3D printing of hydroxyapatite polymer-based composites for bone tissue engineering

2017 ◽  
Vol 37 (8) ◽  
pp. 741-746 ◽  
Author(s):  
Carola Esposito Corcione ◽  
Francesca Gervaso ◽  
Francesca Scalera ◽  
Francesco Montagna ◽  
Tommaso Maiullaro ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Graft Substitute ◽  
Physical Models ◽  
Clinical Images ◽  
Manufacturing Method ◽  
Skeletal Defects ◽  
Custom Made ◽  
Aesthetic Aspect ◽  
Valid Solution ◽  
Bone Structures

Abstract Skeletal defects reconstruction, using custom-made substitutes, represents a valid solution to replacing lost and damaged anatomical bone structures, renew their original function, and at the same time, restore the original aesthetic aspect. Rapid prototyping (RP) techniques allow the construction of complex physical models based on 3D clinical images. However, RP machines usually work with synthetic polymers; therefore, producing custom-made scaffolds using a biocompatible material directly by RP is an exciting challenge. The aim of the present work is to investigate the potentiality of 3D printing as a manufacturing method to produce an osteogenic hydroxyapatite-polylactic acid bone graft substitute.

Custom Designed Orthodontic Attachment Manufactured Using a Biocompatible 3D Printing Material

2017 ◽  
Vol 54 (4) ◽  
pp. 757-758
Author(s):  
Riham Nagib ◽  
Camelia Szuhanek ◽  
Bogdan Moldoveanu ◽  
Meda Lavinia Negrutiu ◽  
Cosmin Sinescu ◽  
...  
Keyword(s):  
3D Printing ◽  
Treatment Planning ◽  
Computer Tomography ◽  
Volumetric Data ◽  
Impacted Teeth ◽  
3D Printing Technology ◽  
Custom Design ◽  
Custom Made ◽  
Materials Used ◽  
Orthodontic Forces

Treatment of impacted teeth often implies placing a bonded attachment and using orthodontic forces to move the tooth into occlusion. The aim of the paper is to describe a novel methodology of manufacturing orthodontic attachments for impacted teeth using the latest CAD software and 3D printing technology. A biocompatible acrylic based resin was used to print a custom made attachment designed based on the volumetric data aquired through cone bean computer tomography. Custom design of the attachment simplified clinical insertion and treatment planning and 3D printing made its manufacturing easier. Being a first trial, more reasearch is needed to improve the methodology and materials used.

scholarly journals 3D Printed Clamps for In Vitro Tensile Tests of Human Gracilis and the Superficial Third of Quadriceps Tendons

2021 ◽  
Vol 11 (6) ◽  
pp. 2563
Author(s):  
Ivan Grgić ◽  
Vjekoslav Wertheimer ◽  
Mirko Karakašić ◽  
Željko Ivandić
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Tensile Tests ◽  
Biomechanical Properties ◽  
Testing Procedure ◽  
Laboratory Equipment ◽  
Fused Deposition ◽  
Custom Made ◽  
3D Printed

Recent soft tissue studies have reported issues that occur during experimentation, such as the tissue slipping and rupturing during tensile loads, the lack of standard testing procedure and equipment, the necessity for existing laboratory equipment adaptation, etc. To overcome such issues and fulfil the need for the determination of the biomechanical properties of the human gracilis and the superficial third of the quadriceps tendons, 3D printed clamps with metric thread profile-based geometry were developed. The clamps’ geometry consists of a truncated pyramid pattern, which prevents the tendons from slipping and rupturing. The use of the thread application in the design of the clamp could be used in standard clamping development procedures, unlike in previously custom-made clamps. Fused deposition modeling (FDM) was used as a 3D printing technique, together with polylactic acid (PLA), which was used as a material for clamp printing. The design was confirmed and the experiments were conducted by using porcine and human tendons. The findings justify the usage of 3D printing technology for parts manufacturing in the case of tissue testing and establish independence from the existing machine clamp system, since it was possible to print clamps for each prepared specimen and thus reduce the time for experiment setup.

Proposal of custom made wrist orthoses based on 3D modelling and 3D printing

2017 ◽  
Author(s):  
Mauren Abreu de Souza ◽  
Cristiane Schmitz ◽  
Marcelo Marega Pinhel ◽  
Joao A. Palma Setti ◽  
Percy Nohama
Keyword(s):  
3D Printing ◽  
3D Modelling ◽  
Custom Made

scholarly journals Application of 3D printing and distributed manufacturing during the first-wave of COVID-19 pandemic. Our experience at a third-level university hospital.

2020 ◽  
Author(s):  
Ruben Perez-Mañanes ◽  
Sonia García de San José ◽  
Manuel Desco-Menéndez ◽  
Ignacio Sánchez-Arcilla ◽  
Esmeralda González-Fernández ◽  
...  
Keyword(s):  
3D Printing ◽  
Hospital Environment ◽  
Production Model ◽  
Maximum Efficiency ◽  
Special Importance ◽  
Distributed Manufacturing ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Custom Made

Abstract Background 3D printing and distributed manufacturing represent a paradigm shift in the health system that is becoming critical during the COVID-19 pandemic. University hospitals are also taking on the role of manufacturers of custom-made solutions thanks to 3D printing technology. Case Presentation We present a monocentric observational case study regarding the distributed manufacturing of three groups of products during the period of the COVID-19 pandemic from 14 March to 10 May 2020: personal protective equipment, ventilatory support, and diagnostic and consumable products. Networking during this period has enabled the delivery of a total of 17,276 units of products manufactured using 3D printing technology. The most manufactured product was the face shields and ear savers, while the one that achieved the greatest clinical impact was the mechanical ventilation adapters and swabs. The products were manufactured by individuals in 57.3% of the cases, and our hospital acted as the main delivery node in a hub with 10 other hospitals. The main advantage of this production model is the fast response to stock needs, being able to adapt almost in real time.Conclusions The role of 3D printing in the hospital environment allows the reconciliation of in-house and distributed manufacturing with traditional production, providing custom-made adaptation of the specifications, as well as maximum efficiency in the working and availability of resources, which is of special importance at critical times for health systems such as the current COVID-19 pandemic.

scholarly journals Early Outcomes of Patient-Specific Modular Cones for Substitution of Methaphysial and Diaphysial Bone Defects in Revision Knee Arthroplasty

2019 ◽  
Vol 25 (2) ◽  
pp. 9-18 ◽  
Author(s):  
A. A. Cherny ◽  
A. N. Kovalenko ◽  
S. S. Bilyk ◽  
A. O. Denisov ◽  
A. V. Kazemirskiy ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Scoring Systems ◽  
Bone Defects ◽  
Patient Specific ◽  
Implant Fixation ◽  
Diaphyseal Bone ◽  
Custom Made ◽  
The Stability ◽  
Valid Solution

The aim of this study was the assessment of early outcomes of patient-specific three-dimensional titanium cones with specified porosity parameters to compensate for extensive metaphysical-diaphyseal bone defects in RTKA.Materials and Methods. Since 2017 till 2019 30 patient-specific titanium cones (12 femoral and 18 tibial) implanted during 26 RTKAS. Clinical outcomes evaluated using KSS, WOMAC and fjS-12 scoring systems on average 10 (2–18) months after surgery. At the same time the stability of implant fixation analyzed using frontal, lateral and axial knee roentgenograms.Results. During all procedures there were no technical difficulties in positioning and implantation of custom-made titanium cones. At the time of preparation of the publication, none of the patients had indications for further surgical intervention, as well as intra- and postoperative complications. Six months after surgery all scores improved significantly: KSS from 23 (2–42, SD 19.96) to 66.5 (62–78, SD 7.68), WOMAC from 59 (56–96, SD 28.31) to 32.25 (19–46, SD 11.76), the index FJS-12 was 29.16 points (0–68.75, SD 30.19). The average scores continued to improve up to 18 months: KSS — 97.5 (88–108, SD 9.14), WOMAC — 16.5 (9–24, SD 6.45), FJS-12 — 45.85 (25–75, SD 22.03). No radiolucent lines were noticed during this period of observation.Conclusion. The original additive technology of designing and producing patient-specific titanium cones for compensation of extensive metaphyseal-diaphyseal bone defects in RTKA is a valid solution at least in the short term. A longer follow-up period is required to assess its medium-and long-term reliability compared to existing alternative surgical solutions.

scholarly journals 3D Printed Model of Airway for Clinical Simulation

2020 ◽  
Vol 8 (2) ◽  
pp. 50-56
Author(s):  
Maheswaran Viyannan ◽  
Pananghat A. Kumar ◽  
Sreedharkumar Eswarswamy ◽  
Gunaseelan Murugesan ◽  
Karthikeyan Ramaraju
Keyword(s):  
3D Printing ◽  
Medical Curriculum ◽  
Functional Model ◽  
Tracheobronchial Tree ◽  
Training System ◽  
Physical Models ◽  
Printing Technology ◽  
Clinical Simulation ◽  
3D Printing Technology ◽  
Axial Ct

Background: The present medical curriculum aims at training the students to be proficient in performing techniques required for clinical practice. This is best achieved through clinical simulation, which has emerged as a successful method for clinical learning. Residents in respiratory medicine need to be trained in the procedure of bronchoscopy for which a functional model of the airway is required. Airway mannequins for this purpose can be produced using 3D printing technology, which involves the usage of sophisticated software. Subjects and Methods: Serial axial CT images of the chest, revealing details of the respiratory tract were selected as the base resource to recreate the bronchial tree by 3D printing. This DICOM (Digital Imaging and Communications in Medicine) images after conversion into STL (Stero lithography) format were transferred into a 3D printer and physical models were made from these data, using Vero clear and rubber. This model which had a life-like form and consistency required for practicing the skill was connected to an airway mannequin using an adaptor to practice the skill. Conclusions: Axial CT scan images provide the base data for reconstructing the airway of a patient, using 3D printing technology and appropriate software. Such reconstructions can be used to produce a functional model of the airway, which can be used for training in bronchoscopy. The training system could be connected to a monitor thereby facilitating tracking of the probe of the bronchoscope. Repeated trials make the trainees perfect their technique. Our attempt to replicating the tracheobronchial tree for such training has been a success.

scholarly journals Transfiguring Healthcare: Three-Dimensional Printing in Pharmaceutical Sciences; Trends during COVID-19: A Review

2021 ◽  
pp. 207-218
Author(s):  
K. G. Siree ◽  
T. M. Amulya ◽  
T. M. Pramod Kumar ◽  
S. Sowmya ◽  
K. Divith ◽  
...  
Keyword(s):  
3D Printing ◽  
Medical Devices ◽  
Three Dimensional ◽  
Pharmaceutical Sciences ◽  
Three Dimensional Printing ◽  
Custom Made ◽  
High Degree ◽  
The Impact ◽  
Dimensional Printing ◽  
Shed Light

Three-dimensional (3D) printing is a unique technique that allows for a high degree of customisation in pharmacy, dentistry and in designing of medical devices. 3D printing satiates the increasing exigency for consumer personalisation in these fields as custom-made medicines catering to the patients’ requirements are novel advancements in drug therapy. Current research in 3D printing indicates towards reproducing an organ in the form of a chip; paving the way for more studies and opportunities to perfecting the existing technique. In addition, we will also attempt to shed light on the impact of 3D printing in the COVID-19 pandemic.

Thermoplastic 3D Printing-An Additive Manufacturing Method for Producing Dense Ceramics

2014 ◽  
Vol 12 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Uwe Scheithauer ◽  
Eric Schwarzer ◽  
Hans-Jürgen Richter ◽  
Tassilo Moritz
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Manufacturing Method

3D Printing of Medical Models: A Literature Review

2017 ◽  
Author(s):  
Xingjian Wei ◽  
Li Zeng ◽  
Zhijian Pei
Keyword(s):  
3D Printing ◽  
Literature Review ◽  
Medical Curriculum ◽  
Industrial Applications ◽  
Physical Models ◽  
Research Directions ◽  
Anatomical Structures ◽  
Medical Models ◽  
3D Printed ◽  
Anatomy Teaching

Medical models are physical models of human or animal anatomical structures such as skull and heart. Such models are used in simulation and planning of complex surgeries. They can also be utilized for anatomy teaching in medical curriculum. Traditionally, medical models are fabricated by paraffin wax or silicone casting. However, this method is time-consuming, of low quality, and not suitable for personalization. Recently, 3D printing technologies are used to fabricate medical models. Various applications of 3D printed medical models in surgeries and anatomy teaching have been reported, and their advantages over traditional medical models have been well-documented. However, 3D printing of medical models bears some special challenges compared to industrial applications of 3D printing. This paper reviews more than 50 publications on 3D printing of medical models between 2006 and 2016, and discusses knowledge gaps and potential research directions in this field.

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