment. However, technically successful angioplasty does not always result in the healing of ulcers. The pathomechanism of this phenomenon is still not fully understood, but inadequate angiogenesis in tissue repair may play an essential role. Changes in pro- and anti-angiogenic factors among patients with DFS are not always clear and conclusive. In particular, some studies underline the role of decreased concentration of pro-angiogenic factors and higher levels of anti-angiogenic mediators. Nevertheless, there are still controversial issues, including the paradox of impaired wound healing despite high concentrations of some pro-angiogenic factors, dynamics of their expression during the healing process, and their mutual relationships. Exploring this process among diabetic patients may provide new insight into well-known methods of treatment and show their real benefits and chances for improving outcomes.

Association of traditional complementary and alternate medicine usage with quality of life of diabetic patients in a Malaysian tertiary hospital

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Chinedum Ogbonnaya Eleazu ◽  
Aniza Abd Aziz ◽  
Tay Chuu Suen ◽  
Lam Chun-Hau ◽  
Chin Elynn ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Diabetic Foot ◽  
Heart Diseases ◽  
Tertiary Hospital ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Diabetic Foot Ulcers ◽  
Content Type ◽  
Significant Difference

Purpose This study aims to design to assess the traditional, complementary and alternate medicine (TCAM) usage and its association with the quality of life (QOL) of Type 2 diabetic patients in a tertiary hospital (Hospital Universiti Sains Malaysia) in Malaysia. Design/methodology/approach A total of 300 respondents included in this study were divided into the following two major categories: TCAM (34.33% of respondents) and non-TCAM users (65.67% of the respondents), respectively. The mean ages of the respondents were 59.3 ± 10.2 for the TCAM users and 57.7 ± 12.0 for the non-TCAM users. Findings A greater percentage of non-TCAM users reported poor control of diabetes (14.7%) and blood glucose (55.8%) compared with the TCAM users (9.7% and 48.5%, respectively). Further, the diabetic patients on TCAM reported lower rates of coma, stroke and kidney problems but higher rates of diabetic foot ulcers, heart diseases and retinopathy than the non-TCAM users. Additionally, the diabetic patients with TCAM usage had a significantly better physical (p = 0.02) and overall (p = 0.03) qualities of life compared to the non-TCAM users. However, psychological, social and environmental health did not show any significant difference. Originality/value The prevalence of TCAM usage among diabetic patients was lower than in other comparable studies. Diabetic patients on TCAM reported lower rates of coma, stroke and kidney problems but higher rates of diabetic foot ulcers, heart diseases and retinopathy than the non-TCAM users. Further, diabetes patients on TCAM reported better QOL compared to non-TCAM users especially in terms of physical health.

scholarly journals Propolis as an Adjuvant in the Healing of Human Diabetic Foot Wounds Receiving Care in the Diagnostic and Treatment Centre from the Regional Hospital of Talca

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Verónica Mujica ◽  
Roxana Orrego ◽  
Roberto Fuentealba ◽  
Elba Leiva ◽  
Jessica Zúñiga-Hernández
Keyword(s):  
Diabetic Foot ◽  
Healing Process ◽  
Regional Hospital ◽  
Controlled Study ◽  
Serum Samples ◽  
Major Health Problem ◽  
Treatment Centre ◽  
Anti Inflammatory ◽  
Design And Methods

Objective. Diabetic foot wounds are a relevant diabetes complication and a major health problem. It has been described that propolis has health benefits due to its anti-inflammatory, antioxidant, and support in the healing process. The current study assessed the effect of propolis as an adjuvant in the healing of human diabetic foot ulcers. This was evaluated in a randomized placebo-controlled study of subjects receiving care in the Diagnostic and Treatment Centre from the Regional Hospital of Talca, Chile. Research Design and Methods. Randomized subjects received ambulatory healing treatment for diabetes foot wounds with propolis spray (3%), which was applied to cover the entire wound surface each time it was dressed from week 0 until cicatrization or 8 weeks as a maximum. Two serum samples were taken (day 0 and end of the study) for cytokine and oxidative stress analyses. Also, macro- and microscopy were analyzed in the process of wound healing. Results. The study comprised 31 subjects with type 2 diabetes in treatment for diabetic foot wounds in the Diagnostic and Treatment Centre from the Regional Hospital of Talca. Propolis promotes a reduction of the wound’s area by an average of 4 cm2, related to an increase in the connective tissue deposit compared to the control. Also, propolis increased the glutathione (GSH) and GSH/glutathione disulfide (GSSG) ratio (p<0.02), depleted tumor necrosis factor- (TNF-) α, and increased interleukin- (IL-) 10 levels. Topical propolis did not modify the biochemical parameters in the serum of the studied subjects. Conclusions. The topical use of propolis turned out to be an interesting therapeutic strategy as an adjuvant in the care of diabetes foot wounds due to its ability to improve and promote healing based on its anti-inflammatory and antioxidant profile. This trial is registered with NCT03649243.

scholarly journals A comparative study of foot infections in diabetic and non-diabetic patients with reference to etiopathogenesis, clinical features and outcome

2020 ◽  
Vol 7 (5) ◽  
pp. 1496
Author(s):  
Venkata Reddy M. ◽  
Varun Deep K. ◽  
Inamdar P.
Keyword(s):  
Hospital Stay ◽  
Clinical Features ◽  
Diabetic Foot ◽  
Healing Process ◽  
Significant Proportion ◽  
Diabetic Patients ◽  
Group A ◽  
Wagner’S Grade ◽  
Group B ◽  
Prolonged Hospital

Background: Infections in the foot are more common with significant proportion of world’s population remaining bare foot, minor skin trauma is a frequent cause of local infection. The present study was conducted with an aim to study various foot infections and compare the findings in diabetic and non diabetic patients with reference to etiopathogenesis, clinical features, management, duration of hospital stay and outcome.Methods: The present study was conducted in Mamata General Hospital, Khammam, Telangana state from October 2016 to September 2018. A total of 50 cases were divided into 2 groups, Group A included 25 patients with diabetic foot infection and Group B included 25 patients with non diabetic foot infections.Results: In diabetics 6th decade and in non-diabetics 4th-6th decade was the most common age group presenting with foot infections. Cellulitis of the foot was the most common in both diabetics (40%) and non-diabetics (52%). Wagner’s grade 4 lesions were more common in diabetics (28%) than in non-diabetics (8%). The most common site of lesion in diabetics was dorsum (40%) and in non-diabetics was toes (40%). The incidence of neuropathy was significantly higher in diabetics (72%) than in non-diabetics (20%). Rate of amputation was high in diabetics (12%) compared to non-diabetics (8%). The average number days in a hospital stay in diabetics was 42.27 days and in non-diabetics it was 28.96 days.Conclusion: Diabetic patients have increased severity of infections, delayed healing process, need more active interventions. As compared to the non-diabetic patients, they do show high risk of amputations and prolonged hospital stay.

Characteristics of microbial drug resistance and its correlates in chronic diabetic foot ulcer infections

2014 ◽  
Vol 63 (10) ◽  
pp. 1377-1385 ◽  
Author(s):  
Thokur S. Murali ◽  
Shettigar Kavitha ◽  
Jain Spoorthi ◽  
Deepika V. Bhat ◽  
Alevoor S. Bharath Prasad ◽  
...  
Keyword(s):  
Immune Response ◽  
Wound Healing ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Bacterial Strains ◽  
Microbial Drug Resistance

While virulence factors and the biofilm-forming capabilities of microbes are the key regulators of the wound healing process, the host immune response may also contribute in the events following wound closure or exacerbation of non-closure. We examined samples from diabetic and non-diabetic foot ulcers/wounds for microbial association and tested the microbes for their antibiotic susceptibility and ability to produce biofilms. A total of 1074 bacterial strains were obtained with staphylococci, Pseudomonas, Citrobacter and enterococci as major colonizers in diabetic samples. Though non-diabetic samples had a similar assemblage, the frequency of occurrence of different groups of bacteria was different. Gram-negative bacteria were found to be more prevalent in the diabetic wound environment while Gram-positive bacteria were predominant in non-diabetic ulcers. A higher frequency of monomicrobial infection was observed in samples from non-diabetic individuals when compared to samples from diabetic patients. The prevalence of different groups of bacteria varied when the samples were stratified according to age and sex of the individuals. Several multidrug-resistant strains were observed among the samples tested and most of these strains produced moderate to high levels of biofilms. The weakened immune response in diabetic individuals and synergism among pathogenic micro-organisms may be the critical factors that determine the delicate balance of the wound healing process.

scholarly journals Development of the composition and technology of effervescent tablets for the prevention of cerebral circulation disorders in the elderly

2021 ◽  
Vol 40 (2) ◽  
pp. 77-82
Author(s):  
Konstantin N. Listov ◽  
Roman A. Yakovlev
Keyword(s):  
Heart Diseases ◽  
Antioxidant Properties ◽  
The Elderly ◽  
Raw Material ◽  
Laboratory Animals ◽  
Small Laboratory ◽  
Human Lifespan ◽  
Age Related ◽  
Experimental Drug ◽  
Oncological Diseases

Increasing the level of antioxidants in the human body plays an important role in increasing longevity. Studies on small laboratory animals showed that in the main group with an increased content of antioxidant enzymes, life expectancy was 20% higher than in the comparison group with age and heart diseases. Thus, the hypothesis is confirmed that a high content of active free radical molecules causes aging and the data obtained on small laboratory animals will increase the human lifespan. This fact is associated with the occurrence of heart and oncological diseases, as well as other age-related pathologies. In order to prevent the development of the above diseases, a drug was developed with an innovative composition of complex-compatible components. The experimental drug contains substances with an increased content of antioxidants for the prevention of cerebrovascular accidents, such as dihydroquercetin and black grape extract. And also vitamins and amino acids: succinic acid, ascorbic acid, glycine. The choice of the composition of the experimental drug was carried out on the basis of the antioxidant properties of these groups of substances, which are widely known, and their combined use will become a potentiated synergy of the selected components and complement their effect. Due to the fact that the classical technology for the production of effervescent dosage forms does not allow combining the components of the composition of the experimental drug, the task of developing an individual technology for combining the acid and alkaline fractions of the formulation by separating the components at the stage of the technological process of drying the raw material was solved. Thanks to this, it became possible to separate the granulation of acid and alkaline components, which made it possible to stabilize the tabletting mixture (3 tables, bibliography: 8 refs.).

The role of the cord blood platelet gel in the management of a diabetic foot with tendon exposure

2021 ◽  
Author(s):  
Mafalda Massara ◽  
Giulia Pucci ◽  
Giuseppe Stilo ◽  
Antonino Alberti ◽  
Rosangela Surace ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Cord Blood ◽  
Diabetic Foot ◽  
Healing Process ◽  
Limb Ischemia ◽  
Blood Platelet ◽  
Arterial Disease ◽  
Diabetic Patients ◽  
Platelet Gel ◽  
Vital Functions

Diabetic foot infection is frequent in diabetic patients and is due to neuropathy, trauma or peripheral arterial disease. The presence of an abscess requires urgent drainage and specific antibiotic therapy. Patients with critical limb ischemia need revascularization and, subsequently the intervention of a plastic surgeon is often required in cases of exposure of tendons and ligaments. During the COVID-19 pandemic, a patient was refered to our department with an abscess on the dorsum of the left foot. After urgent drainage with tendon exposure, he started specific antibiotic therapy and underwent tibial vessels angioplasty. After infection healing cord blood platelet gel was applied, accelerating the healing process, with injection of its liquid part into the exposed tendons, thus retaining the vital functions of the tendons.

scholarly journals Targeting MMP-9 in Diabetic Foot Ulcers

2019 ◽  
Vol 12 (2) ◽  
pp. 79 ◽  
Author(s):  
Jeffrey I. Jones ◽  
Trung T. Nguyen ◽  
Zhihong Peng ◽  
Mayland Chang
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcers ◽  
Wound Healing Process ◽  
Diabetic Foot Ulcers ◽  
Novel Approach ◽  
Medical Need ◽  
Diabetic Wound Healing ◽  
Diabetic Wounds

Diabetic foot ulcers (DFUs) are significant complications of diabetes and an unmet medical need. Matrix metalloproteinases (MMPs) play important roles in the pathology of wounds and in the wound healing process. However, because of the challenge in distinguishing active MMPs from the two catalytically inactive forms of MMPs and the clinical failure of broad-spectrum MMP inhibitors in cancer, MMPs have not been a target for treatment of DFUs until recently. This review covers the discovery of active MMP-9 as the biochemical culprit in the recalcitrance of diabetic wounds to healing and targeting this proteinase as a novel approach for the treatment of DFUs. Active MMP-8 and MMP-9 were observed in mouse and human diabetic wounds using a batimastat affinity resin and proteomics. MMP-9 was shown to play a detrimental role in diabetic wound healing, whereas MMP-8 was beneficial. A new class of selective MMP-9 inhibitors shows clinical promise for the treatment of DFUs.

scholarly journals Antibacterial and anti-inflammatory activity of extracts and major constituents derived from Stachytarpheta indica Linn. leaves and their potential implications for wound healing

2021 ◽  
Author(s):  
Vajira Asela Agampodi ◽  
Peter Katavic ◽  
Christopher Collet ◽  
Trudi Collet
Keyword(s):  
Wound Healing ◽  
Plant Extracts ◽  
Colorimetric Assay ◽  
Morphological Changes ◽  
Healing Process ◽  
Human Keratinocytes ◽  
Wound Healing Process ◽  
Keratinocyte Proliferation ◽  
Anti Inflammatory ◽  
Treatment Of Wounds

Abstract Wounds of various types continue to have a severe socioeconomic impact on the cost of health care. Globally, there has been increased interest surrounding the identification of bioactive compounds that promote or modulate the wound healing process. Stachytarpheta indica Linn. is traditionally used to heal wounds and relieve inflammation, however, the theorised pharmacological properties have not yet been scientifically validated. In this study, dried and ground plant leaves were extracted with water and methanol, which were then subjected to various analyses. Antimicrobial activity of the plant extracts and isolated compounds was determined using well diffusion assays, while the minimum inhibitory concentrations were determined with a colorimetric assay. Morphological changes of human keratinocytes in response to plant extracts were observed with differential interference contrast microscope imaging. Cell viability, proliferation and migratory effects post-treatment with the plant extracts were also evaluated via colorimetric cytotoxicity assays and a real-time cell analyser protocol. Anti-inflammatory effects of plant extracts and isolated compounds were evaluated by flow cytometry and cyclooxygenase and lipoxygenase enzyme inhibition assays. Three active compounds i.e. ipolamiide, verbascoside and iso-verbascoside, were isolated from S. indica leaves. Verbascoside demonstrated broad-range antibacterial activity and imposed strong inhibition at 9.77 μg/mL against Staphylococci spp. S. indica extracts (0.1-0.2 mg/mL) were shown to improve human keratinocyte proliferation up to 60 % and induce morphological changes by producing cytoplasmic projections at concentrations higher than 0.4 mg/mL. Plant extracts (6.25-100 μg/mL) and individual compounds (3.125-50 μg/mL) elicited strong anti-inflammatory effects by suppressing the expression of interleukin-8 and inhibiting cyclooxygenase-1 and 5-lipoxygenase enzymes. Collectively, these results indicate that plant extracts and isolated compounds derived from S. indica have the potential to inhibit bacterial growth, promote tissue regeneration and reduce inflammation, hence, potentially providing the basis for a novel therapeutic for the treatment of wounds.

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