The G-Protein-Coupled Serotonin Receptor SER-1 Regulates Egg Laying and Male Mating Behaviors in Caenorhabditis elegans

After the uptake, the environmental toxicants may cause the toxicity on organisms by activating or inhibiting certain G protein-coupled receptors (GPCRs). Nevertheless, the roles of GPCRs in mediating the response...

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G protein-coupled receptors: The choreographers of innate immunity in Caenorhabditis elegans

PLoS Pathogens ◽

10.1371/journal.ppat.1009151 ◽

2021 ◽

Vol 17 (1) ◽

pp. e1009151

Author(s):

Siddharth R. Venkatesh ◽

Varsha Singh

Keyword(s):

Innate Immunity ◽

Caenorhabditis Elegans ◽

G Protein ◽

G Protein Coupled Receptors ◽

G Protein Coupled

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Translational Fusion of a G‐protein Coupled‐Receptor from the Hookworm Ancylostoma ceylanicum Expressed in Caenorhabditis elegans

The FASEB Journal ◽

10.1096/fasebj.2019.33.1_supplement.649.8 ◽

2019 ◽

Vol 33 (S1) ◽

Author(s):

Brandon Norman ◽

Lauren DeLong ◽

Myra Dickey ◽

Mollie Jewell ◽

Patti T. Erickson ◽

...

Keyword(s):

Caenorhabditis Elegans ◽

G Protein ◽

G Protein Coupled Receptor ◽

Ancylostoma Ceylanicum ◽

Translational Fusion ◽

G Protein Coupled

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Neuronal control of lipid metabolism by STR‐2 G protein‐coupled receptor promotes longevity in Caenorhabditis elegans

Aging Cell ◽

10.1111/acel.13160 ◽

2020 ◽

Vol 19 (6) ◽

Cited By ~ 2

Author(s):

Anubhuti Dixit ◽

Anjali Sandhu ◽

Souvik Modi ◽

Meghana Shashikanth ◽

Sandhya P. Koushika ◽

...

Keyword(s):

Lipid Metabolism ◽

Caenorhabditis Elegans ◽

G Protein ◽

G Protein Coupled Receptor ◽

Neuronal Control ◽

G Protein Coupled

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3-Iodothyronamine Induces Diverse Signaling Effects at Different Aminergic and Non-Aminergic G-Protein Coupled Receptors

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/a-1022-1554 ◽

2019 ◽

Vol 128 (06/07) ◽

pp. 395-400 ◽

Cited By ~ 3

Author(s):

Heike Biebermann ◽

Gunnar Kleinau

Keyword(s):

Body Temperature ◽

G Protein ◽

Intracellular Signaling ◽

Serotonin Receptor ◽

Fine Tuning ◽

Specific Cell ◽

Knock Out ◽

Alpha2 Adrenoceptor ◽

Knock Out Mice ◽

G Protein Coupled

AbstractThe thyroid hormone metabolite 3-iodothyronamine (3-T1AM) exerts diverse physiological reactions such as a decrease of body temperature, and negative inotropic and chronotropic effects. This observed pleomorphic effect in physiology can be barely explained by interaction with only one target protein such as the trace-amine receptor 1 (TAAR1), a class A G-protein coupled receptor (GPCR). Moreover, Taar1 knock-out mice still react to 3-T1AM through physiological responses with a rapid decrease in body temperature. These facts propelled our group and others to search for further targets for this molecule.The group of TAARs evolved early in evolution and, according to sequence similarities, they are closely related to adrenoceptors and other aminergic receptors. Therefore, several of these receptors were characterized by their potential to interplay with 3-T1AM. Indeed, 3-T1AM acts as a positive allosteric modulator on the beta2-adrenoceptor (ADRB2) and as a biased agonist on the serotonin receptor 1B (5HT1b) and the alpha2-adrenoceptor (ADRA2A). In addition, 3-T1AM was reported to be a weak antagonist at a non-aminergic muscarinic receptor (M3).These findings impressively reflect that such trace amines can unselectively and simultaneously function at different receptors expressed by one cell or at different tissues. In conclusion, the role of 3-T1AM is hypothesized to concert the fine-tuning of specific cell reactions by the accentuation of certain pathways dependent on distinct receptors. 3-T1AM acts as a regulator of signals by blocking, modulating, or inducing simultaneously distinct intracellular signaling cascades via different GPCRs.

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Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease

Molecules ◽

10.3390/molecules25215186 ◽

2020 ◽

Vol 25 (21) ◽

pp. 5186 ◽

Cited By ~ 1

Author(s):

Serena Silvestro ◽

Giovanni Schepici ◽

Placido Bramanti ◽

Emanuela Mazzon

Keyword(s):

G Protein ◽

Serotonin Receptor ◽

Molecular Mechanisms ◽

Transient Receptor Potential ◽

Neurological Diseases ◽

In Vivo Studies ◽

Receptor Subtype ◽

Transient Receptor Potential Vanilloid ◽

Neuroprotective Effects ◽

G Protein Coupled

Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with antidepressant, anxiolytic, anticonvulsant and antipsychotic effects. Thanks to all these properties, the interest of the scientific community for it has grown. Indeed, CBD is a great candidate for the management of neurological diseases. The purpose of our review is to summarize the in vitro and in vivo studies published in the last 15 years that describe the biochemical and molecular mechanisms underlying the effects of CBD and its therapeutic application in neurological diseases. CBD exerts its neuroprotective effects through three G protein coupled-receptors (adenosine receptor subtype 2A, serotonin receptor subtype 1A and G protein-coupled receptor 55), one ligand-gated ion channel (transient receptor potential vanilloid channel-1) and one nuclear factor (peroxisome proliferator-activated receptor γ). Moreover, the therapeutical properties of CBD are also due to GABAergic modulation. In conclusion, CBD, through multi-target mechanisms, represents a valid therapeutic tool for the management of epilepsy, Alzheimer’s disease, multiple sclerosis and Parkinson’s disease.

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