The effects of Juglans regia L. (walnut) extract on certain biochemical paramaters and in the prevention of tissue damage in brain, kidney, and liver in CCl4 applied Wistar rats

2015 ◽  
Vol 40 (3) ◽  
Author(s):  
Sevinç Aydın ◽  
Zehra Gökçe ◽  
Ökkeş Yılmaz
Keyword(s):  
Fatty Acids ◽  
Carbon Tetrachloride ◽  
Tissue Damage ◽  
Wistar Rats ◽  
Juglans Regia ◽  
Male Rats ◽  
Protective Effects ◽  
The Brain ◽  
Wistar Male Rats ◽  
Liver Tissues

AbstractObjective: The purpose of this study is to demonstrate protective effects of walnut samples on CClMethods: Walnut fruits were extracted and then subjected to vitamin and flavonoid analyses. The extracts obtained were injected intraperitoneally every other day to Wistar male rats given carbon tetrachloride (CClResults: Given the results achieved, it was found that the levels of fatty acids increased in the brain and kidney tissues after CClConclusion: Our data indicates that walnut extract has protective effects against LPO formation in the brain, kidney and liver tissues.

Protective effect of vanillin against carbon tetrachloride (CCl4)-induced oxidative brain injury in rats

2011 ◽  
Vol 28 (7) ◽  
pp. 655-662 ◽  
Author(s):  
Mohamed Makni ◽  
Yassine Chtourou ◽  
Mohamed Barkallah ◽  
Hamadi Fetoui
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Brain Damage ◽  
Glutathione Transferase ◽  
Single Injection ◽  
Male Rats ◽  
Control Group ◽  
Protective Effects ◽  
Degree Of Protection ◽  
Oxidative Brain Injury

This study investigated the protective effects of vanillin against acute brain damage induced by carbon tetrachloride (CCl4) in rats. The study was performed on 32 male rats divided into four groups: a control group, vanillin group ([Va] 150 mg/kg/day, intraperitoneally [i.p.]) and CCl4 toxication groups received a single injection of CCl4 (1 ml/kg, i.p.; CCl4 and Va + CCl4 groups). The degree of protection in brain tissue was evaluated by the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase, glutathione transferase, glutathione peroxidase and nitric oxide (NO). Vanillin showed a significant brain-protective effect by decreasing the level of lipid peroxidation and NO2 and elevated the activities of antioxidative enzymes and level of GSH. Consequently vanillin blocked oxidative brain damage induced by CCl4 in rats.

scholarly journals The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet

2019 ◽  
Vol 56 (2) ◽  
pp. 337-340
Author(s):  
Daniela Miricescu ◽  
Daniela Gabriela Balan ◽  
Catalina Radulescu ◽  
Radu Radulescu ◽  
Iulia-Ioana Stanescu ◽  
...  
Keyword(s):  
Vitamin E ◽  
Drug Delivery Systems ◽  
Wistar Rats ◽  
Male Rats ◽  
Control Group ◽  
Daily Dose ◽  
Hypercaloric Diet ◽  
Antioxidant Effects ◽  
Wistar Male Rats ◽  
Biomarkers Of Oxidative Stress

PLGA (Poli-lactic-co-glycolic acid) nanoparticles (NPs) are curently used as drug delivery systems for many types of drugs including antioxidants such as vitamin E. The main aim of our study was to test the antioxidant effects of PLGA-vitamin E on Wistar male rats. Two groups of Wistar rats received a hypercaloric diet for 21 days: the first group received besides the hypercaloric diet a daily dose of PLGA loaded with vitamin E and the control group received only the hypercaloric diet. Spleen cellular lysate has been used to detect biomarkers of oxidative stress such as malondialdehyde, glutathione, advanced human oxidative protein and vitamin E. After 3 weeks of treatment, statistical significant changes have been detected between the two groups.

The role of Echinacea extract to protect the damage effects of gammaradiation on some biochemical constituents in male albino rats

2016 ◽  
Author(s):  
A. G. Ahmed ◽  
Nahed Abdelaziz ◽  
H. M. El-Shennawy ◽  
A. N. El Shahat ◽  
R. G. Hamza
Keyword(s):  
Tissue Damage ◽  
Male Rats ◽  
Albino Rats ◽  
Protective Effects ◽  
Severe Damage ◽  
Biochemical Alterations ◽  
Radiation Induced ◽  
Effects Of Radiation ◽  
Echinacea Extract

The present study was designed to determine the possible protective effects of E. purpurea extracts (EPE) against gamma (g-) radiation exposure (6Gy) induced biochemical alterations and oxidative tissue damage (liver and testes) in male rats given EPE (100 mg/kg/day for 8 weeks) prior to g-irradiation. It has been found that g-irradiation led to hepatic and testicular oxidative stress with concomitant increase in liver function enzymes. Serum lipid profile and hormone level has also been found altered. Rats dosed with EPE before exposure to g-rays showed significantly less severe damage and remarkable improvement in all of the measured parameters when compared to irradiated rats. It could be concluded that EPE attenuates the deleterious effects of radiation-induced biochemical disorders and tissue damage (liver and testes).

Camel milk and bee honey regulate profibrotic cytokine gene transcripts in liver cirrhosis induced by carbon tetrachloride

2016 ◽  
Vol 94 (11) ◽  
pp. 1141-1150 ◽  
Author(s):  
Kadry Sadek ◽  
Doha Beltagy ◽  
Ebeed Saleh ◽  
Reham Abouelkhair
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Antioxidant Properties ◽  
Resistance Index ◽  
Camel Milk ◽  
Male Rats ◽  
Protective Effects ◽  
Cytokine Gene ◽  
Glucose Levels ◽  
Gene Transcripts

The lack of studies regarding the mechanism of the protective effects of camel milk and bee honey against hepatotoxic compounds led us to perform this study. Thirty-six male rats were divided into two main groups. The first group (n = 9) comprised control non-cirrhotic rats. The rats of the second group (n = 27) were administered carbon tetrachloride (CCl4) by intraperitoneal injection to induce liver cirrhosis. The cirrhotic rats were then divided into three equal subgroups, each comprising nine animals, as follows: (i) cirrhotic rats, (ii) cirrhotic rats treated with camel milk, and (iii) cirrhotic rats treated with camel milk and bee honey. The present findings revealed that CCl4 elevated the activities of liver enzymes, blood glucose levels, non-esterified fatty acids (NEFA) in the serum and glycogen content in the liver. On the other hand, CCl4 significantly decreased phosphorylase activity in the liver tissue and significantly increased carbohydrate intolerance and insulin resistance index (HOMA-IR). Moreover, CCl4 induced a significant increase in oxidative stress, along with increased expression of the profibrotic cytokine genes TNF-α and TGF-β. However, camel milk either alone or in combination with bee honey ameliorated these toxic actions. The antioxidant properties of these protective agents and their effects of downregulating certain procirrhotic cytokine gene transcripts underlie this protection.

Catecholamine turnover in the brain and the regulation of luteinizing hormone and corticosterone in starved male rats

1982 ◽  
Vol 100 (2) ◽  
pp. 168-176 ◽  
Author(s):  
K. M. Pirke ◽  
B. Spyra
Keyword(s):  
Luteinizing Hormone ◽  
Wistar Rats ◽  
Preoptic Area ◽  
Plasma Corticosterone ◽  
Male Rats ◽  
Dopamine Turnover ◽  
Noradrenergic Neurons ◽  
Catecholamine Turnover ◽  
Male Wistar Rats ◽  
The Brain

Abstract. The effect of starvation was studied in male Wistar rats. After only 2 days of food deprivation, LH concentrations in serum are greatly suppressed, while a significant increase in plasma corticosterone occurs after 5 days' starvation. The noradrenaline and dopamine turnover in the basal hypothalamus is decreased after 2 days. The catecholamine turnover is also reduced in the preoptic area, and in the median eminence. Injection of the catecholamine precursor l-dopa (100 mg/kg) can prevent the increase of plasma corticosterone, but not the decrease of LH. The α-agonist clonidine (150 μg/kg), but neither the β-agonist salbutamol (0.5 mg/kg), nor the dopamine agonist apomorphine (1.0 mg/kg) can prevent the starvation induced corticosterone increase. The decrease of plasma LH is not influenced by the dopamine or noradrenaline agonists. From these data, it appears that a decreased activity of noradrenergic neurons may be responsible for the corticosterone increase in the plasma of starved rats.

scholarly journals Study of Protective Effects of Gold Nano Particles on the Liver Toxicity Induced by Carbon-Tetrachloride (CCl4) in Male Rats

2017 ◽  
Vol 19 (7) ◽  
Author(s):  
Mohammad Reza Shahraki ◽  
Hamideh Mirshekari ◽  
Fereshteh Badini ◽  
Mohammad Reza Arab ◽  
Elham Shahraki
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Toxicity ◽  
Nano Particles ◽  
Male Rats ◽  
Protective Effects ◽  
Gold Nano Particles

Protective Effects of Purple Grape Juice on Carbon Tetrachloride-Induced Oxidative Stress in Brains of Adult Wistar Rats

2008 ◽  
Vol 11 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Caroline Dani ◽  
Matheus A.B. Pasquali ◽  
Marcos R. Oliveira ◽  
Fernanda M. Umezu ◽  
Mirian Salvador ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Grape Juice ◽  
Protective Effects
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