URINARY EXCRETION OF FREE CORTISOL IN IMPAIRED RENAL FUNCTION

1975 ◽  
Vol 78 (1) ◽  
pp. 86-90 ◽  
Author(s):  
P. Sederberg-Olsen ◽  
C. Binder ◽  
H. Kehlet
Keyword(s):  
Renal Function ◽  
Urinary Excretion ◽  
Impaired Renal Function ◽  
Filtration Rate ◽  
Urinary Cortisol ◽  
Dose Rates ◽  
Total Cortisol ◽  
Free Cortisol ◽  
Free Urinary Cortisol

ABSTRACT Total cortisol and free, non protein-bound cortisol in plasma and urinary excretion of unconjugated free cortisol were measured during iv infusion of cortisol at varying dose rates in eight patients with impaired renal function. The results showed that free urinary cortisol decreased with decreased glomerular filtration rate (GFR), also compared to free cortisol level in plasma. An increase in free cortisol in plasma had no influence on GFR. It is concluded that determination of free urinary cortisol, otherwise useful in diagnosing Cushing's syndrome, may be of less value in patients with impaired renal function.

URINARY EXCRETION OF FREE CORTISOL IN HYPERCALCAEMIA

1973 ◽  
Vol 74 (1) ◽  
pp. 122-126 ◽  
Author(s):  
F. Schønau Jorgensen ◽  
H. Kehlet
Keyword(s):  
Urinary Excretion ◽  
Hpa Axis ◽  
Animal Studies ◽  
Urinary Cortisol ◽  
Free Cortisol ◽  
Free Urinary Cortisol ◽  
Urinary Cortisol Excretion ◽  
Cortisol Excretion

ABSTRACT Human and animal studies have uniformly demonstrated increased hypothalamic-pituitary-adrenocortical (HPA) activity during acute hypercalcaemia. The HPA-activity during chronic hypercalcaemia was investigated by means of free urinary cortisol excretion. No difference in HPA activity could be demonstrated between a hyperparathyroid hypercalcaemic and a normocalcaemic group of patients. Based on these results it is suggested that during chronic hypercalcaemia, the HPA feed back mechanism overcomes the influence of hypercalcaemia on the HPA-axis.

scholarly journals Impaired Glomerular Filtration Rate in Type 2 Diabetes Mellitus Subjects: A Nationwide Cross-Sectional Study in Thailand

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Naowanit Nata ◽  
Ram Rangsin ◽  
Ouppatham Supasyndh ◽  
Bancha Satirapoj
Keyword(s):  
Risk Factors ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Impaired Renal Function ◽  
Filtration Rate ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Background. Type 2 diabetic mellitus (T2DM) patients with impaired renal function have a higher risk of mortality, and often progress to end-stage renal disease. The study aims to determine the prevalence of kidney disease and investigate the relationship between various factors and impaired renal function in a large population of patients with T2DM. Methods. We conducted a cross-sectional study among 30,377 patients from a nationwide diabetes study involving 602 Thai hospitals. Impaired glomerular filtration rate (GFR) was defined as <60 mL/min per 1.73 m2. Multivariate logistic regression was used to determine the association between standard risk factors and impaired GFR. Results. The prevalence of impaired GFR in a T2DM population was 39.2%. After adjusting for multiple risk factors, advanced age (adjusted OR 11.69 (95%CI=3.13 to 43.61)), macroalbuminuria (adjusted OR 3.54 (95%CI=1.50 to 8.40)), high serum uric acid (adjusted OR 2.06 (95%CI=1.73 to 2.46)), systolic BP 130-139 mmHg (adjusted OR 3.21 (95%CI=1.30 to 7.96)), hemoglobinA1C (HA1C) <6% (adjusted OR 3.71 (95%CI=1.65 to 8.32)), and HA1C >7% (adjusted OR 2.53 (95%CI=1.38 to 4.63)) were found to be associated with a significantly increased risk of impaired GFR among T2DM patients. Conclusion. Almost 40% of patients with T2DM in a nationwide cross-sectional study in Thailand had impaired GFR. Advanced age, albuminuria, hyperuricemia, hypertension, HA1C <6%, and HA1C >7% were independently associated with increased prevalence of impaired GFR.

Tripotassium dicitrato bismuthate: absorption and urinary excretion of bismuth in patients with normal and impaired renal function

2007 ◽  
Vol 5 (5) ◽  
pp. 491-502 ◽  
Author(s):  
G. TREIBER ◽  
U. GLADZIWA ◽  
T. H. ITTEL ◽  
S. WALKER ◽  
F. SCHWEINSBERGS ◽  
...  
Keyword(s):  
Renal Function ◽  
Urinary Excretion ◽  
Impaired Renal Function

scholarly journals Heterogeneity in the Association Between Prediabetes Categories and Development of Impaired Renal Function in A 5-Year Follow-Up 

2020 ◽  
Author(s):  
Marjan Manouchehri ◽  
Lucía Cea-Soriano ◽  
Josep Franch-Nadal ◽  
Antonio Ruiz ◽  
Albert Goday ◽  
...  
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Incidence Rate ◽  
Impaired Renal Function ◽  
Filtration Rate ◽  
Cox Regression ◽  
Rank Test ◽  
Diagnostic Categories

Abstract Background: Impaired renal function (IRF) in patients with diabetes impose a significant health burden. This study evaluates the association of three diagnostic categories of with a reduction on glomerular filtration rate Methods: We used data from PREDAPS prospective study a cohort of 1072 subjects with prediabetes and another cohort of 772 subjects without prediabetes were follow-up from 2012 to 2017. Prediabetes was defined according to American Association of Diabetes (ADA) criteria. IRF was defined as having a glomerular filtration rate < 60 mL/min/1.73 m2. Incidence rate of IRF according to prediabetes and diagnostic categories of prediabetes as well as Kaplan Meir figures were calculated. Hazard ratios (HR) for the association of the prediabetes diagnostic categories of prediabetes with IRF, adjusting for potential confounders, were estimated by Cox regression models.Results: IRF Incidence rate per 100 person-years in subjects without prediabetes was 1.72 (95% confidence interval [CI]: 1.34-2.21) and 1.79 (95%CI: 1.45-2.20) for those with prediabetes stage, log rank test p= 0.84. Prediabetes was associated with an adjusted HR of IRF onset of 0.76 (95% CI: 0. 54-1.07). Corresponding HR for diagnostic categories were 0.68 (95%CI:0.40-1.15) for those with both altered parameters, 0.68 (95%CI: 00.40-1.15) for those with only impaired HbA1c and 1.12 (95%CI: 0.68-1.85) for those with only impaired FPG. Conclusions: The present study reflects an overall trend towards a slightly decreased risk of IRF onset associated to prediabetes except for individuals with only isolated impaired FPG. Further studies are warranted to fully assess the renal progression of each group.

scholarly journals A CASE STUDY SHOWED THAT GUDA-ARDRAK KALPA IS EFFECTIVE IN THE MANAGEMENT OF CKD

2021 ◽  
pp. 78-81
Author(s):  
Madan Prateek ◽  
Singh N.R
Keyword(s):  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Impaired Renal Function ◽  
Filtration Rate ◽  
Eating Habits ◽  
Rapid Urbanization ◽  
Artery Disease ◽  
Lifestyle Diseases

Chronic Kidney Disease (CKD) includes many pathophysiological processes related to impaired renal function and decreased reformist Glomerular Filtration Rate (GFR). The rapid economic development and globalization have promoted the progress of epidemiology, which has led to rapid urbanization, major changes in lifestyle, and changes in eating habits. Regarding non-communicable or suspicious lifestyle diseases such as hypertension, diabetes, coronary artery disease, malignant tumor and Chronic Kidney Infection (CKD), here we describe in detail the CKD case of a 30-year-old patient. There is no direct description of infection in Ayurvedic science, so we can only compare the disease and Ayurvedic view points based on the comprehensible understanding of Ayurvedic cases. This is an agreement with a good cure effect. Guda-Ardrak (Electuarium Ginger-Jaggery) was used in Kalpa (a separate Ayurvedic therapy) with milk for 19 days. This seal exhibits reduced serum creatinine levels, increased appetite and increased alertness. This case study shows that Guda-Ardrak Kalpa is an effective CKD treatment option.

The Effect of Impaired Renal Function on the Plasma Concentration and Urinary Excretion of Metoprolol Metabolites

1980 ◽  
Vol 5 (2) ◽  
pp. 181-191 ◽  
Author(s):  
K.-J. Hoffmann ◽  
C.-G. Regårdh ◽  
M. Aurell ◽  
M. Ervik ◽  
L. Jordö
Keyword(s):  
Renal Function ◽  
Plasma Concentration ◽  
Urinary Excretion ◽  
Impaired Renal Function
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