Macro-aspartate aminotransferase (AST): a case report / Makro aspartat aminotransferaz (AST): Bir olgu takdimi

2016 ◽  
Vol 41 (1) ◽  
Author(s):  
Ümmügülsüm Can ◽  
Ersin Sayar ◽  
Muhittin A. Serdar
Keyword(s):  
Case Report ◽  
Polyethylene Glycol ◽  
Physical Examination ◽  
Aspartate Aminotransferase ◽  
Diagnostic Tests ◽  
Present Report ◽  
Evaluation Process ◽  
Reference Interval ◽  
Test Results ◽  
Laboratory Test Results

AbstractAspartate aminotransferase (AST) macroenzyme leads to an increase in AST without the presence of any disease. In present report, an isolated increase of AST was detected in a 6-year old girl following the investigations prior to tonsillectomy. As to her history, physical examination and other laboratory test results, no abnormal findings were detected. AST levels were measured as 591 IU/L and 585 IU/L after repeated tests. While found as <5.4 IU/L (recovery <0.8%, reference interval 42.0-82.2%) after polyethylene glycol (PEG) precipitation, AST was determined as 561 IU/L (recovery 95.4%) as a result of the assessment performed with non-specific human antimouse antibodies (HAMA). No diseases were encountered in the patient, and reason for the increase of AST was considered to be macroAST. Because continuously increased enzyme value may lead to various invasive and expensive diagnostic tests, macroAST should be taken into account in the evaluation process.

scholarly journals Personalized Reference Intervals in Laboratory Medicine: A New Model Based on Within-Subject Biological Variation

2020 ◽  
Author(s):  
Abdurrahman Coşkun ◽  
Sverre Sandberg ◽  
Ibrahim Unsal ◽  
Coskun Cavusoglu ◽  
Mustafa Serteser ◽  
...  
Keyword(s):  
Steady State ◽  
Personalized Medicine ◽  
Clinical Chemistry ◽  
Reference Interval ◽  
Reference Intervals ◽  
Biological Variation ◽  
Test Results ◽  
Steady State Condition ◽  
Laboratory Test Results ◽  
Measurement Results

Abstract Background The concept of personalized medicine has received widespread attention in the last decade. However, personalized medicine depends on correct diagnosis and monitoring of patients, for which personalized reference intervals for laboratory tests may be beneficial. In this study, we propose a simple model to generate personalized reference intervals based on historical, previously analyzed results, and data on analytical and within-subject biological variation. Methods A model using estimates of analytical and within-subject biological variation and previous test results was developed. We modeled the effect of adding an increasing number of measurement results on the estimation of the personal reference interval. We then used laboratory test results from 784 adult patients (&gt;18 years) considered to be in a steady-state condition to calculate personalized reference intervals for 27 commonly requested clinical chemistry and hematology measurands. Results Increasing the number of measurements had little impact on the total variation around the true homeostatic set point and using ≥3 previous measurement results delivered robust personalized reference intervals. The personalized reference intervals of the study participants were different from one another and, as expected, located within the common reference interval. However, in general they made up only a small proportion of the population-based reference interval. Conclusions Our study shows that, if using results from patients in steady state, only a few previous test results and reliable estimates of within-subject biological variation are required to calculate personalized reference intervals. This may be highly valuable for diagnosing patients as well as for follow-up and treatment.

scholarly journals The Flipside of Eradicating a Disease; Human African Trypanosomiasis in a Woman in Rural Democratic Republic of Congo: A Case Report

2019 ◽  
Vol 4 (4) ◽  
pp. 142 ◽  
Author(s):  
Junior Mudji ◽  
Jonathan Benhamou ◽  
Erick Mwamba-Miaka ◽  
Christian Burri ◽  
Johannes Blum
Keyword(s):  
Case Report ◽  
Sleep Disorder ◽  
Human African Trypanosomiasis ◽  
Democratic Republic Of Congo ◽  
Disease Diagnosis ◽  
Tsetse Flies ◽  
Test Results ◽  
African Trypanosomiasis ◽  
Laboratory Test Results ◽  
Two Phases

Human African Trypanosomiasis (HAT) is a neglected disease caused by the protozoan parasites Trypanosoma brucei and transmitted by tsetse flies that progresses in two phases. Symptoms in the first phase include fever, headaches, pruritus, lymphadenopathy, and in certain cases, hepato- and splenomegaly. Neurological disorders such as sleep disorder, aggressive behavior, logorrhea, psychotic reactions, and mood changes are signs of the second stage of the disease. Diagnosis follows complex algorithms, including serological testing and microscopy. Our case report illustrates the course of events of a 41-year old woman with sleep disorder, among other neurological symptoms, whose diagnosis was made seven months after the onset of symptoms. The patient had consulted two different hospitals in Kinshasa and was on the verge of being discharged from a third due to negative laboratory test results. This case report highlights the challenges that may arise when a disease is on the verge of eradication.

scholarly journals Application of Neural Networks in the Tests of Hand Grenade Fuses

2019 ◽  
Vol 68 (1) ◽  
pp. 197-212
Author(s):  
Dariusz Ampuła
Keyword(s):  
Neural Networks ◽  
Artificial Neural Networks ◽  
Diagnostic Tests ◽  
Evaluation Method ◽  
Empirical Test ◽  
Evaluation Process ◽  
Test Results ◽  
Linear Character ◽  
Wide Range ◽  
Artificial Neural

The neural networks, which find currently use in the unusually wide range of problems, in such fields as: finance, medicine, geology or physics, were characterized in the article. It was accent, that neural networks are very sophisticated technique of modelling, able to map extremely complex functions. It was noticed particularly, that neural networks had a non-linear character, what very essentially improve the possibilities of their applications. Some previous applications of neural networks were introduced, both in the area of domestic and foreign, including also military applications. The fuse of UZRGM type (Universal Modernized Fuse of Hand Grenades) was characterized, describing his building and way of action, special attention-getting on the tested features during laboratory diagnostic tests. Necessary technical parameters for the first and the second laboratory diagnostic tests, whose purpose was to build two independent neural networks, on the basis of existing test results and undertaken post-diagnostic decisions were designed. A few artificial neural networks were made and finally the best two independent neural networks were chosen. The main parameters of the chosen active neural networks were introduced in the pictures. Concise information, relating to the built artificial neural networks, for the first and the second laboratory diagnostic tests of the fuses of UZRGM type, was presented in the end of the article. In the summary, clearly distinguished are advantages of the applications of the proposed evaluation method, which significantly shortens an evaluation process of new empirical test results and causes complex automatization of an evaluation process of the tested fuses. Keywords: artificial intelligence, neural networks, activation function, hidden neurons, fuse.

scholarly journals A case of urticaria multiforme with unusual presentation

2019 ◽  
Vol 6 (6) ◽  
pp. 1946
Author(s):  
Mohammad S. Alkhowailed
Keyword(s):  
Case Report ◽  
Physical Examination ◽  
Erythema Multiforme ◽  
Case History ◽  
Diagnostic Tests ◽  
Clinical Manifestations ◽  
Unusual Presentation ◽  
Effective Management ◽  
Urticarial Vasculitis ◽  
Wide Range

Urticaria multiforme is a condition which manifests as acute, polycyclic, annular oedematous pink plaques with an ecchymosis hue that is associated with acral edema. The condition is often misdiagnosed as erythema multiforme, serum-sickness-like reactions, or urticarial vasculitis. Author present a case of acute annular urticaria in a 3-year-old girl who presented with unusual clinical manifestations of the condition. Through this case report, Author aim to emphasize the wide range of morphologic manifestations that can be seen in urticaria multiforme. This can assist pediatric physicians to differentiate urticaria multiforme from other clinical dermatologic conditions and prevent misdiagnosis. A detailed case history and physical examination, along with relevant diagnostic tests can enable prompt and effective management of the condition.

scholarly journals Déjà vu phenomenon as symptom of temporal lobe epilepsy in eight-year-old girl: A case report

2020 ◽  
Vol 11 (1) ◽  
pp. 90-95
Author(s):  
Goran Popović ◽  
Ranka Mirković ◽  
Dejan Bokonjić ◽  
Biljana Milinković ◽  
Tatjana Gavrilović-Elez
Keyword(s):  
Case Report ◽  
Physical Examination ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Diagnostic Tests ◽  
Epileptic Activity ◽  
Epileptic Discharges ◽  
Deja Vu ◽  
Déjà Vu ◽  
The Right

Introduction. Deja vu (franc. Déjà vu) is a phenomenon experienced by two thirds of all people. However, this phenomenon can follow aura during the temporal lobe epilepsy. It is believed that it originates from hippocampus, which plays a major role in generating epileptic discharges. Some authors emphasize that in these patients déjà vu phenomenon is not an aura but rather it sometimes refers to the attack itself. Method. In this case report, an eightyear-old girl suffering from repeated crisis of consciousness is described. Case report. The aim of the study was to present the case of an eightyearold girl who underwent three crisis of consciousness, headache behind the forehead as well as the repeated déjà vu phenomenon. The girl was hospitalized, after which medical history was taken and physical examination, as well as other diagnostic tests, were performed. EEG recording revealed an increased electrocortical epileptic activity above the right frontotemporal region. An antiepileptic therapy (Karbapin) leading to attack control was introduced. Conclusion. It is necessary to give temporal lobe epilepsy in children with déjà vu phenomenon serious consideration.

scholarly journals COVID-19 and Sickle Cell Disease in PICU: Case Report

2020 ◽  
Vol 1 (2) ◽  
Author(s):  
Letícia de Paula Tonial ◽  
Bruno Silva Miranda ◽  
Joelmy Robert Beleza da Silva ◽  
Claudia Moreira de Sousa ◽  
Valeria Cabral Neves Luszcynski ◽  
...  
Keyword(s):  
Case Report ◽  
Physical Examination ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Present Report ◽  
Functional Limitations ◽  
Pediatric Intensive Care ◽  
Early Mobilization ◽  
Signs And Symptoms ◽  
Bed Rest

Sars-Cov 2 viral infection can cause an intense inflammatory reaction, hypoxemia and acute respiratory failure. The disease spreads more easily in chronic comorbidities, such as sickle cell anemia and overweight. Among the various professionals involved in the recovery of patients with Covid-19, the role of the physiotherapist stands out, not only for acting in the management of the disease but also for preventing and rehabilitating the respiratory deficiencies and the functional limitations caused by it. The present report aims to elucidate the multidisciplinary work carried out in the patient with overweight and sickle cell anemia during the period of hospitalization in the Pediatric Intensive Care Unit by Covid-19. This is an observational, longitudinal single-arm case report. The patient’s medical data collection was carried out retrospectively through record, including anamnesis reports, physical examination, and multi-professional procedures used from admission to discharge, including anamnesis reports, physical examination, and multi-professional procedures used from admission to discharge. The present study is a rare case of pediatric Covid-19 with severe signs and symptoms. The treatment performed by the multidisciplinary team resulted in a favorable outcome since the beginning of hospitalization. Physiotherapy, including early mobilization and rehabilitation may help prevent or mitigate sequelae related to bed rest, thus improving physical function and outcomes and reducing length of stay by increasing ventilator free-days.

scholarly journals Feline plasm cell pododermatitis: case report

2020 ◽  
Vol 14 (4) ◽  
pp. 220-225
Author(s):  
Adriane Strack ◽  
Luana Moretto ◽  
Carla Di Concilio ◽  
Francielli Cordeiro Zimermann ◽  
Adriano Tony Ramos ◽  
...  
Keyword(s):  
Case Report ◽  
Physical Examination ◽  
Present Report ◽  
Clinical History ◽  
Histopathological Diagnosis ◽  
Veterinary Clinic ◽  
Immune Mediated ◽  
Mixed Breed ◽  
History Of

Feline Plasmacytic Pododermatitis is an uncommon dermatological disorder that affects one or multiple paw pads and leads to swelling, ulceration, hemorrhage, scaling, erythema, and striation. Its etiopathogenesis is poorly understood, however, an immune-mediated basis is strongly suggested. A two-year-old neutered, mixed breed, male cat was referred to the Veterinary Clinic of the Federal University of Santa Catarina (UFSC), Curitibanos Campus, with a brief clinical history of progressive lesions on palmar and plantar pads for one month. On physical examination, the patient had enlarged popliteal and inguinal lymph nodes, and paw pads with thin, swollen, hyperemic, erythematous, and purple color skin with multiple white striations. Histopathological diagnosis confirmed plasmacytic pododermatitis, and glucocorticoid therapy with prednisolone was prescribed. In the present report, the patient's clinical follow-up was compromised, as the tutor did not perform the prescribed treatment and did not return with the animal for further evaluations.

scholarly journals Sialocele in the cat. A report of 2 cases

2018 ◽  
Vol 66 (3) ◽  
pp. 141 ◽  
Author(s):  
V. TSIOLI (Β. ΤΣΙΩΛΗ) ◽  
G. BRELLOU (Γ. ΜΠΡΕΛΛΟΥ) ◽  
C. SIZIOPKOU (Χ. ΣΙΖΙΟΠΚΟΥ) ◽  
M. VAMVAKEROU (Μ. ΒΑΜΒΑΚΕΡΟΥ) ◽  
V. GEORGAKI (Β. ΓΕΩΡΓΑΚΗ) ◽  
...  
Keyword(s):  
Viscous Fluid ◽  
Physical Examination ◽  
Histopathological Examination ◽  
Lateral Approach ◽  
Sublingual Gland ◽  
Test Results ◽  
Laboratory Test Results ◽  
Cervical Swelling ◽  
Excised Tissues

In the present article the history, physical examination findings, laboratory test results, treatment, follow up and outcome of 2 cats with sialoceles were reported. Both cats were presented with a painless fluctuant cervical swelling. In one cat a ranula was also present. Aspiration of the swellings detected highly viscous fluid and cytology of the aspirates was consistent with the appearance of saliva. A diagnosis of sialocele was made. Both cats were managed by resection of the mandibular and sublingual gland complex through a lateral approach. In case 2 marsupialization of the ranula was also performed. The histopathological examination of the excised tissues in one cat was compatible with chronic inflammation of the mandibular and sublingual gland. The outcome was favorable in both cases and no relapses were detected after a mean follow up time of 13 months.

scholarly journals Cerebral Venous Sinus Thrombosis, Pulmonary Embolism, and Thrombocytopenia After COVID-19 Vaccination in a Taiwanese Man: A Case Report and Literature Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Wei Lin ◽  
Chien-An Ko ◽  
Yueh-Feng Sung ◽  
Yeu-Chin Chen ◽  
Jiunn-Tay Lee ◽  
...  
Keyword(s):  
Case Report ◽  
Sinus Thrombosis ◽  
Neurological Deficits ◽  
Confirmatory Test ◽  
High Dose ◽  
Test Results ◽  
Platelet Factor ◽  
Laboratory Test Results ◽  
D Dimer ◽  
New Onset

Objective: Coronavirus disease (COVID-19) vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but fatal complication observed within 2 weeks of adenovirus-vectored vaccination.Case Report: A 52-year-old male patient, with a family history of autoimmune diseases, presented with a new onset of worsening headache with nausea and vomiting post-vaccination. The patient was diagnosed with VITT based on laboratory findings demonstrating thrombocytopenia, elevated D-dimer, and dural sinus thrombosis identified on neuroimaging. The patient was successfully treated with high-dose immunoglobulin, steroids, and non-heparin anticoagulants, without any neurologic sequelae. Finally, a confirmatory test with anti-platelet factor 4 antibody was strongly positive.Conclusion: Physicians should be vigilant when treating patients presenting with new-onset thunderclap headache, progressive worsening headache, and awakening headache accompanied by nausea or vomiting after vaccination, even if no definite clinical neurological deficits are identified. Emergency laboratory test results for demonstrating elevated D-dimer levels, decreased platelet count, and neuroimaging correlation are integral for diagnosis and must be the standard protocol. Treatment with non-heparin anticoagulants, high-dose intravenous immunoglobulin, and steroids that halt or slow the immune-mediated prothrombotic process should be initiated immediately. Considering the high mortality rate of VITT, treatment should be initiated prior to confirmatory test results.

scholarly journals Verification Postdiagnostic Decisions Tested of Artillery Fuses

2017 ◽  
Vol 44 (1) ◽  
pp. 191-222
Author(s):  
Dariusz Ampuła
Keyword(s):  
Statistical Analysis ◽  
Diagnostic Tests ◽  
Laboratory Tests ◽  
Test Results ◽  
Natural Ageing ◽  
Dynamic Tests ◽  
Correct Evaluation ◽  
Laboratory Test Results ◽  
Long Time

Abstract A statistical analysis of multiyear laboratory test results and dynamic tests chosen type of artillery fuses is presented in this article as the aim to testify influence of natural ageing process on quality indicators during long - time exploitation. The influence of exploitation time on taking shooting test decisions relating the quality of lots after conducted laboratory tests and on different inconsistencies classes which stepped out during these tests were analysed. The analysis of exploitation time influence on diagnostic decisions taking after conducted shooting tests and on occurrence inconsistences in the establish classes were also presented. The conducted statistical analysis suggested assumption, that there is possibility of changing of estimate module in the test’s methodology applied until now. The modification of this estimate module will not influence negatively on the quality of further diagnostic tests conducted, and it will not influence negatively on correct evaluation of prediction process tested elements of ammunition which the artillery fuses are. Performed the statistical analysis can be essentially relevant to modify tests methodology of the artillery fuses.

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