scholarly journals Intrastriatal Transforming Growth Factor   Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells without Differentiation into Dopaminergic Neurons

2004 ◽  
Vol 24 (41) ◽  
pp. 8924-8931 ◽  
Author(s):  
O. Cooper
Keyword(s):  
Parkinson’S Disease ◽  
Growth Factor ◽  
Progenitor Cells ◽  
Dopaminergic Neurons ◽  
Neural Progenitor Cells ◽  
Transforming Growth Factor ◽  
Neural Progenitor ◽  
Growth Factor Delivery ◽  
And Migration ◽  
Proliferation And Migration

Transforming growth factor-β1 primes proliferating adult neural progenitor cells to electrophysiological functionality

Glia ◽  
2013 ◽  
Vol 61 (11) ◽  
pp. 1767-1783 ◽  
Author(s):  
Sabrina Kraus ◽  
Bernadette Lehner ◽  
Nadine Reichhart ◽  
Sebastien Couillard-Despres ◽  
Katrin Wagner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Transforming Growth Factor ◽  
Neural Progenitor ◽  
Transforming Growth Factor Β1

Extracellular Vesicles Derived from Glioblastoma Promote Proliferation and Migration of Neural Progenitor Cells via PI3K-Akt Pathway

2021 ◽  
Author(s):  
Jiabin Pan ◽  
Shiyang Sheng ◽  
Ling Ye ◽  
Yizhao Ma ◽  
Lisha Qiu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Progenitor Cells ◽  
Cell Lines ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Mtor Pathway ◽  
Glioblastoma Cell ◽  
And Migration ◽  
Glioblastoma Cell Lines ◽  
Proliferation And Migration

Abstract BackgroundGlioblastomas are lethal brain tumors under the current combinatorial therapeutic strategy that includes surgery, chemo- and radio-therapies. Extensive changes in the tumor microenvironment is a key reason for resistance to chemo- or radio-therapy and frequent tumor recurrences. Understanding the tumor-nontumor cell interaction in TME is critical for developing new therapy. Glioblastomas are known to recruit normal cells in their environs to sustain growth and encroachment into other regions. Neural progenitor cells (NPCs) have been noted to migrate towards the site of glioblastomas, however, the detailed mechanisms underlying glioblastoma-mediated NPCs’ alteration remain unkown. MethodsWe utilized two classic glioblastoma cell lines, U87- and A172, and collected EVs in the culture medium of those two lines. Mouse NPCs (mNPCs) were co-cultured with U87- or A172-derived EVs. EVs-treated mNPCs’ prolifeartion and migration were examined. Proteomic analysis and western-blot were utilized to identify the underlying mechanisms of glioblastoma EVs-induced alterations in mNPCs.ResultsWe show that glioblastoma cell lines U87- and A172-derived EVs dramatically promoted NPCs proliferation and migration. Mechanistic studies identify that EVs achieve their functions via activating PI3K-Akt-mTOR pathway in recipient cells. Inhibiting PI3K-Akt reversed the elevated prolfieration and migration of glioblastoma EVs-treated mNPCs. ConclusionOur findings demonstrate that EVs play a key role in intercellular communication in tumor microenvironment. Inhibition of the tumorgenic EVs-mediated PI3K-Akt-mTOR pathway activation might be a novel strategy to shed light on glioblastoma therapy.

Forskolin cooperating with growth factor on generation of dopaminergic neurons from human fetal mesencephalic neural progenitor cells

2004 ◽  
Vol 362 (2) ◽  
pp. 117-121 ◽  
Author(s):  
Xuan Wang ◽  
Xiaoxia Li ◽  
Kun Wang ◽  
Huifang Zhou ◽  
Bing Xue ◽  
...  
Keyword(s):  
Growth Factor ◽  
Progenitor Cells ◽  
Dopaminergic Neurons ◽  
Neural Progenitor Cells ◽  
Neural Progenitor

scholarly journals Neural Progenitor Cells Derived from Human Embryonic Stem Cells as an Origin of Dopaminergic Neurons

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Parinya Noisa ◽  
Taneli Raivio ◽  
Wei Cui
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Embryonic Stem Cells ◽  
Progenitor Cells ◽  
Human Embryonic Stem Cells ◽  
Dopaminergic Neurons ◽  
Neural Progenitor Cells ◽  
Embryonic Stem ◽  
Neural Progenitor

Human embryonic stem cells (hESCs) are able to proliferatein vitroindefinitely without losing their ability to differentiate into multiple cell types upon exposure to appropriate signals. Particularly, the ability of hESCs to differentiate into neuronal subtypes is fundamental to develop cell-based therapies for several neurodegenerative disorders, such as Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease. In this study, we differentiated hESCs to dopaminergic neurons via an intermediate stage, neural progenitor cells (NPCs). hESCs were induced to neural progenitor cells by Dorsomorphin, a small molecule that inhibits BMP signalling. The resulting neural progenitor cells exhibited neural bipolarity with high expression of neural progenitor genes and possessed multipotential differentiation ability. CBF1 and bFGF responsiveness of these hES-NP cells suggested their similarity to embryonic neural progenitor cells. A substantial number of dopaminergic neurons were derived from hES-NP cells upon supplementation of FGF8 and SHH, key dopaminergic neuron inducers. Importantly, multiple markers of midbrain neurons were detected, includingNURR1, PITX3, andEN1, suggesting that hESC-derived dopaminergic neurons attained the midbrain identity. Altogether, this work underscored the generation of neural progenitor cells that retain the properties of embryonic neural progenitor cells. These cells will serve as an unlimited source for the derivation of dopaminergic neurons, which might be applicable for treating patients with Parkinson’s disease.

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