Postpartum thyroid dysfunction in Bangkok: A geographical variation in the prevalence

1990 ◽  
Vol 122 (2) ◽  
pp. 283-287 ◽  
Author(s):  
Rajata Rajatanavin ◽  
La-or Chailurkit ◽  
Kanokporn Tirarungsikul ◽  
Wirawat Chalayondeja ◽  
Uraiwan Jittivanich ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Fine Needle Aspiration Biopsy ◽  
Post Partum ◽  
Thyroid Function Test ◽  
Needle Aspiration ◽  
Iodine Intake ◽  
Thyroid Autoantibodies ◽  
Function Test ◽  
Postpartum Thyroid Dysfunction

Abstract To determine the prevalence of thyroid dysfunction in Thai postpartum women, we evaluated thyroid function and thyroid autoantibodies in 812 consecutive unselected women at 1.5 months post partum. At 3.5 months post partum 570 women without previous thyroid abnormality returned for a second set of thyroid function test. The prevalence of thyroid dysfunction was 1.1%, which was less than that reported from other countries. Various types of postpartum thyroid dysfunction, namely, transient thyrotoxicosis followed by transient hypothyroidism, transient thyrotoxicosis or hypothyroidism occurring alone or permanent hypothyroidism were encountered. Eight out of 9 patients with thyroid dysfunction had thyroid autoantibodies. Fine needle aspiration biopsy of the thyroid was done in 4 patients and all showed lymphocytic thyroiditis. Even though Bangkok is an iodine surfeit area, iodine intake is relatively lower than in other areas where the prevalence of postpartum thyroid dysfunction is much higher. The discrepancy in geographic prevalence of postpartum thyroid dysfunction may result from the interaction of immunogenetic heterogeneity of different ethnic background, environmental iodine intake, and other unidentified environmental factors.

scholarly journals Thyroid disorder in pregnancy and postpartum with neonatal outcome a study in tertiary care centre

2019 ◽  
Vol 8 (5) ◽  
pp. 1795
Author(s):  
Bharati Das ◽  
Puspanjali Khuntia
Keyword(s):  
Thyroid Function ◽  
Post Partum ◽  
Tertiary Care ◽  
Thyroid Function Test ◽  
Thyroid Disorders ◽  
Thyroid Disorder ◽  
New Born ◽  
Pregnancy And Postpartum ◽  
Function Test ◽  
In Pregnancy

Background: Thyroid disorders are well known entity in pregnancy. Both mother and baby have to suffer from the consequences.  Lot of works has been done and many guidelines too came out over the years but what is actual understanding of the disease process by the mothers about themselves and for their babies especially in developing country like India remained uncovered. This has been analysed in present study.Methods: It is a prospective observational study done in the post-partum programmed department of SCB medical college and hospital, a tertiary care center in eastern part of India for 3 years period. Thyroid dysfunction of the mothers and new born screening of thyroid function of their babies has been assessed.Results: During this period total no of the babies along with their mothers were evaluated were 3762. Total no of thyroid disorders detected in 85 (2.25%) of mothers, among which hypothyroidism in 79 (2.09%) and hyperthyroidism in 6 (0.16%) were found. From total 85 cases, 79 (93%) mothers were hypothyroid   and 6 (7%) were hyperthyroid. Among the hypothyroid mothers 32 (40.5%) were diagnosed before present pregnancy and (59.5%) were diagnosed during pregnancy. In the babies of hypothyroid mother, new born screening for thyroid function was done only in 14 (17.7%) cases between 5-10 days.Conclusions: Thyroid screening should be done in pregnancy as universal screening instead of high-risk cases. Documentation and interdepartmental coordination are very much essential in thyroid disorders for further decision by the physician for necessity of continuation of treatment and thyroid function test in the post-partum period for the mothers and its long-term consequences. It also guides the neonatologist or pediatrician doing thyroid function test of their babies. Ideally All newborns should be screened for congenital hypothyroidism as a part of new born screening (NBS) programmed. Effective communication with the mother and the family is very much essential for monitoring and treatment of both mother and the baby.

Different aetiologies in post-partum thyroiditis?

1983 ◽  
Vol 104 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Per Anders Dahlberg ◽  
Rolf Jansson
Keyword(s):  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Thyroid Dysfunction ◽  
Post Partum ◽  
Lymphocytic Infiltration ◽  
Graves Disease ◽  
Thyroid Autoantibodies ◽  
Radioiodine Uptake ◽  
Thyroid Cytology

Abstract. During a 4 year period 19 women with post-partum onset of thyroid dysfunction have been seen in our clinic. Five women had high radioiodine uptake thyrotoxicosis (Graves' disease). Twelve women had hypothyroid symptoms starting within 3–6 months of delivery. All of these women had thyroid microsomal and/or cytoplasmic autoantibodies and thyroid lymphocytic infiltration suggesting aggravation of pre-existing subclinical autoimmune thyroiditis (Hashimoto's disease). At follow-up thyroid function gradually improved in all but signs of persistent thyroid hypofunction remained in seven. Thus women developing symptomatic postpartum hypothyroidism should be followed regularly and when thyroxine treatment is commenced in the post-partum period, it has to be continued indefinitely in many cases. Two women presented with transient low radioiodine uptake thyrotoxicosis and a small painless goitre. Thyroid cytology revealed thyroiditis but they had no thyroid autoantibodies. When followed after a succeeding delivery none of these women developed post-partum thyroid dysfunction in contrast to women in the autoimmune group. Probably the aetiology of thyroid dysfunction in these 2 women was different.

scholarly journals Thyroid function test in abnormal uterine bleeding

2018 ◽  
Vol 12 (2) ◽  
pp. 74-78
Author(s):  
Pramod Kattel
Keyword(s):  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Pap Smear ◽  
Abnormal Uterine Bleeding ◽  
Thyroid Function Test ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Pathological Examination ◽  
Overt Hypothyroidism ◽  
Function Test

Aims: To evaluate and detect the thyroid dysfunction in patients with abnormal uterine bleeding (AUB) from puberty to menopause.Methods: This is an observational descriptive study of 90 patients of abnormal uterine bleeding at Paropakar Maternity and Women’s Hospital, Kathmandu from 17th January 2016 to 16th January 2017. Besides thyroid function test Pap smear, endometrial biopsy and histo-pathological examination of uterus following hysterectomy was done in selected cases.Results: The incidence of AUB was 6.2 % with mean age of 37 years. The most common presenting complaint was menorrhagia (36.7%) followed by metrorrhagia (23.3%). Thyroid dysfunction accounted for 20% of AUB with major share occupied by subclinical hypothyroidism (11%) and least by hyperthyroidism (1%). The most common association of thyroid dysfunction with AUB was overt hypothyroidism (27.3%) with menorrhagia. Non-structural cases of AUB accounted for 30.4% of thyroid dysfunction.Conclusions: This study shows that thyroid dysfunction plays significant role for AUB so it is wise enough to perform TFT on routine basis in order to avoid unnecessary hormonal treatment with Estrogen, Progesterone or their combination and even the hysterectomies.

scholarly journals A Rapidly Enlarging Thyroid Nodule- Aspergillus Abscess

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A915-A915
Author(s):  
Ivana Sheu ◽  
Almoatazbellah M Idriss
Keyword(s):  
Thyroid Nodule ◽  
Thyroid Function ◽  
Thyroid Function Test ◽  
Needle Aspiration ◽  
Thyroid Lesion ◽  
Suppurative Thyroiditis ◽  
Fine Needle ◽  
Function Test ◽  
Acute Suppurative Thyroiditis ◽  
Disseminated Aspergillosis

Abstract Introduction: Acute suppurative thyroiditis is a rare thyroid disorder with high mortality often due to bacterial or fungal infection. Here we present a case of a rapidly enlarging thyroid nodule in the setting of disseminated aspergillosis. Case: A 31 year old female with lupus on immunosuppressants first presented with weakness to the emergency department with workup finding multiple pulmonary, intracranial and vertebral lesions and a left thyroid nodule. On thyroid ultrasound the nodule was solid, hypoechoic, 1.5x2.3x2.7cm with irregular margins and no echogenic foci. Thyroid function tests: Total T3 52ng/dL (80-210ng/dL), Free T4 2.26ng/dL (0.6-1.12ng/dL), TSH 0.015µIU/mL (0.45-4.12µIU/mL). The patient was started on voriconazole for disseminated aspergillosis with plan for outpatient thyroid workup. However with further brain lesion growth, the patient was readmitted with incidental finding of thyroid nodule developing into a multiloculated, septated, fluid filled 5x2.9x4cm lesion after 3 months. Fine needle aspiration of the thyroid lesion resulted in negative bacterial and fungal cultures, no malignant cells, positive fungal elements consistent with aspergillus on cytology. The patient was continued on antifungal therapy (switched to cresemba due to voriconazole side effects) with thyroid lesion regression to 2.4x0.6x1.3cm at 6 months and 1.8x1.1x1.6cm at 12 months. Her thyroid function test normalized ~ 1 month after initial set of labs and the patient remained clinically euthyroid throughout her course. Discussion: Thyroid infections are limited due to the thyroid’s high iodine content, capsular encasement and rich vascularity. Acute suppurative thyroiditis (AST) due to aspergillus is a rare finding that can present solo or as a part of disseminated infection especially in immunocompromised individuals. Early presentation is often asymptomatic with possible thyroid function test abnormalities that self resolve in a couple weeks. Occasionally patients present with obstructive symptoms or findings of thyroid storm. Diagnosis is done through fine needle aspiration or autopsy, with treatment options including surgery, antifungals or both. Due to the high mortality of fungal AST, with improved outcomes with early diagnosis, it is important to consider AST as a part of the differential diagnosis in immunocompromised patients with systemic illness.

scholarly journals Status of Thyroid Disorder among the Thyroid Function Test Samples Received in a Laboratory among Postmenopausal Women: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (234) ◽  
Author(s):  
Manoranjan Shrestha ◽  
Reshmi Shrestha
Keyword(s):  
Postmenopausal Women ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Thyroid Function Test ◽  
Cross Sectional Study ◽  
Reference Laboratory ◽  
Sectional Study ◽  
Cross Sectional ◽  
Function Test

Introduction: Thyroid dysfunction prevalence is high in females worldwide which increases with age. Postmenopausal and elderly women are particularly at risk of developing comorbidities and mortality related to thyroid dysfunction. We aimed to study the prevalence of thyroid dysfunction in postmenopausal women in the National Reference Laboratory of Nepal. Methods: A descriptive cross-sectional study was conducted in National Reference Laboratory from January 2019 to June 2019 including postmenopausal females, ≥49 years. The database of thyroid function test result was used for statistical analysis and proportion of thyroid dysfunction was calculated. The data was collected after approval from the institutional review committee. Statistical Package for Social Sciences version 21 was used to study descriptive data. Results: Out of a total of 160 postmenopausal females with thyroid function tests, 71 (44.4%) had thyroid dysfunction. Subclinical hypothyroidism was the frequently occurring thyroid dysfunction 51 (32%) followed by subclinical hyperthyroidism 13 (8%), hypothyroidism 3 (2%) and hyperthyroidism 3 (2%). In our study population, thyroid dysfunction peaked at 49 to 58 years of age interval 53 (33.1%) and subclinical hypothyroidism was the most frequent form 38 (23.7%). Conclusions: Subclinical hypothyroidism was the common thyroid dysfunction in postmenopausal age which peaked at 49 to 58 years of age group. Early postmenopausal females are predisposed to increased risk of comorbidities (cardiovascular disease, osteoporosis with high fracture, depression) which could be exacerbated with thyroid dysfunction; therefore awareness of thyroid dysfunction prevalence and thyroid screening for early management seems appropriate in Nepalese postmenopausal women.

Thyroid Disease in Pregnancy

2008 ◽  
Vol 04 (01) ◽  
pp. 100
Author(s):  
N Pearce Elizabeth ◽  
M Leung Angela
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Thyroid Function Test ◽  
Autoimmune Thyroid ◽  
Thyroid Screening ◽  
Function Test ◽  
In Pregnancy

The spectrum of thyroid disease in pregnancy has implications for both the mother and the developing fetus. Here we review the interpretation of thyroid function test values, thyrotoxicosis, hypothyroidism, iodine requirements, autoimmune thyroid disease, and thyroid screening recommendations as they pertain to pregnant women. It should be noted that the management of thyroid dysfunction in pregnancy should be closely co-ordinated with obstetricians and other providers.

scholarly journals Thyroid Dysfunction and Cytological Patterns among Patients Requested for Thyroid Function Test in an Endemic Goiter Area of Gondar, North West Ethiopia

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Daniel Asmelash ◽  
Kumlgn Tesfa ◽  
Belete Biadgo
Keyword(s):  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Endemic Goiter ◽  
Wide Spectrum ◽  
Nodular Goiter ◽  
Thyroid Function Test ◽  
Subclinical Hyperthyroidism ◽  
Cross Sectional ◽  
Function Test ◽  
Study Participants

Background. Thyroid dysfunction is the most common endocrine disorder in clinical practice, and about half of the population with thyroid dysfunction remains undiagnosed. There is a fairly wide spectrum of thyroid dysfunction, which can be identified by patterns of thyroid function test results. The prevalence of thyroid dysfunction among the population varies in different studies. Methods. A cross-sectional study was conducted from February 8th to April 8th, 2017, among patients who requested for the thyroid function test in an endemic goiter area at the Gondar Hospital, University of Gondar. A pretested structured questionnaire was used to collect the data. Three milliliters of blood samples was collected in a plain test tube and centrifuged for serum separation. The thyroid function test was done by using the MINI-VIDAS automation following the manufacturer manual (Setema PLC, Italy). Data were entered and analyzed using SPSS version 20. Descriptive statistics were used for data presentation, and P value < 0.05 was considered significant. Result. Of the total 384 study participants, 346 (90.1%) were females and the study participants’ mean age was 38 ± 13.9 years. The overall thyroid dysfunction prevalence was 26.3% (101): 1.6% was identified as subclinical hypothyroidism, 0.5% hypothyroidism, 9.6% subclinical hyperthyroidism, and 14.6% hyperthyroidism, and 23.4% had goiter. Furthermore, for cytological pattern analysis, 144 study participants who fulfilled indications for fine-needle aspiration cytology (FNAC) in thyroid nodules were included. Of the total, 3 (2.1%) had thyroid carcinoma, 46 (32%) had cystic degenerated follicular cells, and 82 (57%) had nodular thyroid goiter. In addition, a clinical presentation of a total of 144 study participants, showed lymphadenites in 7 participants (4.8%), hypertension in 9 (6.2%), and cardiac failure in 12 (8.3%). Conclusion. The prevalence of thyroid dysfunction was high. The majority of thyroid dysfunction cases were newly diagnosed and more common in females. In addition, the most common disorders were subclinical hyperthyroidism and hyperthyroidism. Follicular cell with cyst degeneration and thyroid nodular goiter were the predominant FNAC findings. For early diagnosis and appropriate intervention in goiter endemic areas, the thyroid function test should be closely monitored.

scholarly journals Amyloid Goiter with Diffuse Lipomatosis

2011 ◽  
Vol 3 (2) ◽  
pp. 97-99
Author(s):  
Bulent Citgez ◽  
Mehmet Uludag ◽  
Gurkan Yetkin ◽  
Ismail Akgun ◽  
Senay Yener ◽  
...  
Keyword(s):  
Fine Needle Aspiration Biopsy ◽  
Thyroid Function Test ◽  
Needle Aspiration ◽  
Pathological Examination ◽  
Test Results ◽  
Recent Onset ◽  
Normal Limits ◽  
Amyloid Goiter ◽  
Function Test ◽  
Local Examination

ABSTRACT We report a case of a 37-year-old man who presented with a neck swelling associated with recent onset respiratory distress. The patient was receiving hemodialysis due to chronic renal failure three times a week for 8 years. Local examination showed a diffuse thyroid enlargement. The thyroid function test results of the patient were within normal limits. At the ultrasonography examination, there was a 17 × 11 mm nodule at the isthmus with a hypoechoic halo containing calcified foci. The fine needle aspiration biopsy (FNAB) of the nodule at the isthmus that contained calcification revealed adenomatous nodule rich in cells, which showed degeneration and follicular neoplasia. Total thyroidectomy was planned due to the patient's ongoing symptoms and dyspnea. The pathological examination revealed diffuse lipomatosis and amyloidosis.

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