scholarly journals Mild cold effects on hunger, food intake, satiety and skin temperature in humans

2016 ◽  
Vol 5 (2) ◽  
pp. 65-73 ◽  
Author(s):  
M Langeveld ◽  
C Y Tan ◽  
M R Soeters ◽  
S Virtue ◽  
G K Ambler ◽  
...  
Keyword(s):  
Food Intake ◽  
Energy Expenditure ◽  
Skin Temperature ◽  
Energy Intake ◽  
Cold Exposure ◽  
Vital Signs ◽  
Free Food ◽  
Cold Response ◽  
Hunger Sensation

Background Mild cold exposure increases energy expenditure and can influence energy balance, but at the same time it does not increase appetite and energy intake. Objective To quantify dermal insulative cold response, we assessed thermal comfort and skin temperatures changes by infrared thermography. Methods We exposed healthy volunteers to either a single episode of environmental mild cold or thermoneutrality. We measured hunger sensation and actual free food intake. After a thermoneutral overnight stay, five males and five females were exposed to either 18°C (mild cold) or 24°C (thermoneutrality) for 2.5 h. Metabolic rate, vital signs, skin temperature, blood biochemistry, cold and hunger scores were measured at baseline and for every 30 min during the temperature intervention. This was followed by an ad libitum meal to obtain the actual desired energy intake after cold exposure. Results We could replicate the cold-induced increase in REE. But no differences were detected in hunger, food intake, or satiety after mild cold exposure compared with thermoneutrality. After long-term cold exposure, high cold sensation scores were reported, which were negatively correlated with thermogenesis. Skin temperature in the sternal area was tightly correlated with the increase in energy expenditure. Conclusions It is concluded that short-term mild cold exposure increases energy expenditure without changes in food intake. Mild cold exposure resulted in significant thermal discomfort, which was negatively correlated with the increase in energy expenditure. Moreover, there is a great between-subject variability in cold response. These data provide further insights on cold exposure as an anti-obesity measure.

scholarly journals Cold-induced hyperphagia requires AgRP-neuron activation in mice

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Jennifer Deem ◽  
Chelsea L Faber ◽  
Christian Pedersen ◽  
Bao Anh Phan ◽  
Sarah A Larsen ◽  
...  
Keyword(s):  
Food Intake ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Cold Exposure ◽  
Energy Homeostasis ◽  
Cold Environment ◽  
Energy Demands ◽  
Acute Cold Exposure ◽  
Neuron Activation ◽  
Increase Food Intake

To maintain energy homeostasis during cold exposure, the increased energy demands of thermogenesis must be counterbalanced by increased energy intake. To investigate the neurobiological mechanisms underlying this cold-induced hyperphagia, we asked whether agouti-related peptide (AgRP) neurons are activated when animals are placed in a cold environment and, if so, whether this response is required for the associated hyperphagia. We report that AgRP-neuron activation occurs rapidly upon acute cold exposure, as do increases of both energy expenditure and energy intake, suggesting the mere perception of cold is sufficient to engage each of these responses. We further report that silencing of AgRP neurons selectively blocks the effect of cold exposure to increase food intake but has no effect on energy expenditure. Together, these findings establish a physiologically important role for AgRP neurons in the hyperphagic response to cold exposure.

scholarly journals Cold-induced hyperphagia requires AgRP neuron activation in mice

2020 ◽  
Author(s):  
Jennifer D. Deem ◽  
Chelsea L. Faber ◽  
Christian Pedersen ◽  
Bao Anh Phan ◽  
Sarah A. Larsen ◽  
...  
Keyword(s):  
Food Intake ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Cold Exposure ◽  
Energy Homeostasis ◽  
Cold Environment ◽  
Energy Demands ◽  
Acute Cold Exposure ◽  
Neuron Activation ◽  
Increase Food Intake

ABSTRACTTo maintain energy homeostasis during cold exposure, the increased energy demands of thermogenesis must be counterbalanced by increased energy intake. To investigate the neurobiological mechanisms underlying this cold-induced hyperphagia, we asked whether agouti-related peptide (AgRP) neurons are activated when animals are placed in a cold environment and, if so, whether this response is required for the associated hyperphagia. We report that AgRP-neuron activation occurs rapidly upon acute cold exposure, as do increases of both energy expenditure and energy intake, suggesting the mere perception of cold is sufficient to engage each of these responses. We further report that silencing of AgRP neurons selectively blocks the effect of cold exposure to increase food intake. Together, these findings establish a physiologically important role for AgRP neurons in the hyperphagic response to cold exposure.

Effects of PYY3–36 and GLP-1 on energy intake, energy expenditure, and appetite in overweight men

2014 ◽  
Vol 306 (11) ◽  
pp. E1248-E1256 ◽  
Author(s):  
Julie Berg Schmidt ◽  
Nikolaj Ture Gregersen ◽  
Sue D. Pedersen ◽  
Johanne L. Arentoft ◽  
Christian Ritz ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Synergistic Effect ◽  
Energy Intake ◽  
Fat Metabolism ◽  
Vital Signs ◽  
Healthy Male ◽  
Double Blinded ◽  
Male Subjects ◽  
Infusion Period ◽  
Blood Variables

Our aim was to examine the effects of GLP-1 and PYY3–36, separately and in combination, on energy intake, energy expenditure, appetite sensations, glucose and fat metabolism, ghrelin, and vital signs in healthy overweight men. Twenty-five healthy male subjects participated in this randomized, double-blinded, placebo-controlled, four-arm crossover study (BMI 29 ± 3 kg/m2, age 33 ± 9 yr). On separate days they received a 150-min intravenous infusion of 1) 0.8 pmol·kg−1·min−1 PYY3–36, 2) 1.0 pmol·kg−1·min−1 GLP-1, 3) GLP-1 + PYY3–36, or 4) placebo. Ad libitum energy intake was assessed during the final 30 min. Measurements of appetite sensations, energy expenditure and fat oxidation, vital signs, and blood variables were collected throughout the infusion period. No effect on energy intake was found after monoinfusions of PYY3–36 (−4.2 ± 4.8%, P = 0.8) or GLP-1 (−3.0 ± 4.5%, P = 0.9). However, the coinfusion reduced energy intake compared with placebo (−30.4 ± 6.5%, P < 0.0001) and more than the sum of the monoinfusions ( P < 0.001), demonstrating a synergistic effect. Coinfusion slightly increased sensation of nausea ( P < 0.05), but this effect could not explain the effect on energy intake. A decrease in plasma ghrelin was found after all treatments compared with placebo (all P < 0.05); however, infusions of GLP-1 + PYY3–36 resulted in an additional decrease compared with the monoinfusions (both P < 0.01). We conclude that coinfusion of GLP-1 and PYY3–36 exerted a synergistic effect on energy intake. The satiating effect of the meal was enhanced by GLP-1 and PYY3–36 in combination compared with placebo. Coinfusion was accompanied by slightly increased nausea and a decrease in plasma ghrelin, but neither of these factors could explain the reduction in energy intake.

scholarly journals Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Joanna Moro ◽  
Catherine Chaumontet ◽  
Patrick C. Even ◽  
Anne Blais ◽  
Julien Piedcoq ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Dietary Protein ◽  
Protein Deficiency ◽  
Protein Diet ◽  
Growing Rats ◽  
Low Protein ◽  
Protein Diets

AbstractTo study, in young growing rats, the consequences of different levels of dietary protein deficiency on food intake, body weight, body composition, and energy balance and to assess the role of FGF21 in the adaptation to a low protein diet. Thirty-six weanling rats were fed diets containing 3%, 5%, 8%, 12%, 15% and 20% protein for three weeks. Body weight, food intake, energy expenditure and metabolic parameters were followed throughout this period. The very low-protein diets (3% and 5%) induced a large decrease in body weight gain and an increase in energy intake relative to body mass. No gain in fat mass was observed because energy expenditure increased in proportion to energy intake. As expected, Fgf21 expression in the liver and plasma FGF21 increased with low-protein diets, but Fgf21 expression in the hypothalamus decreased. Under low protein diets (3% and 5%), the increase in liver Fgf21 and the decrease of Fgf21 in the hypothalamus induced an increase in energy expenditure and the decrease in the satiety signal responsible for hyperphagia. Our results highlight that when dietary protein decreases below 8%, the liver detects the low protein diet and responds by activating synthesis and secretion of FGF21 in order to activate an endocrine signal that induces metabolic adaptation. The hypothalamus, in comparison, responds to protein deficiency when dietary protein decreases below 5%.

scholarly journals Resting Energy Expenditure and Cold Induced Thermogenesis in Patients with Overt Hyperthyroidism

2021 ◽  
Author(s):  
Claudia Irene Maushart ◽  
Jaël Rut Senn ◽  
Rahel Catherina Loeliger ◽  
Judith Siegenthaler ◽  
Fabienne Bur ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Skin Temperature ◽  
Cold Exposure ◽  
Resting Energy Expenditure ◽  
Free T4 ◽  
Free T3 ◽  
Euthyroid State ◽  
Overt Hyperthyroidism ◽  
Resting Energy

Abstract Context Thyroid hormone is crucial for the adaptation to cold. Objective To evaluate the effect of hyperthyroidism on resting energy expenditure (REE), cold-induced thermogenesis (CIT) and changes in body composition and weight. Design Prospective cohort study. Setting Endocrine outpatient clinic at tertiary referral center. Patients Eighteen patients with overt hyperthyroidism. Main Outcome Measures We measured REE during hyperthyroidism, after restoring euthyroid TH levels and after 3 months of normal thyroid function. In fourteen patients energy expenditure (EE) was measured before and after a mild cold exposure of two hours and CIT was the difference between EEcold and EEwarm. Skin temperatures at eight positions were recorded during the study visits. Body composition was assessed by dual X-ray absorption. Results Free T4 (fT4) and free T3 (fT3) decreased significantly over time (fT4, p=0.0003; fT3, p=0.0001). REE corrected for lean body mass (LBM) decreased from 42 ± 6.7 kcal/24h/kg LBM in the hyperthyroid to 33±4.4 kcal/24h/kg LBM (-21%, p&lt;0.0001 vs hyperthyroid) in the euthyroid state and three months later to 33 ± 5.2 kcal/24h/kg LBM (-21%, p=0.0022 vs. hyperthyroid, overall p&lt;0.0001). Free T4 (p=0.0001) and free T3 (p&lt;0.0001) were predictors of REE. CIT did not change from the hyperthyroid to the euthyroid state (p=0.96). Hyperthyroidism led to increased skin temperature at warm ambient conditions but did not alter core body temperature, nor skin temperature after cold exposure. Weight regain and body composition were not influenced by REE and CIT during the hyperthyroid state. Conclusions CIT is not increased in patients with overt hyperthyroidism.

Nutrition: Macronutrient metabolism

2020 ◽  
pp. 1839-1854
Author(s):  
Keith N. Frayn ◽  
Rhys D. Evans
Keyword(s):  
Amino Acids ◽  
Food Intake ◽  
Energy Expenditure ◽  
Complex Systems ◽  
Metabolic Control ◽  
Energy Intake ◽  
Energy Supply ◽  
The Body ◽  
Daily Lives ◽  
Storage Pools

Food intake is sporadic and, in many cultures, occurs in three daily boluses. At the same time, energy expenditure is continuous and can vary to a large extent independently of the pattern of energy intake, although fixed or predictable demands (e.g. through occupation) means that in most persons food intake and energy expenditure are soon balanced. The body has developed complex systems that direct excess nutrients into storage pools; as they are needed, they also regulate the mobilization of nutrients from these pools. Carbohydrate, lipid, and protein (the latter a source of amino acids) are the three types of energy supply that are stored variably and assimilated from food each day. That we can carry on our daily lives without thinking about whether to store or mobilize fuels, and which to use, attests to the remarkable efficiency and refinement of these systems of metabolic control.

Effect of heat acclimatization on artificial and natural cold acclimatization in man

1962 ◽  
Vol 17 (5) ◽  
pp. 751-753 ◽  
Author(s):  
T. R. A. Davis
Keyword(s):  
Skin Temperature ◽  
Rectal Temperature ◽  
Cold Exposure ◽  
Technical Assistance ◽  
Heat Exposure ◽  
Heat Acclimatization ◽  
Response Measurement ◽  
Cold Response ◽  
Cold Acclimatization ◽  
Chamber Temperature

The seasonal changes in oxygen consumption, rectal temperature, and skin temperature in response to a 1-hr nude exposure to 14.1 C were measured once monthly in six subjects between October and February. The same measurements were obtained in another group nude exposed 8 hr daily to a chamber temperature of 13.5 C. Shivering decreased as a result of the seasonal and chamber cold exposure ( P < 0.01). Heat production also decreased as a result of both types of exposure ( P < 0.05) but never decreased to basal values. Skin temperature in the seasonal group exhibited no change, whereas a small fall occurred in the chamber group ( P < 0.05). Although no rectal temperature change was demonstrated in the seasonal group, there was a significant fall in the rectal temperature in the chamber group. After the period of chamber and seasonal cold acclimatization, both groups were subjected to 21 days of heat acclimatization followed by another cold-response measurement. In both groups the changes induced by winter exposure and chamber exposure were not influenced by heat exposure. Since previous studies have demonstrated the lack of influence of cold exposure on heat acclimatization, it is concluded that heat and cold acclimatization are not mutually exclusive and can exist simultaneously in man. Note: (With the Technical Assistance of D. R. Johnston, F. W. Jacks, and W. Rawlings) Submitted on October 6, 1961

scholarly journals What processes are involved in the appetite response to moderate increases in exercise-induced energy expenditure?

1999 ◽  
Vol 58 (1) ◽  
pp. 107-113 ◽  
Author(s):  
Neil A. King
Keyword(s):  
Food Intake ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Weak Coupling ◽  
Eating Behaviour ◽  
Tight Coupling ◽  
Living Situation ◽  
Energy Value ◽  
Exercise Induced ◽  
Response To Exercise

It is intuitive that an energy deficit induced by exercise induces an automatic increased drive for food (hunger and energy intake). However, the absence of a compensatory increase in energy intake (EI) in response to an exercise-induced increase in energy expenditure (EE) is now well documented. Thus, there is a weak coupling between exercise-induced increases in EE and EI. One paradox related to the phenomenon of a weak coupling between the exercise-induced EE and EI is the observation of a positive relationship between physical activity and food intake in the long-term free-living situation (i.e. tight coupling between EE and EI). It is possible, therefore, that a period of transition (uncoupling) occurs in the short-term, before a steady-state (coupling) condition is achieved. It is likely that a combination of physiological and behavioural adaptations occur in order to achieve a tight coupling between EE and EI. The precise physiological and behavioural changes that take place to obtain a new equilibrium (i.e. coupling between EE and EI) are still undetermined. The expectation that exercise-induced increases in EE should drive up hunger and food intake tends to be based on the concept of a strong coupling between physiology and behaviour. However, because of the individual's strong volitional control over eating behaviour, the psychological influences on the appetite response to exercise should not be undervalued. The psychological position of the individual (e.g. dietary restraint, food-related cognitions, reasons for exercising) could have a very strong influence on the food intake response to exercise. Misjudgements concerning the energy value of the food (EI) relative to the energy value of the exercise (EE) could be one possibility why exercise fails to be a successful method of weight loss for some individuals.

scholarly journals Effects of Room Temperature, Seasonal Condition and Food Intake on Finger Skin Temperature during Cold Exposure Test for Diagnosing Hand-Arm Vibration Syndrome.

1998 ◽  
Vol 36 (2) ◽  
pp. 166-170 ◽  
Author(s):  
Noriaki HARADA ◽  
Mieko IWAMOTO ◽  
Md Shawkatuzzaman LASKAR ◽  
Iwao HIROSAWA ◽  
Minoru NAKAMOTO ◽  
...  
Keyword(s):  
Food Intake ◽  
Skin Temperature ◽  
Cold Exposure ◽  
Room Temperature ◽  
Finger Skin Temperature ◽  
Vibration Syndrome ◽  
Exposure Test ◽  
Finger Skin

scholarly journals Validation of the Danish 7-day pre-coded food diary among adults: energy intake v. energy expenditure and recording length

2009 ◽  
Vol 102 (12) ◽  
pp. 1838-1846 ◽  
Author(s):  
Anja Biltoft-Jensen ◽  
Jeppe Matthiessen ◽  
Lone B. Rasmussen ◽  
Sisse Fagt ◽  
Margit V. Groth ◽  
...  
Keyword(s):  
Food Intake ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Group Level ◽  
Food Diary ◽  
Dietary Survey ◽  
Limits Of Agreement ◽  
Free Living ◽  
Food Items ◽  
In The Beginning

Under-reporting of energy intake (EI) is a well-known problem when measuring dietary intake in free-living populations. The present study aimed at quantifying misreporting by comparing EI estimated from the Danish pre-coded food diary against energy expenditure (EE) measured with a validated position-and-motion instrument (ActiReg®). Further, the influence of recording length on EI:BMR, percentage consumers, the number of meal occasions and recorded food items per meal was examined. A total of 138 Danish volunteers aged 20–59 years wore the ActiReg® and recorded their food intake for 7 consecutive days. Data for 2504 participants from the National Dietary Survey 2000–2 were used for comparison of characteristics and recording length. The results showed that EI was underestimated by 12 % on average compared with EE measured by ActiReg® (PreMed AS, Oslo, Norway). The 95 % limits of agreement for EI and EE were − 6·29 and 3·09 MJ/d. Of the participants, 73 % were classified as acceptable reporters, 26 % as under-reporters and 1 % as over-reporters. EI:BMR was significantly lower on 1–3 consecutive recording days compared with 4–7 recording days (P < 0·03). Percentage consumers of selected food items increased with number of recording days. When recording length was 7 d, the number of reported food items per meal differed between acceptable reporters and under-reporters. EI:BMR was the same on 4 and 7 consecutive recording days. This was, however, a result of under-reporting in the beginning and the end of the 7 d reporting. Together, the results indicate that EI was underestimated at group level and that a 7 d recording is preferable to a 4 d recording period.

Sign in / Sign up

Export Citation Format

Share Document