STUDIES ON EOSINOPHIL GRANULOCYTES.

1967 ◽  
Vol 56 (2) ◽  
pp. 221-224 ◽  
Author(s):  
A. P. Baker ◽  
F. Bergman ◽  
B. Josefsson ◽  
K. G. Paul
Keyword(s):  
Mast Cells ◽  
Adult Male ◽  
Rapid Growth ◽  
Levator Ani ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Levator Ani Muscle ◽  
Eosinophil Granulocytes ◽  
Anterior Prostate ◽  
Long Acting

ABSTRACT Castrated, adult male rats were given a long-acting androgen in doses that caused a rapid growth of the anterior prostate lobes, the seminal vesicles, and the levator ani muscle. There was no decrease in the number of mast cells, and no increase in the number of eosinophils.

THE GROWTH OF THE VENTRAL PROSTATE THE DORSOLATERAL PROSTATE, THE COAGULATING GLANDS AND THE SEMINAL VESICLES IN CASTRATED MALE RATS INJECTED WITH ACTH AND/OR INSULIN

1969 ◽  
Vol 62 (4) ◽  
pp. 694-710 ◽  
Author(s):  
Lars-Eric Tisell ◽  
Lennart Angervall
Keyword(s):  
Morphological Changes ◽  
Levator Ani ◽  
Regular Insulin ◽  
Reproductive Organs ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Ventral Prostate ◽  
Levator Ani Muscle ◽  
Adrenal Steroids ◽  
Protamine Zinc Insulin

ABSTRACT The growth of the ventral and the dorsolateral prostate, the coagulating glands, seminal vesicles and levator ani muscle was studied in castrated male rats after fifteen days of daily injections with ACTH or insulin alone, or in combination. ACTH was given in a dose of 8 IU daily. Insulin was administered in increasing daily doses, i. e. regular insulin up to 8 IU and protamine zinc insulin up to 10 IU. After ACTH treatment there were variable histological signs of stimulation of the dorsolateral prostate, while the other accessory reproductive organs showed no response. Regular insulin produced no quantitative or morphological changes in the accessory reproductive organs, and no morphological signs of increased secretion of the adrenal steroids. Administration of ACTH and regular insulin in combination stimulated the growth of all the accessory reproductive organs. Protamine zinc insulin produced prolonged hypoglycaemia and morphological signs of increase secretion of adrenal steroids, thus the adrenals became enlarged and the thymus atrophic. Protamine zinc insulin stimulated growth of all the accessory reproductive organs, a stimulation which was further accentuated after combination with ACTH. Possible mechanisms for the action of insulin on the male accessory reproductive organs are discussed. The varying response of the different parts of the prostate and the seminal vesicles emphasizes the importance of the simultaneous examination of these organs.

MAMMOGENIC EFFECTS OF METHANDROSTENOLONE IN CASTRATED RATS

1963 ◽  
Vol 42 (4) ◽  
pp. 601-614 ◽  
Author(s):  
K. Ahrén ◽  
A. Arvill ◽  
Ä. Hjalmarson
Keyword(s):  
Levator Ani ◽  
Mammary Glands ◽  
Seminal Vesicles ◽  
Female Rats ◽  
Male Rats ◽  
Weight Increase ◽  
Levator Ani Muscle ◽  
List Type ◽  
Alveolar Development ◽  
Dose Levels

ABSTRACT Methandrostenolone (17β-hydroxy-17α-methyl-androsta-1,4-dien-3-one) was injected in 4 dose-levels (0.05, 0.5, 2.5 and 5.0 mg daily for 28 days) into castrated male rats, and the response of the mammary glands, the seminal vesicles and the levator ani muscle studied. One dose-level (2.5 mg daily for 28 days) was injected into castrated female rats, and the response of the mammary glands, the vagina and the uterus studied. The main results were as follows: The 0.05 mg dose did not stimulate the seminal vesicles but produced a slight weight increase of the levator ani muscle. The 0.5 mg dose had only a minimal effect on the seminal vesicles but had a much more pronounced effect on the levator ani muscle. The 2 higher doses, however, markedly stimulated both the seminal vesicles and the levator ani muscle. In the mammary glands methandrostenolone produced not only lobule-alveolar development, as do most other androgens, but in addition induced growth and development of the mammary duct system, as found with oestrogenic compounds. The lobule-alveolar development, found after treatment with the various dose-levels of methandrostenolone, quantitatively, more closely followed the growth of the levator ani muscle than the development of the seminal vesicles. In the castrated female rats methandrostenolone stimulated vaginal opening, brought about slight cornification of the vaginal epithelium and caused a marked weight increase of the uterus. These effects cannot be explained solely on the basis of the androgenic activity of this compound, but seem to indicate that methandrostenolone has an oestrogenic activity when injected into castrated rats.

RECOVERY OF GONADAL FUNCTION IN MALE RATS TREATED NEONATALLY WITH 17β-OESTRADIOL BENZOATE

1964 ◽  
Vol 47 (2) ◽  
pp. 200-208 ◽  
Author(s):  
Fred A. Kind ◽  
Manuel Maqueo ◽  
A. Folch Pi
Keyword(s):  
Testosterone Propionate ◽  
Levator Ani ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Ventral Prostate ◽  
Levator Ani Muscle ◽  
Gonadal Function ◽  
Gonadal Activity ◽  
Oestradiol Benzoate ◽  
Old Rats

ABSTRACT Groups of five day old rats were injected with 120 or 240 μg of oestradiol benzoate. When examined at the age of fifty days, the animal presented atrophied testes and marked decreases in the weights of ventral prostate, seminal vesicles and levator ani muscle. Treatment with pregnant mare's serum or with testosterone propionate given from day 20 through day 50 fully restored the gonadal activity. The dose of PMS needed to restore spermatogenesis was 10 IU which was given every third day. Testosterone propionate, 1 mg, given daily was equally effective.

EFFECT OF TESTOSTERONEPHENYLPROPIONATE AND 19-NORTESTOSTERONEPHENYLPROPIONATE ON THE SEMINAL VESICLES, THE LEVATOR ANI MUSCLE AND THE MAMMARY GLANDS OF CASTRATED MALE RATS

1962 ◽  
Vol 39 (4) ◽  
pp. 584-598 ◽  
Author(s):  
K. Ahrén ◽  
A. Arvill ◽  
Å. Hjalmarson
Keyword(s):  
Levator Ani ◽  
Mammary Glands ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Weight Increase ◽  
Levator Ani Muscle ◽  
List Type ◽  
Minimal Weight ◽  
Alveolar Development ◽  
Marked Weight

ABSTRACT The response of the seminal vesicles, the levator ani muscle and the mammary glands to testosteronephenylpropionate (TPP) and 19-nortestosteronephenylpropionate (19-norTPP) was studied in castrated male rats. The development of these structures was compared with that found in male rats with intact testes. The main results were as follows: 1) Daily injections of 0.01 mg of TPP produced slight weight increase in the seminal vesicles and levator ani muscle and stimulated a slight but obvious lobule-alveolar development in the mammary glands. The same dose of 19-norTPP produced only a minimal weight increase in the seminal vesicles but produced an obvious development of the levator ani muscle and the mammary glands. 2) Daily injections of 0.05 mg of TPP caused a marked weight increase in the seminal vesicles and levator ani muscle and produced a marked lobule-alveolar development in the mammary glands. The same dose of 19-norTPP produced only a slight weight increase in the seminal vesicles but brought about a marked development of the levator ani muscle and the mammary glands. 3) Daily injections of 0.5 mg of 19-norTPP caused a marked development of the seminal vesicles comparable to that found in rats with intact testes. The levator ani muscle and the mammary glands after this treatment were, however, much more stimulated than in rats with intact testes. These results indicate 1) that the ratio between the effects of these compounds on the seminal vesicles and on the Ievator ani muscle depends on the dose-level and 2) that the development of the mammary glands is correlated more to the growth of the Ievator ani muscle than to the development of the seminal vesicles.

ANDROGENIC PROPERTIES AND ADRENAL DEPRESSANT ACTIVITY OF MEGESTROL ACETATE OBSERVED IN CASTRATED MALE RATS

1975 ◽  
Vol 78 (2) ◽  
pp. 316-324 ◽  
Author(s):  
Lars-Eric Tisell ◽  
Håkan Salander
Keyword(s):  
Body Weight ◽  
Levator Ani ◽  
Seminal Vesicles ◽  
The Body ◽  
Megestrol Acetate ◽  
Male Rats ◽  
Levator Ani Muscle ◽  
Morphological Criteria ◽  
Prostatic Diseases ◽  
Higher Doses

ABSTRACT Megestrol acetate (17α-acetoxy-6-dehydro-6-methylprogesterone), a synthetic steroid with high progestational activity, is used in oral contraceptives but also in the treatment of prostatic diseases in man. To investigate whether megestrol acetate has any androgenic properties the growth of the ventral and dorsolateral prostate, the coagulating glands and the seminal vesicles was studied morphologically in castrated rats treated with megestrol acetate and in non-treated castrated rats. The effect of megestrol acetate on the body weight, the levator ani muscle and the adrenals was also studied. Megestrol acetate was administered in daily doses of 0.02 mg, 0.2 mg, 2.0 mg or 20.0 mg for a period of 21 days. Megestrol acetate in the two higher doses retarded growth and gave a low weight for the levator ani muscle at autopsy indicating an anti-anabolic or catabolic action of megestrol acetate in high doses. Megestrol acetate in daily doses of 0.2, 2.0 and 20.0 mg caused an involution of the adrenal glands. After the two higher doses the weight of the adrenals amounted to only about a third of that of the untreated rats. Megestrol acetate in the lower doses had no demonstrable effect on the growth of the accessory reproductive glands. After the two higher doses of megestrol acetate some growth of the dorsal part of the dorsolateral prostate and of the coagulating glands was observed. Only the seminal vesicles exhibited complete morphological criteria of an androgenic stimulation and then only after the largest dose of megestrol acetate. The investigation shows that megestrol acetate has weak androgenic properties which are apparent at a dose per kg body weight approximately 200 times greater than that used in the treatment of prostatic diseases in man.

EFFECTS OF TESTOSTERONE AND NANDROLONE AND SOME OF THEIR ESTERS ON THE PSEUDOCHOLINESTERASE ACTIVITY IN THE LIVER AND SERUM AND ON THE SEMINAL VESICLE AND LEVATOR ANI MUSCLE OF THE RAT

1970 ◽  
Vol 64 (3) ◽  
pp. 531-540 ◽  
Author(s):  
R. S. Leeuwin ◽  
E. Th. Groenewoud
Keyword(s):  
Enzyme Activity ◽  
Seminal Vesicle ◽  
Testosterone Propionate ◽  
Levator Ani ◽  
Daily Administration ◽  
Male Rats ◽  
Levator Ani Muscle ◽  
Prolonged Administration ◽  
Potent Effect ◽  
T Testosterone

ABSTRACT Testosterone (T), testosterone-propionate (TP), testosterone-phenyl-propionate (TPP), nandrolone (N) (19-nor-testosterone) and nandrolone-phenyl-propionate (NPP) were compared for their effects on the pseudocholinesterase activities in the liver and serum of castrated male rats. In addition changes in the weight of the seminal vesicle and the levator ani muscle were studied. After daily administration of 1 mg of the hormones for ten days, T and TPP showed a more marked depression of the pseudocholinesterase activity and seminal vesicle than the corresponding nor-derivatives. TP and TPP have approximately similar effects, exceeding those of T. On the levator ani N and NPP were more effective than T and TPP. At identical total doses, administration of all hormones with intervals of more than one day, produced less depression of the pseudocholinesterase activity and less seminal vesicle growth than daily administration. The effects on the levator ani were less influenced by varying intervals. At an interval of four days TPP still had a potent effect on the enzyme activity and the seminal vesicle, whereas T was almost without effect. Prolonged administration showed that the effects on the enzyme activity and the seminal vesicle of N and NPP could not reach the maximum effects of T and TPP respectively.

EFFECTS OF FOLLICLE-STIMULATING HORMONE AND LUTEINIZING HORMONE ON PLASMA TESTOSTERONE LEVELS IN HYPOPHYSECTOMIZED AND IN INTACT IMMATURE AND ADULT MALE RATS

1974 ◽  
Vol 61 (2) ◽  
pp. 193-198 ◽  
Author(s):  
S. EL SAFOURY ◽  
A. BARTKE
Keyword(s):  
Luteinizing Hormone ◽  
Adult Male ◽  
Follicle Stimulating Hormone ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Plasma Testosterone ◽  
Adult Rats ◽  
Testosterone Levels ◽  
Hypophysectomized Rats ◽  
Stimulating Hormone

SUMMARY The effects of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) on plasma testosterone levels were examined in hypophysectomized and in intact immature and adult male rats. The animals were injected with saline, LH, FSH, or both gonadotrophins twice daily for 3·5 days and were killed 3 h after the last injection. Plasma testosterone levels were measured by radioimmunoassay. In immature hypophysectomized rats, plasma testosterone levels were not changed by treatment with LH, FSH or LH plus FSH. The weight of the testes and of the seminal vesicles was increased only in animals injected with both LH and FSH. In adult hypophysectomized rats, LH caused the expected increase in plasma testosterone levels, while FSH injected alone had no effect. Plasma testosterone levels in rats treated with 5 μg LH and 20 μg FSH were significantly greater than those in animals given 5 μg LH alone. However, the same dose of FSH did not potentiate the action of 25 μg LH on plasma testosterone levels. In adult hypophysectomized rats the weight of testes was not affected by any of the treatments. The weight of the seminal vesicles was increased by the higher dose of LH and addition of FSH caused no further increase. In intact immature and adult rats plasma testosterone levels and the weight of testes were not changed by any of the treatments. Seminal vesicle weight was increased only in adult rats treated with the higher dose of LH together with FSH. The results demonstrate that FSH potentiates the action of low doses of LH on plasma testosterone levels in adult hypophysectomized rats and suggest that FSH may be involved in the regulation of androgen secretion by the rat testis.

Urethral plug-a new secondary male sex characteristic in rat and other rodents

1982 ◽  
Vol 16 (2) ◽  
pp. 151-155 ◽  
Author(s):  
Ivo Kunstýř ◽  
Werner Küpper ◽  
Herwig Weisser ◽  
Susanne Naumann ◽  
Claus Messow
Keyword(s):  
Amino Acid ◽  
Amino Acid Composition ◽  
Adult Male ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Average Weight ◽  
Adult Rats ◽  
Vaginal Plug ◽  
Male Sex ◽  
Proximal Urethra

The plug is an eosinophilic mass, partly homogenous and partly porous, filling the proximal urethra in rats and occasionally extending into the bladder. Its average weight in 131 adult rats was 0·063 g. These plugs are normally present in the urethra of adult male rats, and this seems to be the case for all laboratory Muridae and Cavidae. The absence of a plug in an adult male may be a sign of abnormality associated with failing health. There is an interesting similarity between the amino acid composition of the content of seminal vesicles, that of the urethral plug, and that of the copulatory vaginal plug in female rodents.

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