Design of novel Surfactant Modified Carbon Nanotube PasteElectrochemical Sensor for the Sensitive Investigation of Tyrosineas a Pharmaceutical Drug

Purpose: The novel sodium dodecyl sulfate modified carbon nanotube paste electrode (SDS/CNTPE) was used as a sensitive sensor for the electrochemical investigation of L-tyrosine (TY).Methods: The electrochemical analysis of TY was displayed through cyclic voltammetry (CV)and differential pulse voltammetry (DPV). The surface morphology of SDS/CNTPE and barecarbon nanotube past electrode (BCNTPE) was reviewed trough field emission scanning electronmicroscopy (FESEM).Results: The functioning SDS/CNTPE shows a voltammetric response with superior sensitivitytowards TY. This study was conducted using a phosphate buffer solution having neutral pH(pH=7.0). The correlation between the oxidation peak current of TY and concentration of TYwas achieved linearly in CV method, in the range 2.0×10-6 to 5 ×10-5 M with the detection limit729 nM and limit of quantification 2.43 μM. The investigated voltammetric study at SDS/CNTPEwas also adopted in the examination of TY concentration in a pharmaceutical medicine as a realsample with the recovery of 97% to 98%.Conclusion: The modified electrode demonstrates optimum sensitivity, constancy, reproducibility,and repeatability during the electrocatalytic activity of TY.

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Enhanced voltammetric detection of paracetamol by using carbon nanotube modified electrode as an electrochemical sensor

Journal of Electrochemical Science and Engineering ◽

10.5599/jese.717 ◽

2019 ◽

Vol 10 (1) ◽

pp. 29-40 ◽

Cited By ~ 2

Author(s):

Madikeri M. Charithra ◽

Jamballi G. Manjunatha

Keyword(s):

Carbon Nanotube ◽

Methyl Orange ◽

Electrochemical Sensor ◽

Pharmaceutical Formulations ◽

Differential Pulse ◽

Limit Of Quantification ◽

Experimental Conditions ◽

Voltammetric Detection ◽

Carbon Nanotube Paste Electrode ◽

Paste Electrode

New aspects associated with electro-catalytic activity of poly(methyl orange) modified carbon nanotube paste electrode (PMMCNTPE) towards the detection of paracetamol (PC) which is typically used worldwide as a pain reliever, were explored through implementation of cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. Bare carbon nanotube paste electrode (BCNTPE) was modified by methyl orange using the electropolymerizing method. The effect of pH and influence of potential scan rate were resolved by means of CV technique. It was found that under optimized experimental conditions, PMMCNTPE imparts the analytical curve for PC in the concentration range of 2.0×10-6 – 5.0×10-5 M with detection limit of 3.8×10-8 M and limit of quantification of 1.2×10-8 M. The proposed sensor exhibited acceptable reproducibility, admirable stability, and adequate repeatability. The interference study of PC with dopamine (DA) and folic acid (FA) showed good selectivity of the designed sensor. The feasibility of the constructed electrochemical sensor to detect PC was successfully tested in some pharmaceutical formulations.

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Surfactant modified carbon nanotube paste electrode for the sensitive determination of mitoxantrone anticancer drug

Journal of Electrochemical Science and Engineering ◽

10.5599/jese.368 ◽

2017 ◽

pp. 39 ◽

Cited By ~ 23

Author(s):

Jamballi G. Manjunatha

Keyword(s):

Cyclic Voltammetry ◽

Carbon Nanotube ◽

Detection Limit ◽

Dynamic Range ◽

Sodium Dodecyl ◽

High Sensitivity ◽

Current Response ◽

Limit Of Quantification ◽

Carbon Nanotube Paste Electrode ◽

Paste Electrode

Surfactant modified carbon nanotube paste electrode is prepared as electrochemical sensor with high sensitivity in responding to Mitoxantrone (MTX). Electrochemical oxidation of MTX is investigated in buffered solution by cyclic voltammetry that is found very sensitive method for detection of MTX. It is shown that the sodium dodecyl sulfate modified carbon nanotube paste electrode (SDSMCNTPE) gives enhanced current response for MTX compared to the bare carbon nanotube paste electrode (BCNTPE). Different parameters were tested to optimize the conditions for MTX determination. The effects of different surfactant and surfactant concentration, pH, scan rate, detection limit (LOD), limit of quantification (LOQ) and concentration of MTX on the oxidation peak current values were determined. Excellent results were obtained by cyclic voltammetry using SDSMCNTPE, where two MTX oxidation peaks appeared at 367 and 596 mV vs. SCE. Detailed analysis of the second voltammetric peak showed the linear dynamic range between 2×10−7 and 7×10−6 M MTX with the slope of co-relation coefficient of 0.99271. LOD and LOQ were determined as 3.5 ×10−8 M and 11×10−8 M, respectively. The SDSMCNTPE showed very good reproducibility, high stability in its voltammetric response, high electrochemical sensitivity and low detection limit for MTX.

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Electrochemical Determination of Uric Acid at CdTe Quantum Dot Modified Glassy Carbon Electrodes

Journal of AOAC International ◽

10.5740/jaoacint.14-245 ◽

2015 ◽

Vol 98 (5) ◽

pp. 1260-1266 ◽

Cited By ~ 6

Author(s):

Deng Pan ◽

Shengzhong Rong ◽

Guangteng Zhang ◽

Yannan Zhang ◽

Qiang Zhou ◽

...

Keyword(s):

Uric Acid ◽

Quantum Dot ◽

Glassy Carbon ◽

Semiconductor Nanocrystals ◽

Phosphate Buffer Solution ◽

Differential Pulse ◽

Electrochemical Determination ◽

Buffer Solution ◽

Peak Current ◽

Cdte Quantum Dot

Abstract Cyclic voltammetry and differential pulse voltammetry were used to investigate the electrochemical behavior of uric acid (UA) at a CdTe quantum dot (QD) modified the glassy carbon electrode (GCE). CdTe QDs, as new semiconductor nanocrystals, can greatly improve the peak current of UA. The anodic peak current of UA was linear with its concentration between 1.0 × 10–6 and 4.0 × 10–4 M in 0.1 M pH 5.0 phosphate buffer solution. The LOD for UA at the CdTe electrode (1.0 × 10–7 M) was superior to that of the GCE. In addition, we also determined the effects of scan rate, pH, and interferences of UA for the voltammetric behavior and detection. The results indicated that modified electrode possessed excellent reproducibility and stability. Finally, a new and efficient electrochemical sensor for detecting UA was developed.

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Rapid Electrochemical Monitoring of Tyrosine by Poly (Riboflavin) Modified Carbon Nanotube Paste Electrode as a Sensitive Sensor and its Applications in Pharmaceutical Samples

Biointerface Research in Applied Chemistry ◽

10.33263/briac116.1466114672 ◽

2021 ◽

Vol 11 (6) ◽

pp. 14661-14672

Keyword(s):

Carbon Nanotube ◽

Differential Pulse ◽

Pharmaceutical Samples ◽

Electrocatalytic Effect ◽

Carbon Nanotube Paste Electrode ◽

Sensitive Sensor ◽

Electro Oxidation ◽

Electrochemical Monitoring ◽

Paste Electrode

A poly(riboflavin) modified carbon nanotube paste electrode (PRFMCNTPE) is employed as a compatible and electrocatalytic sensor for the determination of Tyrosine (TYR). The analysis and assessment are carried out through differential pulse voltammetry (DPV) and Cyclic Voltammetry (CV). The surface of the intended sensor is examined through Field Emission Scanning Electron Microscopy (FE-SEM). The modified electrode shows the outstanding electrocatalytic effect for TYR with high selectivity and sensitivity as compared to carbon nanotube paste electrode (CNTPE). The electro-oxidation peak current of TYR and its concentration is found linear from 2 µM to 10 µM with a detection limit (LOD) of 0.45 µM. The developed sensor is productively applied for the determination of TYR in pharmaceutical samples like Tyrosine capsules. The adapted electrode shows good stability, excellent reproducibility, and remarkable sensitivity.

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Carvacrol electrochemical reaction characteristics on screen printed electrode modified with La2O3/Co3O4 nanocomposite

Journal of Electrochemical Science and Engineering ◽

10.5599/jese.637 ◽

2019 ◽

Vol 9 (2) ◽

pp. 113-123 ◽

Cited By ~ 4

Author(s):

Sayed Zia Mohammadi ◽

Hadi Beitollahi ◽

Tahereh Rohani ◽

Hossein Allahabadi

Keyword(s):

Limit Of Detection ◽

Phosphate Buffer Solution ◽

Differential Pulse ◽

Co3o4 Nanoparticles ◽

Electrochemical Characteristics ◽

Screen Printed Electrode ◽

Buffer Solution ◽

Voltammetric Techniques ◽

Screen Printed

Electrochemical characteristics of carvacrol were investigated on a screen-printed electrode (SPE) modified with La2O3/Co3O4 nanocomposite by using voltammetric techniques, which displayed a well-defined peak for sensitive carvacrol determination in phosphate buffer solution (PBS) at pH 7.0. La2O3/Co3O4 nanoparticles demonstrated suitable catalytic activity for carvacrol determination by differential pulse voltammetry (DPV) technique. Besides, determination of carvacrol in a real samples was recognized in the light of electrochemical findings and a validated voltammetric technique for quantitative analysis of carvacrol in a real formulation was proposed. The DPV peak currents were found to be linear in the concentration range of 10.0 to 800.0 μM. The limit of detection (LOD) was found to be 1.0 μM.

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Fabrication of Graphene/Carbon Nanotube Composite Modified Electrode for Selective and Sensitive Determination of Uric Acid

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.641-642.562 ◽

2013 ◽

Vol 641-642 ◽

pp. 562-565

Author(s):

Zheng Xiao Liu ◽

Jian Fei Xia ◽

Zong Hua Wang ◽

Yan Zhi Xia ◽

Fei Fei Zhang ◽

...

Keyword(s):

Carbon Nanotubes ◽

Uric Acid ◽

Carbon Nanotube ◽

Modified Electrode ◽

Phosphate Buffer Solution ◽

Carbon Electrode ◽

Buffer Solution ◽

Sensitive Determination ◽

Carbon Nanotube Composite

A novel composite was firstly synthesized by compositing graphenes (G) and carbon nanotubes (CNTs) and then a new composite modified electrode (G/CNTs/GCE) was prepared by coating the resulting composite on the surface of the glassy carbon electrode (GCE). The composite modified electrode G/CNTs/GCE showed great electrochemical activities which were studied by sensitive determining the electrochemistry behaviors of uric acid (UA). It revealed when the concentration range of UA changed from 1×10-7 mol/L to 1×10-3 mol/L, the peak currents had linear relationship with the concentration of UA in the phosphate buffer solution (PBS) which the value of pH is 7.0. And the linear equation is ip (μA) = 21.55C+28.94 (C: mmol/L), with the related coefficient 0.9964.

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Electro-oxidation of captopril at a gold electrode and its determination in pharmaceuticals and human fluids

Analytical Methods ◽

10.1039/c5ay01619c ◽

2015 ◽

Vol 7 (20) ◽

pp. 8673-8682 ◽

Cited By ~ 36

Author(s):

Nagaraj P. Shetti ◽

Shweta J. Malode ◽

Sharanappa T. Nandibewoor

Keyword(s):

Gold Electrode ◽

Phosphate Buffer Solution ◽

Differential Pulse ◽

Chemical Parameters ◽

Buffer Solution ◽

Solution Ph ◽

Physico Chemical ◽

Electro Oxidation ◽

Pulse Voltammetry ◽

Human Fluids

Gold electrode was used for the oxidation of captopril in phosphate buffer solution pH 3.6 to study the influence of several physico-chemical parameters like potential, scan rate, pH and concentration by cyclic, linear sweep and differential pulse voltammetry.

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Enhanced Electrochemical Determination Of Riboflavin In Biological And Pharmaceutical Samples At Poly (Arginine) Modified Carbon Paste Electrode

METHODS AND OBJECTS OF CHEMICAL ANALYSIS ◽

10.17721/moca.2019.216-223 ◽

2019 ◽

Vol 14 (4) ◽

pp. 216-223 ◽

Cited By ~ 1

Author(s):

Girish Tigari ◽

J.G. Manjunatha ◽

D.K. Ravishankar ◽

G. Siddaraju

Keyword(s):

Carbon Paste Electrode ◽

Limit Of Detection ◽

Phosphate Buffer Solution ◽

Differential Pulse ◽

Modified Carbon Paste Electrode ◽

Current Response ◽

Carbon Paste ◽

Serum Samples ◽

Buffer Solution ◽

Paste Electrode

An electrogenerated Polyarginine modified carbon paste electrode (PAMCPE) was fabricated through a simple electropolymerization procedure. The devised electrode was characterized by cyclic voltammetry (CV) and Field Emission Scanning Electron Microscopy (FESEM). This electrode was utilized for electrocatalytic estimation of Riboflavin (RF) and its instantaneous resolution with ascorbic acid (AA) and folic acid (FA) in phosphate buffer solution (PBS) of pH 6.0 by differential pulse voltammetry (DPV). It was observed to be a very responsive electrode for the electrochemical detection and quantification of RF. It was revealed that PAMCPE generates higher current response towards RF contrast to the bare carbon paste electrode (BCPE). Under optimized condition, the RF oxidation current values were linearly reliant on the RF concentration increment with a limit of detection (LOD) of 9.3·10-8 M using DPV. The stable PAMCPE was effectively applied for estimation of RF in B-complex pill and complex human blood serum samples.

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Sensitive Determination of Epinephrine in the Presence of Ascorbic Acid at Poly(diphenylamine sulfonic acid) Modified Sensor

Sensor Letters ◽

10.1166/sl.2020.4228 ◽

2020 ◽

Vol 18 (4) ◽

pp. 253-258

Author(s):

Gamze Erdoğdu

Keyword(s):

Ascorbic Acid ◽

Sulfonic Acid ◽

Limit Of Detection ◽

Phosphate Buffer Solution ◽

Differential Pulse ◽

Buffer Solution ◽

Sensitive Determination ◽

Pulse Voltammetry ◽

Modified Sensor

A sensitive and simple modified sensor was prepared by electrodeposition of diphenylamine sulfonic acid (DPSA) to the glassy carbon electrode surface by cyclic voltammetry (CV) technique. The electrooxidation of epinephrine (EP) was accomplished by CV and differential pulse voltammetry at poly(DPSA) modified sensor. As a result of the findings, the current values were enhanced and both substances were separated at the modified sensor compared to the bare electrode. There was linearly between the oxidation current and concentration of EP from 0.2 to 100 μM in phosphate buffer solution at pH 7.0. The limit of detection was 5.0 nM and the sensitivity was 0.4205 μA/μM. The determination of EP was successfully and satisfactorily carried out in real samples such as human blood serum and urine at the poly(DPSA) sensor. To the best knowledge of this work, this is the first study that detect the EP in the presence of ascorbic acid at poly(DPSA) sensor in the literature.

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The Application of Glassy Carbon Electrode Modified by Multi-Walled Carbon Nanotubes for the Fast Determination of Hydroquinone in Wastewater

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.955-959.1160 ◽

2014 ◽

Vol 955-959 ◽

pp. 1160-1166

Author(s):

Shao Hua Li ◽

Ying Ying Zhao ◽

Jun Qing Yang ◽

Guo Yan Zhang ◽

Ju Rui Qi

Keyword(s):

Carbon Nanotubes ◽

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Phosphate Buffer Solution ◽

Differential Pulse ◽

Carbon Electrode ◽

Buffer Solution ◽

Multi Walled Carbon Nanotubes ◽

Walled Carbon Nanotubes

A novel multi-walled carbon nanotubes (MWCNTs)-modified glassy carbon electrode (GCE) with excellent stability, repeatability and anti-interference was synthesized and it exhibited an electrocatalytic signal for hydroquinone (HQ) compared to bare GCE, which suggested that the presence of MWCNTs efficiently enhances electron transfer. Various parameters such as pH, modifier volume, and scan rate were optimized using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. Under optimum conditions, linear responses for HQ in 0.1mol·L-1 phosphate buffer solution of pH 6.0 were obtained in the range of 5×10-6 mol·L-1 to 2×10-4 mol·L-1 with detection limits of 2.7×10-6 mol·L-1 (signal-to-noise ratio of 3). Such MWCNTs-modified GCE was successfully applied for the determination of hydroquinone in simulated water samples and can be developed for the the detection of HQ.

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