Self-Harm as a Developmental Outcome in Girls with ADHD: Clinical Significance and Underlying Mechanisms

2015 ◽  
Vol 23 (6) ◽  
pp. 1-6 ◽  
Author(s):  
Stephen P. Hinshaw
Keyword(s):  
Clinical Significance ◽  
Developmental Outcome ◽  
Self Harm ◽  
Underlying Mechanisms ◽  
Girls With Adhd

scholarly journals The Clinical Significance and Mechanisms of REG4 in Human Cancers

2021 ◽  
Vol 10 ◽  
Author(s):  
Junyan Zhang ◽  
Zhi Zhu ◽  
Zhifeng Miao ◽  
Xuanzhang Huang ◽  
Zhe Sun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Significance ◽  
Prognostic Biomarker ◽  
Clinicopathologic Features ◽  
Biological Functions ◽  
Histological Differentiation ◽  
Calcium Dependent ◽  
Advanced Tumor ◽  
New Directions ◽  
Underlying Mechanisms

Regenerating islet-derived type 4 (REG4), a member of the calcium-dependent lectin gene superfamily, is abnormally expressed in various cancers, such as colorectal, gastric, gallbladder, pancreatic, ovarian, prostate, and lung cancer. REG4 is associated with a relatively unfavorable prognosis and clinicopathologic features in cancers, including advanced tumor and nodal stage, histological differentiation, and liver and peritoneal metastasis. Moreover, REG4-positive cancer cells show more frequent resistance to chemoradiotherapy, especially 5-FU-based chemotherapy. REG4 participates in many aspects of carcinogenesis, including cell proliferation, apoptosis, cell cycle, invasion, metastasis, and drug resistance. The underlying mechanisms are complex and involve a series of signaling mediators and multiple pathways. Thus, REG4 may be a potential diagnostic and prognostic biomarker as well as a candidate therapeutic target in cancer patients. In this review, we systematically summarize the advances about the clinical significance, biological functions, and mechanisms underlying REG4 in cancer to provide new directions for future cancer research.

Atrial fibrillation progression and prevention

ESC CardioMed ◽  
2018 ◽  
pp. 2135-2139
Author(s):  
Justin G. L. M. Luermans ◽  
Jordi Heijman ◽  
Isabelle C. Van Gelder ◽  
Harry J. G. M. Crijns
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Clinical Significance ◽  
Cardiovascular Events ◽  
Therapeutic Options ◽  
Major Adverse Cardiovascular Events ◽  
Pathophysiological Mechanisms ◽  
Underlying Mechanisms ◽  
Sinus Rhythm Maintenance

Atrial fibrillation (AF) patients are commonly classified into five groups, first-diagnosed, paroxysmal, persistent, long-standing persistent, or permanent AF, based on the duration of AF and clinical conventions. Progression of AF to longer-lasting forms is common and has important clinical significance, affecting both the success of sinus rhythm maintenance and the occurrence of major adverse cardiovascular events. As such, there is considerable interest in the underlying mechanisms and therapeutic options to prevent AF progression. This chapter discusses the epidemiology, risk factors, and clinical significance of AF progression. It also provides background on the pathophysiological mechanisms of AF progression and highlights options for its management and prevention.

scholarly journals Clinical significance and potential mechanisms of the RNA methyltransferase KIAA1429 in osteosarcoma

2021 ◽  
Author(s):  
Yu Sun ◽  
Yi-wu Lei ◽  
Shu-Fan Ji ◽  
Hao Wu ◽  
Yun Liu ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Cancer Progression ◽  
Enrichment Analysis ◽  
Functional Enrichment Analysis ◽  
Functional Enrichment ◽  
Published Data ◽  
Protein Protein Interaction ◽  
Cell Cycle Pathway ◽  
Diagnostic Capacity ◽  
Underlying Mechanisms

Abstract Background: KIAA1429, a member of the RNA methyltransferase complex, is involved in cancer progression. However, the clinical significance of KIAA1429 in osteosarcoma (OS) and the underlying mechanisms by which it contributes to disease progression remain unclear. Methods: The clinical significance of KIAA1429 in OS was evaluated based on the RT-qPCR, microarray, RNA sequencing, and published data. Two lentivirus-mediated KIAA1429-targeting siRNA constructs were transfected into SW1353 cells, and CCK-8 and flow cytometry assays were applied to investigate the biological function of KIAA1429 in OS cells. KIAA1429-related genes in OS were identified from lists of co-expressed genes (CEGs) and differentially expressed genes (DEGs). Functional enrichment analysis was employed to explore the potential mechanisms by which KIAA1429 contributes to the progression of OS.Results: The mRNA expression of KIAA1429 was notably overexpressed in 250 OS samples than 71 non-cancer samples (SMD=0.74). SROC curve analysis showed that KIAA1429 exhibits diagnostic capacity between OS samples and non-cancer samples (AUC=0.83). Survival analysis showed that overexpression of KIAA1429 was associated with shorter overall survival time. Knocking down KIAA1429 reduced the level of m6A methylation, inhibited proliferation, and accelerated apoptosis in OS cells. A total of 395 KIAA1429-related genes were identified, and were enriched in the cell cycle pathway. Protein–protein interaction (PPI) network analysis showed that CDK1, CCNA2, and CCNB1 were KIAA1429-related genes that act as major network hubs in OS. Conclusion: KIAA1429 plays an oncogenic role in OS and may facilitate the progression of OS through a mechanism involving the regulation of CDK1, CCNA2, and CCNB1.

scholarly journals Clinical Significance And Potential Mechanisms of The RNA Methyltransferase KIAA1429 In Osteosarcoma

2021 ◽  
Author(s):  
Yu Sun ◽  
Yi-wu Lei ◽  
Shu-Fan Ji ◽  
Hao Wu ◽  
Yun Liu ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Cancer Progression ◽  
Enrichment Analysis ◽  
Functional Enrichment Analysis ◽  
Functional Enrichment ◽  
Published Data ◽  
Protein Protein Interaction ◽  
Cell Cycle Pathway ◽  
Diagnostic Capacity ◽  
Underlying Mechanisms

Abstract Background: KIAA1429, a member of the RNA methyltransferase complex, is involved in cancer progression. However, the clinical significance of KIAA1429 in osteosarcoma (OS) and the underlying mechanisms by which it contributes to disease progression remain unclear. Methods: The clinical significance of KIAA1429 in OS was evaluated based on the RT-qPCR, microarray, RNA sequencing, and published data. Two lentivirus-mediated KIAA1429-targeting siRNA constructs were transfected into SW1353 cells, and CCK-8 and flow cytometry assays were applied to investigate the biological function of KIAA1429 in OS cells. KIAA1429-related genes in OS were identified from lists of co-expressed genes (CEGs) and differentially expressed genes (DEGs). Functional enrichment analysis was employed to explore the potential mechanisms by which KIAA1429 contributes to the progression of OS.Results: The mRNA expression of KIAA1429 was notably overexpressed in 250 OS samples than 71 non-cancer samples (SMD=0.74). SROC curve analysis showed that KIAA1429 exhibits diagnostic capacity between OS samples and non-cancer samples (AUC=0.83). Survival analysis showed that overexpression of KIAA1429 was associated with shorter overall survival time. Knocking down KIAA1429 reduced the level of m6A methylation, inhibited proliferation, and accelerated apoptosis in OS cells. A total of 395 KIAA1429-related genes were identified, and were enriched in the cell cycle pathway. Protein–protein interaction (PPI) network analysis showed that CDK1, CCNA2, and CCNB1 were KIAA1429-related genes that act as major network hubs in OS. Conclusion: KIAA1429 plays an oncogenic role in OS and may facilitate the progression of OS through a mechanism involving the regulation of CDK1, CCNA2, and CCNB1.

Eating Habits in Dementia

1989 ◽  
Vol 154 (6) ◽  
pp. 801-806 ◽  
Author(s):  
Charles H. Morris ◽  
R. A. Hope ◽  
Christopher G. Fairburn
Keyword(s):  
Food Intake ◽  
Clinical Significance ◽  
Food Choice ◽  
Eating Habits ◽  
Semistructured Interview ◽  
Underlying Mechanisms

The eating habits of 33 patients with dementia were studied. They were assessed by semistructured interview with a relative who was able to act as an informant for the whole period of the dementia. Changes in eating were found to be common and included both increased and decreased food intake, altered food choice, the consumption of inedible substances and disturbances in the process of eating. The clinical significance of these changes and some likely underlying mechanisms are discussed.

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