Long-Term Side Effects of Breast Cancer on Force Production Parameters

Background: Breast cancer is associated with many therapy-induced side effects that impact patients’ lives from diagnosis to long-term survivorship. Physical activity has become an important and proven supportive measure in treating side effects like loss of muscle strength, fatigue, chemotherapy-induced peripheral neuropathy, lymphedema, and loss of quality of life. Resistance training (RT) is an established exercise intervention for breast cancer patients, but the correct type, timing, intensity, and duration of exercise remain unclear. It is necessary to investigate different resistance training interventions and their effects on breast cancer patients by covering all stages of treatment, beginning with prehabilitation, through the period of acute therapy, to long-term survivorship. Conclusion: Upon evaluation of randomized controlled trials (RCTs) from the past decade, RT was found to be feasible and safe. Furthermore, there is evidence on the impact of RT on muscle strength, CRF and QoL amongst other factors. Studies implementing mixes of aerobic and strength exercises are rather common, but RCTs of RT-only protocols remain scarce. Different strength training protocols at distinct stages of breast cancer treatment have been conducted, but with the complexity of treatments and the variety of training styles, a large field of study remains. Key Messages: Although the overall data on RT for breast cancer patients has increased, there are many different methodological approaches and testing measures as well as gaps in study documentation. There is still very little of the evidence that would facilitate the compilation of standardized and individualized guidelines.

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A Brief Review on Breast cancer treatment and current challenges

World Journal of Current Medical and Pharmaceutical Research ◽

10.37022/wjcmpr.vi.170 ◽

2021 ◽

pp. 27-31

Author(s):

Isha Shah ◽

Nensi Raytthatha

Keyword(s):

Breast Cancer ◽

Side Effects ◽

Cancer Treatment ◽

Effective Treatment ◽

Breast Cancer Survivors ◽

Early Stage ◽

Breast Cancer Treatment ◽

Good News ◽

Number Of Patients

Cancer is a global disease, so rational and effective treatment is needed. Breast cancer is one of the most common cancers in a woman and now the number of patients is increasing day by day. Therefore, development and research are underway for the effective treatment of breast cancer. Breast cancer treatment depends on the stage of cancer and the risk, based on this medical agents should be employed on patients to prevent breast cancer. In addition, breast cancer survival rates are rising which is good news for science but on the other hand the side effects of treatment present new challenges. An early-stage cancer diagnosis can save a patient's active or healthy life due to long-term and varied treatments that can be used for cancer otherwise breast cancer is a life-threatening disease. Breast cancer survivors not only have negative side effects of cancer treatment but also, have many other issues of previous treatment so it is a challenge for researchers. As a result, this review article deals with the effective treatment of breast cancer and its side effects. This review will help researchers better understand the long-term medical implications for breast cancer.

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Breast cancer treatment: survival facts and associated side effects

International Journal of Innovative Science & Technology ◽

10.22270/ijist.v4i1.37 ◽

2019 ◽

pp. 34-40

Author(s):

Drashti Joshi

Keyword(s):

Breast Cancer ◽

Side Effects ◽

Cancer Treatment ◽

Early Stage ◽

Breast Cancer Treatment ◽

The Other ◽

Good News ◽

Cancer Disease ◽

Medical Issues

In the world the cancer is a prevailing disease therefore some rational and effective therapy required. The breast cancer is one of the most common cancers in a woman and now a day’s patients are increase. Therefore, development and research are ongoing on the effective treatment on breast cancer. The breast cancer treatment is depending on the cancer stage disease and risk, based on this therapeutic agent should be employed in the patients to protect the breast cancer disease. Such treatments are reducing the mortality and morbidity but constant monitoring of drug adverse effect. Moreover, it has been seen that the survival rates in breast cancer is rising that is good news for science but on the other side the side effects of the treatments bring new challenges. The early stage diagnosis of the breast cancer can survive the effective or healthy patient life because of long-term and various treatment can be employed on the cancer disease otherwise breast cancer is life threatening illness. Survivors of breast cancer have not only the side effects issues of the cancer therapy treatment but also, they have many other issues of previous treatments therefore it is challenging job for the researchers. Consequently, this review article is dealing with the breast cancer effective treatments and side effects of it. Moreover, it includes the other long-term medical issues after breast cancer diagnosis and treatment. This review will help to the researchers for better understanding of the long-term medical issues in the breast cancer.

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Triggers of Uncertainty About Recurrence and Long-Term Treatment Side Effects in Older African American and Caucasian Breast Cancer Survivors

Oncology Nursing Forum ◽

10.1188/04.onf.633-639 ◽

2004 ◽

Vol 31 (3) ◽

pp. 633-639 ◽

Cited By ~ 93

Author(s):

Karen M. Gil ◽

Merle H. Mishel ◽

Michael Belyea ◽

Barbara Germino ◽

Laura S. Porter ◽

...

Keyword(s):

Breast Cancer ◽

African American ◽

Side Effects ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Term Treatment ◽

Treatment Side Effects ◽

Long Term Treatment

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Breast cancer patients have fewer long-term side effects after partial radiotherapy

Nursing Standard ◽

10.7748/ns.30.30.14.s16 ◽

2016 ◽

Vol 30 (30) ◽

pp. 14-14

Keyword(s):

Breast Cancer ◽

Side Effects ◽

Cancer Patients ◽

Breast Cancer Patients

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Pro-Apoptotic Effects of Estetrol on Long-Term Estrogen-Deprived Breast Cancer Cells and at Low Doses on Hormone-Sensitive Cells

Breast Cancer Basic and Clinical Research ◽

10.1177/1178223419844198 ◽

2019 ◽

Vol 13 ◽

pp. 117822341984419 ◽

Cited By ~ 1

Author(s):

Wei Yue ◽

Carole Verhoeven ◽

Herjan Coelingh Bernnink ◽

Ji-ping Wang ◽

Richard J Santen

Keyword(s):

Breast Cancer ◽

Side Effects ◽

Tumor Regression ◽

Antagonistic Effect ◽

High Dose ◽

Low Doses ◽

Induced Apoptosis ◽

Apoptotic Effects ◽

Mcf 7

Purpose: Postmenopausal women with estrogen receptor-positive breast cancers often respond initially to tamoxifen or aromatase inhibitor therapy. Resistance to these treatments usually develops within 12 to 18 months. Clinical studies have demonstrated that high-dose estrogen can induce regression of these endocrine-resistant tumors. However, side-effects of high-dose estradiol (E2) or diethylstilbestrol (DES) limit their usage. Estetrol (E4) is the most abundant estrogen during pregnancy and has a long half-life and a low potential for side-effects. Estetrol might then provide benefits similar to DES on tumor regression but with lesser toxicity. Methods: In this study, we systematically evaluated the effects of E4 on cell proliferation and apoptosis in wild-type MCF-7 and long-term estrogen-deprived (LTED) MCF-7 cells and compared its effects with E2 and estriol (E3). Results: Estetrol induced apoptosis in LTED cells but stimulated growth of MCF-7 cells at concentrations from 10−11 to 10−8 M. These effects of E4 are similar to those of E2 but require much higher doses. Differing from E2, E4 at 10−12 M induced apoptosis in MCF-7 cells and another pregnancy estrogen, E3, acted similarly. No antagonistic effect of E4 or E3 against E2 occurred when they were combined. Conclusions: The pro-apoptotic effects of E4 and E3 on LTED cells and at low doses on MCF-7 cells indicate that these steroids could be used as therapeutic agents for endocrine-resistant or sensitive breast cancer.

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A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction

Frontiers in Molecular Biosciences ◽

10.3389/fmolb.2021.683389 ◽

2021 ◽

Vol 8 ◽

Author(s):

Christa Corley ◽

Antiño R. Allen

Keyword(s):

Breast Cancer ◽

Side Effects ◽

Cognitive Dysfunction ◽

Breast Cancer Patients ◽

Chemotherapy Treatment ◽

Cancer Treatments ◽

The Usa ◽

Bibliometric Review ◽

Long Term Survivors

Inflammation is considered one of the possible mechanisms behind long-term cognitive dysfunction persistent after chemotherapy treatment. The chemotherapy combination of cyclophosphamide, methotrexate, and fluorouracil (CMF) was one of the older methods of treating breast cancer patients. Decades later, these patients still report experiencing cognitive side effects. In this present bibliometric review, we applied the VOSviewer tool to describe the existing landscape on literature concerning inflammation as it relates to CMF and cognitive dysfunctions. As time progressed, we saw an increase in interest in the topic. By the mid-2010s there were approximately 1,000 publications per year. Terms related to the brain and CNS did not appear until the later years, and terms related to inflammation and breast cancer were very prevalent throughout the three decades. Also, in more recent years, inflammatory markers and plant-derived compounds used to alleviate side effects of the inflammatory response appeared in the search results. The USA remained the most prolific producer of CMF-, inflammation-, and cognitive dysfunction-related papers throughout the three decades followed by Asia and Europe. As research of cognitive dysfunction caused by inflammation due to chemotherapy treatment progresses, more opportunities emerge for therapeutic methods to improve the quality of life for long-term survivors.

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Long-Term Side Effects of Adjuvant Therapy in Primary Breast Cancer Patients: Results of a Web-Based Survey

Breast Care ◽

10.1159/000497233 ◽

2019 ◽

Vol 14 (2) ◽

pp. 111-116 ◽

Cited By ~ 1

Author(s):

Renate Haidinger ◽

Ingo Bauerfeind

Keyword(s):

Breast Cancer ◽

Peripheral Neuropathy ◽

Side Effects ◽

Primary Breast Cancer ◽

Sleep Disturbances ◽

Breast Cancer Survivors ◽

Time Frame ◽

Breast Cancer Patients ◽

Web Based

Background: Chronic treatment sequelae may substantially reduce the long-term quality of life in breast cancer survivors. Methods: We report a comprehensive Web-based survey on the presence of long-term side effects of adjuvant anti-breast cancer therapy in 1,506 patients who had been diagnosed with primary breast cancer at least 1 year before. Results: Fatigue, depression, depressive mood, concentration deficit, pain, changes of mucosa and skin appendages, as well as symptoms of peripheral neuropathy were the most prevalent reported complaints. Chemotherapies - taxane-based regimens in particular - were associated with increased rates of long-term symptoms, including persistent peripheral neuropathy. Overall, the data show a substantial prevalence of a wide variety of potentially treatment-associated symptoms over a protracted time frame after the diagnosis of breast cancer. The burden of symptoms was high for fatigue, depression, sleep disturbances, pain, and peripheral neuropathic symptoms. Conclusion: Estimating the burden of chronic toxicities should contribute to enhance rational decision-making on treatments including chemotherapy in patients with low versus high risk of recurrence.

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