scholarly journals Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women

2007 ◽  
Vol 157 (3) ◽  
pp. 303-310 ◽  
Author(s):  
Mònica Bulló ◽  
Muhammad R Peeraully ◽  
Paul Trayhurn ◽  
J Folch ◽  
Jordi Salas-Salvadó
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Nerve Growth Factor ◽  
Inflammatory Markers ◽  
Normal Weight ◽  
Morbidly Obese ◽  
The Metabolic Syndrome ◽  
Obese Subjects

Objective: Neurotrophins (NTs) could be involved in the development and progression of inflammatory and immune diseases. Because obesity and the metabolic syndrome (MetSyn) are related to a low-grade systemic inflammation, plasma NT levels (neurotrophinemia) could play an important role in the ethiopathogenic mechanisms underlying these metabolic derangements. This is the first study evaluating the plasma NT levels in a group of women with obesity and MetSyn, and also the adipose tissue nerve growth factor (NGF) expression in a small group of them. Methods: Included were 146 adult women with different degrees of adiposity, with or without MetSyn. Plasma NT levels were measured. NGF expression was analyzed in s.c. adipose tissue of a subgroup of morbidly obese and normal-weight females. Results: NGF plasma levels were 1.4-fold higher in overweight and obese subjects. Plasma NGF was, however, lower in a group of morbidly obese subjects than in overweight or obesity, but it remained elevated relative to the normal-weight group. Plasma NGF was significantly correlated with body mass index (BMI), percentage body fat, and waist circumference in non-morbidly obese subjects. NGF was positively related to inflammatory markers. NT3 and brain-derived neurotrophin factor seem to be more related to lipid profile than to BMI, adipose tissue distribution, or peripheral inflammatory markers. Subjects with type 2 diabetes, abdominal fat distribution, or the MetSyn showed significantly higher levels of NGF. The MetSyn was the only independent predictor of the variability observed in the NGF plasma values. Conclusion: NGF is upregulated in obesity, type 2 diabetes, and the MetSyn. Whether this NT may contribute to inflammation and the metabolic derangements associated with body weight gain remains to be elucidated.

Type 2 Diabetes Mellitus and the Metabolic Syndrome Following Sleeve Gastrectomy in Severely Obese Subjects

2008 ◽  
Vol 18 (9) ◽  
pp. 1077-1082 ◽  
Author(s):  
J. Vidal ◽  
A. Ibarzabal ◽  
F. Romero ◽  
S. Delgado ◽  
D. Momblán ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Sleeve Gastrectomy ◽  
The Metabolic Syndrome ◽  
Severely Obese ◽  
Obese Subjects

scholarly journals SIALIC ACID AS A PREDICTOR OF TYPE 2 DIABETES MELLITUS

2008 ◽  
Vol 15 (02) ◽  
pp. 273-280
Author(s):  
M. USMAN KHURSHID ◽  
IBRAHIM US
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Sialic Acid ◽  
Inflammatory Markers ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Glucose Levels ◽  
The Metabolic Syndrome

Inflammatory markers predict type 2 diabetes. Gestational Diabetes Mellitus(GDM) predicts type 2 diabetes. Objective: To examine the association of inflammatory markers with GDM, weinvestigated total sialic acid (TSA) in women with and without previous GDM.Design & methods:All women with GDMand a random sample of women from diabetic center of SirGanga Ram Hospital, Lahore were taken after an interview,an oral glucose tolerance test and anthropometry were performed. A total of 46 women with and 50 women withoutprevious GDM completed the protocol. Results: Mean TSA was significantly higher in women with (71.8±11.1 mg/dl)than without (67.5±9.8 mg/dl) previous GDM (P< 0.05). In a linear regression model, TSA was 4 mg/dl (P< 0.05) higherin women with previous GDM, after adjustment for BMI and fasting insulin sensitivity. In a similar model, current 2-hplasma glucose levels were associated with higher TSA levels after adjustment for waist-to-hip ratio and the log oftriglycerides. TSA was strongly correlated with individual components and aggregates (r = 0.55, P< 0.001) of themetabolic syndrome. Conclusions: Increased TSA levels are associated with previous GDM and are strongly linkedto the metabolic syndrome. These findings in young women suggest that a chronic mild systemic inflammatory responseis an early feature of the metabolic syndrome and that GDM may be a window for its investigation.

scholarly journals The Metabolic Syndrome in Overweight Hispanic Youth and the Role of Insulin Sensitivity

2004 ◽  
Vol 89 (1) ◽  
pp. 108-113 ◽  
Author(s):  
Martha L. Cruz ◽  
Marc J. Weigensberg ◽  
Terry T.-K. Huang ◽  
Geoff Ball ◽  
Gabriel Q. Shaibi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Family History ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Hdl Cholesterol ◽  
Hispanic Youth ◽  
The Metabolic Syndrome

The prevalence of the metabolic syndrome is highest among Hispanic adults. However, studies exploring the metabolic syndrome in overweight Hispanic youth are lacking. Subjects were 126 overweight children (8–13 yr of age) with a family history for type 2 diabetes. The metabolic syndrome was defined as having at least three of the following: abdominal obesity, low high-density lipoprotein (HDL) cholesterol, hypertriglyceridemia, hypertension, and/or impaired glucose tolerance. Insulin sensitivity was determined by the frequently sampled iv glucose tolerance test and minimal modeling. The prevalence of abdominal obesity, low HDL cholesterol, hypertriglyceridemia, systolic and diastolic hypertension, and impaired glucose tolerance was 62, 67, 26, 22, 4, and 27%, respectively. The presence of zero, one, two, or three or more features of the metabolic syndrome was 9, 22, 38, and 30%, respectively. After controlling for body composition, insulin sensitivity was positively related to HDL cholesterol (P &lt; 0.01) and negatively related to triglycerides (P &lt; 0.001) and systolic (P &lt; 0.01) and diastolic blood pressure (P &lt; 0.05). Insulin sensitivity significantly decreased (P &lt; 0.001) as the number of features of the metabolic syndrome increased. In conclusion, overweight Hispanic youth with a family history for type 2 diabetes are at increased risk for cardiovascular disease and type 2 diabetes, and this appears to be due to decreased insulin sensitivity. Improving insulin resistance may be crucial for the prevention of chronic disease in this at-risk population.

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