scholarly journals Status of Thyroid Disorder among the Thyroid Function Test Samples Received in a Laboratory among Postmenopausal Women: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (234) ◽  
Author(s):  
Manoranjan Shrestha ◽  
Reshmi Shrestha
Keyword(s):  
Postmenopausal Women ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Thyroid Function Test ◽  
Cross Sectional Study ◽  
Reference Laboratory ◽  
Sectional Study ◽  
Cross Sectional ◽  
Function Test

Introduction: Thyroid dysfunction prevalence is high in females worldwide which increases with age. Postmenopausal and elderly women are particularly at risk of developing comorbidities and mortality related to thyroid dysfunction. We aimed to study the prevalence of thyroid dysfunction in postmenopausal women in the National Reference Laboratory of Nepal. Methods: A descriptive cross-sectional study was conducted in National Reference Laboratory from January 2019 to June 2019 including postmenopausal females, ≥49 years. The database of thyroid function test result was used for statistical analysis and proportion of thyroid dysfunction was calculated. The data was collected after approval from the institutional review committee. Statistical Package for Social Sciences version 21 was used to study descriptive data. Results: Out of a total of 160 postmenopausal females with thyroid function tests, 71 (44.4%) had thyroid dysfunction. Subclinical hypothyroidism was the frequently occurring thyroid dysfunction 51 (32%) followed by subclinical hyperthyroidism 13 (8%), hypothyroidism 3 (2%) and hyperthyroidism 3 (2%). In our study population, thyroid dysfunction peaked at 49 to 58 years of age interval 53 (33.1%) and subclinical hypothyroidism was the most frequent form 38 (23.7%). Conclusions: Subclinical hypothyroidism was the common thyroid dysfunction in postmenopausal age which peaked at 49 to 58 years of age group. Early postmenopausal females are predisposed to increased risk of comorbidities (cardiovascular disease, osteoporosis with high fracture, depression) which could be exacerbated with thyroid dysfunction; therefore awareness of thyroid dysfunction prevalence and thyroid screening for early management seems appropriate in Nepalese postmenopausal women.

scholarly journals Hospital based study to evaluate subclinical hypothyroidism in post-menopausal women

2017 ◽  
Vol 5 (1) ◽  
pp. 153
Author(s):  
Shruthi Kamal V. ◽  
Rajesh S. ◽  
Reshma S.
Keyword(s):  
Postmenopausal Women ◽  
Subclinical Hypothyroidism ◽  
Thyroid Function Test ◽  
Cross Sectional Study ◽  
Overt Hypothyroidism ◽  
Cross Sectional ◽  
Medical College ◽  
Menopausal Women ◽  
Function Test ◽  
Post Menopausal

Background: Very few studies have assessed prevalence of subclinical hypothyroidism in postmenopausal women. In this study, we aimed to assess the prevalence of subclinical hypothyroidism in postmenopausal women.Methods: Hospital based cross - sectional study carried out at Saveetha Medical College, Chennai, during the period of August 2016 to October 2016. Seventy-five women in General Surgery ward/OPD were included in the study. Subjects included in the study were postmenopausal age group between 45 to 85 years, provided they fulfilled inclusion and exclusion criteria. History was noted, serum Thyroid function test was done. Results were noted and analyzed.Results: Out of 75 subjects, 21.3% of postmenopausal women were having subclinical hypothyroidism.Conclusions: Prevalence of Subclinical hypothyroidism is high among postmenopausal women, which leads to overt hypothyroidism. Therefore, routine screening and treatment of this condition is must among postmenopausal women to prevent complications of subclinical hypothyroidism.

Association between Thyroid Function and Erythrocyte Indices in General Population from the Asir Region of Saudi Arabia: A Cross-Sectional Study

2021 ◽  
Vol 20 (1) ◽  
pp. 200-206
Author(s):  
Alqahtani Saif Aboud M
Keyword(s):  
Saudi Arabia ◽  
General Population ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Male Population ◽  
Cross Sectional ◽  
Erythrocyte Indices

The purpose of the current investigation is to evaluate the relationship between erythrocyte indices and thyroid function in a general population from the southern region of Saudi Arabia. In a cross-sectional study conducted on 3,007 subjects examined associations among erythrocyte indices, thyroid-stimulating hormone, and free thyroxine. The average age of the population was 48.40±0.261 years, ranging from 13 years to 90 years, and the most represented age group was <50 years. Thyroid dysfunction was observed in 8.41% of the study population, and the most common thyroid dysfunction was subclinical hypothyroidism followed by clinical hyperthyroidism. Most erythrocyte indices were significantly lower in the hypothyroidism group (both primary and subclinical) in comparison to the euthyroid group stratified by gender. According to our investigation, microcytic hypochromic anemia and normocytic normochromic anemia were detected in patients with hypothyroidism. Furthermore, females with subclinical hypothyroidism had a significantly higher prevalence of anemia than male population.

scholarly journals Thyroid function test in nephrotic syndrome children who are admitted in emergency ward of Government Tirunelveli Medical College and Hospital, India

2018 ◽  
Vol 5 (6) ◽  
pp. 2290
Author(s):  
J. Rukmani ◽  
C. Krishanamurthy ◽  
Denny Clarin
Keyword(s):  
Nephrotic Syndrome ◽  
Thyroid Function ◽  
Genetic Diseases ◽  
Congenital Nephrotic Syndrome ◽  
Thyroid Function Test ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Normal Limits ◽  
Function Test

Background: Nephrotic syndrome in childhood is largely primary or idiopathic, although a small proportion of cases are secondary to infectious agents and other glomerular and systemic diseases. The etiology of nephrotic syndrome is age-dependent. Most cases appearing in the first 3 months of life are referred as congenital nephrotic syndrome (CNS) and are due to genetic diseases. The objective of this study is to study the correlation between thyroid profile and different types of nephrotic syndrome.Methods: This cross-sectional study was done between March 2017 to October 2017 in the Department of Pediatrics Tirunelveli Government Medical College. 40 cases of nephrotic syndrome between 1 to12 years, which include all types of nephrotic syndrome. After history taking and clinical examination, blood samples were collected from the patients for thyroid function test and analyzed with standard techniques.Results: Serum T3, T4, TSH were found to be within normal limits. But TSH values in remission were significantly elevated compared to the first episode.Conclusions: Thyroid profiles in control were within normal range. The T4 and T3 levels in nephrotic syndrome were low and TSH was high. Hypothyroidism was more common in children less than 6 years. 

scholarly journals Triiodothyronin, Thyroxine and Thyrotropin in Vitiligo

2012 ◽  
Vol 9 (2) ◽  
pp. 7-10
Author(s):  
K Subba ◽  
D Karn ◽  
R Khatri
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
Cross Sectional Study ◽  
Thyroid Function Tests ◽  
Thyroid Disorder ◽  
Age Group ◽  
Cross Sectional ◽  
Function Test ◽  
High Level

BackgroundVitiligo is a common pigmentary disorder of the skin, affecting individuals globally. Not only is this ailment psychologically incapacitating, it also has a high incidence of autoimmunity, signifying that its manifestations may be the portrayal of dysfunction of immune system. ObjectiveThe aim of this study is to find out the situations of abnormal thyroid function test (TFT) in vitiligo patients. MethodsA prospective cross sectional study was conducted at the Dhulikhel Hospital, KUTH, Dhulikhel during November 2008 to January 2011 with the objective to assess the thyroid function tests in vitiligo patients. ResultsTotal 66 vitiligo patients with male 30 (45%) and female 36 (55%). Total 26 (39.39%) vitiligo patients have been found to have abnormal thyroid function test. Among them 10 had abnormal T3, seven had abnormal T4 and 12 had abnormal TSH level. Thyroid function test were normal in other vitiligo patients. Total seven vitiligo had high level of T3 than normal value, four male and three female. Two had higher level of T4 above 2.0 ng/dl and all were male, while five had abnormally low level of T4 with three male and two female. There were seven vitiligo patient with increased T3 level and three with decreased T3 level, among them six were males and four were females, the age group was ranged from seven to 68 years old. The T4 level were found abnormal in seven vitiligo patients among which five were males and two were females with the age group ranging from 7 to 51 years. ConclusionsThere has been significant association of thyroid disorder in the patient with vitiligo. Therefore, patient with vitiligo need to undergo thyroid function test to rule out the thyroid disorder and prevent from long-term complications.DOI: http://dx.doi.org/10.3126/kumj.v9i2.6279Kathmandu Univ Med J 2011;9(2):7-10 

scholarly journals Thyroid Dysfunction and Cytological Patterns among Patients Requested for Thyroid Function Test in an Endemic Goiter Area of Gondar, North West Ethiopia

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Daniel Asmelash ◽  
Kumlgn Tesfa ◽  
Belete Biadgo
Keyword(s):  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Endemic Goiter ◽  
Wide Spectrum ◽  
Nodular Goiter ◽  
Thyroid Function Test ◽  
Subclinical Hyperthyroidism ◽  
Cross Sectional ◽  
Function Test ◽  
Study Participants

Background. Thyroid dysfunction is the most common endocrine disorder in clinical practice, and about half of the population with thyroid dysfunction remains undiagnosed. There is a fairly wide spectrum of thyroid dysfunction, which can be identified by patterns of thyroid function test results. The prevalence of thyroid dysfunction among the population varies in different studies. Methods. A cross-sectional study was conducted from February 8th to April 8th, 2017, among patients who requested for the thyroid function test in an endemic goiter area at the Gondar Hospital, University of Gondar. A pretested structured questionnaire was used to collect the data. Three milliliters of blood samples was collected in a plain test tube and centrifuged for serum separation. The thyroid function test was done by using the MINI-VIDAS automation following the manufacturer manual (Setema PLC, Italy). Data were entered and analyzed using SPSS version 20. Descriptive statistics were used for data presentation, and P value < 0.05 was considered significant. Result. Of the total 384 study participants, 346 (90.1%) were females and the study participants’ mean age was 38 ± 13.9 years. The overall thyroid dysfunction prevalence was 26.3% (101): 1.6% was identified as subclinical hypothyroidism, 0.5% hypothyroidism, 9.6% subclinical hyperthyroidism, and 14.6% hyperthyroidism, and 23.4% had goiter. Furthermore, for cytological pattern analysis, 144 study participants who fulfilled indications for fine-needle aspiration cytology (FNAC) in thyroid nodules were included. Of the total, 3 (2.1%) had thyroid carcinoma, 46 (32%) had cystic degenerated follicular cells, and 82 (57%) had nodular thyroid goiter. In addition, a clinical presentation of a total of 144 study participants, showed lymphadenites in 7 participants (4.8%), hypertension in 9 (6.2%), and cardiac failure in 12 (8.3%). Conclusion. The prevalence of thyroid dysfunction was high. The majority of thyroid dysfunction cases were newly diagnosed and more common in females. In addition, the most common disorders were subclinical hyperthyroidism and hyperthyroidism. Follicular cell with cyst degeneration and thyroid nodular goiter were the predominant FNAC findings. For early diagnosis and appropriate intervention in goiter endemic areas, the thyroid function test should be closely monitored.

scholarly journals Lifestyle is associated with thyroid function in subclinical hypothyroidism: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kejun Wu ◽  
Yu Zhou ◽  
Sujie Ke ◽  
Jingze Huang ◽  
Xuelin Gao ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Sleep Quality ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Influencing Factor ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Iodine Excess ◽  
Secretory Capacity

Abstract Background Few studies have focused on the association between lifestyle and subclinical hypothyroidism (SCH). The purpose of this study was to investigate the association between lifestyle and thyroid function in SCH. Methods This study was a part of a community-based and cross-sectional study, the Epidemiological Survey of Thyroid Diseases in Fujian Province, China. A total of 159 participants with SCH (81 males and 78 females) and 159 euthyroid (87 males and 72 females) participants without any missing data were included in the analysis. General information and lifestyle information including sleep, exercise, diet and smoking habits of the participants was collected by questionnaire and Pittsburgh sleep quality index scale (PSQI) was collected. Thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), thyroid globulin antibody (TgAb) and urine iodine concentration (UIC) were tested. Thyroid homeostasis parameter thyroid’ s secretory capacity (SPINA-GT), Jostel’s TSH index (TSHI), thyrotroph T4 sensitivity index (TTSI) were calculated. Logistic regression and multiple linear regression were performed to assess associations. Results Compared with euthyroid subjects, patients with SCH were more likely to have poor overall sleep quality (15.1 vs.25.8 %, P = 0.018) and l less likely to stay up late on weekdays (54.7 vs. 23.9 % P < 0.001). In SCH group, exercise was the influencing factor of TSH (β= -0.224, P = 0.004), thyroid secretory capacity (β = 0.244, P = 0.006) and thyrotropin resistance (β = 0.206, P = 0.009). Iodine excess was the influencing factor of thyroid secretory capacity (β = 0.209, P = 0.001) and pituitary thyroid stimulating function (β = 0.167, P = 0.034). Smoking was the influencing factor of pituitary thyroid stimulating function (β = 0.161, P = 0.040). Staying up late on weekends was the influencing factor of thyroid secretory capacity (β = 0.151, P = 0.047). After adjusting for possible confounders, logistic regression showed that those with poor overall sleep quality assessed by PSQI and iodine excess had an increased risk of SCH (OR 2.159, 95 %CI 1.186–3.928, P = 0.012 and OR 2.119, 95 %CI 1.008–4.456, P = 0.048, respectively). Conclusions Lifestyle including sleep, smoking, diet and exercise was closely related to thyroid function especially thyroid homeostasis in SCH.

scholarly journals Frequency of subclinical hypothyroidism in chronic kidney disease patients.

2021 ◽  
Vol 28 (09) ◽  
pp. 1326-1330
Author(s):  
Tahir Rashid ◽  
Irfan Mirza ◽  
Abdul Rauf ◽  
Syed Hassan Mustafa ◽  
Talha Durrani ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Standard Deviation ◽  
Kidney Disease ◽  
Thyroid Function ◽  
Clinical Examination ◽  
Subclinical Hypothyroidism ◽  
Cross Sectional Study ◽  
Thyroid Function Tests ◽  
Sectional Study ◽  
Cross Sectional

Objective: Objective of this study was to determine the frequency of sub clinical hypothyroidism among chronic kidney disease patients in our population. Study Design: Descriptive Cross sectional study. Settings: Department of Nephrology, Khyber Teaching Hospital Peshawar. Period: February 2018 to September 2018. Material & Methods: A total of 145 chronic kidney disease patients were included in this study. Thyroid function tests (TFT, s) were performed in all patients along with history and clinical examination. Sub clinical hypothyroidism was defined as high TSH (normal value 0.27-4.0 µIU/ml) and normal Free T47. (0.93 – 1.70 ng/dl). Results: Our study shows that Mean age was 55 years with standard deviation ± 2.83. Eighty seven (60%) patients were male and 58(40%) patients were female. Moreover, 25% patients had subclinical hypothyroidism. Conclusion: Our study concludes that the incidence of subclinical hypothyroidism in chronic kidney disease was found to be 25% in our population.

scholarly journals Occurrence of subclinical and overt hypothyroidism among chronic kidney disease patients

2020 ◽  
Vol 8 (9) ◽  
pp. 3284
Author(s):  
Dilip Kumar Jha ◽  
Gregory Minj ◽  
Umesh Prasad ◽  
Yuvraj Lahre ◽  
Diljeet Bodra
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
Overt Hypothyroidism ◽  
Sectional Study ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Serum T3

Background: Chronic kidney disease (CKD) is one of the vital health problems worldwide leading to increased global morbidity and mortality. Thyroid dysfunction including hypothyroidism, hyperthyroidism and non-thyroidal illness has been reported in CKD patients. This study was conducted to determine the prevalence of subclinical and overt hypothyroidism among chronic kidney disease patients. This study also tried to correlate thyroid function abnormalities with severity of renal failure.Method: In this observational and cross sectional study, 100 patients of CKD who were admitted in Department of Medicine, Rajendra institute of medical sciences, Ranchi were studied for thyroid function abnormalities. Result: This study found that glomerular filtration rate (GFR) is positively correlated with serum T3 and T4 level (i.e. with decreasing renal function both T3 and T4 levels decreased). Serum creatinine levels were negatively correlated with serum T3 and T4 level.Conclusions: From this study it was established that CKD is associated with thyroid dysfunction characterized by low serum fT3 and fT4 with high TSH in some cases.

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